Environmental factors influencing the development and spread of antibiotic resistance
Open accessAbstract
Antibiotic resistance and its wider implications present us with a growing healthcare crisis. Recent research points to the environment as an important component for the transmission of resistant bacteria and in the emergence of resistant pathogens. However, a deeper understanding of the evolutionary and ecological processes that lead to clinical appearance of resistance genes is still lacking, as is knowledge of environmental dispersal barriers. This calls for better models of how resistance genes evolve, are mobilized, transferred and disseminated in the environment. Here, we attempt to define the ecological and evolutionary environmental factors that contribute to resistance development and transmission. Although mobilization of resistance genes likely occurs continuously, the great majority of such genetic events do not lead to the establishment of novel resistance factors in bacterial populations, unless there is a selection pressure for maintaining them or their fitness costs are negligible. To enable preventative measures it is therefore critical to investigate under what conditions and to what extent environmental selection for resistance takes place. In addition, understanding dispersal barriers is not only key to evaluate risks, but also to prevent resistant pathogens, as well as novel resistance genes, from reaching humans.
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Insufficient drainage infrastructure, common to urban informal settlements, can allow human and animal sewage to pool in low-lying locations resulting in a short dispersal route between environmental reservoirs of resistance and the surrounding population, making dissemination more likely.
“Insufficient drainage infrastructure, which is common to urban informal settlements, can allow human and animal sewage to pool in low-lying locations resulting in a short dispersal route between environmental reservoirs of resistance and the surrounding population, making dissemination more likely 51 .”
From Urban informal settlements as hotspots of antimicrobial resistance and the need to curb environmental transmission. (2020) · cites this paper as [51]
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Experimental — accuracy not yet measuredRaw sewage may contain antibiotic residues at concentrations that can support the horizontal transfer of resistance genes among human pathogens, or theoretically, the mobilization of antibiotic resistance genes from environmental bacteria to human pathogens.
“Raw sewage may contain antibiotic residues (originating from human waste, animal waste, or drug manufacturing effluent) at concentrations that can support the horizontal transfer of resistance genes among human pathogens, or theoretically, the mobilization of antibiotic resistance genes from environmental bacteria to human pathogens (directly or via gut commensals) 51-53 .”
From Urban informal settlements as hotspots of antimicrobial resistance and the need to curb environmental transmission. (2020) · cites this paper as [51]
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- Authors
- Bengtsson-Palme, J., Kristiansson, E., & Larsson, D. G. J.
- Affiliations
- Chalmers University of Technology (SE)
- University of Gothenburg (SE)
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-10-24
- Volume
- 42
- Issue
- 1
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- PMC
- PMC5812547
- OpenAlex
- W2766807003
- Cited by
- 1,167
- References
- 151
- Citations by year
- 2026: 125 · 2025: 156 · 2024: 156 · 2023: 127 · 2022: 164 · 2021: 150 · 2020: 157 · 2019: 94 · 2018: 37 · 2017: 1
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Microbiology Reviews (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Chalmers Research (Chalmers University of Technology) (submittedVersion)
- Funders
- Swedish Research Council (2013-8633, 2015-02492)
- FORMAS (2012-86, 2015-750, 2016-786)
- MISTRA (2004-147)
- Topics
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Keywords
- antibiotic resistance, environmental factors, drug-resistant bacteria, resistance gene dissemination, horizontal gene transfer, environmental selection pressure, dispersal barriers, ecological factors, fitness cost of resistance
- MeSH terms
- Drug Resistance, Microbial, Environment, Bacterial Physiological Phenomena, Evolution, Molecular
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