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Ancient links between Siberians and Native Americans revealed by subtyping the Y chromosome haplogroup Q1a

Malyarchuk, Boris, Derenko, Miroslava, Denisova, Galina, Maksimov, Arkady, Wozniak, Marcin, Grzybowski, Tomasz, Dambueva, Irina, Zakharov, Ilya·2011·Journal of Human Genetics
DOI 10.1038/jhg.2011.64
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Abstract

To investigate the structure of Y chromosome haplogroups R-M207 and Q-M242 in human populations of North Asia, we have performed high-resolution genotyping using both single nucleotide polymorphisms and short tandem repeat (STR)-based approaches of 121 M207- and M242-derived samples from 885 males of 16 ethnic groups of Siberia and East Asia. As a result, the following Y chromosome haplogroups were revealed: R1b1b1-M73 (2.0%), R1b1b2-M269 (0.7%), R2-M124 (1.1%), Q1a*-MEH2 (0.5%), Q1a2-M25 (0.1%), Q1a3*-M346 (9.2%) and Q1a3a-M3 (0.2%). Despite the low coalescence age of haplogroup Q1a3*-M346, which is estimated in South Siberia as about 4.5±1.5 thousand years ago (Ka), divergence time between these Q1a3*-M346 haplotypes and Amerindian-specific haplogroup Q1a3a-M3 is equal to 13.8±3.9 Ka, pointing to a relatively recent entry date to America. In addition, unique cluster of haplotypes belonging to Q1a*-MEH2 was found in Koryaks inhabiting the Sea of Okhotsk coast (at a frequency of 10.3%). Although the level of STR diversity associated with Q1a*-MEH2 is very low, this lineage appears to be closest to the extinct Palaeo-Eskimo individuals belonging to the Saqqaq culture arisen in the New World Arctic about 5.5 Ka. This finding suggests that Q1a*-MEH2 likely traces a population migration originating in Northeast Siberia across the Bering Strait.

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Cited by

Metadata

Authors
Malyarchuk, B., Derenko, M., Denisova, G., Maksimov, A., Wozniak, M., Grzybowski, T., Dambueva, I., & Zakharov, I.
Venue
Journal of Human Genetics
Publisher
Springer Science and Business Media LLC
Published
2011-06-16
Volume
56
Issue
8
Pages
583-588
ISSN
  • 1434-5161
  • 1435-232X
DOI
10.1038/jhg.2011.64
Cited by
51
References
1
Language
en
Licence
www.springer.com/tdm (tdm)

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