The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery
Open accessAbstract
There is a need to develop early biomarkers of acute kidney injury following cardiac surgery, where morbidity and mortality are increased by its presence. Plasma cystatin C (CyC) and plasma and urine Neutrophil Gelatinase Associated Lipocalin (NGAL) have been shown to detect kidney injury earlier than changes in plasma creatinine in critically ill patients. In order to determine the utility of urinary CyC levels as a measure of kidney injury, we prospectively collected plasma and urine from 72 adults undergoing elective cardiac surgery for analysis. Acute kidney injury was defined as a 25% or greater increase in plasma creatinine or renal replacement therapy within the first 72 hours following surgery. Plasma CyC and NGAL were not useful predictors of acute kidney injury within the first 6 hours following surgery. In contrast, both urinary CyC and NGAL were elevated in the 34 patients who later developed acute kidney injury, compared to those with no injury. The urinary NGAL at the time of ICU arrival and the urinary CyC level 6 hours after ICU admission were most useful for predicting acute kidney injury. A composite time point consisting of the maximum urinary CyC achieved in the first 6 hours following surgery outperformed all individual time points. Our study suggests that urinary CyC and NGAL are superior to conventional and novel plasma markers in the early diagnosis of acute kidney injury following adult cardiac surgery.
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Cited by
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The development of a machine learning inpatient acute kidney injury prediction model.
Koyner, J. L., Carey, K. A., Edelson, D. P., & Churpek, M. M. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003123 · Cited by 323
Self-citationNeutrophil Gelatinase-Associated Lipocalin: A� Promising Biomarker for Human Acute Kidney Injury
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Metadata
- Authors
- Koyner, J. L., Bennett, M. R., Worcester, E. M., Ma, Q., Raman, J., Jeevanandam, V., Kasza, K. E., O'Connor, M. F., Konczal, D. J., Trevino, S., Devarajan, P., & Murray, P. T.
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 74
- Issue
- 8
- Pages
- 1059-1069
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W1973013098
- Cited by
- 377
- References
- 45
- FWCI
- 25.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Koyner, J. L., Bennett, M. R., Worcester, E. M., Ma, Q., Raman, J., Jeevanandam, V., Kasza, K. E., O'Connor, M. F., Konczal, D. J., Trevino, S., Devarajan, P., & Murray, P. T. (2008). Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery. Kidney International. https://doi.org/10.1038/ki.2008.341
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