The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution
Open accessAbstract
Around all human activity, there are zones of pollution with pesticides, heavy metals, pharmaceuticals, personal care products and the microorganisms associated with human waste streams and agriculture. This diversity of pollutants, whose concentration varies spatially and temporally, is a major challenge for monitoring. Here, we suggest that the relative abundance of the clinical class 1 integron-integrase gene, intI1, is a good proxy for pollution because: (1) intI1 is linked to genes conferring resistance to antibiotics, disinfectants and heavy metals; (2) it is found in a wide variety of pathogenic and nonpathogenic bacteria; (3) its abundance can change rapidly because its host cells can have rapid generation times and it can move between bacteria by horizontal gene transfer; and (4) a single DNA sequence variant of intI1 is now found on a wide diversity of xenogenetic elements, these being complex mosaic DNA elements fixed through the agency of human selection. Here we review the literature examining the relationship between anthropogenic impacts and the abundance of intI1, and outline an approach by which intI1 could serve as a proxy for anthropogenic pollution.
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Cites
Planetary Boundaries: Exploring the Safe Operating Space for Humanity
Rockström, J., Steffen, W., Noone, K., Persson, Å., Chapin, F. S. I., Lambin, E., Lenton, T. M., Scheffer, M., Folke, C., Schellnhuber, H. J., et al. (2009) · Ecology and Society · doi:10.5751/es-03180-140232 · Cited by 7,187
Sampling the Antibiotic Resistome
D'Costa, V. M., McGrann, K. M., Hughes, D. W., & Wright, G. D. (2006) · Science · doi:10.1126/science.1120800 · Cited by 1,594
Hegstad, K., Langsrud, S., Lunestad, B. T., Scheie, A. A., Sunde, M., & Yazdankhah, S. P. (2010) · Microbial Drug Resistance · doi:10.1089/mdr.2009.0120 · Cited by 396 · cited 5×
“…Review Shows co-selection of antibiotic and heavy metal resistance Seiler and Berendonk (2012) Diverse Various Review Shows co-selection of antibiotic and disinfectant resistance Hegstad et al. (2010) Abbreviations: Ab, antibiotic; intI2, class 2 integron-integrase gene; qPCR, quantitative PCR.”
BackgroundInfluential
Cited by
Antibiotic resistance in the environment
Larsson, D. G. J., & Flach, C.-F. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00649-x · Cited by 3,164
Karkman, A., Pärnänen, K., & Larsson, D. G. J. (2019) · Nature Communications · doi:10.1038/s41467-018-07992-3 · Cited by 628
Co-occurrence of antibiotic and metal resistance genes revealed in complete genome collection
Li, L.-G., Xia, Y., & Zhang, T. (2017) · The ISME Journal · doi:10.1038/ismej.2016.155 · Cited by 528
Ortúzar, M., Esterhuizen, M., Olicón-Hernández, D. R., González-López, J., & Aranda, E. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.869332 · Cited by 425
Zhao, R., Feng, J., Liu, J., Fu, W., Li, X., & Li, B. (2019) · Water Research · doi:10.1016/j.watres.2018.12.034 · Cited by 383
Metadata
- Authors
- Gillings, M. R., Gaze, W. H., Pruden, A., Smalla, K., Tiedje, J. M., & Zhu, Y.-G.
- Venue
- The ISME Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-12-12
- Volume
- 9
- Issue
- 6
- Pages
- 1269-1279
- ISSN
- 1751-7362 (ISSN-L)
- 1751-7370
- OpenAlex
- W2050116248
- Cited by
- 1,331
- References
- 3
- FWCI
- 31.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
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