The DOI matches its Crossref record; 75 of the 77 references it cites were found in a registry or an index.
Role for Hedgehog signaling in hepatic stellate cell activation and viability
Open accessAbstract
Hepatic stellate cells (HSC) have a complex phenotype that includes both neural and myofibroblastic features. The Hedgehog (Hh) pathway has been shown to direct the fate of neural and myofibroblastic cells during embryogenesis and during tissue remodeling in adults. Therefore, we hypothesized that Hh signaling may regulate the fate of HSC in adults. In this study, we find that freshly isolated stellate cells from adult Patched-lacZ transgenic mice exhibit beta-galactosidase activity, indicating Hh pathway activity. Transcripts of Hh ligands, the Hh pathway receptor, and Hh-regulated transcription factors are expressed by stellate cells from mice, rats, and humans. Transfection experiments in a cell line using a Hh-inducible luciferase reporter demonstrate constitutive Hh pathway activity. Moreover, neutralizing antibodies to Hh increase apoptosis, while viability is restored by treatment with Hh ligand. In vitro treatment of primary stellate cells with cyclopamine (Cyc), a pharmacologic inhibitor of the Hh pathway, inhibits activation and slightly decreases cell survival, while a single injection of Cyc into healthy adult mice reduces activation of HSC by more than 50% without producing obvious liver damage. Our findings reveal a novel mechanism, namely the Hh pathway, that regulates the activation and viability of HSC.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“NKT cells secrete HSC activating ligands sonic hedgehog (Shh) and osteopontin (Opn) in the MCD mouse model of NASH (117–120).”
From Hepatic Stellate Cell-Immune Interactions in NASH (2022) · cites this paper as [117]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
Skalli, O., Ropraz, P., Trzeciak, A. M., Benzonana, G., Gillessen, D., & Gabbiani, G. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.6.2787 · Cited by 1,622
Bataller, R. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524282c1 · Cited by 1,480
Inhibition of Hedgehog signaling by direct binding of cyclopamine to SmoothenedPreprint
Chen, J., Taipale, J., Cooper, M. K., & Beachy, P. A. (2002) · Genes & Development · doi:10.1101/gad.1025302 · Cited by 1,464
The Hedgehog and Wnt signalling pathways in cancer
Taipale, J., & Beachy, P. A. (2001) · Nature · doi:10.1038/35077219 · Cited by 1,394
Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development
Porter, J. A., Young, K. E., & Beachy, P. A. (1996) · Science · doi:10.1126/science.274.5285.255 · Cited by 1,360
Activating Smoothened mutations in sporadic basal-cell carcinoma
Xie, J., Murone, M., Luoh, S.-M., Ryan, A. M., Gu, Q., Zhang, C., Bonifas, J. M., Lam, C.-W., Hynes, M., Goddard, A. D., et al. (1998) · Nature · doi:10.1038/34201 · Cited by 1,333
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
Taipale, J., Chen, J., Cooper, M. K., Wang, B., Mann, R. K., Milenković, L., Scott, M. P., & Beachy, P. A. (2000) · Nature · doi:10.1038/35023008 · Cited by 1,314
Cited by
Sorted by citations
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842
Mechanisms of Hepatic Fibrogenesis
Friedman, S. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.003 · Cited by 2,687
Yamaguchi, K., Yang, L., McCall, S. J., Huang, J., Yu, X. X., Pandey, S., Bhanot, S., Monia, B. P., Li, Y.-X., & Diehl, A. M. (2007) · Hepatology · doi:10.1002/hep.21655 · Cited by 1,067
Self-citationHepatic stellate cells in liver development, regeneration, and cancer
Yin, C., Evason, K. J., Asahina, K., & Stainier, D. Y. R. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66369 · Cited by 719
Metabolic zonation of the liver: The oxygen gradient revisited
Kietzmann, T. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.012 · Cited by 499
Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis
Anderson, N., & Borlak, J. T. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.00001 · Cited by 395
Omenetti, A., Porrello, A., Jung, Y., Yang, L., Popov, Y. V., Choi, S. S., Witek, R. P., Alpini, G. D., Venter, J., VanDongen, H. M. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35875 · Cited by 346
Self-citationHedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism
Chen, Y., Choi, S. S., Michelotti, G. A., Chan, I. S., Swiderska‐Syn, M., Karaca, G., Xie, G., Moylan, C. A., Garibaldi, F., Premont, R. T., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.115 · Cited by 289
Self-citationHedgehog signaling in the liver
Omenetti, A., Choi, S. S., Michelotti, G. A., & Diehl, A. M. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.10.003 · Cited by 285
Self-citationLiver zonation: Novel aspects of its regulation and its impact on homeostasis
Gebhardt, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i26.8491 · Cited by 275
Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis
Sicklick, J. K., Li, Y.-X., Jayaraman, A., Kannangai, R., Qi, Y. P., Vivekanandan, P., Ludlow, J. W., Owzar, K., Chen, W., Torbenson, M. S., et al. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi292 · Cited by 276
Self-citationWeiskirchen, R., & Tacke, F. (2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2014.11.03 · Cited by 279
Syn, W., Jung, Y., Omenetti, A., Abdelmalek, M. F., Guy, C. D., Yang, L., Wang, J., Witek, R. P., Fearing, C. M., Pereira, T. A., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.051 · Cited by 257
Self-citationPrinciples of Liver Regeneration and Growth Homeostasis
Michalopoulos, G. K. (2012) · Comprehensive physiology · doi:10.1002/cphy.c120014 · Cited by 278
Choi, S. S., Omenetti, A., Witek, R. P., Moylan, C. A., Syn, W.-K., Jung, Y., Yang, L., Sudan, D. L., Sicklick, J. K., Michelotti, G. A., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00292.2009 · Cited by 219
Self-citationHyun, J., Wang, S., Kim, J., Rao, K. M., Park, S. Y., Chung, I., Ha, C., Kim, S., Yun, Y., & Jung, Y. (2016) · Nature Communications · doi:10.1038/ncomms10993 · Cited by 221
Hedgehog signaling maintains resident hepatic progenitors throughout life
Sicklick, J. K., Li, Y.-X., Melhem, A., Schmelzer, E., Zdanowicz, M., Huang, J., Caballero, M., Fair, J. H., Ludlow, J. W., McClelland, R., et al. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00456.2005 · Cited by 212
Self-citationLearning from Jekyll to control Hyde: Hedgehog signaling in development and cancer
Barakat, M. T., Humke, E. W., & Scott, M. P. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.05.003 · Cited by 215
Non-alcoholic fatty liver disease: What the clinician needs to know
Machado, M. V. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i36.12956 · Cited by 215
Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells
Yang, L., Wang, Y., Mao, H., Fleig, S. V., Omenetti, A., Brown, K. D., Sicklick, J. K., Li, Y., & Diehl, A. M. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.07.032 · Cited by 204
Self-citationHedgehog Signaling Is Critical for Normal Liver Regeneration After Partial Hepatectomy in Mice
Ochoa, B., Syn, W., Delgado, I., Karaca, G., Jung, Y., Wang, J., Zubiaga, A. M., Fresnedo, O., Omenetti, A., Zdanowicz, M., et al. (2010) · Hepatology · doi:10.1002/hep.23525 · Cited by 190
Self-citationOmenetti, A., Yang, L., Li, Y., McCall, S. J., Jung, Y., Sicklick, J. K., Huang, J., Choi, S. S., Suzuki, A., & Diehl, A. M. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700537 · Cited by 178
Self-citationJung, Y., Brown, K. D., Witek, R. P., Omenetti, A., Yang, L., Vandongen, M., Milton, R. J., Hines, I. N., Rippe, R. A., Spahr, L., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.02.022 · Cited by 171
Self-citationPhilips, G., Chan, I. S., Swiderska, M., Schroder, V. T., Guy, C. D., Karaca, G., Moylan, C. A., Venkatraman, T. N., Feuerlein, S., Syn, W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023943 · Cited by 164
Self-citationSignals from dying hepatocytes trigger growth of liver progenitors
Jung, Y., Witek, R. P., Syn, W., Choi, S. S., Omenetti, A., Premont, R. T., Guy, C. D., & Diehl, A. M. (2010) · Gut · doi:10.1136/gut.2009.204354 · Cited by 161
Self-citationHedgehog signalling in liver pathophysiology
Machado, M. V., & Diehl, A. M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.10.017 · Cited by 155
Self-citationThe niche of stellate cells within rat liver #
Sawitza, I., Kordes, C., Reister, S., & Häussinger, D. (2009) · Hepatology · doi:10.1002/hep.23184 · Cited by 145
Fetal alcohol exposure impairs hedgehog cholesterol modification and signaling
Li, Y., Yang, H., Zdanowicz, M., Sicklick, J. K., Qi, Y. P., Camp, T., & Diehl, A. M. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700516 · Cited by 141
Self-citationHyun, J., Wang, S., Kim, J., Kim, G. J., & Jung, Y. (2015) · Scientific Reports · doi:10.1038/srep14135 · Cited by 137
Jung, Y., McCall, S. J., Li, Y., & Diehl, A. M. (2007) · Hepatology · doi:10.1002/hep.21660 · Cited by 122
Self-citationThe hedgehog pathway regulates remodelling responses to biliary obstruction in rats
Omenetti, A., Popov, Y. V., Jung, Y., Choi, S. S., Witek, R. P., Yang, L., Brown, K. D., Schuppan, D., & Diehl, A. M. (2008) · Gut · doi:10.1136/gut.2008.148619 · Cited by 125
Self-citationThe role of Hedgehog signaling in fibrogenic liver repair
Choi, S. S., Omenetti, A., Syn, W., & Diehl, A. M. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.10.015 · Cited by 117
Self-citationEvidence for epithelial-mesenchymal transitions in adult liver cells
Sicklick, J. K., Choi, S. S., Bustamante, M., McCall, S. J., Pérez, E. H., Huang, J., Li, Y., Rojkind, M., & Diehl, A. M. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00102.2006 · Cited by 115
Self-citationPereira, T. A., Witek, R. P., Syn, W., Choi, S. S., Bradrick, S. S., Karaca, G., Agboola, K. M., Jung, Y., Omenetti, A., Moylan, C. A., et al. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.147 · Cited by 114
Self-citationMimeault, M., & Batra, S. K. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002329 · Cited by 119
Blocking the hedgehog pathway inhibits hepatoblastoma growth #
Eichenmüller, M., Gruner, I., Hagl, B., Häberle, B., Müller‐Höcker, J., von Schweinitz, D., & Kappler, R. (2008) · Hepatology · doi:10.1002/hep.22649 · Cited by 111
Omenetti, A., & Diehl, A. M. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00543.2007 · Cited by 107
Self-citationsiRNA- and miRNA-based therapeutics for liver fibrosis
Zhao, Z., Lin, C., & Cheng, K. (2019) · Translational research · doi:10.1016/j.trsl.2019.07.007 · Cited by 106
Zisser, A., Ipsen, D. H., & Tveden‐Nyborg, P. (2021) · Biomedicines · doi:10.3390/biomedicines9040365 · Cited by 112
Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice
Choi, S. S., Sicklick, J. K., Ma, Q., Yang, L., Huang, J., Qi, Y. P., Chen, W., Li, Y.-X., Goldschmidt‐Clermont, P. J., & Diehl, A. M. (2006) · Hepatology · doi:10.1002/hep.21375 · Cited by 102
Self-citationYamaguchi, K., Yang, L., McCall, S. J., Huang, J., Yu, X. X., Pandey, S., Bhanot, S., Monia, B. P., Li, Y.-X., & Diehl, A. M. (2007) · Hepatology · doi:10.1002/hep.21988 · Cited by 102
Self-citationCellular basis of hepatic fibrosis and its role in inflammation and cancer
Kocabayoglu, P. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s368 · Cited by 101
Pritchett, J. P., Harvey, E., Athwal, V. S., Berry, A. A., Rowe, C., Oakley, F., Moles, A., Mann, D. A., Bobola, N., Sharrocks, A. D., et al. (2012) · Hepatology · doi:10.1002/hep.25758 · Cited by 97
Yu, F., Lu, Z., Chen, B., Wu, X., Dong, P., & Zheng, J. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12655 · Cited by 91
RetractedKietzmann, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092347 · Cited by 90
Novel Aspects of the Liver Microenvironment in Hepatocellular Carcinoma Pathogenesis and Development
Tu, T., Budzinska, M. A., Maczurek, A. E., Cheng, R., Bartolomeo, A. D., Warner, F. J., McCaughan, G. W., McLennan, S. V., & Shackel, N. A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15069422 · Cited by 90
Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus
Nielsen, C. M., & Dymecki, S. M. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.01.032 · Cited by 89
Gaikwad, A. V., Eapen, M. S., McAlinden, K. D., Chia, C., Larby, J., Myers, S., Dey, S., Haug, G., Markos, J., Glanville, A. R., et al. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2020.1795832 · Cited by 87
An Overview of Hedgehog Signaling in Fibrosis
Hu, L., Lin, X., Lu, H., Chen, B., & Bai, Y. (2014) · Molecular Pharmacology · doi:10.1124/mol.114.095141 · Cited by 85
Hedgehog signaling and gastrointestinal cancer
Saqui–Salces, M., & Merchant, J. L. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.03.008 · Cited by 87
Africa, J. A., Behling, C. A., Brunt, E. M., Zhang, N., Luo, Y. J., Wells, A., Hou, J., Belt, P. H., Kohil, R., Lavine, J. E., et al. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.02.030 · Cited by 82
Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver Disease
Wiering, L., Subramanian, P., & Hammerich, L. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.02.010 · Cited by 80
Role of canonical Hedgehog signaling pathway in liver
Gao, L., Zhang, Z., Zhang, P., Yu, M., & Yang, T. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.28089 · Cited by 80
Hepatic Stellate Cell-Immune Interactions in NASH
Carter, J. K., & Friedman, S. L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.867940 · Cited by 79
Xu, Y., Chenna, V., Hu, C., Sun, H.-X., Khan, M. A., Bai, H., Yang, X., Zhu, Q., Sun, Y., Maitra, A., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0950 · Cited by 79
El-Agroudy, N. N., El‐Naga, R. N., El‐Razeq, R. A., & El‐Demerdash, E. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13611 · Cited by 76
He, X., Sai, X., Chen, C., Zhang, Y., Xu, X., Zhang, D., & Pan, W. (2013) · Parasites & Vectors · doi:10.1186/1756-3305-6-272 · Cited by 71
Regulation of Hepatic Stellate Cell Phenotypes in Metabolic Dysfunction–Associated Steatohepatitis
Kisseleva, T., Ganguly, S., Murad, R., Wang, A., & Brenner, D. A. (2025) · Gastroenterology · doi:10.1053/j.gastro.2025.03.010 · Cited by 75
Pereira, T. A., Xie, G., Choi, S. S., Syn, W., Voieta, I., Lü, J., Chan, I. S., Swiderska, M., Amaral, K. B., Antunes, C., et al. (2012) · Liver International · doi:10.1111/liv.12016 · Cited by 64
Self-citationRole of Hedgehog Signaling in Vasculature Development, Differentiation, and Maintenance
Chapouly, C., Guimbal, S., Hollier, P.-L., & Renault, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123076 · Cited by 65
Hirose, Y., Itoh, T., & Miyajima, A. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.06.018 · Cited by 63
Mechanisms of Disease Progression in NASH
Bohinc, B. N., & Diehl, A. M. (2012) · Clinics in Liver Disease · doi:10.1016/j.cld.2012.05.002 · Cited by 64
Self-citationHepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels
Matz-Soja, M., Aleithe, S., Marbach, E., Böttger, J., Arnold, K., Schmidt-Heck, W., Kratzsch, J., & Gebhardt, R. (2014) · Cell Communication and Signaling · doi:10.1186/1478-811x-12-11 · Cited by 60
Role for hedgehog pathway in regulating growth and function of invariant NKT cells
Syn, W., Witek, R. P., Curbishley, S. M., Jung, Y., Choi, S. S., Enrich, B., Omenetti, A., Agboola, K. M., Fearing, C. M., Tilg, H., et al. (2009) · European Journal of Immunology · doi:10.1002/eji.200838890 · Cited by 58
Self-citationDelivery and Targeting of miRNAs for Treating Liver Fibrosis
Kumar, V., & Mahato, R. I. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1497-x · Cited by 55
The hedgehog pathway in nonalcoholic fatty liver disease
Machado, M. V., & Diehl, A. M. (2018) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2018.1448752 · Cited by 52
Self-citationHepatic stellate cells and astrocytes
Schachtrup, K., Moan, N. L., Passino, M. A., & Akassoglou, K. (2011) · Cell Cycle · doi:10.4161/cc.10.11.15828 · Cited by 52
Liang, R., Šumová, B., Cordazzo, C., Mallano, T., Zhang, Y., Wohlfahrt, T., Dees, C., Ramming, A., Krasowska, D., Michalska-Jakubus, M. M., et al. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209698 · Cited by 51
The diversity and plasticity of adult hepatic progenitor cells and their niche
Chen, J., Chen, L., Zern, M. A., Theise, N. D., Diehl, A. M., Liu, P., & Duan, Y. (2017) · Liver International · doi:10.1111/liv.13377 · Cited by 51
Self-citationJung, I. H., Jung, D., Park, Y. N., Song, S. Y., & Park, S. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027941 · Cited by 50
Choi, S. S., Witek, R. P., Yang, L., Omenetti, A., Syn, W., Moylan, C. A., Jung, Y., Karaca, G., Teaberry, V. S., Pereira, T. A., et al. (2010) · Hepatology · doi:10.1002/hep.23649 · Cited by 50
Self-citationTargeting PDGFR ‐β in Cholangiocarcinoma
Fingas, C. D., Mertens, J. C., Razumilava, N., Bronk, S. F., Sirica, A. E., & Gores, G. J. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02687.x · Cited by 49
Hedgehog Signaling in Pancreatic Fibrosis and Cancer
Bai, Y., Bai, Y., Dong, J., Li, Q., Jin, Y., Chen, B., & Zhou, M. (2016) · Medicine · doi:10.1097/md.0000000000002996 · Cited by 47
Transcriptional regulation of stellate cell activation
Friedman, S. L. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04585.x · Cited by 47
Interleukin-15 increases hepatic regenerative activity
Suzuki, A., McCall, S. J., Choi, S. S., Sicklick, J. K., Huang, J., Qi, Y. P., Zdanowicz, M., Camp, T., Li, Y., & Diehl, A. M. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.04.008 · Cited by 45
Self-citationLee, C., Kim, M.-J., Han, J., Yoon, M. H., & Jung, Y. (2021) · Biomedicines · doi:10.3390/biomedicines9111598 · Cited by 48
Shinozaki, S., Ohnishi, H., Hama, K., Kita, H., Yamamoto, H., Osawa, H., Sato, K., Tamada, K., Mashima, H., & Sugano, K. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21372 · Cited by 44
Attenuation of early liver fibrosis by pharmacological inhibition of smoothened receptor signaling
Pratap, A., Singh, S. P., Mundra, V., Yang, N., Panakanti, R., Eason, J. D., & Mahato, R. I. (2012) · Journal of drug targeting · doi:10.3109/1061186x.2012.719900 · Cited by 43
Role of Hedgehog Signaling Pathway in NASH
Machado, M. V., & Diehl, A. M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060857 · Cited by 43
Self-citationYan, J., Huang, H., Liu, Z., Shen, J., Ni, J., Han, J., Wang, R., Lin, D.-R., Hu, B., & Jin, L. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.11.017 · Cited by 42
Growth factor- and cytokine-driven pathways governing liver stemness and differentiation
Sánchez, A. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i41.5148 · Cited by 41
Sonic hedgehog ligand partners with caveolin-1 for intracellular transport
Mao, H., Diehl, A. M., & Li, Y. (2009) · Laboratory Investigation · doi:10.1038/labinvest.2008.163 · Cited by 39
Self-citationMicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling
Hyun, J., & Jung, Y. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i29.6652 · Cited by 38
Younis, M. A., Sato, Y., Elewa, Y. H. A., & Harashima, H. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.08.021 · Cited by 37
Magistri, P., Leonard, S. Y., Tang, C., Chan, J. C., Lee, T. E., & Sicklick, J. K. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.12.010 · Cited by 37
Self-citationGarg, C., Khan, H., Kaur, A., Singh, T. G., Sharma, V., & Singh, S. K. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106194 · Cited by 39
Lin, N., Tang, Z., Deng, M., Zhong, Y., Lin, J., Yang, X., Peng, X., & Xu, R. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.05.029 · Cited by 36
The contributions of mesoderm-derived cells in liver development
Li, Y., Li, L., Lamaoqiezhong, Wang, X., Wang, W., Wang, Y., & Xu, C. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.09.003 · Cited by 35
Self-citationMatz‐Soja, M., Hovhannisyan, A., & Gebhardt, R. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.01.032 · Cited by 36
Rangwala, F. A., Williams, K. P., Smith, G. R., Thomas, Z., Allensworth, J. L., Lyerly, H. K., Diehl, A. M., Morse, M. A., & Devi, G. R. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-402 · Cited by 33
Self-citationSpace of Disse: a stem cell niche in the liver
Häussinger, D., & Kordes, C. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0283 · Cited by 37
Pratap, A., Panakanti, R., Yang, N., Eason, J. D., & Mahato, R. I. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0246-z · Cited by 30
Tennakoon, A. H., Izawa, T., Wijesundera, K. K., Murakami, H., Katou-Ichikawa, C., Tanaka, M., Golbar, H. M., Kuwamura, M., & Yamate, J. (2014) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2014.09.008 · Cited by 29
Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse
Hyun, J., Choi, S. S., Diehl, A. M., & Jung, Y. (2013) · Journal of Molecular Histology · doi:10.1007/s10735-013-9532-5 · Cited by 30
Self-citationMcMillin, M., Galindo, C., Pae, H. Y., Frampton, G. A., Patre, P. L. D., Quinn, M. A., Whittington, E., & DeMorrow, S. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.07.015 · Cited by 30
Ocker, M. (2009) · International Journal of Oncology · doi:10.3892/ijo_00000314 · Cited by 28
Thyroid hormone in the regulation of hepatocellular carcinoma and its microenvironment
Manka, P. P., Coombes, J. D., Boosman, R. J., Gauthier, K. C., Papa, S., & Syn, W. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.055 · Cited by 29
Gant61 ameliorates CCl4-induced liver fibrosis by inhibition of Hedgehog signaling activity
Jiayuan, S., Yan, J., Xiangzhen, W., Liu, Z., Jian, N., Hu, B., & Lifang, J. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114853 · Cited by 28
Hedgehog Signaling in Human Medullary Thyroid Carcinoma: A Novel Signaling Pathway
Bohinc, B. N., Michelotti, G. A., & Diehl, A. M. (2013) · Thyroid · doi:10.1089/thy.2012.0474 · Cited by 26
Self-citationNon-Alcoholic Steatohepatitis Pathogenesis: Role of Repair in Regulating the Disease Progression
Jung, Y., & Diehl, A. M. (2010) · Digestive Diseases · doi:10.1159/000282092 · Cited by 26
Self-citation
Metadata
- Authors
- Sicklick, J. K., Li, Y.-X., Choi, S. S., Qi, Y., Chen, W., Bustamante, M., Huang, J., Zdanowicz, M., Camp, T., Torbenson, M. S., Rojkind, M., & Diehl, A. M.
- Affiliations
- Duke University (US)
- George Washington University (US)
- Johns Hopkins University (US)
- Corresponding author
- Diehl, Anna Mae
- Venue
- Laboratory Investigation
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 85
- Issue
- 11
- Pages
- 1368-1380
- ISSN
- 0023-6837 (ISSN-L)
- OpenAlex
- W1981442583
- Cited by
- 179
- References
- 77
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 9 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 13 · 2018: 10 · 2017: 13 · 2016: 9 · 2015: 9 · 2014: 11 · 2013: 9 · 2012: 11
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Laboratory Investigation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (RO1 DK053792, AA010154)
- National Institute on Alcohol Abuse and Alcoholism (R01 AA01541, R01AA012059, R01AA010154)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007713, R01DK053792)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Keywords
- Hedgehog signaling, hepatic stellate cells, stellate cell activation, cell viability, apoptosis, cyclopamine, Patched1, liver fibrosis, myofibroblast differentiation
- MeSH terms
- Animals, Antibodies, beta-Galactosidase, Cell Survival, Cells, Cultured, Clone Cells, Dose-Response Relationship, Drug, Humans, Ligands, Luciferases, Male, Mice, Inbred C57BL, Mice, Transgenic, Recombinant Proteins, Veratrum Alkaloids, Signal Transduction, Trans-Activators, Apoptosis, Genes, Reporter, Hepatocytes, Mice, Hedgehog Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
