The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
The Aryl Hydrocarbon Receptor Mediates UVB Radiation–Induced Skin Tanning
Open accessAbstract
Melanogenesis is the vital response to protect skin cells against UVB-induced DNA damage. Melanin is produced by melanocytes, which transfer it to surrounding keratinocytes. Recently, we have shown that the aryl hydrocarbon receptor (AhR) is part of the UVB-stress response in epidermal keratinocytes. UVB triggers AhR signaling by generating the AhR ligand 6-formylindolo(3,2-b)carbazole from tryptophan. We show here that normal murine melanocytes express functional AhR. Using standard UVB tanning protocols, AhR-deficient mice were shown to tan significantly weaker than wild-type mice; in these mice, tyrosinase activity in the epidermis was lower as well. Tanning responses and tyrosinase activity, however, were normal in keratinocyte-specific conditional AhR knockout mice, indicating that release of melanogenic keratinocyte factors is unaffected by the UVB-AhR signaling pathway and that the diminished tanning response in AhR(-/-) mice is confined to the level of melanocytes. Accordingly, the number of dihydroxyphenylalanin-positive melanocytes increased significantly less on UVB irradiation in AhR(-/-) mice than in wild-type mice. This difference in melanocyte number was associated with a significantly reduced expression of stem cell factor-1 and c-kit in melanocytes of AhR(-/-) mice. Thus, the environmental signal sensor AhR links solar UVB radiation to skin pigmentation.
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“PAHs are potent activators of the aryl hydrocarbon receptor (AhR), which is a ligand-dependent transcription factor expressed in keratinocytes and melanocytes (Fritsche et al. 2007; Jux et al. 2011).”
From Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis (2018) · cites this paper as Jux et al. 2011
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Denison, M. S., & Nagy, S. R. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135828 · Cited by 1,895
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B. (2008) · Nature · doi:10.1038/nature06881 · Cited by 1,634
Dominant role of the niche in melanocyte stem-cell fate determination
Nishimura, E. K., Jordan, S. A., Oshima, H., Yoshida, H., Osawa, M., Moriyama, M., Jackson, I. J., Barrandon, Y., Miyachi, Y., & Nishikawa, S. (2002) · Nature · doi:10.1038/416854a · Cited by 906
Schmidt, J. V., Su, G. H., Reddy, J. K., Simon, M. C., & Bradfield, C. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6731 · Cited by 902
AH RECEPTOR SIGNALING PATHWAYS
Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899
Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.
Burbach, K. M., Poland, A., & Bradfield, C. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.8185 · Cited by 831
The mammalian basic helix–loop–helix/PAS family of transcriptional regulators
Kewley, R. J., Whitelaw, M. L., & Chapman‐Smith, A. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(03)00211-5 · Cited by 602
Physiological factors that regulate skin pigmentation
Yamaguchi, Y., & Hearing, V. J. (2009) · BioFactors · doi:10.1002/biof.29 · Cited by 495
Fritsche, E., Schäfer, C., Calles, C., Bernsmann, T., Bernshausen, T., Wurm, M., Hübenthal, U., Cline, J. E., Hajimiragha, H., Schroeder, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701764104 · Cited by 437
Self-citationRannug, A., Rannug, U., Rosenkranz, H. S., Winqvist, L., Westerholm, R. N., Agurell, E., & Grafström, A.-K. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47743-5 · Cited by 357
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Piao, M. J., Ahn, M. J., Kang, K. A., Ryu, Y. S., Hyun, Y. J., Shilnikova, K., Zhen, A. X., Jeong, J. W., Choi, Y. H., Kang, H. K., et al. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2197-9 · Cited by 339
“PAHs are potent activators of the aryl hydrocarbon receptor (AhR), which is a ligand-dependent transcription factor expressed in keratinocytes and melanocytes (Fritsche et al. 2007; Jux et al. 2011).”
Pollution and skin: from epidemiological and mechanistic studies to clinical implications.
Krutmann, J., Liu, W., Li, L., Pan, X., Crawford, M., Sore, G., & Seite, S. (2014) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2014.08.008 · Cited by 290
Self-citationChemistry and Properties of Indolocarbazoles
Janosik, T., Rannug, A., Rannug, U., Wahlström, N., Slätt, J., & Bergman, J. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00186 · Cited by 198
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Metadata
- Authors
- Jux, B., Kadow, S., Luecke, S., Rannug, A., Krutmann, J., & Esser, C.
- Affiliations
- Leibniz Institute of Environmental Medicine (DE)
- Karolinska Institutet (SE)
- Corresponding author
- Esser, Charlotte
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 131
- Issue
- 1
- Pages
- 203-210
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1966603244
- Cited by
- 156
- References
- 38
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 3 · 2023: 9 · 2022: 7 · 2021: 7 · 2020: 12 · 2019: 10 · 2018: 12 · 2017: 9 · 2016: 12 · 2015: 11 · 2014: 9 · 2013: 10 · 2012: 12
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- aryl hydrocarbon receptor, UV-B radiation, tanning, melanogenesis, melanocytes, keratinocytes, FICZ, tryptophan metabolism, tyrosinase activity, CD117, melanocyte proliferation, skin pigmentation, conditional knockout mice
- MeSH terms
- Epidermal Cells, Animals, Cell Count, Cell Differentiation, Cells, Cultured, Epidermis, Melanins, Melanocytes, Mice, Inbred C57BL, Skin Pigmentation, Ultraviolet Rays, Keratinocytes, Receptors, Aryl Hydrocarbon, Mice, Knockout, Mice
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