The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia
Open accessAbstract
Dermal papilla cells (DPCs) taken from male androgenetic alopecia (AGA) patients undergo premature senescence in vitro in association with the expression of p16(INK4a), suggesting that DPCs from balding scalp are more sensitive to environmental stress than nonbalding cells. As one of the major triggers of senescence in vitro stems from the cell "culture shock" owing to oxidative stress, we have further investigated the effects of oxidative stress on balding and occipital scalp DPCs. Patient-matched DPCs from balding and occipital scalp were cultured at atmospheric (21%) or physiologically normal (2%) O2. At 21% O2, DPCs showed flattened morphology and a significant reduction in mobility, population doubling, increased levels of reactive oxygen species and senescence-associated β-Gal activity, and increased expression of p16(INK4a) and pRB. Balding DPCs secreted higher levels of the negative hair growth regulators transforming growth factor beta 1 and 2 in response to H2O2 but not cell culture-associated oxidative stress. Balding DPCs had higher levels of catalase and total glutathione but appear to be less able to handle oxidative stress compared with occipital DPCs. These in vitro findings suggest that there may be a role for oxidative stress in the pathogenesis of AGA both in relation to cell senescence and migration but also secretion of known hair follicle inhibitory factors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Increased oxidative stress and mitochondrial stress were implicated in causing androgenetic alopecia (permanent hair loss) (Ho et al., 2019; Upton et al., 2015).”
From Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact (2020) · cites this paper as Upton et al., 2015
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche
Mohyeldin, A., Garzón-Muvdi, T., & Quiñones‐Hinojosa, A. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.07.007 · Cited by 1,601
PATTERNED LOSS OF HAIR IN MAN: TYPES AND INCIDENCE
Hamilton, J. B. (1951) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1951.tb31971.x · Cited by 1,002
Male Pattern Baldness: classification and Incidence
Norwood, O. T. (1975) · Southern Medical Journal · doi:10.1097/00007611-197511000-00009 · Cited by 893
Induction of hair growth by implantation of cultured dermal papilla cells
Jahoda, C. A. B., Horne, K. A., & OLIVER, R. F. (1984) · Nature · doi:10.1038/311560a0 · Cited by 637
Hair follicle dermal papilla cells at a glance
Driskell, R. R., Clavel, C., Rendl, M., & Watt, F. M. (2011) · Journal of Cell Science · doi:10.1242/jcs.082446 · Cited by 450
The effects of stress and aging on glutathione metabolism
Maher, P. A. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.02.005 · Cited by 426
Kyprianou, N., & Jt, I. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-10-1515 · Cited by 413
Effects of hypoxia on human mesenchymal stem cell expansion and plasticity in 3D constructs
Grayson, W. L., Zhao, F., Izadpanah, R., Bunnell, B. A., & Ma, T. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20571 · Cited by 409
Control of murine hair follicle regression (catagen) by TGF‐β1 in vivo
Foitzik, K., Lindner, G., Müller‐Röver, S., Maurer, M., Botchkareva, N., Botchkarev, V. A., Handjiski, B., Metz, M., Hibino, T., Soma, T., et al. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.5.752 · Cited by 371
Regulation of cellular senescence by p53
Itahana, K., Dimri, G., & Campisi, J. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02228.x · Cited by 365
Cited by
Sorted by citations
Androgenetic alopecia: a review
Lolli, F., Pallotti, F., Rossi, A., Fortuna, M. C., Caro, G., Lenzi, A., Sansone, A., & Lombardo, F. P. (2017) · Endocrine · doi:10.1007/s12020-017-1280-y · Cited by 582
da Silveira, W. A., Fazelinia, H., Rosenthal, S. B., Laiakis, E. C., Kim, M. S., Meydan, C., Kidane, Y., Rathi, K. S., Smith, S. M., Stear, B., et al. (2020) · Cell · doi:10.1016/j.cell.2020.11.002 · Cited by 402
“Increased oxidative stress and mitochondrial stress were implicated in causing androgenetic alopecia (permanent hair loss) (Ho et al., 2019; Upton et al., 2015).”
BackgroundFocus on the Contribution of Oxidative Stress in Skin Aging
Papaccio, F., D’Arino, A., Caputo, S., & Bellei, B. (2022) · Antioxidants · doi:10.3390/antiox11061121 · Cited by 452
Tissue engineering of human hair follicles using a biomimetic developmental approach
Abaci, H. E., Coffman, A., Doucet, Y., Chen, J., Jacków, J., Wang, E., Guo, Z., Shin, J. U., Jahoda, C. A., & Christiano, A. M. (2018) · Nature Communications · doi:10.1038/s41467-018-07579-y · Cited by 307
Yuan, A., Xia, F., Bian, Q., Wu, H., Gu, Y., Wang, T., Wang, R., Huang, L., Huang, Q., Rao, Y., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c05272 · Cited by 215
Metadata
- Authors
- Upton, J. H., Hannen, R. F., Bahta, A. W., Farjo, N., Farjo, B., & Philpott, M. P.
- Affiliations
- Queen Mary University of London (GB)
- Corresponding author
- Philpott, Michael P.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 135
- Issue
- 5
- Pages
- 1244-1252
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1979998542
- Cited by
- 233
- References
- 56
- Citations by year
- 2026: 33 · 2025: 38 · 2024: 30 · 2023: 27 · 2022: 19 · 2021: 28 · 2020: 24 · 2019: 9 · 2018: 7 · 2017: 8 · 2016: 9
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council
- Topics
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- androgenetic alopecia, dermal papilla cells, premature senescence, oxidative stress, p16INK4a, reactive oxygen species, hydrogen peroxide, TGF-β1, TGF-beta2, catalase, glutathione, hair follicle, cell migration
- MeSH terms
- Adult, Alopecia, Biopsy, Needle, Catalase, Cell Movement, Cells, Cultured, Glutathione, Humans, Male, Middle Aged, Oxygen, Scalp, Case-Control Studies, Cellular Senescence, Reactive Oxygen Species, Oxidative Stress, Cyclin-Dependent Kinase Inhibitor p16, Dermis, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
