The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Sleep restriction increases the neuronal response to unhealthy food in normal-weight individuals
Open accessAbstract
Context Sleep restriction alters responses to food. However, the underlying neural mechanisms for this effect are not well understood.Objective The purpose of this study was to determine whether there is a neural system that is preferentially activated in response to unhealthy compared with healthy foods.Participants Twenty-five normal-weight individuals, who normally slept 7-9 h per night, completed both phases of this randomized controlled study.Intervention Each participant was tested after a period of five nights of either 4 or 9 h in bed. Functional magnetic resonance imaging (fMRI) was performed in the fasted state, presenting healthy and unhealthy food stimuli and objects in a block design. Neuronal responses to unhealthy, relative to healthy food stimuli after each sleep period were assessed and compared.Results After a period of restricted sleep, viewing unhealthy foods led to greater activation in the superior and middle temporal gyri, middle and superior frontal gyri, left inferior parietal lobule, orbitofrontal cortex, and right insula compared with healthy foods. These same stimuli presented after a period of habitual sleep did not produce marked activity patterns specific to unhealthy foods. Further, food intake during restricted sleep increased in association with a relative decrease in brain oxygenation level-dependent (BOLD) activity observed in the right insula.Conclusion This inverse relationship between insula activity and food intake and enhanced activation in brain reward and food-sensitive centers in response to unhealthy foods provides a model of neuronal mechanisms relating short sleep duration to obesity.
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“Neuroimaging studies have highlighted a role of the neuronal reward network in response to foods as an attempt to explain enhanced food intake after periods of sleep restriction.75–77”
From Sleep Duration and Quality: Impact on Lifestyle Behaviors and Cardiometabolic Health: A Scientific Statement From the American Heart Association (2016) · cites this paper as [76]
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Research works printed but not linked: 2
- St-Onge M-P, McReynolds A, Trivedi Z, Roberts A, Sy M, Hirsch J . Sleep restriction leads to increased activation of brain regions sensitive to food stimuli. Am J Clin Nutr 2012; 95: 818–824. · DOI · Paper page
- St-Onge MP, Roberts AL, Chen J, Kelleman M, O'Keeffe M, RoyChoudhury A et al. Short sleep duration increases energy intakes but does not change energy expenditure in normal-weight individuals. Am J Clin Nutr 2011; 94: 410–416. · DOI · Paper page
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St-Onge, M.-P., Grandner, M. A., Brown, D., Conroy, M. B., Jean-Louis, G., Coons, M., & Bhatt, D. L. (2016) · Circulation · doi:10.1161/cir.0000000000000444 · Cited by 1,044
Self-citationPanel, C. C., Watson, N. F., Badr, M. S., Belenky, G., Bliwise, D. L., Buxton, O. M., Buysse, D., Dinges, D. F., Gangwisch, J., Grandner, M. A., et al. (2015) · Sleep · doi:10.5665/sleep.4886 · Cited by 906
Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures
Potter, G. D., Skene, D. J., Arendt, J., Cade, J. E., Grant, P. J., & Hardie, L. J. (2016) · Endocrine Reviews · doi:10.1210/er.2016-1083 · Cited by 781
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Chaput, J., McHill, A. W., Cox, R. C., Broussard, J. L., Dutil, C., da Costa, B. G. G., Sampasa‐Kanyinga, H., & Wright, K. P. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00747-7 · Cited by 733
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Reutrakul, S., & Van Cauter, E. (2018) · Metabolism · doi:10.1016/j.metabol.2018.02.010 · Cited by 584
Metadata
- Authors
- St-Onge, M.-P., Wolfe, S., Sy, M., Shechter, A., & Hirsch, J.
- Affiliations
- St. Luke's-Roosevelt Hospital Center (US)
- Columbia University (US)
- ORCID
- Shechter, A
- Venue
- International Journal of Obesity
- Published
- 2013-06-19
- Volume
- 38
- Issue
- 3
- Pages
- 411-416
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- PMC
- PMC3883872
- OpenAlex
- W1986570905
- Cited by
- 229
- References
- 45
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 13 · 2023: 19 · 2022: 15 · 2021: 16 · 2020: 22 · 2019: 30 · 2018: 19 · 2017: 23 · 2016: 20 · 2015: 15 · 2014: 10 · 2013: 5
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL091352)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK026687, T32DK007559)
- National Center for Research Resources (UL1RR024156, M01RR000032)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- sleep restriction, unhealthy food, food reward, insula, orbitofrontal cortex, temporal cortex, dietary intake, obesity, short sleep duration, normal-weight individuals, cerebral oxygenation
- MeSH terms
- Adult, Appetite, Brain, Brain Mapping, Cues, Eating, Fasting, Female, Food, Humans, Hunger, Magnetic Resonance Imaging, Male, Photic Stimulation, Reward, Sleep Deprivation
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