The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Impacts of anthropogenic activity on the ecology of class 1 integrons and integron-associated genes in the environment
Open accessAbstract
The impact of human activity on the selection for antibiotic resistance in the environment is largely unknown, although considerable amounts of antibiotics are introduced through domestic wastewater and farm animal waste. Selection for resistance may occur by exposure to antibiotic residues or by co-selection for mobile genetic elements (MGEs) which carry genes of varying activity. Class 1 integrons are genetic elements that carry antibiotic and quaternary ammonium compound (QAC) resistance genes that confer resistance to detergents and biocides. This study aimed to investigate the prevalence and diversity of class 1 integron and integron-associated QAC resistance genes in bacteria associated with industrial waste, sewage sludge and pig slurry. We show that prevalence of class 1 integrons is higher in bacteria exposed to detergents and/or antibiotic residues, specifically in sewage sludge and pig slurry compared with agricultural soils to which these waste products are amended. We also show that QAC resistance genes are more prevalent in the presence of detergents. Studies of class 1 integron prevalence in sewage sludge amended soil showed measurable differences compared with controls. Insertion sequence elements were discovered in integrons from QAC contaminated sediment, acting as powerful promoters likely to upregulate cassette gene expression. On the basis of this data, >1 × 1019 bacteria carrying class 1 integrons enter the United Kingdom environment by disposal of sewage sludge each year.
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Citations
Cites
The spread of CTX-M-type extended-spectrum β-lactamases
Rossolini, G. M., D'Andrea, M. M., & Mugnaioli, C. (2008) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2007.01867.x · Cited by 487
Cited by
Rizzo, L., Manaia, C., Merlin, C., Schwartz, T., Dagot, C., Ploy, M. C., Michael, I., & Fatta-Kassinos, D. (2013) · Science of The Total Environment · doi:10.1016/j.scitotenv.2013.01.032 · Cited by 2,493
Environmental factors influencing the development and spread of antibiotic resistance
Bengtsson-Palme, J., Kristiansson, E., & Larsson, D. G. J. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux053 · Cited by 1,167
The Scourge of Antibiotic Resistance: The Important Role of the Environment
Finley, R. L., Collignon, P., Larsson, D. G. J., McEwen, S. A., Li, X.-Z., Gaze, W. H., Reid-Smith, R., Timinouni, M., Graham, D. W., & Topp, E. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit355 · Cited by 636
Self-citationMicrobial hitchhikers harbouring antimicrobial-resistance genes in the riverine plastisphere
Zadjelovic, V., Wright, R. J., Borsetto, C., Quartey, J., Cairns, T. N., Langille, M. G. I., Wellington, E. M. H., & Christie-Oleza, J. A. (2023) · Microbiome · doi:10.1186/s40168-023-01662-3 · Cited by 87
Self-citationImpact of Next-Generation Sequencing Technology in Plant–Microbe Interaction Study
Kumari, A., Sumer, S., Jalan, B., Nongbri, P. L., & Laskar, M. A. (2017) · Microbial Applications Vol.1 · doi:10.1007/978-3-319-52666-9_13 · Cited by 13
Metadata
- Authors
- Gaze, W. H., Zhang, L., Abdouslam, N. A., Hawkey, P. M., Calvo-Bado, L., Royle, J., Brown, H., Davis, S., Kay, P., Boxall, A. B. A., & Wellington, E. M. H.
- Venue
- The ISME Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-03-03
- Volume
- 5
- Issue
- 8
- Pages
- 1253-1261
- ISSN
- 1751-7362 (ISSN-L)
- 1751-7370
- OpenAlex
- W2020214312
- Cited by
- 437
- References
- 1
- FWCI
- 14.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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