The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Increases in Cerebral Interstitial Fluid Adenosine Concentration during Hypoxia, Local Potassium Infusion, and Ischemia
Abstract
This study used the brain dialysis technique to test the hypothesis that the adenosine concentration of cerebral interstitial fluid increases during situations in which cerebral oxygen supply is inadequate for oxygen demand. Sealed 300-μm hollow dialysis fibers were implanted in the caudate nucleus of pentobarbital-anesthetized rats and perfused at 2 μl/min with artificial cerebrospinal fluid. In vitro tests indicated the recovery of adenosine, inosine, and hypoxanthine from the external medium to be ∼20% at 2 μl/min and close to 100% at 0.1 μl/min. Three in vivo interventions were tested: hypoxia/hypotension (P a o 2 = 41.9 mm Hg; MABP = 42.8 mm Hg; n = 9), local potassium infusion (n = 4), and cerebral anoxia/ischemia (n = 10). These interventions produced 10-, 4-, and 30-fold increases in perfusate adenosine concentration, respectively, as well as increases in perfusate concentrations of inosine and hypoxanthine. A separate group of rats (n = 9) perfused at 0.1 μl/min yielded estimates of cerebral interstitial fluid adenosine, inosine, and hypoxanthine concentrations of 1.26, 3.30, and 7.19 μ M, respectively. These results are consistent with the adenosine hypothesis for the regulation of CBF.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A stereotaxic atlas of the rat brain
Pellegrino, L. J., & Cushman, A. J. (1967) · Plenum Press eBooks · Cited by 4,688
A stereotaxic atlas of the rat brain
Brodal, P. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90013-5 · Cited by 2,782
Hagberg, H., Lehmann, A., Sandberg, M., Nyström, B., Jacobson, I., & Hamberger, A. (1985) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1985.56 · Cited by 660
BERNE, R. M., RUBIO, R., & CURNISH, R. R. (1974) · Circulation Research · doi:10.1161/01.res.35.2.262 · Cited by 513
Self-citationPurine levels in the intact rat brain. Studies with an implanted perfused hollow fibre
Zetterström, T., Vernet, L., Ungerstedt, U., Tossman, U., Jonzon, B., & Fredholm, B. B. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90338-x · Cited by 387
Local chemical and neurogenic regulation of cerebral vascular resistance.
Kuschinsky, W., & Wahl, M. (1978) · Physiological Reviews · doi:10.1152/physrev.1978.58.3.656 · Cited by 344
The Role of Adenosine in the Regulation of Cerebral Blood Flow
Winn, H. R., Rubio, G. R., & Berne, R. M. (1981) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1981.29 · Cited by 233
Self-citationCerebral microcirculation and metabolism
Tindall, S. C. (1982) · Surgical Neurology · doi:10.1016/0090-3019(82)90346-9 · Cited by 227
Lehmann, A., Isacsson, H., & Hamberger, A. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb13572.x · Cited by 215
Brain adenosine production in the rat during 60 seconds of ischemia.
Winn, H. R., Rubio, R., & Berne, R. M. (1979) · Circulation Research · doi:10.1161/01.res.45.4.486 · Cited by 213
Self-citation
Cited by
Adenosine: A Mediator of the Sleep-Inducing Effects of Prolonged Wakefulness
Porkka-Heiskanen, T., Strecker, R. E., Thakkar, M., Bjørkum, A. A., Greene, R. W., & McCarley, R. W. (1997) · Science · doi:10.1126/science.276.5316.1265 · Cited by 1,252
Oxygen radical mechanisms of brain injury following ischemia and reperfusion
Traystman, R. J., Kirsch, J. R., & Koehler, R. C. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.4.1185 · Cited by 653
Cunha, R. A. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(00)00034-6 · Cited by 631
Benveniste, H. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07243.x · Cited by 523
Adenosine receptors and brain diseases: neuroprotection and neurodegeneration
Gomes, C. V., Kaster, M. P., Tomé, A. R., Agostinho, P. M., & Cunha, R. A. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.12.001 · Cited by 419
Metadata
- Authors
- Van Wylen, D. G. L., Park, T. S., Rubio, R., & Berne, R. M.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1986-10
- Volume
- 6
- Issue
- 5
- Pages
- 522-528
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2035047534
- Cited by
- 261
- References
- 21
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Increases in Cerebral Interstitial Fluid Adenosine Concentration during Hypoxia, Local Potassium Infusion, and Ischemia. https://app.cochat.ai/papers/10.1038/jcbfm.1986.97
- The paper
- Van Wylen, D. G. L., Park, T. S., Rubio, R., & Berne, R. M. (1986). Increases in Cerebral Interstitial Fluid Adenosine Concentration during Hypoxia, Local Potassium Infusion, and Ischemia. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.1986.97
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
