Bacterial proteases, untapped antimicrobial drug targets

Genes required for mycobacterial growth defined by high density mutagenesis

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Antibacterial drug discovery in the resistance era

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Serine Protease Mechanism and Specificity

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β-Lactams and β-Lactamase Inhibitors: An Overview

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Recent Advances in Zinc Enzymology

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Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases

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Activated ClpP kills persisters and eradicates a chronic biofilm infection

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Antibiotic Adjuvants: Rescuing Antibiotics from Resistance

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Emerging principles in protease-based drug discovery

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The Proteasome of Mycobacterium tuberculosis Is Required for Resistance to Nitric Oxide

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Dysregulation of bacterial proteolytic machinery by a new class of antibiotics

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HIV-1 protease: mechanism and drug discovery

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Signal peptidases.

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Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2

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Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence

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Clp ATPases are required for stress tolerance, intracellular replication and biofilm formation in Staphylococcus aureus

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Crystal structure of a bacterial signal peptidase in complex with a β-lactam inhibitor

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Something old, something new: revisiting natural products in antibiotic drug discovery

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Loss of m-AAA protease in mitochondria causes complex I deficiency and increased sensitivity to oxidative stress in hereditary spastic paraplegia

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The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes

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Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase.

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Anthrax Pathogenesis

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Cyclomarins A−C, New Antiinflammatory Cyclic Peptides Produced by a Marine Bacterium (Streptomyces sp.)

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Sequence and structure of Clp P, the proteolytic component of the ATP-dependent Clp protease of Escherichia coli.

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In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice

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Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects

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Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases

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ClpP of Bacillus subtilis is required for competence development, motility, degradative enzyme synthesis, growth at high temperature and sporulation

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Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

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The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

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Mechanism of action of globomycin.

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Inhibitors selective for mycobacterial versus human proteasomes

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β-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors of <i>Staphylococcus aureus</i>

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Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection

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The Natural Product Cyclomarin Kills Mycobacterium Tuberculosis by Targeting the ClpC1 Subunit of the Caseinolytic Protease

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The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active against Mycobacterium tuberculosis In Vivo

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β‐Lactones as Privileged Structures for the Active‐Site Labeling of Versatile Bacterial Enzyme Classes

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Clp chaperones and proteases are central in stress survival, virulence and antibiotic resistance of Staphylococcus aureus

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Proteases in bacterial pathogenesis

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Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP

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Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase

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Secretion, processing and activation of bacterial extracellular proteases

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Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections

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The ClpC ATPase of Listeria monocytogenes is a general stress protein required for virulence and promoting early bacterial escape from the phagosome of macrophages

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walK and clpP Mutations Confer Reduced Vancomycin Susceptibility in Staphylococcus aureus

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A small-molecule antivirulence agent for treating Clostridium difficile infection

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AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control

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Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin

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Validation of the Essential ClpP Protease in Mycobacterium tuberculosis as a Novel Drug Target

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Structural Basis of Mycobacterial Inhibition by Cyclomarin A

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ClpP: A structurally dynamic protease regulated by AAA+ proteins

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A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome

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Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP

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Activators of Cylindrical Proteases as Antimicrobials: Identification and Development of Small Molecule Activators of ClpP Protease

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Molecular features of the sortase enzyme family

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Staphylococcus aureus ClpC Is Required for Stress Resistance, Aconitase Activity, Growth Recovery, and Death

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Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization

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β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus USA300 Is Increased by Inactivation of the ClpXP Protease

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The ClpP Protease of Streptococcus pneumoniae Modulates Virulence Gene Expression and Protects against Fatal Pneumococcal Challenge

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Bacterial proteolytic complexes as therapeutic targets

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Myxobacterium-Produced Antibiotic TA (Myxovirescin) Inhibits Type II Signal Peptidase

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Medicinal Chemistry Optimization of Acyldepsipeptides of the Enopeptin Class Antibiotics

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Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery

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Total Synthesis of Cyclomarin A, a Marine Cycloheptapeptide with Anti-Tuberculosis and Anti-Malaria Activity

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Restriction of the Conformational Dynamics of the Cyclic Acyldepsipeptide Antibiotics Improves Their Antibacterial Activity

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Bacterial caseinolytic proteases as novel targets for antibacterial treatment

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The Lon Protease Is Essential for Full Virulence in Pseudomonas aeruginosa

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Mitochondrial matrix proteases as novel therapeutic targets in malignancy

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A Complete Pathway Model for Lipid A Biosynthesis in Escherichia coli

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Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I

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Identifying Vulnerable Pathways in Mycobacterium tuberculosis by Using a Knockdown Approach

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Antibacterial Activity of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase

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Insights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) Protein

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Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent

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Oral Immunization with ATP-Dependent Protease-Deficient Mutants Protects Mice against Subsequent Oral Challenge with VirulentSalmonella entericaSerovar Typhimurium

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Additional Routes to Staphylococcus aureus Daptomycin Resistance as Revealed by Comparative Genome Sequencing, Transcriptional Profiling, and Phenotypic Studies

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Distinct Specificities of Mycobacterium tuberculosis and Mammalian Proteasomes for N-Acetyl Tripeptide Substrates

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Stress-Induced ClpP Serine Protease ofListeria monocytogenesIs Essential for Induction of Listeriolysin O-Dependent Protective Immunity

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Inhibitors of Helicobacter pylori Protease HtrA Found by ‘Virtual Ligand’ Screening Combat Bacterial Invasion of Epithelia

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Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity

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Total chemical synthesis of lassomycin and lassomycin-amide

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The LonA Protease Regulates Biofilm Formation, Motility, Virulence, and the Type VI Secretion System in Vibrio cholerae

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Structure–activity relationships of globomycin analogues as antibiotics

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Initial Efforts toward the Optimization of Arylomycins for Antibiotic Activity

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Roles of the membrane-reentrant β-hairpin-like loop of RseP protease in selective substrate cleavage

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Inhibitors of Bacterial Signal Peptidase: A Series of 6-(Substituted oxyethyl)penems.

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A β‐Lactone‐Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice

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