Cited by 13Neonatal and fetal brain pathologyFetal and Pediatric Neurological DisordersInfant Development and Preterm Care

Clinical impact of term-equivalent magnetic resonance imaging in extremely low-birth-weight infants at a regional NICU

Melbourne, L, Chang, T, Murnick, J, Zaniletti, I, Glass, P, Massaro, A N·2016·Journal of Perinatology

Abstract

Objective To evaluate the clinical impact of routine term-equivalent magnetic resonance imaging (TE-MRI) for extremely low-birth-weight infants at a regional neonatal intensive care unit.Study design This is a single-center retrospective study evaluating preterm survivors who underwent TE-MRI. MRI abnormalities were compared between infants with and without cranial ultrasonography (CUS) abnormalities. Cost analysis comparing imaging modalities was also performed.Results TE-MRI use increased from 17% in 2006 to 76% in 2010. MRI detected new findings in nearly half of infants, whether or not they had known ultrasound abnormalities. MRI detected more cerebellar (18% vs 6%, P=0.04) and moderate white matter injury (12% vs 7%, P<0.001), and altered simulated neurological prognosis across developmental domains. The cost of TE-MRI was $1600, which was comparable to serial CUSs.Conclusion TE-MRI detects new abnormalities and impacts developmental prognosis in the extremely low birth weight, which supports its use despite the added financial cost.

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Crossref · 10.1038/jp.2016.116

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  • MRI is essential in the NICU because of its ability to deliver precise assessment of white matter, gray matter, and posterior fossa abnormalities with functional capabilities that exceed those of ultrasound.

    “Magnetic resonance imaging (MRI) is essential in the NICU because of its ability to deliver precise assessment ofwhitematter, graymatter, and posterior fossa abnormalities with functional capabilities that exceed those of ultrasound (23 , 24).”

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Authors
Melbourne, L., Chang, T., Murnick, J., Zaniletti, I., Glass, P., & Massaro, A. N.
Affiliations
  • Children's National (US)
  • Children's Hospital Association (US)
Corresponding author
Massaro, A N
Venue
Journal of Perinatology
Published
2016-07-28
Volume
36
Issue
11
Pages
985-989
ISSN
  • 0743-8346 (ISSN-L)
  • 1476-5543
OpenAlex
W2507023716
Cited by
13
References
26
Citations by year
2024: 3 · 2022: 2 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2
FWCI
1.94
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Perinatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
Keywords
extremely low birth weight infants, neonatal brain injury, cranial ultrasound, white matter injury, cerebellar lesions, neurodevelopmental prognosis, neonatal intensive care
MeSH terms
Brain, Echoencephalography, Female, Humans, Infant, Newborn, Infant, Premature, Diseases, Intensive Care Units, Neonatal, Magnetic Resonance Imaging, Male, Retrospective Studies, Ultrasonography, Case-Control Studies, Statistics, Nonparametric, Infant, Extremely Low Birth Weight, Infant, Extremely Premature

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