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Cited by 278

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Influence of Acidosis on Lipid Peroxidation in Brain Tissues in vitro

Siesjö, Bo K., Bendek, George, Koide, Tohru, Westerberg, Eva, Wieloch, Tadeusz·1985·Journal of Cerebral Blood Flow & Metabolism
DOI 10.1038/jcbfm.1985.32
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Abstract

To study the influence of acidosis on free radical formation and lipid peroxidation in brain tissues, homogenates fortified with ferrous ions and, in some experiments, with ascorbic acid were equilibrated with 5–15% O 2 at pH values of 7.0, 6.5, 6.0, and 5.0, with subsequent measurements of thiobarbituric acid-reactive (TBAR) material, as well as of water- and lipid-soluble antioxidants (glutathione, ascorbate, and α-tocopherol) and phospholipid-bound fatty acids (FAs). Moderate to marked acidosis (pH 6.5–6.0) was found to grossly exaggerate the formation of TBAR material and the decrease in α-tocopherol content and to enhance degradation of phospholipid-bound, polyenoic FAs. These effects were reversed at pH 5.0, suggesting a pH optimum at pH 6.0–6.5. It is concluded that acidosis of a degree encountered in ischemic brain tissues has the potential of triggering increased free radical formation. This effect may involve increased formation of the protonated form of superoxide radicals, which is strongly prooxidant and lipid soluble, and/or the decompartmentalization of iron bound to cellular macromolecules like ferritin.

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Metadata

Authors
Siesjö, B. K., Bendek, G., Koide, T., Westerberg, E., & Wieloch, T.
Venue
Journal of Cerebral Blood Flow & Metabolism
Publisher
SAGE Publications
Published
1985-06
Volume
5
Issue
2
Pages
253-258
ISSN
  • 0271-678X (ISSN-L)
  • 1559-7016
DOI
10.1038/jcbfm.1985.32
OpenAlex
W1975273455
Cited by
278
References
30
FWCI
10.92
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Influence of Acidosis on Lipid Peroxidation in Brain Tissues in vitro. https://app.cochat.ai/papers/10.1038/jcbfm.1985.32
The paper
Siesjö, B. K., Bendek, G., Koide, T., Westerberg, E., & Wieloch, T. (1985). Influence of Acidosis on Lipid Peroxidation in Brain Tissues in vitro. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.1985.32

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.