AH RECEPTOR SIGNALING PATHWAYS

The nuclear receptor superfamily: the second decade

Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964 · see citing works

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212 · see citing works

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443 · see citing works

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

Murre, C., Page-McCaw, P., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90682-x · Cited by 2,713 · see citing works

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617 · see citing works

2,3,7,8-Tetrachlorodibenzo-<i>p</i>-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

Poland, A., & Knutson, J. C. (1982) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.22.040182.002505 · Cited by 2,515 · see citing works

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

Benezra, R., Davis, R. L., Lockshon, D., Turner, D. L., & Weintraub, H. M. (1990) · Cell · doi:10.1016/0092-8674(90)90214-y · Cited by 2,202 · see citing works

Purification and Characterization of Hypoxia-inducible Factor 1

Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,069 · see citing works

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

Murre, C., Page-McCaw, P., Vaessin, H., Caudy, M. A., Jan, L. Y., Jan, Y. N., Cabrera, C. V., Buskin, J. N., Hauschka, S. D., Lassar, A. B., et al. (1989) · Cell · doi:10.1016/0092-8674(89)90434-0 · Cited by 1,815 · see citing works

The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

Weintraub, H. M., Davis, R. L., Tapscott, S. J., Thayer, M., Krause, M., Benezra, R., Blackwell, T. K., Turner, D. L., Rupp, R. A. W., Hollenberg, S. M., et al. (1991) · Science · doi:10.1126/science.1846704 · Cited by 1,562 · see citing works

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

Wang, G. L., & Semenza, G. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4304 · Cited by 1,468 · see citing works

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase

Poland, A., Glover, E., & Kende, A. S. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33205-2 · Cited by 1,370 · see citing works

Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor

Fernandez-Salguero, P., Pineau, T., Hilbert, D. M., McPhail, T., Lee, S. S. T., Kimura, S., Nebert, D. W., Rudikoff, S., Ward, J. M., & Gonzalez, F. J. (1995) · Science · doi:10.1126/science.7732381 · Cited by 1,075 · see citing works

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

Kociba, R. J., Keyes, D. G., Beyer, J., Carreon, R. M., Wade, C. E., Dittenber, D. A., Kalnins, R., Frauson, L. E., Park, C. N., Barnard, S. D., et al. (1978) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(78)90075-3 · Cited by 1,057 · see citing works

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

Kaartinen, V., Voncken, J. W., Shuler, C. F., Warburton, D., Bu, D., Heisterkamp, N., & Groffen, J. (1995) · Nature Genetics · doi:10.1038/ng1295-415 · Cited by 1,031 · see citing works

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.

Semenza, G. L., Nejfelt, M. K., Chi, S. M., & Antonarakis, S. E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5680 · Cited by 990 · see citing works

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development

Rudnicki, M. A., Braun, T. W., Hinuma, S., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90508-a · Cited by 984 · see citing works

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

Hoffman, E. C., Reyes, H., Chu, F., Sander, F. C., Conley, L. H., Brooks, B. A., & Hankinson, O. (1991) · Science · doi:10.1126/science.1852076 · Cited by 958 · see citing works

Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.

Schmidt, J. V., Su, G. H., Reddy, J., Simon, M., & Bradfield, C. (1996) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.93.13.6731 · Cited by 932 · see citing works

Transforming growth factor–β3 is required for secondary palate fusion

Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J., & Doetschman, T. (1995) · Nature Genetics · doi:10.1038/ng1295-409 · Cited by 908 · see citing works

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

Burbach, K. M., Poland, A., & Bradfield, C. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.8185 · Cited by 831 · see citing works

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

Reyes, H., Reisz‐Porszasz, S., & Hankinson, O. (1992) · Science · doi:10.1126/science.256.5060.1193 · Cited by 777 · see citing works

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

Davis, R. L., Cheng, P.-F., Lassar, A. B., & Weintraub, H. (1990) · Cell · doi:10.1016/0092-8674(90)90088-v · Cited by 765 · see citing works

MyoD family: a paradigm for development?Preprint

Olson, E. N. (1990) · Genes & Development · doi:10.1101/gad.4.9.1454 · Cited by 718 · see citing works

Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death

Braun, T. W., Rudnicki, M. A., Arnold, H.-H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90507-9 · Cited by 702 · see citing works

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

Turner, R., & Tjian, R. (1989) · Science · doi:10.1126/science.2494701 · Cited by 680 · see citing works

PAS is a dimerization domain common to Drosophila Period and several transcription factors

Huang, Z.-S., Edery, I., & Rosbash, M. (1993) · Nature · doi:10.1038/364259a0 · Cited by 550 · see citing works

Steroid hormone receptors compete for factors that mediate their enhancer function.

Meyer, M., Gronemeyer, H., Turcotte, B., Bocquel, M., Tasset, D., & Chambon, P. (1989) · Cell · doi:10.1016/0092-8674(89)90918-5 · Cited by 542 · see citing works

Association of the Ah receptor with the 90-kDa heat shock protein.

Perdew, G. H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68314-0 · Cited by 517 · see citing works

Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

Sutter, T. R., Tang, Y. M., Hayes, C. L., Wo, Y. Y., Jabs, E. W., Li, X., Yin, H., Cody, C. W., & Greenlee, W. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36803-5 · Cited by 508 · see citing works

Transcriptional regulation of the rat NAD(P)H:quinone reductase gene

Favreau, L. V., & Pickett, C. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64358-7 · Cited by 497 · see citing works

The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development

Nambu, J. R., Lewis, J. O., Wharton, K. A., & Crews, S. T. (1991) · Cell · doi:10.1016/0092-8674(91)90292-7 · Cited by 493 · see citing works

Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals: effects, mechanisms, and animal models

Pohjanvirta, R., & Tuomisto, J. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06814-0 · Cited by 472 · see citing works

The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis.

Denison, M. S., Fisher, J. M., & Whitlock, J. P. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77819-3 · Cited by 451 · see citing works

Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene.Preprint

Sakai, D. D., Helms, S. R., Carlstedt‐Duke, J., Gustafsson, J.-Α., ROTTMAN, F. M., & Yamamoto, K. R. (1988) · Genes & Development · doi:10.1101/gad.2.9.1144 · Cited by 448 · see citing works

Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer.Preprint

Ellenberger, T., Fass, D., Arnaud, M., & Harrison, S. C. (1994) · Genes & Development · doi:10.1101/gad.8.8.970 · Cited by 445 · see citing works

The AH-receptor: genetics, structure and function

Swanson, H. I., & Bradfield, C. A. (1993) · Pharmacogenetics · doi:10.1097/00008571-199310000-00001 · Cited by 437 · see citing works

The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states

Nebert, D. W., & Gelboin, H. V. (1969) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(69)90253-7 · Cited by 420 · see citing works

An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers

Sun, X.-H., & Baltimore, D. (1991) · Cell · doi:10.1016/0092-8674(91)90653-g · Cited by 404 · see citing works

cDNA cloning and structure of mouse putative Ah receptor

Ema, M., Sogawa, K., Watanabe, N., Chujoh, Y., Matsushita, N., Gotoh, O., Funae, Y., & Fujii-Kuriyama, Y. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91185-s · Cited by 395 · see citing works

The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene.

Conney, A. H., Miller, E. C., & Miller, J. A. (1956) · PubMed · Cited by 394 · see citing works

2,3,7,8,-Tetrachlorodibenzo-p-dioxin: segregation of toxocity with the Ah locus.

Poland, A., & Glover, E. A. (1980) · PubMed · Cited by 393 · see citing works

DNA Binding Specificities and Pairing Rules of the Ah Receptor, ARNT, and SIM Proteins

Swanson, H. I., Chan, W. K., & Bradfield, C. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.44.26292 · Cited by 388 · see citing works

OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins

Strubin, M., Newell, J. W., & Matthias, P. (1995) · Cell · doi:10.1016/0092-8674(95)90500-6 · Cited by 376 · see citing works

Teratology studies with 2,4,5-trichlorophenoxyacetic acid and 2,3,7,8-tetrachlorodibenzo-P-dioxin

COURTNEY, K. (1971) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(71)90282-1 · Cited by 374 · see citing works

Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine.

Pitot, H. C., Goldsworthy, T. L., Campbell, H. A., & Poland, A. (1980) · PubMed · Cited by 372 · see citing works

Isolation of timeless by PER Protein Interaction: Defective Interaction Between timeless Protein and Long-Period Mutant PER L

Gekakis, N., Sáez, L., Delahaye-Brown, A.-M., Myers, M. P., Sehgal, A., Young, M. W., & Weitz, C. J. (1995) · Science · doi:10.1126/science.270.5237.811 · Cited by 371 · see citing works

The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product

Crews, S. T., Thomas, J. B., & Goodman, C. S. (1988) · Cell · doi:10.1016/0092-8674(88)90538-7 · Cited by 352 · see citing works

Cloning and expression of a human Ah receptor cDNA.

Dolwick, K. M., Schmidt, J. V., Carver, L. A., Swanson, H. I., & Bradfield, C. A. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13282-3 · Cited by 348 · see citing works

Targets for Dioxin: Genes for Plasminogen Activator Inhibitor-2 and Interleukin-1β

Sutter, T. R., Guzmán, K., Dold, K. M., & Greenlee, W. F. (1991) · Science · doi:10.1126/science.1925598 · Cited by 337 · see citing works

Genetic Expression of Aryl Hydrocarbon Hydroxylase Activity

Poland, A., Glover, E. A., Robinson, J. R., & Nebert, D. W. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)79769-3 · Cited by 329 · see citing works

Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors.

Ema, M., Ohe, N., Suzuki, M., Mimura, J., Sogawa, K., Ikawa, S., & Fujii-Kuriyama, Y. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46990-6 · Cited by 329 · see citing works

The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy.

Pollenz, R. S., Sattler, C. A., & Poland, A. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10014-x · Cited by 313 · see citing works

Analysis of the four alleles of the murine aryl hydrocarbon receptor

Poland, A., Palen, D., & Glover, E. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09833-5 · Cited by 303 · see citing works

A B-cell coactivator of octamer-binding transcription factors

Gstaiger, M., Knoepfel, L., Georgiev, O., Schaffner, W., & Hovens, C. M. (1995) · Nature · doi:10.1038/373360a0 · Cited by 302 · see citing works

Medial edge epithelium transforms to mesenchyme after embryonic palatal shelves fuse

Fitchett, J. E., & Hay, E. D. (1989) · Developmental Biology · doi:10.1016/s0012-1606(89)80017-x · Cited by 279 · see citing works

Tubulogenesis in Drosophila: a requirement for the trachealess gene product.Preprint

Isaac, D. D., & Andrew, D. J. (1996) · Genes & Development · doi:10.1101/gad.10.1.103 · Cited by 271 · see citing works

trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila.Preprint

Wilk, R., Weizman, I., & Shilo, B. (1996) · Genes & Development · doi:10.1101/gad.10.1.93 · Cited by 264 · see citing works

Identification of Functional Domains of the Aryl Hydrocarbon Receptor Nuclear Translocator Protein (ARNT)

Reisz‐Porszasz, S., Probst, M. R., Fukunaga, B. N., & Hankinson, O. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.6075 · Cited by 255 · see citing works

Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer.

Denison, M. S., Fisher, J. M., & Whitlock, J. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2528 · Cited by 254 · see citing works

Separable Regulatory Elements Governing myogenin Transcription in Mouse Embryogenesis

Cheng, T.-C., Wallace, M., Merlie, J. P., & Olson, E. N. (1993) · Science · doi:10.1126/science.8392225 · Cited by 254 · see citing works

Dual roles of the 90-kDa heat shock protein hsp90 in modulating functional activities of the dioxin receptor. Evidence that the dioxin receptor functionally belongs to a subclass of nuclear receptors which require hsp90 both for ligand binding activity and repression of intrinsic DNA binding activity.

Pongratz, I., MASON, G. G. F., & Poellinger, L. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42274-0 · Cited by 246 · see citing works

Genetic Expression of Aryl Hydrocarbon Hydroxylase by 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Evidence for a Receptor Mutation in Genetically Non-responsive Mice

POLAND, A., & GLOVER, E. (1975) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10636-6 · Cited by 243 · see citing works

The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells

Nambu, J. R., Franks, R. G., Hu, S., & Crews, S. T. (1990) · Cell · doi:10.1016/0092-8674(90)90288-p · Cited by 241 · see citing works

A critical review of the developmental toxicity and teratogenicity of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin: Recent advances toward understanding the mechanism

Couture, L. A., Abbott, B. D., & Birnbaum, L. S. (1990) · Teratology · doi:10.1002/tera.1420420606 · Cited by 240 · see citing works

In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition.

Dolwick, K. M., Swanson, H. I., & Bradfield, C. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8566 · Cited by 239 · see citing works

Association of the dioxin receptor with the Mr 90,000 heat shock protein: A structural kinship with the glucocorticoid receptor

Denis, M. G., Cuthill, S., Wikström, A., Poellinger, L., & Gustafsson, J. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80566-7 · Cited by 234 · see citing works

A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene

Citri, Y., Colot, H. V., Jacquier, A. C., Yu, Q., Hall, J. C., Baltimore, D., & Rosbash, M. (1987) · Nature · doi:10.1038/326042a0 · Cited by 231 · see citing works

Consequences of heteromeric interactions among helix-loop-helix proteins.

Kadesch, T. R. (1993) · PubMed · Cited by 217 · see citing works

The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein.

Wilhelmsson, A., Cuthill, S., Denis, M. G., Wikström, A., Gustafsson, J.-Å., & Poellinger, L. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08081.x · Cited by 198 · see citing works

A DNA-binding factor specific for xenobiotic responsive elements of P-450c gene exists as a cryptic form in cytoplasm: its possible translocation to nucleus.

Fujisawa‐Sehara, A., Yamane, M., & Fujii-Kuriyama, Y. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.16.5859 · Cited by 197 · see citing works

Developmental expression of two members of a new class of transcription factors: I. Expression of aryl hydrocarbon receptor in the C57BL/6N mouse embryo

Abbott, B. D., Birnbaum, L. S., & Perdew, G. H. (1995) · Developmental Dynamics · doi:10.1002/aja.1002040204 · Cited by 195 · see citing works

Ligand-Dependent Recruitment of the Arnt Coregulator Determines DNA Recognition by the Dioxin Receptor

Whitelaw, M. L., Pongratz, I., Wilhelmsson, A., Gustafsson, J.-Å., & Poellinger, L. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.4.2504 · Cited by 191 · see citing works

Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation.

Sogawa, K., Nakano, R., Kobayashi, A., Kikuchi, Y., Ohe, N., Matsushita, N., & Fujii-Kuriyama, Y. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.1936 · Cited by 191 · see citing works

Tissue specific expression of the rat Ah-receptor and ARNT mRNAs

Carver, L. A., Hogenesch, J. B., & Bradfield, C. A. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.15.3038 · Cited by 178 · see citing works

The human CYP1A2 gene and induction by 3-methylcholanthrene. A region of DNA that supports AH-receptor binding and promoter-specific induction.

Quattrochi, L. C., Vu, T., & Tukey, R. H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37466-5 · Cited by 177 · see citing works

Carcinogenicity of TCDD: Experimental, Mechanistic, and Epidemiologic Evidence

Huff, J., Lucier, G. W., & Tritscher, A. M. (1994) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.34.040194.002015 · Cited by 169 · see citing works

Fos is a Preferential Target of Glucocorticoid Receptor Inhibition of AP-1 Activity In Vitro

Kerppola, T. K., Luk, D. C., & Curran, T. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.6.3782 · Cited by 167 · see citing works

Potent transactivation domains of the Ah receptor and the Ah receptor nuclear translocator map to their carboxyl termini.

Jain, S., Dolwick, K. M., Schmidt, J. V., & Bradfield, C. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31725-3 · Cited by 164 · see citing works

Identification of Transactivation and Repression Functions of the Dioxin Receptor and Its Basic Helix-Loop-Helix/PAS Partner Factor Arnt: Inducible versus Constitutive Modes of Regulation

Whitelaw, M. L., Gustafsson, J.-Α., & Poellinger, L. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8343 · Cited by 161 · see citing works

Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins.

Dang, C. V., Dolde, C. E., Gillison, M. L., & Kato, G. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.2.599 · Cited by 159 · see citing works

Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1-450 by 3-methylcholanthrene.

Okey, A. B., Vella, L. M., & Harper, P. A. (1989) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)11526-5 · Cited by 158 · see citing works

Dioxin-responsive genes: examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction.

Heuvel, J. P. V., Clark, G. C., Kohn, M. C., Tritscher, A. M., Greenlee, W. F., Lucier, G. W., & Bell, D. A. (1994) · PubMed · Cited by 154 · see citing works

PER Protein Interactions and Temperature Compensation of a Circadian Clock in Drosophila

Huang, Z. J., Curtin, K. D., & Rosbash, M. (1995) · Science · doi:10.1126/science.7855598 · Cited by 152 · see citing works

The 90-kDa heat shock protein is essential for Ah receptor signaling in a yeast expression system.

Carver, L. A., Jackiw, V., & Bradfield, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43782-9 · Cited by 151 · see citing works

A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Arnt.

Matsushita, N., Sogawa, K., Ema, M., Yoshida, A., & Fujii-Kuriyama, Y. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36885-1 · Cited by 149 · see citing works

Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment.

Schmidt, J., Carver, L. A., & Bradfield, C. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80668-1 · Cited by 146 · see citing works

Suppression of B cell differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Tucker, A. N., Vore, S. J., & Luster, M. I. (1986) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10260-5 · Cited by 143 · see citing works

Immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in strains of mice with different susceptibility to induction of aryl hydrocarbon hydroxylase

Vecchi, A., Sironi, M., Canegrati, M. A., Recchia, M., & Garattini, S. K. (1983) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(83)90288-0 · Cited by 140 · see citing works

A Cellular Factor Stimulates Ligand-Dependent Release of hsp90 from the Basic Helix-Loop-Helix Dioxin Receptor

McGuire, J., Whitelaw, M. L., Pongratz, I., Gustafsson, J.-Α., & Poellinger, L. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.4.2438 · Cited by 137 · see citing works

Evidence for direct action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thymic epithelium

Greenlee, W. F., Dold, K. M., Irons, R. D., & Osborne, R. (1985) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(85)90373-4 · Cited by 134 · see citing works

Regulation of Erythropoietin Production: New Insights Into Molecular Mechanisms of Oxygen Homeostasis

Semenza, G. L. (1994) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(18)30134-5 · Cited by 133 · see citing works

Photoaffinity labeling of the Ah receptor.

Poland, A., Glover, E. A., Ebetino, F. H., & Kende, A. S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84570-2 · Cited by 133 · see citing works

Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles.

Poland, A., & Glover, E. A. (1990) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09468-4 · Cited by 132 · see citing works

Distinct roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the basic helix-loop-helix and PAS domains

Antonsson, C., Whitelaw, M., McGuire, J., Gustafsson, J.-Å., & Poellinger, L. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.756 · Cited by 129 · see citing works

Heat shock protein hsp90 regulates dioxin receptor function in vivo.

Whitelaw, M., McGuire, J., Picard, D., Gustafsson, J.-Å., & Poellinger, L. (1995) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.92.10.4437 · Cited by 129 · see citing works

An estimate of the maximum in vivo covalent binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to rat liver protein, ribosomal RNA, and DNA.

Poland, A., & Glover, E. A. (1979) · PubMed · Cited by 123 · see citing works

Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity, and tissue-specific expression.

Jaiswal, A. K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36651-6 · Cited by 117 · see citing works

TCDD alters medial epithelial cell differentiation during palatogenesis

Abbott, B. D., & Birnbaum, L. S. (1989) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(89)90010-0 · Cited by 117 · see citing works

Dioxin induces transforming growth factor-alpha in human keratinocytes

Choi, E., Toscano, D. G., Ryan, J. A., Riedel, N. G., & Toscano, W. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92861-9 · Cited by 115 · see citing works

Analysis of the Upstream Elements of the Xenobiotic Compound-Inducible and Positionally Regulated Glutathione S-Transferase Ya Gene

Paulson, K. E., Darnell, J. E., Jr., Rushmore, T. H., & Pickett, C. B. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.5.1841 · Cited by 114 · see citing works

TCDD-induced altered expression of growth factors may have a role in producing cleft palate and enhancing the incidence of clefts after coadministration of retinoic acid and TCDD

Abbott, B. D., & Birnbaum, L. S. (1990) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(90)90337-t · Cited by 114 · see citing works

Influence of the Ah locus on the humoral immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: Evidence for Ah-receptor-dependent and Ah-receptor-independent mechanisms of immunosuppression

Kerkvliet, N. I., Steppan, L. B., Brauner, J. A., Deyo, J. A., Henderson, M. C., Tomar, R. S., & Buhler, D. R. (1990) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(90)90356-y · Cited by 114 · see citing works

Polychlorinated Dibenzo-p-dioxins and Polychlorinated Dibenzofurans: The Risks to Human Health. A Review

Skene, S. A., Dewhurst, I. C., & Greenberg, M. (1989) · Human Toxicology · doi:10.1177/096032718900800301 · Cited by 111 · see citing works

Protein-DNA interactions at a dioxin-responsive enhancer. Evidence that the transformed Ah receptor is heteromeric

Elferink, C. J., Gasiewicz, T. A., & Whitlock, J. P. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30561-6 · Cited by 108 · see citing works

Variation in the molecular mass of the Ah receptor among vertebrate species and strains of rats

Poland, A., & Glover, E. A. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90811-4 · Cited by 106 · see citing works

Sensitivity to suppression of cytotoxic T cell generation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on the Ah genotype of the murine host

Nagarkatti, P. S., Sweeney, G. D., Gauldie, J., & Clark, D. A. (1984) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(84)90261-8 · Cited by 104 · see citing works

2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin‐ induced cleft palate in the mouse: Evidence for alterations in palatal shelf fusion

Pratt, R. M., Dencker, L., & Diewert, V. M. (1984) · Teratogenesis Carcinogenesis and Mutagenesis · doi:10.1002/tcm.1770040505 · Cited by 104 · see citing works

Enhanced Suppressor Cell Activity as a Mechanism of Immunosuppression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Clark, D. A., Gauldie, J., Szewczuk, M. R., & Sweeney, G. D. (1981) · Experimental Biology and Medicine · doi:10.3181/00379727-168-41275 · Cited by 101 · see citing works

Selective effects of 2,3,7,8-tetrachlorodibenzo- p -dioxin and corticosteroid on in vitro lymphocyte maturation.

Luster, M. I., Germolec, D. R., Clark, G., Wiegand, G., & Rosenthal, G. J. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.3.928 · Cited by 98 · see citing works

Classes of hepatic microsomal mixed function oxidase inducers

Snyder, R., & Remmer, H. (1979) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(79)90030-5 · Cited by 98 · see citing works

Transcriptional activation function of the mouse Ah receptor nuclear translocator.

Li, H., Dong, L., & Whitlock, J. P. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46900-1 · Cited by 97 · see citing works

Orientation of the heterodimeric aryl hydrocarbon (dioxin) receptor complex on its asymmetric DNA recognition sequence.

Bacsi, S. G., Reisz‐Porszasz, S., & Hankinson, O. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08562-1 · Cited by 97 · see citing works

Kinetic and equilibrium studies of Ah receptor-ligand binding: use of [125I]2-iodo-7,8-dibromodibenzo-p-dioxin.

Bradfield, C. A., Kende, A. S., & Poland, A. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09356-3 · Cited by 97 · see citing works

Developmental expression of two members of a new class of transcription factors: II. Expression of aryl hydrocarbon receptor nuclear translocator in the C57BL/6N mouse embryo

Abbott, B. D., & Probst, M. R. (1995) · Developmental Dynamics · doi:10.1002/aja.1002040205 · Cited by 96 · see citing works

Control of CNS midline transcription by asymmetric E-box-like elements: similarity to xenobiotic responsive regulation

Wharton, K. A., Franks, R. G., Kasai, Y., & Crews, S. T. (1994) · Development · doi:10.1242/dev.120.12.3563 · Cited by 95 · see citing works

The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human hypoxia-inducible factor 1α and Drosophila single-minded

Nambu, J. R., Chen, W., Hu, S. N., & Crews, S. T. (1996) · Gene · doi:10.1016/0378-1119(96)00060-1 · Cited by 92 · see citing works

Immunosuppressive activities of polychlorinated dibenzofuran congeners: Quantitative structure-activity relationships and interactive effects

Davis, D., & Safe, S. (1988) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(88)90344-4 · Cited by 92 · see citing works

Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development.

Dahmane, N., Charron, G., Lopes, C., Yaspo, M., Maunoury, C., Decorte, L., Sinet, P., Bloch, B., & Delabar, J. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9191 · Cited by 90 · see citing works

Transcriptional Activation by the Mouse Ah Receptor.

Ma, Q., Dong, L., & Whitlock, J. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.21.12697 · Cited by 89 · see citing works

Dioxin Induces Localized, Graded Changes in Chromatin Structure: Implications forCyp1A1Gene Transcription

Okino, S. T., & Whitlock, J. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.7.3714 · Cited by 85 · see citing works

Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo.

Wu, L., & Whitlock, J. P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.11.4811 · Cited by 83 · see citing works

Control of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Multiple dioxin-responsive domains 5'-ward of the cytochrome P1-450 gene.

Jones, P. B., Durrin, L. K., Fisher, J. M., & Whitlock, J. P. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)62665-7 · Cited by 80 · see citing works

The murine Ah locus: a new allele and mapping to chromosome 12

Poland, A., Glover, E., & Taylor, B. A. (1987) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13026-5 · Cited by 79 · see citing works

Single–minded and Down syndrome?

Chen, H., Chrast, R., Rossier, C., Gos, A., Antonarakis, S. E., Kudoh, J., Yamaki, A., Shindoh, N., Maeda, H., Minoshima, S., et al. (1995) · Nature Genetics · doi:10.1038/ng0595-9 · Cited by 76 · see citing works

The Basic Helix-Loop-Helix/PAS Factor Sim Is Associated with hsp90:

McGuire, J., Coumailleau, P., Whitelaw, M. L., Gustafsson, J.-Α., & Poellinger, L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.52.31353 · Cited by 75 · see citing works

Direct suppression of antibody responses by chlorinated dibenzodioxins in cultured spleen cells from (C57BL/6 × C3H)F1 and DBA/2 mice

Holsapple, M. P., Dooley, R. K., McNerney, P. J., & McCay, J. A. (1986) · Immunopharmacology · doi:10.1016/0162-3109(86)90001-9 · Cited by 74 · see citing works

Mutagenicity testing of 2,3,7,8-tetrachlorodibenzo-p-dioxin in histidine auxotrophs of Salmonella typhimurium

Geiger, L. E., & Neal, R. A. (1981) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(81)90459-2 · Cited by 65 · see citing works

Interactions among vertebrate helix-loop-helix proteins in yeast using the two-hybrid system.

Staudinger, J. L., Perry, M., Elledge, S. J., & Olson, E. N. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53440-2 · Cited by 58 · see citing works

Functional analysis of the transcriptional promoter for the CYP1A1 gene.

Jones, K. W., & Whitlock, J. P. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.10.5098 · Cited by 58 · see citing works

Organization and characterization of the rat class 3 aldehyde dehydrogenase gene

Asman, D. C., Takimoto, K., Pitot, H. C., Dunn, T., & Lindahl, R. G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31421-2 · Cited by 57 · see citing works

Characterization of multiple forms of the Ah receptor: recognition of a dioxin-responsive enhancer involves heteromer formation

Gasiewicz, T. A., Elferink, C. J., & Henry, E. C. (1991) · Biochemistry · doi:10.1021/bi00225a026 · Cited by 57 · see citing works

Purification of the DNA binding form of dioxin receptor. Role of the Arnt cofactor in regulation of dioxin receptor function.

Mason, G. G., Witte, A., Whitelaw, M., Antonsson, C., McGuire, J., Wilhelmsson, A., Poellinger, L., & Gustafsson, J.-Å. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41799-6 · Cited by 55 · see citing works

Genetics of aryl hydrocarbon hydroxylase induction in mice: Additive inheritance in crosses between C3H/HeJ and DBA/2J

Thomas, P. E., & Hutton, J. J. (1973) · Biochemical Genetics · doi:10.1007/bf00486177 · Cited by 48 · see citing works

Hepatotoxicity and carcinogenicity in female Sprague-Dawley rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): A pathology working group reevaluation

Goodman, D. G., & Sauer, R. M. (1992) · Regulatory Toxicology and Pharmacology · doi:10.1016/0273-2300(92)90036-9 · Cited by 47 · see citing works

Immunosuppression without liver induction by subchronic exposure to 2,7-dichlorodibenzo-p-dioxin in adult female B6C3F1 mice

Holsapple, M. P. (1986) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(86)90227-9 · Cited by 44 · see citing works

Transcriptional activation domains of the single-minded bHLH protein are required for CNS midline cell development

Franks, R. G., & Crews, S. T. (1994) · Mechanisms of Development · doi:10.1016/0925-4773(94)90013-2 · Cited by 41 · see citing works

Mechanisms of chemically-induced cleft palate

Pratt, R. M. (1983) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(83)90343-7 · Cited by 28 · see citing works

Halogenated aryl hydrocarbon-induced suppression of the in vitro plaque-forming cell response to sheep red blood cells is not dependent on the Ah receptor

Davis, D., & Safe, S. H. (1991) · Immunopharmacology · doi:10.1016/0162-3109(91)90023-r · Cited by 28 · see citing works

Guidelines for nomenclature of genetically determined biochemical variants in the house mouse, Mus musculus

Committee on Standardized Genetic Nomenclature for Mice (1973) · Biochemical Genetics · doi:10.1007/bf00486072 · Cited by 27 · see citing works

Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment

Ankley, G. T., Bennett, R. S., Erickson, R. J., Hoff, D. J., Hornung, M. W., Johnson, R. D., Mount, D. R., Nichols, J. W., Russom, C. L., Schmieder, P. K., et al. (2009) · Environmental Toxicology and Chemistry · doi:10.1002/etc.34 · Cited by 2,734 · see citing works

Activation of the Aryl Hydrocarbon Receptor by Structurally Diverse Exogenous and Endogenous Chemicals

Denison, M. S., & Nagy, S. R. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135828 · Cited by 1,895 · see citing works

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B. (2008) · Nature · doi:10.1038/nature06881 · Cited by 1,634 · see citing works

Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity

Hill, A. J., Teraoka, H., Heideman, W., & Peterson, R. E. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi110 · Cited by 1,380 · see citing works

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

Tian, H., McKnight, S. L., & Russell, D. W. (1997) · Genes &amp; Development · doi:10.1101/gad.11.1.72 · Cited by 1,351 · see citing works

INDUCTION OF CYTOCHROME P4501A1

Whitlock, J. P. (1999) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.103 · Cited by 1,126 · see citing works

The PAS Superfamily: Sensors of Environmental and Developmental Signals

Gu, Y.-Z., Hogenesch, J. B., & Bradfield, C. A. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.519 · Cited by 1,023 · see citing works

Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis

Nebert, D. W., Roe, A. L., Dieter, M. Z., Solis, W. A., Yang, Y., & Dalton, T. P. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00310-x · Cited by 997 · see citing works

Modulation of oestrogen receptor signalling by association with the activated dioxin receptor

Ohtake, F., Takeyama, K., Μatsumoto, T., Kitagawa, H., Yamamoto, Y., Nohara, K., Tohyama, C., Krust, A., Mimura, J., Chambon, P., et al. (2003) · Nature · doi:10.1038/nature01606 · Cited by 798 · see citing works

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

Tian, H., Hammer, R. E., Matsumoto, A. M., Russell, D. W., & McKnight, S. L. (1998) · Genes &amp; Development · doi:10.1101/gad.12.21.3320 · Cited by 647 · see citing works

Aryl hydrocarbon receptors: diversity and evolution

Hahn, M. E. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00070-4 · Cited by 642 · see citing works

Cytochrome P450-mediated metabolism of estrogens and its regulation in human

Tsuchiya, Y., Nakajima, M., & Yokoi, T. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.10.007 · Cited by 616 · see citing works

A CLOCK Polymorphism Associated with Human Diurnal Preference

Katzenberg, D. R., Young, T. B., Finn, L. A., Lin, L., King, D. P., Takahashi, J. S., & Mignot, E. J.-M. (1998) · SLEEP · doi:10.1093/sleep/21.6.569 · Cited by 587 · see citing works

Feedback control of AHR signalling regulates intestinal immunity

Schiering, C., Wincent, E., Metidji, A., Iseppon, A., Li, Y., Potocnik, A. J., Omenetti, S., Henderson, C. J., Wolf, C. R., Nebert, D. W., et al. (2017) · Nature · doi:10.1038/nature21080 · Cited by 537 · see citing works

Aryl hydrocarbon receptor and intestinal immunity

Lamas, B., Natividad, J. M., & Sokol, H. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0019-2 · Cited by 530 · see citing works

Ligand binding and activation of the Ah receptor

Denison, M. S., Pandini, A., Nagy, S. R., Baldwin, E. P., & Bonati, L. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00063-7 · Cited by 485 · see citing works

Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention

Androutsopoulos, V. P., Tsatsakis, A. M., & Spandidos, D. A. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-187 · Cited by 477 · see citing works

Endocrine Insights into the Evolution of Metamorphosis in Insects

Truman, J. W., & Riddiford, L. M. (2002) · Annual Review of Entomology · doi:10.1146/annurev.ento.47.091201.145230 · Cited by 445 · see citing works

The aryl hydrocarbon receptor: a perspective on potential roles in the immune system

Stevens, E. A., Mezrich, J. D., & Bradfield, C. A. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03054.x · Cited by 415 · see citing works

Ligand-dependent Interaction of the Aryl Hydrocarbon Receptor with a Novel Immunophilin Homolog in Vivo*

Carver, L. A., & Bradfield, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11452 · Cited by 428 · see citing works

AHR in the intestinal microenvironment: safeguarding barrier function

Stockinger, B., Shah, K., & Wincent, E. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00430-8 · Cited by 414 · see citing works

Indolocarbazole natural products: occurrence, biosynthesis, and biological activity

Sánchez, C., Méndez, C., & Salas, J. A. (2006) · Natural Product Reports · doi:10.1039/b601930g · Cited by 408 · see citing works

The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity

Metidji, A., Omenetti, S., Crotta, S., Li, Y., Nye, E., Ross, E., Li, V., Maradana, M. R., Schiering, C., & Stockinger, B. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.010 · Cited by 402 · see citing works

Development of neuroendocrine lineages requires the bHLH–PAS transcription factor SIM1Preprint

Michaud, J. L., Rosenquist, T. A., May, N. R., & Fan, C. (1998) · Genes & Development · doi:10.1101/gad.12.20.3264 · Cited by 391 · see citing works

Hepatitis B Virus X-Associated Protein 2 Is a Subunit of the Unliganded Aryl Hydrocarbon Receptor Core Complex and Exhibits Transcriptional Enhancer Activity

Meyer, B., Pray-Grant, M. G., Heuvel, J. P. V., & Perdew, G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.978 · Cited by 390 · see citing works

Aryl Hydrocarbon Receptor–Independent Toxicity of Weathered Crude Oil during Fish Development

Incardona, J. P., Carls, M. G., Teraoka, H., Sloan, C. A., Collier, T. K., & Scholz, N. L. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8230 · Cited by 382 · see citing works

The aryl hydrocarbon receptor: A comparative perspective

Hahn, M. E. (1998) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/s0742-8413(98)10028-2 · Cited by 366 · see citing works

p27Kip1 induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cellsPreprint

Kolluri, S. K., Weiss, C., Koff, A., & Göttlicher, M. (1999) · Genes & Development · doi:10.1101/gad.13.13.1742 · Cited by 364 · see citing works

Biological impact of environmental polycyclic aromatic hydrocarbons (ePAHs) as endocrine disruptors

Zhang, Y., Dong, S., Wang, H., Tao, S., & Kiyama, R. (2016) · Environmental Pollution · doi:10.1016/j.envpol.2016.03.050 · Cited by 362 · see citing works

Inhibition and induction of human cytochrome P450 (CYP) enzymes

Pelkonen, O., MÄEENPÄEÄ, J., Taavitsainen, P., Rautio, A., & Raunio, H. (1998) · Xenobiotica · doi:10.1080/004982598238886 · Cited by 358 · see citing works

Cellular thiols and redox-regulated signal transduction

Sen, C. K. (2001) · Current topics in cellular regulation · doi:10.1016/s0070-2137(01)80001-7 · Cited by 345 · see citing works

Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish

Groh, K. J., Pakdel, F., Segner, H. E., Kah, O., & Eggen, R. I. L. (2007) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2007.03.005 · Cited by 335 · see citing works

Expression of ARNT, ARNT2, HIF1α, HIF2α and Ah receptor mRNAs in the developing mouse

Jain, S., Maltepe, E., Lu, M. M., Simon, C., & Bradfield, C. A. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00038-0 · Cited by 333 · see citing works

IMPACT OF CELLULAR METABOLISM ON THE BIOLOGICAL EFFECTS OF BENZO[A]PYRENE AND RELATED HYDROCARBONS†

Miller, K. P., & Ramos, K. S. (2001) · Drug Metabolism Reviews · doi:10.1081/dmr-100000138 · Cited by 332 · see citing works

Activation of the Ah Receptor by Tryptophan and Tryptophan Metabolites

Heath‐Pagliuso, S., Rogers, W. J., Tullis, K. M., Seidel, S. D., Cenijn, P. H., Brouwer, A., & Denison, M. S. (1998) · Biochemistry · doi:10.1021/bi980087p · Cited by 331 · see citing works

Heart Malformation Is an Early Response to TCDD in Embryonic Zebrafish

Antkiewicz, D. S., Burns, C. G., Carney, S. A., Peterson, R. E., & Heideman, W. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi073 · Cited by 323 · see citing works

Hair Follicle Stem Cell-Specific PPARγ Deletion Causes Scarring Alopecia

Karnik, P., Tekeste, Z., McCormick, T. S., Gilliam, A. C., Price, V. H., Cooper, K. D., & Mirmirani, P. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.369 · Cited by 321 · see citing works

Developmental toxicity of 4-ring polycyclic aromatic hydrocarbons in zebrafish is differentially dependent on AH receptor isoforms and hepatic cytochrome P4501A metabolism

Incardona, J. P., Day, H. L., Collier, T. K., & Scholz, N. L. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.09.018 · Cited by 319 · see citing works

Activation of the Ah Receptor Signal Transduction Pathway by Bilirubin and Biliverdin

Phelan, D., Winter, G. M., Rogers, W. J., Lam, J., & Denison, M. S. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0814 · Cited by 318 · see citing works

The Role of the Aryl Hydrocarbon Receptor Pathway in Mediating Synergistic Developmental Toxicity of Polycyclic Aromatic Hydrocarbons to Zebrafish

Billiard, S. M., Timme‐Laragy, A. R., Wassenberg, D. M., Cockman, C. J., & Giulio, R. T. D. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl011 · Cited by 301 · see citing works

Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family

Hahn, M. E., Karchner, S. I., Shapiro, M. A., & Perera, S. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13743 · Cited by 278 · see citing works

A Novel Role for the Dioxin Receptor in Fatty Acid Metabolism and Hepatic Steatosis

Lee, J. H., Wada, T., Febbraio, M., He, J., Matsubara, T., Lee, M. J., Gonzalez, F. J., & Xie, W. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.033 · Cited by 277 · see citing works

Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptorPreprint

Duncan, D. M., Burgess, E. A., & Duncan, I. (1998) · Genes & Development · doi:10.1101/gad.12.9.1290 · Cited by 278 · see citing works

Aryl Hydrocarbon Receptor 2 Mediates 2,3,7,8-Tetrachlorodibenzo-p-dioxin Developmental Toxicity in Zebrafish

Prasch, A. L. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg202 · Cited by 273 · see citing works

Tryptophan and indole metabolism in immune regulation

Fiore, A., & Murray, P. J. (2021) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.12.001 · Cited by 262 · see citing works

Estrogen-induced cardiorenal protection: potential cellular, biochemical and molecular mechanisms.

Dubey, R. K., & Jackson, E. K. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.280.3.f365 · Cited by 263 · see citing works

A Direct Interaction between the Aryl Hydrocarbon Receptor and Retinoblastoma Protein

Ge, N.-L., & Elferink, C. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.35.22708 · Cited by 258 · see citing works

The Aryl Hydrocarbon Receptor-Activating Effect of Uremic Toxins from Tryptophan Metabolism: A New Concept to Understand Cardiovascular Complications of Chronic Kidney Disease

Sallée, M., Dou, L., Cérini, C., Poitevin, S., Brunet, P., & Burtey, S. (2014) · Toxins · doi:10.3390/toxins6030934 · Cited by 255 · see citing works

Review: Hypoxia-Inducible Factor-1 (HIF-1): A Novel Transcription Factor in Immune Reactions

Hellwig‐Bürgel, T., Stiehl, D. P., Wagner, A. E., Metzen, E., & JELKMANN, W. E. B. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.297 · Cited by 255 · see citing works

The Comparative Toxicogenomics Database (CTD).

Mattingly, C. J., Colby, G. T., Forrest, J. N., & Boyer, J. L. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6028 · Cited by 253 · see citing works

Human CYP1B1 Is Regulated by Estradiol via Estrogen Receptor

Tsuchiya, Y., Nakajima, M., Kyo, S., Kanaya, T., Inoue, M., & Yokoi, T. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0166 · Cited by 249 · see citing works

Identification of toxicologically predictive gene sets using cDNA microarrays

Thomas, R. S., Rank, D. R., Penn, S. G., Zastrow‐Hayes, G., Hayes, K. R., Pande, K., Glover, E. A., Silander, T., Craven, M. W., Reddy, J. K., et al. (2001) · Molecular Pharmacology · doi:10.1124/mol.60.6.1189 · Cited by 241 · see citing works

Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types

Walisser, J. A., Glover, E., Pande, K., Liss, A. L., & Bradfield, C. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504757102 · Cited by 212 · see citing works

Characterization of the AhR−hsp90−XAP2 Core Complex and the Role of the Immunophilin-Related Protein XAP2 in AhR Stabilization

Meyer, B. K., & Perdew, G. H. (1999) · Biochemistry · doi:10.1021/bi982223w · Cited by 232 · see citing works

Recruitment of the NCoA/SRC-1/p160 Family of Transcriptional Coactivators by the Aryl Hydrocarbon Receptor/Aryl Hydrocarbon Receptor Nuclear Translocator Complex

Beischlag, T. V., Wang, S., Rose, D. W., Torchia, J., Reisz‐Porszasz, S., Muhammad, K., Nelson, W. E., Probst, M. R., Rosenfeld, M. G., & Hankinson, O. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4319-4333.2002 · Cited by 223 · see citing works

Tissue-Specific Expression of AHR2, ARNT2, and CYP1A in Zebrafish Embryos and Larvae: Effects of Developmental Stage and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure

Andreasen, E. A. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.2.403 · Cited by 222 · see citing works

Cross-talk between the Aryl Hydrocarbon Receptor and Hypoxia Inducible Factor Signaling Pathways

Chan, W. K., Yao, G., Gu, Y.-Z., & Bradfield, C. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.12115 · Cited by 221 · see citing works

Cutting Edge: Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo- p -dioxin Generates a Population of CD4+CD25+ Cells with Characteristics of Regulatory T Cells

Funatake, C. J., Marshall, N. B., Steppan, L. B., Mourich, D. V., & Kerkvliet, N. I. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4184 · Cited by 219 · see citing works

Resistance to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity and Abnormal Liver Development in Mice Carrying a Mutation in the Nuclear Localization Sequence of the Aryl Hydrocarbon Receptor

Bunger, M. K., Moran, S. M., Glover, E., Thomae, T. L., Lahvis, G. P., Lin, B. C., & Bradfield, C. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209594200 · Cited by 215 · see citing works

Characterization of the Ah Receptor-associated Protein, ARA9

Carver, L. A., LaPres, J. J., Jain, S. R., Dunham, E. E., & Bradfield, C. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33580 · Cited by 207 · see citing works

The molecular basis for differential dioxin sensitivity in birds: Role of the aryl hydrocarbon receptor

Karchner, S. I., Franks, D. G., Kennedy, S. W., & Hahn, M. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509950103 · Cited by 207 · see citing works

Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis

Alexander, D. L., Ganem, L. G., Fernández‐Salguero, P. M., Gonzalez, F. J., & Jefcoate, C. R. E. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.22.3311 · Cited by 201 · see citing works

Cloning and characterization of the zebrafish (Danio rerio) aryl hydrocarbon receptor

Tanguay, R. L., Abnet, C. C., Heideman, W., & Peterson, R. E. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(98)00252-8 · Cited by 194 · see citing works

AhR signalling and dioxin toxicity

Sorg, O. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.10.039 · Cited by 189 · see citing works

Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1α

Chilov, D., Camenisch, G., Kvietikova, I., Ziegler, U., Gassmann, M., & Wenger, R. H. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.8.1203 · Cited by 192 · see citing works

Temporal and Dose-Dependent Hepatic Gene Expression Patterns in Mice Provide New Insights into TCDD-Mediated Hepatotoxicity

Boverhof, D. R., Burgoon, L. D., Tashiro, C. H. M., Chittim, B. G., Harkema, J. R., Jump, D. Β., & Zacharewski, T. R. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi162 · Cited by 188 · see citing works

Functions of the aryl hydrocarbon receptor in the skin

Esser, C., Bargen, I., Weighardt, H., Haarmann-Stemmann, T., & Krutmann, J. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0394-4 · Cited by 187 · see citing works

Point Mutation in Intron Sequence Causes Altered Carboxyl-Terminal Structure in the Aryl Hydrocarbon Receptor of the Most 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Resistant Rat Strain

Pohjanvirta, R., Wong, J. M. Y., Li, W., Harper, P. A., Tuomisto, J., & Okey, A. B. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.1.86 · Cited by 137 · see citing works

Binding of polycyclic aromatic hydrocarbons (PAHs) to teleost aryl hydrocarbon receptors (AHRs)

Billiard, S. M., Hahn, M. E., Franks, D. G., Peterson, R. E., Bols, N. C., & Hodson, P. V. (2002) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(02)00105-7 · Cited by 181 · see citing works

The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development

Qin, H., & Powell‐Coffman, J. A. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.02.004 · Cited by 179 · see citing works

The Zebrafish (Danio rerio) Aryl Hydrocarbon Receptor Type 1 Is a Novel Vertebrate Receptor

Andreasen, E. A., Hahn, M. E., Heideman, W., Peterson, R. E., & Tanguay, R. L. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.2.234 · Cited by 175 · see citing works

The Aryl Hydrocarbon Receptor Functions as a Tumor Suppressor of Liver Carcinogenesis

Fan, Y., Boivin, G. P., Knudsen, E. S., Nebert, D. W., Xia, Y., & Puga, A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-3090 · Cited by 178 · see citing works

Relative Contributions of Affinity and Intrinsic Efficacy to Aryl Hydrocarbon Receptor Ligand Potency

Hestermann, E. V., Stegeman, J. J., & Hahn, M. E. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2000.9026 · Cited by 177 · see citing works

Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling

Fiore, A., Zeitler, L., Russier, M., Groß, A., Hiller, M.-K., Parker, J. L., Stier, L. J., Köcher, T., Newstead, S. L., & Murray, P. J. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.02.007 · Cited by 175 · see citing works

Ah receptor and NF-κB interactions: mechanisms and physiological implications

Tian, Y., Rabson, A. B., & Gallo, M. A. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00068-6 · Cited by 176 · see citing works

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the mRNA expression of critical genes associated with cholesterol metabolism, bile acid biosynthesis, and bile transport in rat liver: A microarray study

Fletcher, N., Wahlström, D., Lundberg, R., Nilsson, C. B., Nilsson, K. C., Stockling, K., Hellmold, H., & Håkansson, H. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.12.003 · Cited by 174 · see citing works

The Role of Aryl Hydrocarbon Receptor in the Pathogenesis of Cardiovascular Diseases

Korashy, H. M., & El‐Kadi, A. O. S. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600632063 · Cited by 173 · see citing works

The role of the aryl hydrocarbon receptor in the female reproductive system

Hernández‐Ochoa, I., Karman, B. N., & Flaws, J. A. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.09.037 · Cited by 171 · see citing works

Zebrafish as a novel experimental model for developmental toxicology

Teraoka, H., Dong, W., & Hiraga, T. (2003) · Congenital Anomalies · doi:10.1111/j.1741-4520.2003.tb01036.x · Cited by 169 · see citing works

Epigallocatechin Gallate Inhibits Aryl Hydrocarbon Receptor Gene Transcription through an Indirect Mechanism Involving Binding to a 90 kDa Heat Shock Protein

Palermo, C. M., Westlake, C. A., & Gasiewicz, T. A. (2005) · Biochemistry · doi:10.1021/bi047433p · Cited by 167 · see citing works

Reproductive and developmental toxicity of dioxin in fish

King‐Heiden, T. C., Mehta, V., Xiong, K. M., Lanham, K. A., Antkiewicz, D. S., Ganser, A. M., Heideman, W., & Peterson, R. E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.027 · Cited by 166 · see citing works

Applications of Gene Arrays in Environmental Toxicology: Fingerprints of Gene Regulation Associated with Cadmium Chloride, Benzo(a)pyrene, and Trichloroethylene

Bartosiewicz, M. J., Penn, S. G., & Buckpitt, A. R. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.0110971 · Cited by 166 · see citing works

Aryl Hydrocarbon Receptor Activation by TCDD Reduces Inflammation Associated with Crohn's Disease

Benson, J. M., & Shepherd, D. M. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq360 · Cited by 165 · see citing works

Structural and Functional Characterization of the Aryl Hydrocarbon Receptor Ligand Binding Domain by Homology Modeling and Mutational Analysis

Pandini, A., Denison, M. S., Song, Y., Soshilov, A. A., & Bonati, L. (2007) · Biochemistry · doi:10.1021/bi061460t · Cited by 160 · see citing works

Repression of Aryl Hydrocarbon Receptor (AHR) Signaling by AHR Repressor: Role of DNA Binding and Competition for AHR Nuclear Translocator

Evans, B. R., Karchner, S., Allan, L., Pollenz, R., Tanguay, R. L., Jenny, M. J., Sherr, D., & Hahn, M. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.040204 · Cited by 173 · see citing works

Aryl Hydrocarbon Receptor-Deficient Mice Generate Normal Immune Responses to Model Antigens and Are Resistant to TCDD-Induced Immune Suppression

Vorderstrasse, B. A., Steppan, L. B., Silverstone, A. E., & Kerkvliet, N. I. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2000.9122 · Cited by 162 · see citing works

Identification and Functional Characterization of Two Highly Divergent Aryl Hydrocarbon Receptors (AHR1 and AHR2) in the TeleostFundulus heteroclitus

Karchner, S. I., Powell, W. H., & Hahn, M. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33814 · Cited by 160 · see citing works

Aryl Hydrocarbon Receptor Activation Produces Heart-Specific Transcriptional and Toxic Responses in Developing Zebrafish

Carney, S. A., Chen, J., Burns, C. G., Xiong, K. M., Peterson, R. E., & Heideman, W. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.025304 · Cited by 159 · see citing works

The Aryl Hydrocarbon Receptor Displaces p300 from E2F-dependent Promoters and Represses S Phase-specific Gene Expression

Marlowe, J. L., Knudsen, E. S., Schwemberger, S. J., & Puga, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404315200 · Cited by 159 · see citing works

Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR)

Seok, S.-H., Ma, Z.-X., Feltenberger, J. B., Chen, H., Chen, H., Scarlett, C., Lin, Z., Satyshur, K. A., Cortopassi, M., Jefcoate, C. R., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000631 · Cited by 157 · see citing works

The Aryl Hydrocarbon Receptor Mediates UVB Radiation–Induced Skin Tanning

Jux, B., Kadow, S., Luecke, S., Rannug, A., Krutmann, J., & Esser, C. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.269 · Cited by 156 · see citing works

DNA binding and protein interactions of the AHR/ARNT heterodimer that facilitate gene activation.

Swanson, H. I. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00066-2 · Cited by 158 · see citing works

Unexpected diversity of aryl hydrocarbon receptors in non‐mammalian vertebrates: insights from comparative genomics

Hahn, M. E., Karchner, S. I., Evans, B. R., Franks, D. G., Merson, R. R., & Lapseritis, J. M. (2006) · Journal of Experimental Zoology Part A: Comparative Experimental Biology · doi:10.1002/jez.a.323 · Cited by 153 · see citing works

A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis

Kobayashi, S., Okamoto, H., Iwamoto, T., Toyama, Y., Tomatsu, T., Yamanaka, H., & Momohara, S. (2008) · Lara D. Veeken · doi:10.1093/rheumatology/ken259 · Cited by 155 · see citing works

Translesion Synthesis by Human DNA Polymerase κ on a DNA Template Containing a Single Stereoisomer of dG-(+)- or dG-(−)-anti-N2-BPDE (7,8-Dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene)

Suzuki, N., Ohashi, E., Kolbanovskiy, A., Geacintov, N. E., Grollman, A. P., Ohmori, H., & Shibutani, S. (2002) · Biochemistry · doi:10.1021/bi020049c · Cited by 155 · see citing works

AHR1B, a new functional aryl hydrocarbon receptor in zebrafish: tandem arrangement of <i>ahr1b</i> and <i>ahr2</i> genes

Karchner, S. I., Franks, D. G., & Hahn, M. E. (2005) · Biochemical Journal · doi:10.1042/bj20050713 · Cited by 151 · see citing works

Induction of Mouse UDP-Glucuronosyltransferase mRNA Expression in Liver and Intestine by Activators of Aryl-Hydrocarbon Receptor, Constitutive Androstane Receptor, Pregnane X Receptor, Peroxisome Proliferator-Activated Receptor α, and Nuclear Factor Erythroid 2-Related Factor 2

Buckley, D. B., & Klaassen, C. D. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.024190 · Cited by 150 · see citing works

PD98059 Is an Equipotent Antagonist of the Aryl Hydrocarbon Receptor and Inhibitor of Mitogen-Activated Protein Kinase Kinase

Reiners, J. J., Lee, J., Clift, R. E., Dudley, D. T., & Myrand, S. P. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.3.438 · Cited by 148 · see citing works

Aryl Hydrocarbon Receptor Is Critical for Homeostasis of Invariant γδ T Cells in the Murine Epidermis

Kadow, S., Jux, B., Zahner, S. P., Wingerath, B., Chmill, S., Clausen, B. E., Hengstler, J. G., & Esser, C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100912 · Cited by 146 · see citing works

Deciphering the Nutraceutical Potential of Raphanus sativus—A Comprehensive Overview

Manivannan, A., Kim, J., Kim, D., Lee, E.-S., & Lee, H. (2019) · Nutrients · doi:10.3390/nu11020402 · Cited by 146 · see citing works

The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model

Avilla, M. N., Malecki, K. M. C., Hahn, M. E., Wilson, R. H., & Bradfield, C. A. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00476 · Cited by 141 · see citing works

The Ah Receptor:\nAdaptive Metabolism, Ligand Diversity,\nand the Xenokine Model

Avilla, M. N., (8962787), K. M. C. M., Hahn, M. E., Wilson, R. H., & Bradfield, C. A. (2020) · Figshare · doi:10.1021/acs.chemrestox.9b00476.ls01

The aryl hydrocarbon receptor system

Barouki, R., Aggerbeck, Μ., Aggerbeck, L. P., & Coumoul, X. (2012) · Drug metabolism and drug interactions · doi:10.1515/dmdi-2011-0035 · Cited by 154 · see citing works

Aryl Hydrocarbon Receptor-Mediated Signal Transduction

Rowlands, J. C., & Gustafsson, J.-Å. (1997) · Critical Reviews in Toxicology · doi:10.3109/10408449709021615 · Cited by 490 · see citing works

Analysis of the Aryl Hydrocarbon Receptor (<scp>Ah</scp><scp>R</scp>) Signal Transduction Pathway

Denison, M. S., Rogers, J. M., Rushing, S. R., Jones, C. L., Tetangco, S. C., & Heath‐Pagliuso, S. (2002) · Current Protocols in Toxicology · doi:10.1002/0471140856.tx0408s11 · Cited by 55 · see citing works