The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Changes in Extracellular Calcium Activity in Cerebral Ischaemia
Open accessAbstract
Changes in extracellular ion activities were measured during partial ischaemia of the cerebral cortex of primates anaesthetised with α-chloralose. Triple-barrelled, double-ion-sensitive microelectrodes were used to measure the extracellular potassium (K e) and calcium (Ca e) activity at the same point simultaneously. The ion changes were related to local cerebral blood flow, and it was shown that at a blood flow of approximately 10 ml 100 g−1 min−1, there is a threshold below which ion homeostasis is disturbed. This is associated with a dramatic rise in K e and fall in Ca e. Ca e falls from a normal value of 1.31 ± 0.1 mm to approximately 0.28 mm in densely ischaemic tissue. In ischaemia, K e reaches 13.4 ± 3.8 mm before Ca e begins to fall. The fall in Ca e, although related to reduced blood flow, is closely associated with and follows the rise in K e. The change in Ca e is probably due to an increase in membrane permeability, as a result of either depolarisation or a critical lowering of cellular energy reserves.
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Cites
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Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia.
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Self-citationDepolarization and calcium entry in squid giant axons
Baker, P. F., Hodgkin, A. L., & Ridgway, E. B. (1971) · The Journal of Physiology · doi:10.1113/jphysiol.1971.sp009641 · Cited by 728
Myocardial calcium and magnesium in acute ischemic injury.
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Self-citationKinetics of calcium accumulation in acute myocardial ischemic injury.
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Further study of the role of calcium in synaptic transmission
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Extracellular ionic variations during spreading depression
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Cited by
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Viability thresholds and the penumbra of focal ischemia
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Calcium in Ischemic Cell Death
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Higgs, M. H., Slee, S. J., & Spain, W. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1792-06.2006 · Cited by 124
Metadata
- Authors
- Harris, R. J., Symon, L., Branston, N. M., & Bayhan, M.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1981-06
- Volume
- 1
- Issue
- 2
- Pages
- 203-209
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2045573157
- Cited by
- 353
- References
- 19
- FWCI
- 17.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Harris, R. J., Symon, L., Branston, N. M., & Bayhan, M. (1981). Changes in Extracellular Calcium Activity in Cerebral Ischaemia. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.1981.21
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
