Cited by 19Genetic Associations and EpidemiologyAdipokines, Inflammation, and Metabolic DiseasesNutrition, Genetics, and Disease

Associations of variations in the MRF2/ARID5B gene with susceptibility to type 2 diabetes in the Japanese population

Wang, Guoqin, Watanabe, Masafumi, Imai, Yasushi, Hara, Kazuo, Manabe, Ichiro, Maemura, Koji, Horikoshi, Momoko, Ozeki, Atsuko +5 more·2012·Journal of Human Genetics

Abstract

Modulator recognition factor-2 (Mrf2/AT-rich interaction domain (Arid)5b) has been revealed to be involved in pathogenesis of atherosclerosis and adipogenesis. Single-nucleotide polymorphisms (SNPs) in the MRF2/ARID5B gene are associated with coronary artery disease (CAD) and has been proposed as a candidate gene for type 2 diabetes (T2D). The study was aimed to determine whether any of the four MRF2/ARID5B SNPs (rs2893880, rs10740055, rs7087507 and rs10761600) associated with susceptibility to CAD are also associated with T2D, and to determine whether SNP genotype influences the levels of adiponectin and other clinical factors. Association of MRF2/ARID5B SNPs was investigated in 500 diabetic patients from the Department of Metabolic Diseases at the University of Tokyo and 243 hospital-based nondiabetic individuals from the Institute for Adult Disease Asahi Life Foundation Hospital and 500 community-based nondiabetic individuals from the Hiroshima Atomic Bomb Casualty Council Health Management Center. Associations of haplotypes of these SNP with levels of adiponectin and other clinical factors were evaluated when the data was available. We found rs2893880C, rs10740055A, rs7087507A and rs10761600T were increasingly associated with T2D in terms of allele/genotype frequencies of each SNP and their haplotype combinations. Individuals with haplotype CAAT indicated an 1.86 times higher prevalence of diabetes compared with individuals with GCGA (OR 1.86 (95% confidence interval (CI) 1.43-2.41)). Furthermore, CAAT significantly associated with adiponectin levels and other clinical factors. In conclusion, polymorphisms on the MRF2/ARID5B gene were associated with susceptibility to T2D as well as adiponectin and other clinical factors, which was in a completely concordant way with their associations with CAD.

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Crossref · 10.1038/jhg.2012.101

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Authors
Wang, G., Watanabe, M., Imai, Y., Hara, K., Manabe, I., Maemura, K., Horikoshi, M., Ozeki, A., Itoh, C., Sugiyama, T., Kadowaki, T., Yamazaki, T., & Nagai, R.
Affiliations
  • The University of Tokyo (JP)
  • Hiroshima Atomic Bomb Casualty Council (JP)
  • The Institute of Medical Science, Asahi Life Foundation (JP)
Corresponding author
  • Wang, Guoqin
  • Watanabe, Masafumi
Venue
Journal of Human Genetics
Published
2012-09-13
Volume
57
Issue
11
Pages
727-733
ISSN
  • 1434-5161 (ISSN-L)
  • 1435-232X
OpenAlex
W2047079412
Cited by
19
References
34
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 3
FWCI
1.15
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Human Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • National Institute of Biomedical Innovation
  • Japan Society for the Promotion of Science (24390199)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords
type 2 diabetes, single nucleotide polymorphisms, genetic susceptibility, haplotypes, adiponectin, coronary artery disease, Japanese population
MeSH terms
Aged, Coronary Artery Disease, Diabetes Mellitus, Type 2, DNA-Binding Proteins, Female, Gene Frequency, Haplotypes, Humans, Male, Middle Aged, Transcription Factors, Linkage Disequilibrium, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Asian People, Adiponectin

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