Identification of Ketoconazole as an AhR-Nrf2 Activator in Cultured Human Keratinocytes: The Basis of Its Anti-Inflammatory Effect
Tsuji, Gaku, Takahara, Masakazu, Uchi, Hiroshi, Matsuda, Tetsuo, Chiba, Takahito, Takeuchi, Satoshi, Yasukawa, Fumiko, Moroi, Yoichi +1 more·2012·Journal of Investigative Dermatology
Cited by (170)
Items 101–170 of 170
- Implications of tryptophan photoproduct FICZ in oxidative stress and terminal differentiation of keratinocytesMasutaka Furue, Hiroshi Uchi, Chikage Mitoma, Akiko Hashimoto‐Hachiya, Yuka Tanaka, Takamichi Ito, Gaku Tsuji · 2019 · Giornale Italiano di Dermatologia e Venereologia
- ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasisChi‐Ruei Huang, Ting‐Wei Chang, Chung‐Ta Lee, Chih‐Jie Shen, Wen‐Chang Chang, Ben‐Kuen Chen · 2021 · Oncogenesis
- Nitroxide delivery system for Nrf2 activation and skin protectionBen Yehuda Greenwald, Maya, Frušić-Zlotkin, Marina, Soroka, Yoram, Sasson, Shmuel Ben, Bianco-Peled, Havazelet, Bitton, Ronit, Kohen, Ron · 2015 · European Journal of Pharmaceutics and Biopharmaceutics
- Antioxidant Activities and Mechanisms of Tomentosin in Human KeratinocytesSeyoung Yang, See‐Hyoung Park, Sae Woong Oh, Kitae Kwon, Eunbi Yu, Chae Won Lee, Youn Kyoung Son, Changmu Kim, Byoung‐Hee Lee, Jae Youl Cho et al. · 2022 · Antioxidants
- Tryptophan, an important link in regulating the complex network of skin immunology response in atopic dermatitisYaxin Huang, Lingna Chen, Fuming Liu, Xia Xiong, Yongliang Ouyang, Yongqiong Deng · 2024 · Frontiers in Immunology
- Protease-activated receptor-2 activates NQO-1 via Nrf2 stabilization in keratinocytesDo Young Kim, Do Young Kim, Hyojung Son, Yoon Jee Kim, Sang Ho Oh · 2013 · Journal of Dermatological Science
- Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulationMark A. Dugo, Fengxiang X. Han, Paul Bernard Tchounwou · 2012 · Reviews on Environmental Health
- Antagonizing Effects of Clematis apiifolia DC. Extract against Benzo[a]pyrene-Induced Damage to Human KeratinocytesSeung Eun Lee, See‐Hyoung Park, Ju Ah Yoo, Kitae Kwon, Ji Woong Kim, Sae Woong Oh, Se Jin Park, Jangsoon Kim, Eunbi Yu, Byung Seok Han et al. · 2019 · Oxidative Medicine and Cellular Longevity
- The role of aryl hydrocarbon receptor in vitiligo: a reviewYiting Li, Yibin Zeng, Zile Chen, Xi Tan, Xingyu Mei, Zhouwei Wu · 2024 · Frontiers in Immunology
- Xenobiotic Receptors and Their Mates in Atopic DermatitisDeborah Minzaghi, Petra Pavel, Sandrine Dubrac · 2019 · International Journal of Molecular Sciences
- Resveratrol exhibits neuroprotection against paraquat-induced PC12 cells via heme oxygenase 1 upregulation by decreasing MiR-136-5p expressionLi Zhang, Min-Na Dong, Jun Deng, Chun-Hai Zhang, Mingwei Liu · 2022 · Bioengineered
- Decrease of reactive oxygen species and reciprocal increase of nitric oxide in human dermal endothelial cells by Bidens pilosa extract: A possible explanation of its beneficial effect on livedo vasculopathyFutoshi Kohda, Masakazu Takahara, Akiko Hachiya, Kenjiro Takei, Gaku Tsuji, Kazuhiko Yamamura, Masutaka Furue · 2013 · Journal of Dermatological Science
- Nrf2 Activation in Keratinocytes: A Central Role in Diabetes‐Associated Wound HealingSrinivasan Kaussikaa, Murali Krishna Prasad, Kunka Mohanram Ramkumar · 2024 · Experimental Dermatology
- The AHR–NRF2–JDP2 gene battery: Ligand–induced AHR transcriptional activationKenly Wuputra, Wen‐Hung Hsu, Chia‐Chen Ku, Ya-Han Yang, Kung‐Kai Kuo, Fang‐Jung Yu, Hsin-Su Yu, Kyosuke Nagata, Deng‐Chyang Wu, Chao‐Hung Kuo et al. · 2025 · Biochemical Pharmacology
- Reduction of CC-chemokine ligand 5 by aryl hydrocarbon receptor ligandsSaori Morino‐Koga, Hiroshi Uchi, Gaku Tsuji, Masakazu Takahara, Junboku Kajiwara, Teruaki Hirata, Masutaka Furue · 2013 · Journal of Dermatological Science
- Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblastsKenly Wuputra, Ming-Ho Tsai, Kohsuke Kato, Ya-Han Yang, Jia-Bin Pan, Chia‐Chen Ku, Michiya Noguchi, Shotaro Kishikawa, Koji Nakade, Hua‐Ling Chen et al. · 2021 · Cell Biology and Toxicology
- Revival of AHR Agonist for the Treatment of Atopic Dermatitis: TapinarofMasutaka Furue, Takeshi Nakahara · 2020 · Current Treatment Options in Allergy
- Impurities contained in antifungal drug ketoconazole are potent activators of human aryl hydrocarbon receptorAneta Grycová, Aneta Dořičáková, Zdeněk Dvořák · 2015 · Toxicology Letters
- Anti-Inflammatory and Pro-Differentiating Properties of the Aryl Hydrocarbon Receptor Ligands NPD-0614-13 and NPD-0614-24: Potential Therapeutic Benefits in PsoriasisGiorgia Cardinali, Enrica Flori, Arianna Mastrofrancesco, Sarah Mosca, Monica Ottaviani, Maria Lucia Dell’Anna, Mauro Truglio, Antonella Vento, Marco Zaccarini, Christos C. Zouboulis et al. · 2021 · International Journal of Molecular Sciences
- The role of PPAR in fungal keratitisHongyan Zhou, Hong Zhang, Miaomiao Bi, Wensong Zhang · 2024 · Frontiers in Immunology
- Inhibition of Ectodermal-Neural Cortex 1 Protects Neural Cells from Apoptosis Induced by Hypoxia and HypoglycemiaHongtao Lei, Jing Li, Zhi Quan Zhao, Li Liu · 2016 · Journal of Molecular Neuroscience
- Ethyl 2,4-dicarboethoxy pantothenate, a derivative of pantothenic acid, prevents cellular damage initiated by environmental pollutants through Nrf2 activationMariko Yokota, Shoichi Yahagi, Hitoshi Masaki · 2018 · Journal of Dermatological Science
- Aryl hydrocarbon receptor (AhR) agonist β-naphthoflavone regulated gene networks in human primary trophoblastsRami El Dairi, Pasi Huuskonen, Markku Pasanen, Jaana Rysä · 2020 · Reproductive Toxicology
- Difamilast, a Topical Phosphodiesterase 4 Inhibitor, Produces Soluble ST2 via the AHR–NRF2 Axis in Human KeratinocytesGaku Tsuji, Ayako Yumine, Koji Kawamura, Masaki Takemura, Makiko Kido‐Nakahara, Kazuhiko Yamamura, Takeshi Nakahara · 2024 · International Journal of Molecular Sciences
- The AhRR-c.565C>G transversion may increase total antioxidant capacity levels of the seminal plasma in infertile menGholam Ali Josarayi, Azadeh Mohammad‐Hasani, Younes Aftabı, Emadoddin Moudi, Abasalt Hosseinzadeh Colagar · 2017 · Environmental Science and Pollution Research
- The Therapeutic Aryl Hydrocarbon Receptor–Modulating Agent Tapinarof Regulates SEMA3A Expression in Human Keratinocytes through NRF2Gaku Tsuji, Ayako Yumine, Kazuhiko Yamamura, Masaki Takemura, Makiko Kido‐Nakahara, Takamichi Ito, Takeshi Nakahara · 2023 · Journal of Investigative Dermatology
- Atopic dermatitis-related anti-inflammatory in vitro effects of a plant extract mixtureNina Heinemann, Franziska Rademacher, Henning Vollert, Regine Gläser, Jürgen Harder · 2025 · Scientific Reports
- Itraconazole cis-diastereoisomers activate aryl hydrocarbon receptor AhR and pregnane X receptor PXR and induce CYP1A1 in human cell lines and human hepatocytesMartina Štěpánková, Barbora Pastorková, Petr Bachleda A, Zdeněk Dvořák · 2017 · Toxicology
- 6-Formylindolo(3,2-b)carbazole Dampens Inflammation and Reduces Endotoxin-Induced Kidney Injury via Nrf2 ActivationHevna Dhulkifle, Tahseen S. Sayed, Hanan H. Abunada, Sara M. Abulola, Ali Alhoshani, Hesham Mohamed Korashy, Zaid H. Maayah · 2023 · Chemical Research in Toxicology
- Induction of Semaphorin 3A by Resveratrol and Pinostilbene via Activation of the AHR-NRF2 Axis in Human KeratinocytesGaku Tsuji, Ayako Yumine, Koji Kawamura, Masaki Takemura, Takeshi Nakahara · 2024 · Antioxidants
- Ketoconazole pretreatment ameliorates carbon tetrachloride-induced acute liver injury in rats by suppressing inflammation and oxidative stressYun-song Zhou, Chong Peng, Zunming Zhou, Ke‐Er Huang · 2019 · The Journal of Toxicological Sciences
- Schisandra chinensis Protects the Skin from Global Pollution by Inflammatory and Redox Balance Pathway Modulations: An In Vitro StudyEdwige Ranouille, Carine Boutot, Emilie Bony, Oriane Bombarde, Sarah Grosjean, Antoine Lazewski, Jean‐Yves Berthon, Edith Filaire · 2018 · Cosmetics
- Holistic development of coal tar lotion by embedding design of experiments (DoE) technique: preclinical investigationsMandeep Sharma, Gajanand Sharma, Bhupinder Singh, Vandana Dhiman, Sanjay Kumar Bhadada, Om Prakash Katare · 2020 · Expert Opinion on Drug Delivery
- Q-switched Nd:YAG laser protects human keratinocytes from oxidative stress and inflammation via AhR–Nrf2 pathwayAlessandra Fusco, Vittoria Savio, Brunella Perfetto, Maria Donniacuo, Elena Shadrina, Giovanna Donnarumma, Adone Baroni · 2023 · Lasers in Medical Science
- Genetic variants affecting chemical mediated skin immunotoxicityIsisdoris Rodrigues de Souza, Patrícia Savio de Araujo-Souza, Daniela Morais Leme · 2022 · Journal of Toxicology and Environmental Health. Part B, Critical Reviews
- Investigation of the association of endothelial nitric oxide synthase (eNOS)-T786C gene polymorphism with the risk of male infertility in an Iranian populationFaezeh Sadat Mousavi-Nasab, Abasalt Hosseinzadeh Colagar · 2020 · Environmental Science and Pollution Research
- Navigating the landscape of psoriasis therapy: novel targeted pathways and emerging trendsSrinath Innani, Yashika Tomar, Vikas Rana, Gautam Singhvi · 2023 · Expert Opinion on Therapeutic Targets
- Molecular exploration of hidden pleiotropic activities of azoles on dermatophytes in human tinea corporis infectionKhalid Saad Alharbi, Navneet Joshi, Yogendra Prasad Singh, Waleed Hassan Almalki, Imran Ahmed Kazmi, Fahad Ahmed Al-Abbasi, Sami Ibrahim Alzarea, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Gaurav Gupta · 2022 · Journal de Mycologie Médicale
- The role of the aromatic hydrocarbon receptor in the pathogenesis of atopic dermatitisPavel V. Gorodnichev · 2023 · Vestnik dermatologii i venerologii
- AhR restricts axon regeneration by balancing neuronal stress and growth response after injuryDalia Halawani, Yiqun Wang, Jiaxi Li, Daniel Halperin, Haofei Ni, Molly S. Estill, Aarthi Ramakrishnan, Li Shen, Arthur Sefiani, Cédric G. Geoffroy et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- I3C protects IPEC-J2 cells by inhibiting ferroptosis through activation of the AhR-Nrf2-SLC7A11-GPX4 pathwaysHaoran Jiang, Yalei Zhang, Xiwen Hu, Chengcheng Guo, Liguang Shi, Wenjuan Xun · 2025 · International Immunopharmacology
- The Aryl Hydrocarbon Receptor (AhR) as an Environmental Stress Sensor and Regulator of Skin Barrier Function: Molecular Mechanisms and Therapeutic OpportunitiesRebecca Justiniano, Georg T. Wondrak · 2016 · Springer eBooks
- A Mouse Model of Trichophyton Inflammation Based on Trichophytin-induced Contact HypersensitivityTomoya Nakamura, Naoki Yoshida, Akiko Nishibu, Takashi Mochizuki · 2019 · Medical Mycology Journal
- Chemical Allergen‐Induced Skin Cell ActivationStefan F. Martin, Philipp R. Esser · 2014
- Zingerone Enhances Fertility Markers in Both Male and Female Rats and Increases Aryl Hydrocarbon Receptor ExpressionBasma Ghazi Eid, Abeer Hanafy, Atif Hasan, Thikryat Neamatalla · 2020 · International Journal of Pharmacology
- Lipoxin A4 alleviates inflammation in Aspergillus fumigatus-stimulated human corneal epithelial cells by Nrf2/HO-1 signaling pathway.Xudong Peng, Xiaojia Zhu, Junjie Luan, Jing Lin, Yingxue Zhang, Qian Wang, Guiqiu Zhao · 2022 · PubMed Central
- AHR: The Overlooked Mediator in Skincare─Bridging Environmental Sensing and Skin PhysiologyXiaoxu Hu, Ruihong Zhu, Yu Zhen, Qing Li, Yiyun Liu, Tong Xu, Guang Yang, Yangsheng Chen, Heidi Qunhui Xie, Sherry Li Xu et al. · 2026 · Environment & Health
- Aryl hydrocarbon receptor mediates the maintenance and immune regulatory functions of gut-resident macrophagesMee-Sun Kim, Young-In Kim, Sunkyung Kim, Sun-Young Chang · 2026 · Environment International
- Plant extract mixture shows anti-inflammatory and barrier-strengthening effects and activates aryl hydrocarbon receptor in a 2D psoriasis modelNina Heinemann, Franziska Rademacher, Henning Vollert, Regine Gläser, Jürgen Harder · 2026 · Scientific Reports
- Transcription Factor Regulation of Epidermal Differentiation and InflammationUyanga Batzorig, Grace Zhang, George L. Sen · 2026 · Cells
- Pivotal role of the aryl hydrocarbon receptor in modulations caused by benzo[a]pyrene and ketoconazole in the estrogenic responses induced by 17β-estradiol in male goldfishZdeněk Dvořák · 2016 · Environmental Science and Pollution Research
- Up-regulation of Nrf-2 and Nqo1 Expression by Bidens Pilosa Extract in Human KeratinocytesMasakazu AKAHARA, Kazuyo Kita, Konosuke Nagae, Akiko HACHIYA, Ran HIDAKA, Tomoyo ISOTANI, Kazuko Doi, Kenjiro Takei, Masutaka Furue · 2013 · The Nishinihon Journal of Dermatology
- Roles of the Aryl Hydrocarbon Receptor in the SkinMasakazu Takahara · 2014 · The Nishinihon Journal of Dermatology
- Influence of Air Pollution on SkinSparsha Saxena, Golara Honari · 2017 · CRC Press eBooks
- The Aryl Hydrocarbon Receptor senses the Henna pigment Lawsone and mediates Yin-Yang effects on skin homeostasisL. Lozza, Pedro Moura-Alves, Teresa Domaszewska, Carolina Lage Crespo, I. Streață, A. Kreuchwig, M. Bechtle, Marion Klemm, Ulrike Zedler, Silviu Ungureanu Bogdan et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
- Influence of Air Pollution on SkinSparsha Saxena, Golara Honari · 2017 · CRC Press eBooks
- Regulation of Anti-inflammatory and Anti-oxidative Effects by Liranaftate through Aryl Hydrocarbon Receptor on Human KeratinocytesMasakazu Takahara, Kenjiro Takei, Akiko Hachiya, Yoshihiro MIZOTE, Mika Murai, Yoshiko Sasaki, Fumitaka Ohno, Noriko OKABE, Nobutoshi Take, Akiko Masuda et al. · 2014 · The Nishinihon Journal of Dermatology
- Research Progress of Benvitimod in the Treatment of Atopic Dermatitis春辉 马 · 2023 · Advances in Clinical Medicine
- Antifungal Monotherapy in Acne: Topical Ketoconazole 2% Cream Versus Adapalene Gel in Treating Acne Vulgaris: A Comparative StudyEman Mohamed Salah, Nermeen Ibrahim Bedair, Alaa Sabri Farid, Manal Ahmed Sharara · 2025 · Journal of Cutaneous Medicine and Surgery
- Sasa veitchii extract mitigates disruption of skin barrier function in a mouse model of dry skinMinako Ogawa‐Tominaga, Michie Katsuta, Mitsutoshi Tominaga, Kenji Takamori, Akihiko Asahina, Minoru Narita, Yozo Ishiuji · 2025 · Heliyon
- Additional file 2 of Gut microbiota-derived tryptophan metabolites alleviate liver injury via AhR/Nrf2 activation in pyrrolizidine alkaloids-induced sinusoidal obstruction syndromeShang, Haitao, Huang, Chao, Xiao, Zhuanglong, Yang, Pengcheng, Shengyan Zhang, Hou, Xiaohua, Zhang, Lei · 2024 · Figshare
- Additional file 1 of Gut microbiota-derived tryptophan metabolites alleviate liver injury via AhR/Nrf2 activation in pyrrolizidine alkaloids-induced sinusoidal obstruction syndromeShang, Haitao, Huang, Chao, Xiao, Zhuanglong, Yang, Pengcheng, Shengyan Zhang, Hou, Xiaohua, Zhang, Lei · 2024 · Figshare
- Adverse outcome pathway-informed machine learning for predicting vascular toxicity of emerging organic pollutantsAubin Siewetcheu Toukak, Wenjie Gao, Shouqiang Wan, Ning Li, Guanyi Chen · 2026 · Environmental Science Processes & Impacts
- Comparative 28-day mouse study of topically applied aryl hydrocarbon receptor ligands: microbiota-derived indoles, therapeutic tapinarof, pollutants 2,3,7,8-tetrachlorodibenzo-p-dioxin and diesel exhaust particlesSubhash Singh Solanki, Syeda Mashnia Tasnim, Lauren Thompson, Madhusudhan Alle, Brandon Ward, Andrzej T. Slominski, Zorica Janjetović, Teresa Maria Jóźwicka, Patrycja Maria Erdmańska, Deborah Minzaghi et al. · 2026 · Chemico-Biological Interactions
- Etude du rôle du récepteur aux hydrocarbures aromatiques au niveau de la physiologie cutanéeRaphael Coatmeur · 2022
- AHR/NRF2 Dual Agonist Prediction and Natural Compound Screening Based on Machine Learning: A New Strategy for the Treatment of Atopic DermatitisYu Zhen, Qi Li, Xiaoxu Hu, Xiaorui Liu, Zhijie Shao, Heidi Qunhui Xie, Bin Zhao, Sherry Li Xu · 2026 · International Journal of Molecular Sciences
- Para-Phenylenediamine Activates AhR and Nrf2 Pathways With Asymmetric Nrf2-to-AhR Crosstalk in HaCaT KeratinocytesJin Ju Lee, Kyung‐Ah Cho, Kyuhee Jeong, So‐Youn Woo, Ji Yeon Byun, You Won Choi, Joo Young Roh, Hae Young Choi · 2026 · Annals of Dermatology
- BindingDB Entry 50017637: Identification of triazolopyridine derivatives as a new class of AhR agonists and evaluation of anti-psoriasis effect in a mouse model.BindingDB · 2023 · UC San Diego
- Bioactive 10-nm graphene oxide modulates AhR-associated keratinocyte signaling and attenuates atopic dermatitis-like inflammationSung-Ae Cha, Nari Shin, Jaechul Ryu, KyungSun Kang · 2026 · Biomaterials Advances
- ビデンス・ピローサエキスによるヒト表皮細胞の Nrf-2 および Nqo1 産生亢進高原 正和, 北和代, 航之介 永江, Akiko Hachiya, Ran HIDAKA, 磯谷 智世, 土井和子, 竹井賢二郎, 古江 増隆 · 2013 · The Nishinihon Journal of Dermatology