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Prognostic Impact of p62 Expression in Cutaneous Malignant Melanoma
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High levels of the autophagy adaptor protein and substrate p62 constitute a prognostic marker of malignant melanoma.
“High levels of autophagy adaptor protein and substrate p62 constitute a prognostic marker of malignant melanoma90, although other work indicates that p62 expression increases, then decreases late in disease progression91.”
From Mechanisms and prevention of UV‐induced melanoma (2018) · cites this paper as [90]
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Final Version of 2009 AJCC Melanoma Staging and Classification
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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.
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Autophagy Suppresses Tumorigenesis through Elimination of p62
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p62 at the crossroads of autophagy, apoptosis, and cancer
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Physiological significance of selective degradation of p62 by autophagy
Komatsu, M., & Ichimura, Y. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.017 · Cited by 524
Selective degradation of p62 by autophagy
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Metadata
- Authors
- Ellis, R. A., Horswell, S., Ness, T., Lumsdon, J., Tooze, S. A., Kirkham, N., Armstrong, J. L., & Lovat, P. E.
- Affiliations
- James Cook University Hospital (GB)
- Institute of Cancer Research (GB)
- Royal Victoria Infirmary (GB)
- Newcastle University (GB)
- University of Sunderland (GB)
- Corresponding author
- Lovat, Penny E.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 134
- Issue
- 5
- Pages
- 1476-1478
- ISSN
- 0022-202X (ISSN-L)
- PMC
- PMC3954816
- OpenAlex
- W1973691911
- Cited by
- 50
- References
- 8
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 2 · 2018: 8 · 2017: 6 · 2016: 7 · 2015: 1 · 2014: 2
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Sunderland Repository (University of Sunderland) (acceptedVersion)
- Newcastle University ePrints (Newcastle Univesity) (cc-by-nc)
- Funders
- Wellcome Trust
- Cancer Research UK (15153, A3601)
- Topics
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- p62, cutaneous melanoma, autophagy, prognostic factors, disease-free survival, melanoma-specific mortality, selective autophagy, ubiquitinated protein degradation, tumor progression, metastasis, apoptosis, oncogenes, prognostic score, gene set enrichment analysis
- MeSH terms
- Sequestosome-1 Protein, Melanoma, Cutaneous Malignant, Cutaneous Malignant Melanoma, Autophagy, Humans, Melanoma, Prognosis, Retrospective Studies, Risk Factors, Skin Neoplasms, Biomarkers, Tumor, Adaptor Proteins, Signal Transducing
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