Small molecules: the missing link in the central dogma
Abstract
Small molecules have critical roles at all levels of biological complexity and yet remain orphans of the central dogma. Chemical biologists, working with small molecules, expand our understanding of these central elements of life.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Small molecular interactions are critical for biological regulation in both intracellular processes and cell-to-cell communications, up to the even broader coordination between organs in an organism.
“Additionally, small molecular interactions are critical for biological regulation in both intracellular processes and cell-to-cell communications, up to the even broader coordination between organs in an organism (Schreiber, 2005).”
From Mapping the multiscale structure of biological systems (2021) · cites this paper as Schreiber, 2005
Cites
The Structure of Haplotype Blocks in the Human Genome
Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M., et al. (2002) · Science · doi:10.1126/science.1069424 · Cited by 5,863 · see citing works
Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665 · see citing works
A Planning Strategy for Diversity‐Oriented Synthesis
Burke, M. D., & Schreiber, S. L. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200300626 · Cited by 1,493 · see citing works
Self-citationLessons from natural molecules
Clardy, J., & Walsh, C. T. (2004) · Nature · doi:10.1038/nature03194 · Cited by 1,178 · see citing works
Haggarty, S. J., Koeller, K. M., Wong, J. C., Grozinger, C. M., & Schreiber, S. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0430973100 · Cited by 1,066 · see citing works
Self-citationMolecular recognition of DNA by small molecules
Dervan, P. B. (2001) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(01)00262-0 · Cited by 905 · see citing works
Wang, L., & Schultz, P. G. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200460627 · Cited by 653 · see citing works
Chemical etiology of nucleic acid structure
Eschenmoser, A. (1999) · Science · doi:10.1126/science.284.5423.2118 · Cited by 611 · see citing works
Li, X., & Liu, D. R. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200400656 · Cited by 538 · see citing works
Exploring biology with small organic molecules
Stockwell, B. R. (2004) · Nature · doi:10.1038/nature03196 · Cited by 473 · see citing works
Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays
Kuruvilla, F. G., Shamji, A. F., Sternson, S. M., Hergenrother, P. J., & Schreiber, S. L. (2002) · Nature · doi:10.1038/416653a · Cited by 368 · see citing works
Self-citationPerturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
Ramanathan, A., Wang, C., & Schreiber, S. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502267102 · Cited by 357 · see citing works
Self-citationGenetic Control by Metabolite‐Binding Riboswitches
Winkler, W. C., & Breaker, R. R. (2003) · ChemBioChem · doi:10.1002/cbic.200300685 · Cited by 294 · see citing works
Biosynthesis of Polyketides in Heterologous Hosts
Pfeifer, B. A., & Khosla, C. (2001) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.65.1.106-118.2001 · Cited by 263 · see citing works
From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule Probes
Strausberg, R. L., & Schreiber, S. L. (2003) · Science · doi:10.1126/science.1083395 · Cited by 260 · see citing works
Self-citationIntegration of Growth Factor and Nutrient Signaling
Shamji, A. F., Nghiem, P., & Schreiber, S. L. (2003) · Molecular Cell · doi:10.1016/j.molcel.2003.08.016 · Cited by 186 · see citing works
Self-citationThree-part inventions: intracellular signaling and induced proximity.
Crabtree, G., & Schreiber, S. L. (1996) · TIBS -Trends in Biochemical Sciences. Regular ed · doi:10.1016/s0968-0004(96)20027-1 · Cited by 135 · see citing works
Self-citationKim, Y.-K., Arai, M. A., Arai, T., Lamenzo, J. O., Dean, E. F., Patterson, N. J., Clemons, P. A., & Schreiber, S. L. (2004) · Journal of the American Chemical Society · doi:10.1021/ja048170p · Cited by 130 · see citing works
Self-citationHaggarty, S. J., Clemons, P. A., & Schreiber, S. L. (2003) · Journal of the American Chemical Society · doi:10.1021/ja035413p · Cited by 61 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Relating protein pharmacology by ligand chemistry
Keiser, M. J., Roth, B. L., Armbruster, B. N., Ernsberger, P., Irwin, J. J., & Shoichet, B. K. (2007) · Nature Biotechnology · doi:10.1038/nbt1284 · Cited by 2,402 · see citing works
Enumeration of 166 Billion Organic Small Molecules in the Chemical Universe Database GDB-17
Ruddigkeit, L., van Deursen, R., Blum, L. C., & Reymond, J.-L. (2012) · Journal of Chemical Information and Modeling · doi:10.1021/ci300415d · Cited by 1,505 · see citing works
Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance.
Cowen, L. E., & Steinbach, W. J. (2008) · Eukaryotic Cell · doi:10.1128/ec.00041-08 · Cited by 285 · see citing works
Guo, B., Chen, B., Liu, A., Zhu, W., & Yao, S. (2012) · Current Drug Metabolism · doi:10.2174/138920012803341401 · Cited by 80 · see citing works
Mapping the multiscale structure of biological systems
Schaffer, L. V., & Ideker, T. (2021) · Cell Systems · doi:10.1016/j.cels.2021.05.012 · Cited by 75 · see citing works
- Authors
- Schreiber, S. L.
- Affiliations
- Broad Institute (US)
- Corresponding author
- Schreiber, Stuart L
- ORCID
- Schreiber, Stuart L
- Venue
- Nature Chemical Biology
- Published
- 2005-07
- Volume
- 1
- Issue
- 2
- Pages
- 64-66
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2169266986
- Cited by
- 306
- References
- 19
- Citations by year
- 2026: 9 · 2025: 3 · 2024: 12 · 2023: 11 · 2022: 5 · 2021: 10 · 2020: 10 · 2019: 5 · 2018: 10 · 2017: 12 · 2016: 12 · 2015: 11 · 2014: 19 · 2013: 16 · 2012: 18
- FWCI
- 14.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Chemical Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Harvard University
- Genome Canada
- Broad Institute
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Click Chemistry and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Keywords
- small molecules, central dogma, chemical biology, biological complexity
- MeSH terms
- Animals, Biochemical Phenomena, Biochemistry, Chemistry, Humans, Models, Biological, Chemical Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
