The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Specialized microbial metabolites: functions and origins
Abstract
The period from 1950 to date brought about a revolution in the pharmaceutical industry: the use of large-scale fermentation methods to produce drugs (mostly antibiotics). The industrial modification of natural biosynthetic processes led to production methods capable of generating massive amounts of therapeutic agents. Natural products became industrial products. This transition took place in complete absence of any knowledge of the roles and functions of small molecules in nature. This discourse attempts to redirect enquiry into the natural roles of these molecules and the ways in which they regulate microbial populations.
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Definitions of secondary metabolites are inherently diffuse.
“Despite the fact that definitions of secondary metabolites are inherently diffuse (Hartmann, 2007;Pichersky and Lewinsohn, 2011;Davies, 2013), the distinction between primary metabolites, secondary metabolites, and plant hormones has found its way into textbooks and shapes our thinking in plant biology to this day.”
From Plant Secondary Metabolites as Defenses, Regulators, and Primary Metabolites: The Blurred Functional Trichotomy (2020) · cites this paper as Davies, 2013
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Cites
TLR13 Recognizes Bacterial 23 S rRNA Devoid of Erythromycin Resistance–Forming Modification
Oldenburg, M., Krüger, A., Ferstl, R., Kaufmann, A., Nees, G., Sigmund, A., Bathke, B., Lauterbach, H., Suter, M., Dreher, S., et al. (2012) · Science · doi:10.1126/science.1220363 · Cited by 405
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Research works printed but not linked: 14
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- Schreiber, S. L. Small molecules: the missing link in the central dogma. Nat. Chem. Biol. 1, 64–66 (2005). · DOI · Paper page
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- Khokhlov, K. S. et al. The A-factor, responsible for streptomycin biosynthesis by mutant strains of Actinomyces streptomycini. Dokl. Akad. Nauk. SSSR. 177, 232–235 (1967).
- Yim, G., Wang, H. H. & Davies, J. Antibiotics as signaling molecules. Phil. Trans. R. Soc. B 362, 1195–1200 (2007). · DOI
- Walsh, C. T. & Fischbach, M. A. Natural products version 2.0: connecting genes to molecules. J. Am. Chem. Soc. 132, 2469–2493 (2010). · DOI
- Bentley, S. D. et al. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417, 141–147 (2002). · DOI
- Sanchez, J. F., Somoza, A. D., Keller, N. P. & Wang, C. C. Advances in Aspergillus secondary metabolite research in the post-genomic era. Nat. Prod. Rep. 29, 351–371 (2012). · DOI
- Price-Whelan, A., Dietrich, L. E. & Newman, D. K. Rethinking 'secondary' metabolism: physiological roles for phenazine antibiotics. Nat. Chem. Biol. 2, 71–78 (2006). · DOI
- Baltz, R. H. Genomics and the ancient origins of the daptomycin biosynthetic gene cluster. J. Antibiot. (Tokyo) 63, 506–511 (2010). · DOI
- Davies, J. What are antibiotics? Archaic functions for modern activities. Mol. Microbiol 41, 227–1232 (1990).
- Belin, P. et al. The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways. Nat. Prod. Rep 29, 961–979 (2012). · DOI
- Li, J. et al. Lactobacillus reuteri-produced cyclic dipeptides quench agr-mediated expression of toxic shock syndrome toxin-1 in staphylococci. Proc. Natl Acad. Sci. USA 108, 3360–3365 (2011). · DOI
Cited by
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Erb, M., & Kliebenstein, D. J. (2020) · Plant Physiology · doi:10.1104/pp.20.00433 · Cited by 1,333
Metadata
- Authors
- Davies, J.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Davies, Julian
- ORCID
- Davies, Julian
- Venue
- The Journal of Antibiotics
- Published
- 2013-06-12
- Volume
- 66
- Issue
- 7
- Pages
- 361-364
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W2028158620
- Cited by
- 177
- References
- 1
- Citations by year
- 2026: 6 · 2025: 18 · 2024: 17 · 2023: 16 · 2022: 17 · 2021: 16 · 2020: 9 · 2019: 25 · 2018: 8 · 2017: 12 · 2016: 14 · 2015: 12 · 2014: 7
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- The Journal of Antibiotics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- microbial metabolites, natural products, antibiotic biosynthesis, industrial fermentation
- MeSH terms
- Anti-Bacterial Agents, Bacteria, Biological Products, Industrial Microbiology, Bacterial Physiological Phenomena
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