Water-diffusion slowdown in the human visual cortex on visual stimulation precedes vascular responses
Abstract
We used magnetic resonance imaging (MRI) to investigate the temporal dynamics of changes in water diffusion and blood oxygenation level-dependent (BOLD) responses in the brain cortex of eight subjects undergoing visual stimulation, and compared them with changes of the vascular hemoglobin content (oxygenated, deoxygenated, and total hemoglobin) acquired simultaneously from intrinsic optical recordings (near infrared spectroscopy). The group average rise time for the diffusion MRI signal was statistically significantly shorter than those of the BOLD signal and total hemoglobin content optical signal, which is assumed to be the fastest observable vascular signal. In addition, the group average decay time for the diffusion MRI also was shortest. The overall time courses of the BOLD and optical signals were strongly correlated, but the covariance was weaker with the diffusion MRI response. These results suggest that the observed decrease in water diffusion reflects early events that precede the vascular responses, which could originate from changes in the extravascular tissue.
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In human visual cortex, diffusion changes preceded the BOLD response and were closely time locked to stimulation.
“In human visual cortex, these diffusion changes preceded the BOLD response and were closely time locked to stimulation (Darquié et al., 2001; Kohno et al., 2009; Le Bihan et al., 2006).”
From 40 Years of diffusion MRI in the brain: From history to emerging frontiers (2026) · cites this paper as Kohno et al., 2009
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Neurophysiological investigation of the basis of the fMRI signal
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Direct and fast detection of neuronal activation in the human brain with diffusion MRI
Le Bihan, D., Urayama, S.-I., Aso, T., Hanakawa, T., & Fukuyama, H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600644103 · Cited by 272 · see citing works
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40 Years of diffusion MRI in the brain: From history to emerging frontiers
Le Bihan, D. (2026) · Imaging Neuroscience · doi:10.1162/imag.a.1365
“In human visual cortex, these diffusion changes preceded the BOLD response and were closely time locked to stimulation ( Darqui é et al., 2001; Kohno et al., 2009; Le Bihan et al., 2006).”
- Authors
- Kohno, S., Sawamoto, N., Urayama, S.-I., Aso, T., Aso, K., Seiyama, A., Fukuyama, H., & Le Bihan, D.
- Affiliations
- Kyoto University (JP)
- Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
- Corresponding author
- Fukuyama, Hidenao
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2009-04-22
- Volume
- 29
- Issue
- 6
- Pages
- 1197-1207
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2005223471
- Cited by
- 30
- References
- 4
- Citations by year
- 2026: 1 · 2022: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 2
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- water diffusion, diffusion MRI, BOLD signal, visual cortex, visual stimulation, hemoglobin, cerebral blood flow, vascular response, near-infrared spectroscopy, cerebral blood volume
- MeSH terms
- Diffusion, Humans, Photic Stimulation, Time Factors, Visual Cortex, Water
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