The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Resistant hypertension, obstructive sleep apnoea and aldosterone
Open accessAbstract
Obstructive sleep apnoea (OSA) and hypertension commonly coexist. Observational studies indicate that untreated OSA is strongly associated with an increased risk of prevalent hypertension, whereas prospective studies of normotensive cohorts suggest that OSA may increase the risk of incident hypertension. Randomized evaluations of continuous positive airway pressure (CPAP) indicate an overall modest effect on blood pressure (BP). Determining why OSA is so strongly linked to having hypertension in cross-sectional studies, but yet CPAP therapy has limited BP benefit needs further exploration. The CPAP studies do, however, indicate a wide variation in the BP effects of CPAP, with some patients manifesting a large antihypertensive benefit such that a meaningful BP effect can be anticipated in some individuals. OSA is particularly common in patients with resistant hypertension (RHTN). The reason for this high prevalence of OSA is not fully explained, but data suggest that it may be related to the high occurrence of hyperaldosteronism in patients with RHTN. In patients with RHTN, it has been shown that aldosterone levels correlate with severity of OSA and that blockade of aldosterone reduces the severity of OSA. Overall, these findings are consistent with aldosterone excess contributing to worsening of underlying OSA. We hypothesize that aldosterone excess worsens OSA by promoting accumulation of fluid within the neck, which then contributes to increased upper airway resistance.
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Cites
Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension
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Sympathetic neural mechanisms in obstructive sleep apnea.
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High prevalence of unrecognized sleep apnoea in drug-resistant hypertension
Logan, A. G., Perlikowski, S. M., Mente, A., Tisler, A., Tkacova, R., Niroumand, M., Leung, R. S. T., & Bradley, T. D. (2001) · Journal of Hypertension · doi:10.1097/00004872-200112000-00022 · Cited by 960
Prospective Study of Sleep-disordered Breathing and Hypertension: The Sleep Heart Health Study
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Self-citationAldosterone Excretion Among Subjects With Resistant Hypertension and Symptoms of Sleep Apnea
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Self-citationFluid Shift by Lower Body Positive Pressure Increases Pharyngeal Resistance in Healthy Subjects
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Cited by
Funder, J. W., Carey, R. M., Mantero, F., Murad, M. H., Reincke, M., Shibata, H., Stowasser, M., & Young, W. F. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-4061 · Cited by 2,925
European Society of hypertension position paper on ambulatory blood pressure monitoring
O’Brien, E., Parati, G., Stergiou, G., Asmar, R., Beilin, L., Bilo, G., Clement, D., de la Sierra, A., de Leeuw, P., Dolan, E., et al. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328363e964 · Cited by 1,419
Obstructive sleep apnea, hypertension and cardiovascular diseases
Gonzaga, C., Bertolami, A., Bertolami, M., Amodeo, C., & Calhoun, D. (2015) · Journal of Human Hypertension · doi:10.1038/jhh.2015.15 · Cited by 230
Self-citationRecommendations for the management of patients with obstructive sleep apnoea and hypertension
Parati, G., Lombardi, C., Hedner, J., Bonsignore, M. R., Grote, L., Tkacova, R., Lévy, P., Riha, R., Bassetti, C., Narkiewicz, K., et al. (2013) · European Respiratory Journal · doi:10.1183/09031936.00226711 · Cited by 227
Prevalence of obstructive sleep apnea in Asian adults: a systematic review of the literature
Mirrakhimov, A. E., Sooronbaev, T., & Mirrakhimov, E. M. (2013) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-13-10 · Cited by 206
Metadata
- Authors
- Dudenbostel, T., & Calhoun, D. A.
- Venue
- Journal of Human Hypertension
- Published
- 2011-06-09
- Volume
- 26
- Issue
- 5
- Pages
- 281-287
- ISSN
- 0950-9240 (ISSN-L)
- 1476-5527
- OpenAlex
- W2030392902
- Cited by
- 168
- References
- 11
- FWCI
- 7.90
- Type
- journal article
- Language
- en
- Open access
- green
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