Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

Halliday, Matthew R, Rege, Sanket V, Ma, Qingyi, Zhao, Zhen, Miller, Carol A, Winkler, Ethan A, Zlokovic, Berislav V·2016·Journal of Cerebral Blood Flow & Metabolism
DOI 10.1038/jcbfm.2015.44

Cited by (658)

Items 601–658 of 658

  1. Unraveling Alzheimer's disease heterogeneity:
    Eleonora M. Vromen · 2024
  2. Regulation of Cerebral Blood Flow: Response to Cytochrome P450 Lipid Metabolites
    David Rae Harder, Kevin Richard Rarick, Debebe Gebremedhin, Susan S. Cohen · 2018 · Comprehensive physiology
  3. Differential Effects of Huang-Lian-Jie-Du Decoction on Alzheimer's and Normal Rats
    Manru Xu, Yue Zhu, Jinxin Chen, Furong Zhong, Ruoli Wang, Jie Li, Mengyuan Qiao, Yiran Fan, Pan Ren, Mingqi Chen et al. · 2025 · SSRN Electronic Journal
  4. Neurodegenerative diseases and dementia: the role of blood-brain barrier dysfunction (based on recent evidence)
    Oleg Semenovich Levin, З. К. Гехаева · 2025 · The Clinician
  5. Association of APOE ε4 with cerebrospinal fluid protein and amyloid-β 42 levels in Alzheimer's disease
    Renyu Chen, Fang Yuan, Shuai Liu, Hao Wu, Zhihong Shi, Cihan Di, Shiyu Fan, Bing Liang, Yong Ji · 2025 · Journal of Alzheimer s Disease Reports
  6. APOE4-APP interactions exert early influences on cerebrovascular structure and function: implications for Alzheimer’s disease
    Lanboling Guo, Jessica Ruth Gaunt, Calvin Chee Hoe Cheah, Albert I. Chen, Stephanie Claudine, Gavin Stewart Dawe, Eyleen Lay Keow Goh, Sok-Hong Kho, Pawan Kumar, Grace G. Y. Lim et al. · 2025 · Frontiers in Neuroscience
  7. Mural Cells, Microvessels, and Alzheimer’s Disease
    Stephanie K. Bonney, Cara D. Nielson, Andy Y. Shih · 2025 · Physiology in health and disease
  8. The effect of CysLTR1 inhibition on cells of the retinal neurovascular unit in 5xFAD Alzheimer mice
    Daniela Mayr, Julia Preishuber‐Pflügl, Andreas Koller, Susanne Maria Migschitz, Johanna Michael, Barbara Altendorfer, Roland Rabl, David Amschl, Wolfgang Hitzl, Ludwig Aigner et al. · 2025 · Experimental Eye Research
  9. Endothelial-pericyte interactions activate insulin signaling and its implications for blood-brain barrier dysfunction in Alzheimer’s disease
    Zengtao Wang, Vaishnavi Veerareddy, Paulina M. Eberts, Samira M. Azarin, Karunya K. Kandimalla · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  10. NVUAtlas: A Comprehensive Single-Nucleus RNA-Seq Resource for the Human Neurovascular Unit in Alzheimer’s Disease
    Xiaojia Tang, Douglas A. Nelson, Mikel Hernáez, Karunya K. Kandimalla, Krishna R. Kalari · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  11. Additional file 1 of Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer’s disease
    Leon C. D. Smyth, Helen C. Murray, Madison Jean Hill, Eve van Leeuwen, Blake Highet, Nicholas J. Magon, Mahyar Osanlouy, Sophie N. Mathiesen, Mockett, Bruce, Singh-Bains, Malvindar K. et al. · 2022 · Figshare
  12. Additional file 1 of APOE effects on regional tau in preclinical Alzheimer’s disease
    Christina B. Young, Emily Johns, Gabriel Kennedy, Michaël E. Belloy, Philip S. Insel, Michael D. Greicius, Reisa Anne Sperling, Keith A. Johnson, Kathleen L. Poston, Elizabeth C. Mormino · 2023 · Figshare
  13. Additional file 7 of Single-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer’s disease
    Xie, Jieqiong, Lan, Yating, Cuihua Zou, He, Jingfeng, Huang, Qi, Zeng, Jingyi, Mika Pan, Mei, Yujia, Luo, Jiefeng, Zou, Donghua · 2024 · Figshare
  14. Additional file 1 of Single-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer’s disease
    Jieqiong Xie, Lan, Yating, Cuihua Zou, He, Jingfeng, Huang, Qi, Zeng, Jingyi, Mika Pan, Mei, Yujia, Luo, Jiefeng, Zou, Donghua · 2024 · Figshare
  15. Additional file 9 of Single-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer’s disease
    Xie, Jieqiong, Lan, Yating, Cuihua Zou, He, Jingfeng, Huang, Qi, Zeng, Jingyi, Mika Pan, Mei, Yujia, Luo, Jiefeng, Zou, Donghua · 2024 · Figshare
  16. Additional file 10 of Single-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer’s disease
    Xie, Jieqiong, Lan, Yating, Cuihua Zou, He, Jingfeng, Huang, Qi, Zeng, Jingyi, Mika Pan, Mei, Yujia, Luo, Jiefeng, Zou, Donghua · 2024 · Figshare
  17. Additional file 6 of Single-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer’s disease
    Xie, Jieqiong, Lan, Yating, Cuihua Zou, He, Jingfeng, Huang, Qi, Zeng, Jingyi, Mika Pan, Mei, Yujia, Luo, Jiefeng, Zou, Donghua · 2024 · Figshare
  18. Additional file 5 of Single-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer’s disease
    Xie, Jieqiong, Lan, Yating, Cuihua Zou, He, Jingfeng, Huang, Qi, Zeng, Jingyi, Mika Pan, Mei, Yujia, Luo, Jiefeng, Zou, Donghua · 2024 · Figshare
  19. Additional file 4 of Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease
    Usma Munawara, Catanzaro, Michael, Xu, Weili, Tan, Crystal, Hirokawa, Katsuiku, Nabil Bosco, David Dumoulin, Abdelouahed Khalil, Anis Larbi, Simon Lévesque et al. · 2021 · Figshare
  20. Additional file 3 of Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease
    Usma Munawara, Catanzaro, Michael, Xu, Weili, Tan, Crystal, Hirokawa, Katsuiku, Nabil Bosco, David Dumoulin, Abdelouahed Khalil, Anis Larbi, Simon Lévesque et al. · 2021 · Figshare
  21. Additional file 3 of Single-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer’s disease
    Xie, Jieqiong, Lan, Yating, Cuihua Zou, He, Jingfeng, Huang, Qi, Zeng, Jingyi, Mika Pan, Mei, Yujia, Luo, Jiefeng, Zou, Donghua · 2024 · Figshare
  22. Additional file 2 of The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples
    Diana Duarte Lobo, Rui Jorge Nobre, Oliveira Miranda, Catarina, Pereira, Dina, Castelhano, João, José Sereno, Arnulf H. Koeppen, Miguel S. Castelo-Branco, Pereira de Almeida, Luís · 2020 · Figshare
  23. Additional file 1 of The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples
    Diana Duarte Lobo, Rui Jorge Nobre, Oliveira Miranda, Catarina, Pereira, Dina, João Castelhano, José Sereno, Arnulf H. Koeppen, Miguel S. Castelo-Branco, Pereira de Almeida, Luís · 2020 · Figshare
  24. Additional file 2 of Single-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer’s disease
    Xie, Jieqiong, Lan, Yating, Cuihua Zou, He, Jingfeng, Huang, Qi, Zeng, Jingyi, Mika Pan, Mei, Yujia, Luo, Jiefeng, Zou, Donghua · 2024 · Figshare
  25. Additional file 4 of Single-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer’s disease
    Xie, Jieqiong, Lan, Yating, Cuihua Zou, He, Jingfeng, Huang, Qi, Zeng, Jingyi, Mika Pan, Mei, Yujia, Luo, Jiefeng, Zou, Donghua · 2024 · Figshare
  26. Additional file 1 of Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease
    Usma Munawara, Catanzaro, Michael, Xu, Weili, Tan, Crystal, Hirokawa, Katsuiku, Nabil Bosco, David Dumoulin, Abdelouahed Khalil, Anis Larbi, Simon Lévesque et al. · 2021 · Figshare
  27. Additional file 8 of Single-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer’s disease
    Xie, Jieqiong, Lan, Yating, Cuihua Zou, He, Jingfeng, Huang, Qi, Zeng, Jingyi, Mika Pan, Mei, Yujia, Luo, Jiefeng, Zou, Donghua · 2024 · Figshare
  28. Additional file 2 of Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease
    Usma Munawara, Catanzaro, Michael, Xu, Weili, Tan, Crystal, Hirokawa, Katsuiku, Nabil Bosco, David Dumoulin, Abdelouahed Khalil, Anis Larbi, Simon Lévesque et al. · 2021 · Figshare
  29. Caveolin-1–Mediated Blood-brain Barrier Transcytosis Promotes Porphyromonas gingivalis Invasion and Alzheimer’s Disease-Like Changes
    Mei Chenghan, Qixing Zhong, Li Xiaojie, He Yao, Ting Zhang, Bangcheng Zhao, Liu Jiangshang, Zhong Zhihui · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  30. Is there a role for apolipoprotein E in perinatal brain injury?
    Savina Abraham-Pol, Ertan Mayatepek, Mark Dzietko · 2026 · Molecular and Cellular Pediatrics
  31. Targeting proprotein convertase subtilisin/kexin type 9 in aging-associated cardiometabolic and neurological disorders
    Kexin Huang, Jun P. Ren · 2026 · The Journal of Cardiovascular Aging
  32. Marqueurs périphériques de l'inflammation et déclin cognitif au cours de la maladie d'Alzheimer
    Adrien Julian · 2018 · theses.fr (ABES)
  33. Rôle du transporteur ABCA7 dans les mécanismes de transport du cholestérol et des peptides β-amyloïdes au niveau de la barrière hémato-encéphalique et implications dans la maladie d'Alzheimer
    Yordenca Lamartinière · 2018 · theses.fr (ABES)
  34. Tracking pericyte dysfunction in Alzheimer’s disease: The emerging role of cerebrospinal fluid platelet-derived growth factor receptor-β
    Sheng‐Tzung Tsai, Hock‐Kean Liew, Mei-Jen Wang, Wei-Ting Hung, Hsin-Yi Huang · 2026 · Tzu Chi Medical Journal
  35. Human brain pericytes protect the blood–brain barrier from triple‐negative breast cancer cells while promoting tumor aggressiveness
    Eloise Happernegg, Marine Carroué, Julien Cicero, Lucie Dehouck, Fumitaka Shimizu, Takashi Kanda, Chann H. Lagadec, Fabien Gosselet, Xuefen Le Bourhis, Maxime Culot et al. · 2026 · Journal of Cell Communication and Signaling
  36. Circulatory pro‐CTSD binds brain endothelial LRP1 to trigger its lysosomal degradation leading to amyloid beta clearance deficit in Alzheimer's disease mice
    Zhi-Jun Li, Zhao Yang, Dan Zhao, Yihua Qiu, Wen‐Yu Wan, Zeng-Kang Huang, Li Tian, Rui‐Qun Qi, Hongguang Liu, Yuehua Chen et al. · 2026 · Alzheimer s & Dementia
  37. Cerebral blood flow as a mechanistic framework across neurological disease
    Shaan Patel, Shiva A. Nischal, Nikunj K. Patel · 2026 · Discover Neuroscience
  38. Impaired glymphatic clearance as a mechanistic link between brain aging and neurodegenerative disease pathogenesis
    Abida Khan, Abdullah R. Alzahrani, Zia Ur Rehman, Neelam Singla, Faiyaz Shakeel, Yahia Hassan Ali, Intisar Kamil Saeed, Mohd Imran · 2026 · Ageing Research Reviews
  39. Battle of the wall for aromatic “orifice-opening” agents: defending and breaching the blood-brain barrier
    Xiaoman Yang, Jing Zhang, Hao Yu, Yulei Zhao, Guanqun Hou, Shijun Wang, Bingbing Han · 2026 · Chinese Journal of Natural Medicines
  40. The selective vulnerability of the left fimbria in cognitively normal APOE ε4 carriers: a localized structural correlate of high genetic risk for Alzheimer’s disease
    Yihan Suo, Luoyu Wang, Yuanyuan Zhao, Qingqing Wen, Qi Feng, Han Zhang, Zhongxiang Ding · 2026 · Behavioural Brain Research
  41. Perspective Chapter: Neuroimmune Resolution Failure in Alzheimer’s Disease – The Role of Specialized Pro-Resolving Mediators
    Nosipho Treasure Mdluli, Yun‐Chen Chang · 2026 · IntechOpen eBooks
  42. The interplay between gut microbiota and Alzheimer’s disease: mechanistic insights from dysbiosis to disease modulation
    Kakali Das, R Khatun, Sanjana Begum, Koushik Bhattacharyya, Mallika Datta, Dipankar Saha, Anupam Sarma, Prachi Mehta, Bhrigu Kumar Das · 2026 · Metabolic Brain Disease
  43. Tiered Evaluation of Carbosilane Dendrimer–siRNA Nanoplatform from Single-Cell Biocompatibility to Blood-Brain Barrier Model Dynamics and Murine Alzheimer Model Behavior Assessment
    Serafin Zawadzki, Elżbieta Okła, Sylwia Michlewska, Radosław Bednarek, Paula Ortega, F. Javier de la Mata, Juris Jansons, Dace Skrastiņa, Madara Kreišmane, Vladimirs Piļipenko et al. · 2026 · ACS Applied Materials & Interfaces
  44. Neuroinflammation, Pericyte Dysfunction, and Alzheimer’s Disease-Associated Gene Expression and Pathway Activation in the Brain of SARS-CoV-2-Infected Mice
    Akinkunmi O. Lawal, Ikechukwu B. Jacob, Vignesh Karnik, Hongkuan Fan, Saravanan Thangamani, Paul T. Massa, Guirong Wang · 2026 · Viruses
  45. Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
    Daniel Cuervo-Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille · 2026 · FEBS Letters
  46. Theranostic Innovative Strategies for Brain Diseases: New Insights on Neurovascular Unit-Associated Pathological Changes in Neurodegenerative Disorders and Aging
    Giulia Terribile, Matilda Pedrinazzi, Irene Frigerio, Giulio Sancini, Romina Combi · 2026 · International Journal of Molecular Sciences
  47. Cerebral Intramural Cells: A Missing Cellular Link Between Vascular Aging and Alzheimer’s Disease
    Eliza Mihaela Arbănași, Emil Marian Arbănași, Tudor‐Gabriel Boghițoiu, Stephanie Ada Cărare, Bogdan Andrei Cordoș, Kawthar Braysh, Nicoleta Suciu, Laura Chinezu, Doina Ramona Manu, Axel Montagne et al. · 2026 · International Journal of Molecular Sciences
  48. APOE ε4‐related blood–brain barrier disruption and APOE ε4‐independent microstructural abnormalities in white matter hyperintensities
    Yuki Oi, Qian Shen, Seraphina K. Solders, Charlotte S. Rivera, McKenna E. Williams, Emilie T. Reas · 2026 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
  49. Biomarkers of the blood–brain barrier and the neurovascular unit and their relationship with cognitive decline and cognitive frailty
    Juan D. Rodríguez-Callejas, Alberto José Mimenza-Alvarado, Consuelo Lomas‐Soria, Sara G. Aguilar-Navarro · 2026 · Revista de investigaci�n Cl�nica
  50. Vascular cognitive impairment and dementia: current understanding and future directions
    Shivi Garg, Louise D. McCullough · 2026 · npj Dementia
  51. Associations of peripheral inflammation with hippocampal atrophy in Alzheimer's disease
    Hongsheng Xie, Yuhao Li, Ruoqiu Gan, Ziru Zhao, Qin Chen, Zhiyun Jia · 2026 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
  52. Ultrastructure of Glial Cells in iPSC-Derived Unguided Neural Organoids from APOE4/4 Patients with Alzheimer’s Disease
    Eva Šimončičová, Marloes Verkerke, Fernando Gonzàlez Ibáñez, Raphaël Bourgeois, Katherine Picard, Mohammadparsa Khakpour, Julia TCW, Elly M. Hol, Marie‐Ève Tremblay · 2026 · Neuromethods
  53. A pericyte-to-myofibroblast transition links APOE4 to cerebrovascular degeneration
    Braxton Riley Schuldt, Dominic Haworth-Staines, Andrea Pérez Arévalo, Diede W. M. Broekaart, Ashley Harlock, Leon Wang, Anna Bright, Georgia Gallagher, Grace Rabinowitz, Alison Goate et al. · 2026 · Cell
  54. APOE Genotype and Fluid Biomarkers of Blood-Brain Barrier Integrity: A Systematic Review and Meta-Analysis
    Winnie Lucas, Melanie Murphy, Nina Riddell · 2026 · medRxiv
  55. Exploratory effects of coffee-derived exosome-like nanoparticles in a fibrillar amyloid-beta 1–42-induced neurodegenerative rat model: evidence from fluorodeoxyglucose positron emission tomography and phosphorylated tau/amyloid precursor protein expression
    Yusuf Küçükbağrıaçık, Gülistan Sanem Sarıbaş, Kahraman Ateş, Cenan ÖZTÜRK, Eren KAHYAOĞLU, Sezen Kışlal, C. Ceren Akgul, A. Ozgur Karacalioglu, Cüneyt Göksoy, Murat Kantarcıoğlu · 2026 · PeerJ
  56. Age-Stratified Analysis of Blood–Brain Barrier Proteins Identifies Lower Occludin Abundance in the 3xTg-AD Model
    Karen M. Delgado-Minjares, Catalina Flores-Maldonado, Jessica Paulina Campos-Blázquez, Sofía Y. Díaz-Cintra, Jesús Andrade-Guerrero, Wendolin Colín-García, Karen León‐Arcia, Daniel Martínez‐Fong, Rubén Gerardo Contreras, Luis Oskar Soto-Rojas · 2026 · International Journal of Molecular Sciences
  57. Diabetes-Associated Cognitive Dysfunction: Pathophysiology, Molecular Mechanisms, and Emerging Therapeutic Strategies
    Ravin Sarkar, Atul Kabra, Abdulaziz S. Saeedan, Mohd Nazam Ansari · 2026 · ACS Pharmacology & Translational Science
  58. Emerging therapeutic strategies to target APOE4 in Alzheimer's disease
    Wei I. Jiang, 王冰莹, Dengke K. Ma · 2026 · FEBS Journal