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Primary Cutaneous Marginal Zone B-Cell Lymphomas Are Targeted by Aberrant Somatic Hypermutation

Deutsch, Alexander J.A., Frühwirth, Margareta, Aigelsreiter, Ariane, Cerroni, Lorenzo, Neumeister, Peter·2009·Journal of Investigative Dermatology
DOI 10.1038/jid.2008.243
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Abstract

A mechanism inducing genetic instability, termed aberrant somatic hypermutation (ASHM), has been described in diffuse large B-cell lymphoma. To further investigate whether ASHM also occurs in primary cutaneous marginal zone B-cell lymphoma (PCMZL), we studied the mutational profile of PAX5, RhoH/TTF, cMYC, and PIM1 in 11 PCMZLs. A total of 17 sequence variants were found in 8 of 11 lymphomas cases (72.7%), and they displayed the molecular features typical for the ASHM. Further, two mutations, one mutation in PIM1 and one in cMYC, led to amino-acid substitution with potential functional consequences. These data indicate that ASHM is associated with PCMZLs. By mutating regulatory and coding sequences of the targeted genes, ASHM may represent a major contributor to their pathogenesis.

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  1. Bodor, 2005, Aberrant somatic hypermutation and expression of activation-induced cytidine deaminase mRNA in mediastinal large B-cell lymphoma, Br J Haematol, 129, 373, 10.1111/j.1365-2141.2005.05454.x · DOI
  2. Cerroni, 2006, Lymphoproliferative lesions of the skin, J Clin Pathol, 59, 813, 10.1136/jcp.2005.033019 · DOI
  3. Cerroni, 1997, Primary cutaneous marginal zone B-cell lymphoma: a recently described entity of low-grade malignant cutaneous B-cell lymphoma, Am J Surg Pathol, 21, 1307, 10.1097/00000478-199711000-00005 · DOI
  4. Cerroni, 1997, Infection by Borrelia burgdorferi and cutaneous B-cell lymphoma, J Cutan Pathol, 24, 457, 10.1111/j.1600-0560.1997.tb01318.x · DOI
  5. Cesarman, 1987, Mutations in the first exon are associated with altered transcription of c-myc in Burkitt lymphoma, Science, 238, 1272, 10.1126/science.3685977 · DOI
  6. Deutsch, 2007, MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation, Blood, 109, 3500, 10.1182/blood-2006-06-030494 · DOI
  7. Dijkman, 2006, Primary cutaneous follicle center lymphoma and primary cutaneous large B-cell lymphoma, leg type, are both targeted by aberrant somatic hypermutation but demonstrate differential expression of AID, Blood, 107, 4926, 10.1182/blood-2005-08-3443 · DOI
  8. Fink-Puches, 2002, Primary cutaneous lymphomas: applicability of current classification schemes (European Organization for Research and Treatment of Cancer, World Health Organization) based on clinicopathologic features observed in a large group of patients, Blood, 99, 800, 10.1182/blood.V99.3.800 · DOI
  9. Gaidano, 2003, Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma, Blood, 102, 1833, 10.1182/blood-2002-11-3606 · DOI · Paper page
  10. Halldorsdottir, 2008, Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma, Leuk Res, 32, 1015, 10.1016/j.leukres.2007.11.028 · DOI
  11. Küppers, 2001, Mechanisms of chromosomal translocations in B cell lymphomas, Oncogene, 20, 5580, 10.1038/sj.onc.1204640 · DOI
  12. Liu, 2008, Two levels of protection for the B cell genome during somatic hypermutation, Nature, 451, 841, 10.1038/nature06547 · DOI
  13. Matsumoto, 2007, Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium, Nat Med, 13, 470, 10.1038/nm1566 · DOI
  14. Pasqualucci, 2008, AID is required for germinal center-derived lymphomagenesis, Nat Genet, 40, 108, 10.1038/ng.2007.35 · DOI
  15. Pasqualucci, 1998, BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci, Proc Natl Acad Sci USA, 95, 11816, 10.1073/pnas.95.20.11816 · DOI
  16. Pasqualucci, 2001, Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas, Nature, 412, 341, 10.1038/35085588 · DOI · Paper page
  17. Pasqualucci, 2004, Aberrant somatic hypermutation targets an extensive set of genes in diffuse large B-Cell lymphoma, Blood, 104, 428A, 10.1182/blood.V104.11.1528.1528 · DOI
  18. Peng, 1999, Nonimmunoglobulin gene hypermutation in germinal center B cells, Blood, 93, 2167, 10.1182/blood.V93.7.2167 · DOI
  19. Raffeld, 1995, Clustered mutations in the transcriptional activation domain of Myc in 8q24 translocated lymphomas and their functional consequences, Curr Top Microbiol Immunol, 194, 265
  20. Rijlaarsdam, 1993, Cutaneous immunocytomas: a clinicopathologic study of 26 cases, Histopathology, 23, 117, 10.1111/j.1365-2559.1993.tb00469.x · DOI
  21. Rossi, 2005, Aberrant somatic hypermutation in primary mediastinal large B-cell lymphoma, Leukemia, 19, 2363, 10.1038/sj.leu.2403982 · DOI
  22. Shen, 1998, Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes, Science, 280, 1750, 10.1126/science.280.5370.1750 · DOI
  23. Storb, 1998, Cis-acting sequences that affect somatic hypermutation of Ig genes, Immunol Rev, 162, 153, 10.1111/j.1600-065X.1998.tb01438.x · DOI
  24. Wang, 2004, Genome-wide somatic hypermutation, Proc Natl Acad Sci, 101, 7352, 10.1073/pnas.0402009101 · DOI
  25. Willemze, 2005, WHO-EORTC classification for cutaneous lymphomas, Blood, 105, 3768, 10.1182/blood-2004-09-3502 · DOI

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Metadata

Authors
Deutsch, A. J. A., Frühwirth, M., Aigelsreiter, A., Cerroni, L., & Neumeister, P.
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
2009-02
Volume
129
Issue
2
Pages
476-479
ISSN
0022-202X
DOI
10.1038/jid.2008.243
Cited by
34
References
0
Language
en
Licence

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CoChat. (2026). Citation check: Primary Cutaneous Marginal Zone B-Cell Lymphomas Are Targeted by Aberrant Somatic Hypermutation. https://app.cochat.ai/papers/10.1038/jid.2008.243
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Deutsch, A. J. A., Frühwirth, M., Aigelsreiter, A., Cerroni, L., & Neumeister, P. (2009). Primary Cutaneous Marginal Zone B-Cell Lymphomas Are Targeted by Aberrant Somatic Hypermutation. Journal of Investigative Dermatology. https://doi.org/10.1038/jid.2008.243