Sleep restriction leads to increased activation of brain regions sensitive to food stimuli
Open accessAbstract
Background Epidemiologic evidence shows an increase in obesity concurrent with a reduction in average sleep duration among Americans. Although clinical studies propose that restricted sleep affects hormones related to appetite, neuronal activity in response to food stimuli after restricted and habitual sleep has not been investigated.Objective The objective of this study was to determine the effects of partial sleep restriction on neuronal activation in response to food stimuli.Design Thirty healthy, normal-weight [BMI (in kg/m²): 22-26] men and women were recruited (26 completed) to participate in a 2-phase inpatient crossover study in which they spent either 4 h/night (restricted sleep) or 9 h/night (habitual sleep) in bed. Each phase lasted 6 d, and functional magnetic resonance imaging was performed in the fasted state on day 6.Results Overall neuronal activity in response to food stimuli was greater after restricted sleep than after habitual sleep. In addition, a relative increase in brain activity in areas associated with reward, including the putamen, nucleus accumbens, thalamus, insula, and prefrontal cortex in response to food stimuli, was observed.Conclusion The findings of this study link restricted sleep and susceptibility to food stimuli and are consistent with the notion that reduced sleep may lead to greater propensity to overeat.
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Neuroimaging studies highlight a role of the neuronal reward network in response to foods as an explanation for enhanced food intake after sleep restriction.
“Neuroimaging studies have highlighted a role of the neuronal reward network in response to foods as an attempt to explain enhanced food intake after periods of sleep restriction.75–77”
From Sleep Duration and Quality: Impact on Lifestyle Behaviors and Cardiometabolic Health: A Scientific Statement From the American Heart Association (2016) · cites this paper as [75]
Overall neuronal activity measured by fMRI in response to food stimuli was greater after sleep restriction than habitual sleep.
“The overall neuronal activity measured by fMRI in response to food stimuli was greater after sleep restriction than habitual sleep.”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [61]
Areas of brain with increased neuronal activity after sleep deprivation were associated with reward centers.
“The areas of brain with increased neuronal activity after sleep deprivation were associated with reward centers.”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [61]
Total sleep deprivation and partial sleep deprivation lead to greater stimulation of brain regions in response to hedonic food stimuli.
“TSD [60] and PSD [61] lead to greater stimulation of brain regions in response to hedonic food stimuli.”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [61]
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- Authors
- St-Onge, M.-P., McReynolds, A., Trivedi, Z. B., Roberts, A. L., Sy, M., & Hirsch, J.
- Corresponding author
- Sy, Melissa
- ORCID
- McReynolds, Andrew
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 95
- Issue
- 4
- Pages
- 818-824
- ISSN
- 0002-9165 (ISSN-L)
- PMC
- PMC3302360
- OpenAlex
- W2140054916
- Cited by
- 277
- References
- 41
- Citations by year
- 2026: 2 · 2025: 20 · 2024: 18 · 2023: 18 · 2022: 21 · 2021: 16 · 2020: 21 · 2019: 29 · 2018: 15 · 2017: 17 · 2016: 20 · 2015: 20 · 2014: 26 · 2013: 26 · 2012: 7
- FWCI
- 12.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR000040)
- National Heart, Lung, and Blood Institute (R01HL091352)
- National Center for Research Resources (UL1RR024156)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- sleep restriction, food stimuli, food reward, brain activation, appetite, obesity, putamen, nucleus accumbens, thalamus, insula, prefrontal cortex, overeating, sleep duration
- MeSH terms
- Adult, Female, Food, Humans, Magnetic Resonance Imaging, Male, Neurons, New York City, Organ Specificity, Reward, Sleep Deprivation, Prosencephalon, Cross-Over Studies, Overnutrition
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