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Cited by 505

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Animal Models of Atopic Dermatitis

Open access
Jin, Haoli, He, Rui, Oyoshi, Michiko, Geha, Raif S.·2009·Journal of Investigative Dermatology

Abstract

Summary Atopic Dermatitis (AD) is characterized by allergic skin inflammation. A hallmark of AD is a dry itchy skin, due at least in part, to defects in skin genes that are important for maintaning skin barrier function. The pathogenesis of AD remains incompletely understood. Since the description of the Nc/Nga mouse as a spontaneously occurring model of AD, a number of mouse models of AD have been developed. They can be categorized into three groups: 1) Models induced by epicutaneous application of sensitizers; 2) Transgenic mice that either over-express or lack selective molecules; 3) Mice that spontaneously develop AD-like skin lesions. These models have resulted in a better understanding of the pathogenesis of AD. This review discusses these models and emphasizes the role of mechanical skin injury and skin barrier dysfunction in eliciting allergic skin inflammation.

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Crossref · 10.1038/jid.2008.106

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Metadata

Authors
Jin, H., He, R., Oyoshi, M., & Geha, R. S.
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
2009-01
Volume
129
Issue
1
Pages
31-40
ISSN
0022-202X (ISSN-L)
OpenAlex
W2002797131
Cited by
505
References
5
FWCI
15.48
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Animal Models of Atopic Dermatitis. https://app.cochat.ai/papers/10.1038/jid.2008.106
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Jin, H., He, R., Oyoshi, M., & Geha, R. S. (2009). Animal Models of Atopic Dermatitis. Journal of Investigative Dermatology. https://doi.org/10.1038/jid.2008.106

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.