The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
The Effect of Hypothermia on Transient Middle Cerebral Artery Occlusion in the Rat
Open accessAbstract
We investigated the effect of moderate whole body hypothermia (30°C) on transient middle cerebral artery occlusion (MCAO) in the rat. Male Wistar rats were subjected to 2 h of ischemia by inserting a suture into the lumen of the internal carotid artery and occluding the origin of the MCA. Experimental groups were (a) MCAO induced at 37°C body temperature ( n = 15); (b) 30°C body temperature induced prior to ischemia and maintained for 2 h of MCAO and 1 h of reperfusion ( n = 12); and (c) MCAO with regional brain and body temperatures measured in normothermic ( n = 3) and hypothermic MCAO rats ( n = 2). Histopathological evaluation was performed 96 h after reperfusion. All normothermic MCAO animals exhibited ischemic infarct involving the ipsilateral cortex and basal ganglia with infiltration of neutrophils, macrophages, and microvascular proliferation. Hypothermic MCAO animals exhibited minor ischemic damage ranging from selective neuronal injury to small focal areas of infarct with minimal inflammatory response. Our data demonstrate that transient ischemia induced by using the intra-arterial suture method to occlude the MCA results in a reproducible brain lesion and that moderate hypothermia has a profound protective effect on the brain injury after transient MCAO.
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Cited by
Chen, J., Li, Y., Wang, L., Zhang, Z., Lu, D., Lu, M., & Chopp, M. (2001) · Stroke · doi:10.1161/01.str.32.4.1005 · Cited by 1,764
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Self-citationChen, J., Li, Y., Katakowski, M., Chen, X., Wang, L., Lu, D., Lu, M., Gautam, S. C., & Chopp, M. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10691 · Cited by 578
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Metadata
- Authors
- Chen, H., Chopp, M., Zhang, Z. G., & Garcia, J. H.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1992-07
- Volume
- 12
- Issue
- 4
- Pages
- 621-628
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W1972155682
- Cited by
- 274
- References
- 19
- FWCI
- 15.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chen, H., Chopp, M., Zhang, Z. G., & Garcia, J. H. (1992). The Effect of Hypothermia on Transient Middle Cerebral Artery Occlusion in the Rat. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.1992.86
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
