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Perivascular Microapplication of Endothelin-1: A New Model of Focal Cerebral Ischaemia in the Rat
Abstract
In the present study, we describe the effects of perivascular microapplication of the potent vasoconstrictor peptide endothelin-1 (Et-1; (120 pmol in 3 μl), delivered via a guide cannula stereotaxically positioned above the left cerebral artery (MCA) of the conscious male Sprague–Dawley rat. Ten minutes after the administration of Et-1, mean arterial blood pressure had increased by 20% and profound reductions in local cerebral blood flow (up to 93%) were observed within those brain areas supplied by the MCA. In addition, significant increases in local cerebral blood flow were observed within the globus pallidus (100%), substantia nigra pars reticulata (48%), ventrolateral thalamus (65%), and dorsal hippocampus (74%) ipsilateral to the insult. Twenty-four hours following the insult, the pattern of ischaemic damage was similar to that reported previously following permanent occlusion of the rat MCA. It is suggested that perivascular microapplication of Et-1 may provide a useful model for the study of the functional disturbances associated with focal cerebral ischaemia in the conscious rat.
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Cited by
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Shih, A. Y., Li, P., & Murphy, T. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4014-05.2005 · Cited by 413
Macrae, I. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01398.x · Cited by 274
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Bailey, E. L., McCulloch, J., Sudlow, C., & Wardlaw, J. M. (2009) · Stroke · doi:10.1161/strokeaha.108.528430 · Cited by 128
Metadata
- Authors
- Sharkey, J.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1993-09
- Volume
- 13
- Issue
- 5
- Pages
- 865-871
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2085901947
- Cited by
- 228
- References
- 0
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Perivascular Microapplication of Endothelin-1: A New Model of Focal Cerebral Ischaemia in the Rat. https://app.cochat.ai/papers/10.1038/jcbfm.1993.108
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- Sharkey, J. (1993). Perivascular Microapplication of Endothelin-1: A New Model of Focal Cerebral Ischaemia in the Rat. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.1993.108
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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