Severity of Obstructive Sleep Apnea is Related to Aldosterone Status in Subjects with Resistant Hypertension
Open accessIntegrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Very high proportions (60%-84%) of individuals with resistant hypertension have sleep apnea.
“Very high proportions (60%−84%) of individuals with RH have sleep apnea.33,47–49”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [47]
Resistant hypertension has been linked to metabolic derangements, including hyperuricemia, aldosterone excess, and suppressed circulating renin levels (approximately 60% of those with resistant hypertension have suppressed renin levels).
“RH has also been linked to metabolic derangements, including hyperuricemia,17 aldosterone excess,47 and suppressed circulating renin levels (≈60% of those with RH have suppressed renin levels).57”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [47]
The high occurrence of obstructive sleep apnea in patients with resistant hypertension has been attributed to increased fluid retention and accompanying upper airway edema, as suggested by studies positively relating the presence and severity of obstructive sleep apnea to aldosterone excess and high dietary sodium intake.
“The high occurrence of OSA in patients with RH has been attributed to increased fluid retention and accompanying upper airway edema, as suggested by studies positively relating the presence and severity of OSA to aldosterone excess and high dietary sodium intake.47,49,277–279”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [47]
Cites
Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension
Peppard, P. E., Young, T., Palta, M., & Skatrud, J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005113421901 · Cited by 4,973 · see citing works
Marin, J. M., Carrizo, S. J., Vicente, E., & Agusti, A. G. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71141-7 · Cited by 4,678 · see citing works
Obstructive Sleep Apnea as a Risk Factor for Stroke and Death
Yaggi, H. K., Concato, J., Kernan, W. N., Lichtman, J. H., Brass, L. M., & Mohsenin, V. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043104 · Cited by 3,004 · see citing works
Sleep-disordered Breathing and Cardiovascular Disease
SHAHAR, E., WHITNEY, C. W., REDLINE, S., LEE, E. T., NEWMAN, A. B., JAVIER NIETO, F., O'CONNOR, G. T., BOLAND, L. L., SCHWARTZ, J. E., & SAMET, J. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.1.2001008 · Cited by 2,901 · see citing works
Sleep Disordered Breathing and Mortality: Eighteen-Year Follow-up of the Wisconsin Sleep Cohort
(2008) · Sleep · doi:10.5665/sleep/31.8.1071 · Cited by 1,853 · see citing works
Funder, J. W., Carey, R. M., Fardella, C., Gomez-Sanchez, C. E., Mantero, F., Stowasser, M., Young, W. F., & Montori, V. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0104 · Cited by 1,554 · see citing works
Goldberger, J. J., Cain, M. E., Hohnloser, S. H., Kadish, A. H., Knight, B. P., Lauer, M. S., Maron, B. J., Page, R. L., Passman, R. S., Siscovick, D., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189375 · Cited by 1,450 · see citing works
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Calhoun, D. A., Jones, D. W., Textor, S. C., Goff, D. C., Murphy, T. P., Toto, R. D., White, A. J., Cushman, W. C., White, W. B., Sica, D. A., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.189141 · Cited by 1,404 · see citing works
Self-citationSleep Apnea and Cardiovascular Disease
Somers, V. K., White, D. P., Amin, R. S., Abraham, W. T., Costa, F., Culebras, A., Daniels, S. R., Floras, J. S., Hunt, C. E., Olson, L. J., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189420 · Cited by 1,301 · see citing works
Shamsuzzaman, A., Gersh, B. J., & Somers, V. K. (2003) · JAMA · doi:10.1001/jama.290.14.1906 · Cited by 1,179 · see citing works
High prevalence of unrecognized sleep apnoea in drug-resistant hypertension
Logan, A. G., Perlikowski, S. M., Mente, A., Tisler, A., Tkacova, R., Niroumand, M., Leung, R. S. T., & Bradley, T. D. (2001) · Journal of Hypertension · doi:10.1097/00004872-200112000-00022 · Cited by 960 · see citing works
Schwab, R. J., Pasirstein, M., Pierson, R., Mackley, A., Hachadoorian, R., Arens, R., Maislin, G., & Pack, A. I. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200208-866oc · Cited by 952 · see citing works
Hyperaldosteronism Among Black and White Subjects With Resistant Hypertension
Calhoun, D. A., Nishizaka, M. K., Zaman, M. A., Thakkar, R. B., & Weissmann, P. (2002) · Hypertension · doi:10.1161/01.hyp.0000040261.30455.b6 · Cited by 763 · see citing works
Self-citationPatil, S. P., Schneider, H., Schwartz, A. R., & Smith, P. L. (2007) · CHEST Journal · doi:10.1378/chest.07-0040 · Cited by 555 · see citing works
Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans
Somers, V. K., Mark, A. L., Zavala, D. C., & Abboud, F. M. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.67.5.2101 · Cited by 530 · see citing works
Drug Effects on Aldosterone/Plasma Renin Activity Ratio in Primary Aldosteronism
Mulatero, P., Rabbia, F., Milan, A., Paglieri, C., Morello, F., Chiandussi, L., & Veglio, F. (2002) · Hypertension · doi:10.1161/01.hyp.0000038478.59760.41 · Cited by 389 · see citing works
SLEEP APNOEA IN A HYPERTENSIVE POPULATION
Kales, A., Cadieux, R. J., Shaw, L. S. L., Vela‐Bueno, A., Bixler, E., Schneck, D. W., Locke, T., & Soldatos, C. R. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91107-3 · Cited by 384 · see citing works
Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans
Somers, V. K., Mark, A. L., Zavala, D. C., & Abboud, F. M. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.67.5.2095 · Cited by 365 · see citing works
Pratt-Ubunama, M. N., Nishizaka, M. K., Boedefeld, R. L., Cofield, S. S., Harding, S. M., & Calhoun, D. A. (2007) · Chest · doi:10.1378/chest.06-1442 · Cited by 331 · see citing works
Self-citationPrevalence of sleep apnea syndrome among patients with essential hypertension
Lavie, P., Ben-Yosef, R., & Rubin, A. E. (1984) · American Heart Journal · doi:10.1016/0002-8703(84)90628-8 · Cited by 328 · see citing works
Increasing Sleep Duration for a Healthier (and Less Obese?) Population Tomorrow
Young, T. B. (2008) · SLEEP · doi:10.1093/sleep/31.5.593 · Cited by 327 · see citing works
Abnormal vasoactive hormones and 24-hour blood pressure in obstructive sleep apnea
Møller, D. (2003) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)03267-3 · Cited by 314 · see citing works
Gallay, B. J., Ahmad, S., Xu, L., Toivola, B., & Davidson, R. C. (2001) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(01)80117-7 · Cited by 304 · see citing works
Gaddam, K. K. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.11.1159 · Cited by 301 · see citing works
Self-citationDay–Night Variation of Acute Myocardial Infarction in Obstructive Sleep Apnea
Sert Kuniyoshi, F. H., Garcia-Touchard, A., Gami, A. S., Romero-Corral, A., van der Walt, C., Pusalavidyasagar, S., Kara, T., Caples, S. M., Pressman, G. S., Vasquez, E. C., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.04.027 · Cited by 268 · see citing works
Low-renin status in therapy-resistant hypertension: a clue to efficient treatment
Eide, I. K., Torjesen, P. A., Drolsum, A., Babovic, A., & Lilledahl, N. P. (2004) · Journal of Hypertension · doi:10.1097/00004872-200411000-00026 · Cited by 265 · see citing works
Aldosterone Excretion Among Subjects With Resistant Hypertension and Symptoms of Sleep Apnea
Calhoun, D. A., Nishizaka, M. K., Zaman, M. A., & Harding, S. M. (2004) · Chest · doi:10.1378/chest.125.1.112 · Cited by 260 · see citing works
Self-citationŠtrauch, B., Zelinka, T., Hampf, M., Bernhardt, R., & Widimsky, J. (2003) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001554 · Cited by 237 · see citing works
Sleep apnea syndrome and essential hypertension
Williams, A. J., Houston, D., Finberg, S. N., Lam, C., Kinney, J. L., & Santiago, S. (1985) · The American Journal of Cardiology · doi:10.1016/0002-9149(85)90738-6 · Cited by 221 · see citing works
Primary aldosteronism: diagnostic and treatment strategies
Mattsson, C., & Young, W. F. (2006) · Nature Reviews Nephrology · doi:10.1038/ncpneph0151 · Cited by 219 · see citing works
Shiota, S., Ryan, C. M., Chiu, K.-L., Ruttanaumpawan, P., Haight, J. S. J., Arzt, M. E., Floras, J. S., Chan, C. T., & Bradley, T. D. (2007) · Thorax · doi:10.1136/thx.2006.071183 · Cited by 183 · see citing works
Diuretics in Obstructive Sleep Apnea With Diastolic Heart Failure
Bucca, C. B., Brussino, L., Battisti, A., Mutani, R., Rolla, G., Mangiardi, L., & Cicolin, A. (2007) · CHEST Journal · doi:10.1378/chest.07-0311 · Cited by 182 · see citing works
Zhang, Z.-H., Yang, Y., Kang, Y., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01131.2007 · Cited by 123 · see citing works
Boström, K. B., Hedner, J. A., Melander, O., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e328017f6d5 · Cited by 45 · see citing works
Leptin and the ventilatory response to exercise in heart failure
Wolk, R. A., Johnson, B. D., & Somers, V. K. (2003) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.06.007 · Cited by 35 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Carey, R. M., Calhoun, D. A., Bakris, G. L., Brook, R. D., Daugherty, S. L., Dennison-Himmelfarb, C. R., Egan, B. M., Flack, J. M., Gidding, S. S., Judd, E., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000084 · Cited by 1,153 · see citing works
Self-citationObstructive sleep apnea, hypertension and cardiovascular diseases
Gonzaga, C., Bertolami, A., Bertolami, M., Amodeo, C., & Calhoun, D. (2015) · Journal of Human Hypertension · doi:10.1038/jhh.2015.15 · Cited by 230 · see citing works
Self-citationIftikhar, I. H., Valentine, C. W., Bittencourt, L. R. A., Cohen, D. L., Fedson, A. C., Gíslason, T., Penzel, T., Phillips, C. L., Yu-sheng, L., Pack, A. I., et al. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000372 · Cited by 215 · see citing works
Clinical characteristics of patients with resistant hypertension: the RESIST-POL study
Florczak, E., Prejbisz, A., Szwench-Pietrasz, E., Śliwiński, P., Bieleń, P., Klisiewicz, A., Michałowska, I., Warchoł, E., Januszewicz, M., Kała, M., et al. (2013) · Journal of Human Hypertension · doi:10.1038/jhh.2013.32 · Cited by 120 · see citing works
Nicholl, D. D. M., Hanly, P. J., Poulin, M. J., Handley, G. B., Hemmelgarn, B. R., Sola, D. Y., & Ahmed, S. B. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201403-0526oc · Cited by 119 · see citing works
Walia, H. K., Li, H., Rueschman, M., Bhatt, D. L., Patel, S. R., Quan, S. F., Gottlieb, D. J., Punjabi, N. M., Redline, S., & Mehra, R. (2014) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.3946 · Cited by 104 · see citing works
Effect of spironolactone on patients with resistant hypertension and obstructive sleep apnea
Yang, L., Zhang, H., Cai, M., Zou, Y., Jiang, X., Song, L., Liang, E., Bian, J., Wu, H., & Hui, R. (2016) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2015.1131290 · Cited by 99 · see citing works
Krasińska, B., Miazga, A., Cofta, S., Szczepaniak-Chicheł, L., Trafas, T., Krasiński, Z., Pawlaczyk-Gabriel, K., & Tykarski, A. (2016) · Polish Archives of Internal Medicine · doi:10.20452/pamw.3410 · Cited by 43 · see citing works
Resistant Hypertension and Obstructive Sleep Apnea
Khan, A., Patel, N. K., O’Hearn, D. J., & Khan, S. (2013) · International Journal of Hypertension · doi:10.1155/2013/193010 · Cited by 42 · see citing works
Prejbisz, A., Florczak, E., Klisiewicz, A., Dobrowolski, P., Janaszek-Sitkowska, H., Bieleń, P., Szwench-Pietrasz, E., Warchoł-Celińska, E., Kołodziejczyk-Kruk, S., Janas, J., et al. (2013) · Endokrynologia Polska · doi:10.5603/ep.2013.0019 · Cited by 33 · see citing works
- Authors
- Gonzaga, C. C., Gaddam, K. K., Ahmed, M. I., Pimenta, E., Thomas, S. J., Harding, S. M., Oparil, S., Cofield, S. S., & Calhoun, D. A.
- Affiliations
- University of Alabama at Birmingham (US)
- The University of Queensland (AU)
- Corresponding author
- Gonzaga, Carolina C.
- ORCID
- Venue
- Journal of Clinical Sleep Medicine
- Published
- 2010-08-15
- Volume
- 6
- Issue
- 4
- Pages
- 363-368
- ISSN
- 1550-9389 (ISSN-L)
- 1550-9397
- PMC
- PMC2919667
- OpenAlex
- W4294915483
- Cited by
- 188
- References
- 35
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 9 · 2023: 15 · 2022: 10 · 2021: 5 · 2020: 8 · 2019: 11 · 2018: 9 · 2017: 16 · 2016: 17 · 2015: 12 · 2014: 25 · 2013: 9 · 2012: 12
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Sleep Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Funders
- National Heart, Lung, and Blood Institute (R01HL079040, P50HL077100, T32HL007457)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
- Keywords
- obstructive sleep apnea, resistant hypertension, hyperaldosteronism, aldosterone, plasma aldosterone, urinary aldosterone excretion, plasma renin activity, apnea-hypopnea index, OSA severity, hypertensive patients
- MeSH terms
- Adult, Aged, Aldosterone, Cross-Sectional Studies, Drug Resistance, Female, Humans, Hyperaldosteronism, Hypertension, Male, Middle Aged, Prospective Studies, Reference Values, Renin, Risk Factors, Comorbidity, Polysomnography, Sleep Apnea, Obstructive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review