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Cited by 719Liver physiology and pathologyMesenchymal stem cell researchLiver Disease Diagnosis and Treatment

Hepatic stellate cells in liver development, regeneration, and cancer

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Yin, Chunyue, Evason, Kimberley J., Asahina, Kinji, Stainier, Didier Y.R.·2013·Journal of Clinical Investigation
DOI 10.1172/jci66369PMC PMC3635734
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Abstract

Hepatic stellate cells are liver-specific mesenchymal cells that play vital roles in liver physiology and fibrogenesis. They are located in the space of Disse and maintain close interactions with sinusoidal endothelial cells and hepatic epithelial cells. It is becoming increasingly clear that hepatic stellate cells have a profound impact on the differentiation, proliferation, and morphogenesis of other hepatic cell types during liver development and regeneration. In this Review, we summarize and evaluate the recent advances in our understanding of the formation and characteristics of hepatic stellate cells, as well as their function in liver development, regeneration, and cancer. We also discuss how improved knowledge of these processes offers new perspectives for the treatment of patients with liver diseases.

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  • Hepatic stellate cells interplay with hepatocytes via cell-cell contact and soluble mediators that support hepatocyte development and homeostasis.

    “Hepatic stellate cells - liver-resident fibroblasts - are central to liver fibrosis 15 and interplay with hepatocytes via cell-cell contact and soluble mediators that support hepatocyte development and homeostasis 16,17 .”

    From Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis (2024) · cites this paper as [16]

    The Figure 3 passage reports that cell-cell contact with hepatic stellate cells can induce hepatocyte differentiation, and the Conclusions describe growth factors they produce that regulate hepatoblast and hepatocyte proliferation. These passages support the developmental interaction, but they do not establish that the interactions support hepatocyte homeostasis. Page numbers are unavailable in our copy. (LLM, conf=0.83)

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  1. Blaner WS, et al. Hepatic stellate cell lipid drop- lets: a specialized lipid droplet for retinoid storage. Biochim Biophys Acta. 2009;1791(6):467-473.
  2. Lee UE, Friedman SL. Mechanisms of hepatic fibrogenesis. Best Pract Res Clin Gastroenterol. 2011; 25(2):195-206.
  3. Kisseleva T, et al. Myofibroblasts revert to an inac- tive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A. 2012;109(24):9448-9453.
  4. Troeger JS, et al. Deactivation of hepatic stel- late cells during liver fibrosis resolution in mice. Gastroenterology. 2012;143(4):1073-1083 e1022.
  5. Schuppan D, Kim YO. Evolving therapies for liver fibrosis. J Clin Invest. 2013;123(5):1887-1901.
  6. Bachem MG, Meyer D, Melchior R, Sell KM, Gress- ner AM. Activation of rat liver perisinusoidal lipo- cytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis. J Clin Invest. 1992;89(1):19-27.
  7. Friedman SL, Roll FJ, Boyles J, Bissell DM. Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci U S A. 1985; 82(24):8681-8685.
  8. Friedman SL, Roll FJ, Boyles J, Arenson DM, Bissell DM. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J Biol Chem. 1989;264(18):10756-10762.
  9. Greenwel P, Schwartz M, Rosas M, Peyrol S, Gri- maud JA, Rojkind M. Characterization of fat-stor- ing cell lines derived from normal and CCl4-cir- rhotic livers. Differences in the production of interleukin-6. Lab Invest. 1991;65(6):644-653.
  10. Sauvant P, et al. PAV-1, a new rat hepatic stellate cell line converts retinol into retinoic acid, a pro- cess altered by ethanol. Int J Biochem Cell Biol. 2002; 34(8):1017-1029.
  11. Xu L, et al. Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis. Gut. 2005;54(1):142-151.
  12. De Minicis S, et al. Gene expression profiles dur- ing hepatic stellate cell activation in culture and in vivo. Gastroenterology. 2007;132(5):1937-1946.
  13. Yokoi Y, et al. Immunocytochemical detection of desmin in fat-storing cells (Ito cells). Hepatology. 1984;4(4):709-714.
  14. Gard AL, White FP, Dutton GR. Extra-neural glial fibrillary acidic protein (GFAP) immunoreactivity in perisinusoidal stellate cells of rat liver. J Neuroim- munol. 1985;8(4-6):359-375.
  15. Ramadori G, et al. Expression of the gene of the alpha-smooth muscle-actin isoform in rat liver and in rat fat-storing (ITO) cells. Virchows Arch B Cell Pathol Incl Mol Pathol. 1990;59(6):349-357.
  16. Magness ST, Bataller R, Yang L, Brenner DA. A dual reporter gene transgenic mouse demonstrates het- erogeneity in hepatic fibrogenic cell populations. Hepatology. 2004;40(5):1151-1159.
  17. Puche JE, et al. A novel murine model to deplete hepatic stellate cells uncovers their role in amplify- ing liver damage. Hepatology. 2013;57(1):339-350.
  18. Yang L, et al. Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. Stem Cells. 2008;26(8):2104-2113.
  19. Chu J, Sadler KC. New school in liver develop- ment: lessons from zebrafish. Hepatology. 2009; 50(5):1656-1663.
  20. Beis D, Stainier DY. In vivo cell biology: follow- ing the zebrafish trend. Trends Cell Biol. 2006; 16(2):105-112.
  21. Yin C, Evason KJ, Maher JJ, Stainier DY. The bHLH transcription factor Hand2 marks hepatic stellate cells in zebrafish: Analysis of stellate cell entry into the developing liver. Hepatology. 2012;56(5):1958-1970.
  22. Asahina K, Zhou B, Pu WT, Tsukamoto H. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011; 53(3):983-995.
  23. Geerts A. On the origin of stellate cells: mesodermal, endodermal or neuro-ectodermal? J Hepatol. 2004; 40(2):331-334.
  24. Suskind DL, Muench MO. Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells. J Hepatol. 2004;40(2):261-268.
  25. Sicklick JK, et al. Evidence for epithelial-mesenchy- mal transitions in adult liver cells. Am J Physiol Gas- trointest Liver Physiol. 2006;291(4):G575-G583.
  26. Wells RG. The epithelial-to-mesenchymal transi- tion in liver fibrosis: here today, gone tomorrow? Hepatology. 2010;51(3):737-740.
  27. Miyata E, et al. Hematopoietic origin of hepatic stellate cells in the adult liver. Blood. 2008; 111(4):2427-2435.
  28. Baba S, et al. Commitment of bone marrow cells to hepatic stellate cells in mouse. J Hepatol. 2004; 40(2):255-260.
  29. Higashiyama R, et al. Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice. Gastroenterol- ogy. 2009;137(4):1459-1466 e1451.
  30. Kisseleva T, Brenner DA. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. J Hepatol. 2011;56(4):965-972.
  31. Knittel T, et al. Localization of liver myofibrob- lasts and hepatic stellate cells in normal and dis- eased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair. Histochem Cell Biol. 1999;112(5):387-401.
  32. Knittel T, et al. Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology. 1999;117(5):1205-1221.
  33. Ankoma-Sey V, et al. Coordinated induction of VEGF receptors in mesenchymal cell types dur- ing rat hepatic wound healing. Oncogene. 1998; 17(1):115-121.
  34. Perez-Pomares JM, Carmona R, Gonzalez-Iriarte M, Macias D, Guadix JA, Munoz-Chapuli R. Contribu- tion of mesothelium-derived cells to liver sinusoids in avian embryos. Dev Dyn. 2004;229(3):465-474.
  35. Kolterud A, Wandzioch E, Carlsson L. Lhx2 is expressed in the septum transversum mesenchyme that becomes an integral part of the liver and the formation of these cells is independent of func- tional Lhx2. Gene Expr Patterns. 2004;4(5):521-528.
  36. Ijpenberg A, et al. Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis. Dev Biol. 2007;312(1):157-170.
  37. Wandzioch E, Kolterud A, Jacobsson M, Friedman SL, Carlsson L. Lhx2 -/-mice develop liver fibrosis. Proc Natl Acad Sci U S A. 2004;101(47):16549-16554.
  38. Berg T, DeLanghe S, Al Alam D, Utley S, Estrada J, Wang KS. beta-catenin regulates mesenchymal pro- genitor cell differentiation during hepatogenesis. J Surg Res. 2010;164(2):276-285.
  39. Kordes C, Sawitza I, Haussinger D. Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem Biophys Res Commun. 2008; 367(1):116-123.
  40. Mochida S, Ishikawa K, Inao M, Shibuya M, Fujiwara K. Increased expressions of vascular endothelial growth factor and its receptors, flt-1 and KDR/flk-1, in regenerating rat liver. Biochem Biophys Res Commun. 1996;226(1):176-179.
  41. Suzuki K, et al. Expression of vascular permeabil- ity factor/vascular endothelial growth factor in human hepatocellular carcinoma. Cancer Res. 1996; 56(13):3004-3009.
  42. Ogasawara S, et al. Expression of angiogenic fac- tors, basic fibroblast growth factor and vascular endothelial growth factor, in human biliary tract carcinoma cell lines. Hepatol Res. 2001;20(1):97-113.
  43. Lee JS, Semela D, Iredale J, Shah VH. Sinusoidal remodeling and angiogenesis: a new function for the liver-specific pericyte? Hepatology. 2007; 45(3):817-825.
  44. Hellstrom M, Kalen M, Lindahl P, Abramsson A, Betsholtz C. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development. 1999; 126(14):3047-3055.
  45. Semela D, Das A, Langer D, Kang N, Leof E, Shah V. Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function. Gastroenterology. 2008;135(2):671-679.
  46. Kubota H, Yao HL, Reid LM. Identification and characterization of vitamin A-storing cells in fetal liver: implications for functional importance of hepatic stellate cells in liver development and hematopoiesis. Stem Cells. 2007;25(9):2339-2349.
  47. Hentsch B, et al. Hlx homeo box gene is essential for an inductive tissue interaction that drives expan- sion of embryonic liver and gut. Genes Dev. 1996; 10(1):70-79.
  48. Wright DE, Bowman EP, Wagers AJ, Butcher EC, Weissman IL. Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med. 2002;195(9):1145-1154.
  49. Lemaigre FP. Mechanisms of liver development: concepts for understanding liver disorders and design of novel therapies. Gastroenterology. 2009; 137(1):62-79.
  50. Hoppo T, et al. Thy1-positive mesenchymal cells promote the maturation of CD49f-positive hepatic progenitor cells in the mouse fetal liver. Hepatology. 2004;39(5):1362-1370.
  51. Matsumoto K, Miki R, Nakayama M, Tatsumi N, Yokouchi Y. Wnt9a secreted from the walls of hepatic sinusoids is essential for morphogenesis, proliferation, and glycogen accumulation of chick hepatic epithelium. Dev Biol. 2008;319(2):234-247.
  52. Maher JJ. Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride. J Clin Invest. 1993;91(5):2244-2252.
  53. Asahina K, et al. Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and devel- opment of liver. Am J Pathol. 2002;160(6):2191-2205.
  54. Sekhon SS, Tan X, Micsenyi A, Bowen WC, Monga SP. Fibroblast growth factor enriches the embry- onic liver cultures for hepatic progenitors. Am J Pathol. 2004;164(6):2229-2240.
  55. Berg T, et al. Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation. Hepatology. 2007;46(4):1187-1197.
  56. Nagai H, et al. Differentiation of liver epithelial (stem-like) cells into hepatocytes induced by cocul- ture with hepatic stellate cells. Biochem Biophys Res Commun. 2002;293(5):1420-1425.
  57. Libbrecht L, Cassiman D, Desmet V, Roskams T. The correlation between portal myofibroblasts and development of intrahepatic bile ducts and arterial branches in human liver. Liver. 2002;22(3):252-258.
  58. Sawitza I, Kordes C, Reister S, Haussinger D. The niche of stellate cells within rat liver. Hepatology. 2009;50(5):1617-1624.
  59. Zong Y, et al. Notch signaling controls liver devel- opment by regulating biliary differentiation. Devel- opment. 2009;136(10):1727-1739.
  60. Hofmann JJ, Zovein AC, Koh H, Radtke F, Wein- master G, Iruela-Arispe ML. Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development. 2010;137(23):4061-4072.
  61. Suzuki K, Tanaka M, Watanabe N, Saito S, Non- aka H, Miyajima A. p75 Neurotrophin receptor is a marker for precursors of stellate cells and portal fibroblasts in mouse fetal liver. Gastroenterology. 2008;135(1):270-281.
  62. Suzuki A, Iwama A, Miyashita H, Nakauchi H, Tan- iguchi H. Role for growth factors and extracellular matrix in controlling differentiation of prospec- tively isolated hepatic stem cells. Development. 2003; 130(11):2513-2524.
  63. Yanai M, Tatsumi N, Hasunuma N, Katsu K, Endo F, Yokouchi Y. FGF signaling segregates biliary cell- lineage from chick hepatoblasts cooperatively with BMP4 and ECM components in vitro. Dev Dyn. 2008;237(5):1268-1283.
  64. Chistiakov DA. Liver regenerative medicine: advances and challenges. Cells Tissues Organs. 2012; 196(4):291-312.
  65. Rountree CB, Mishra L, Willenbring H. Stem cells in liver diseases and cancer: recent advances on the path to new therapies. Hepatology. 2012;55(1):298-306.
  66. Wang Y, et al. Paracrine signals from mesenchymal cell populations govern the expansion and differ- entiation of human hepatic stem cells to adult liver fates. Hepatology. 2010;52(4):1443-1454.
  67. Okamoto M, Ishida Y, Keogh A, Strain A. Evaluation of the function of primary human hepatocytes co- cultured with the human hepatic stellate cell (HSC) line LI90. Int J Artif Organs. 1998;21(6):353-359.
  68. Mitaka T, Sato F, Mizuguchi T, Yokono T, Mochi- zuki Y. Reconstruction of hepatic organoid by rat small hepatocytes and hepatic nonparenchymal cells. Hepatology. 1999;29(1):111-125.
  69. Curado S, Stainier DY. deLiver'in regeneration: injury response and development. Semin Liver Dis. 2010;30(3):288-295.
  70. Rutherford A, Chung RT. Acute liver failure: mech- anisms of hepatocyte injury and regeneration. Semin Liver Dis. 2008;28(2):167-174.
  71. Tunon MJ, Alvarez M, Culebras JM, Gonzalez-Gal- lego J. An overview of animal models for investi- gating the pathogenesis and therapeutic strategies in acute hepatic failure. World J Gastroenterol. 2009; 15(25):3086-3098.
  72. Alatas FS, et al. Synchronized expressions of hepatic stellate cells and their transactivation and liver regeneration during liver injury in an animal model of cholesatsis. J Pediatr Surg. 2011; 46(12):2284-2290.
  73. Roskams T. Relationships among stellate cell acti- vation, progenitor cells, and hepatic regeneration. Clin Liver Dis. 2008;12(4):853-860, ix.
  74. Pintilie DG, Shupe TD, Oh SH, Salganik SV, Dar- wiche H, Petersen BE. Hepatic stellate cells' involve- ment in progenitor-mediated liver regeneration. Lab Invest. 2010;90(8):1199-1208.
  75. Kalinichenko VV, et al. Foxf1 +/-mice exhibit defec- tive stellate cell activation and abnormal liver regen- eration following CCl4 injury. Hepatology. 2003; 37(1):107-117.
  76. Chen L, et al. HSCs play a distinct role in different phases of oval cell-mediated liver regeneration. Cell Biochem Funct. 2012;30(7):588-596.
  77. Passino MA, Adams RA, Sikorski SL, Akassoglou K. Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR. Science. 2007; 315(5820):1853-1856.
  78. Yang L, et al. Sonic hedgehog is an autocrine viabil- ity factor for myofibroblastic hepatic stellate cells. J Hepatol. 2008;48(1):98-106.
  79. Ochoa B, et al. Hedgehog signaling is critical for normal liver regeneration after partial hepatec- tomy in mice. Hepatology. 2010;51(5):1712-1723.
  80. Pi L, et al. Connective tissue growth factor with a novel fibronectin binding site promotes cell adhe- sion and migration during rat oval cell activation. Hepatology. 2008;47(3):996-1004.
  81. Schuppan D, et al. Collagens in the liver extracellular matrix bind hepatocyte growth factor. Gastroenterology. 1998;114(1):139-152.
  82. Taub R. Liver regeneration: from myth to mecha- nism. Nat Rev Mol Cell Biol. 2004;5(10):836-847.
  83. Karkampouna S, Ten Dijke P, Dooley S, Julio MK. TGFbeta Signaling in Liver Regeneration. Curr Pharm Des. 2012;18(27):4103-4113.
  84. Curado S, Anderson RM, Jungblut B, Mumm J, Schroeter E, Stainier DY. Conditional targeted cell ablation in zebrafish: a new tool for regeneration studies. Dev Dyn. 2007;236(4):1025-1035.
  85. Curado S, et al. The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model. Dis Model Mech. 2010;3(7-8):486-495.
  86. Seitz HK, Stickel F. Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biol Chem. 2006; 387(4):349-360.
  87. Zhang DY, Friedman SL. Fibrosis-dependent mech- anisms of hepatocarcinogenesis. Hepatology. 2012; 56(2):769-775.
  88. Enzan H, et al. Alpha-smooth muscle actin-positive perisinusoidal stromal cells in human hepatocellu- lar carcinoma. Hepatology. 1994;19(4):895-903.
  89. Amann T, et al. Activated hepatic stellate cells pro- mote tumorigenicity of hepatocellular carcinoma. Cancer Sci. 2009;100(4):646-653.
  90. Heindryckx F, Colle I, Van Vlierberghe H. Exper- imental mouse models for hepatocellular carci- noma research. Int J Exp Pathol. 2009;90(4):367-386.
  91. Fausto N, Campbell JS. Mouse models of hepatocel- lular carcinoma. Semin Liver Dis. 2010;30(1):87-98.
  92. Li Y, Tang ZY, Hou JX. Hepatocellular carcinoma: insight from animal models. Nat Rev Gastroenterol Hepatol. 2012;9(1):32-43. 100. Campbell JS, et al. Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatoc- ellular carcinoma. Proc Natl Acad Sci U S A. 2005; 102(9):3389-3394. 101. Hou X, et al. PDGF-CC blockade inhibits patholog- ical angiogenesis by acting on multiple cellular and molecular targets. Proc Natl Acad Sci U S A. 2010; 107(27):12216-12221. 102. Mikula M, Proell V, Fischer AN, Mikulits W. Acti- vated hepatic stellate cells induce tumor progres- sion of neoplastic hepatocytes in a TGF-beta depen- dent fashion. J Cell Physiol. 2006;209(2):560-567. 103. van Zijl F, et al. Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge. Oncogene. 2009;28(45):4022-4033. 104. Zhao W, et al. Activated hepatic stellate cells pro- mote hepatocellular carcinoma development in immunocompetent mice. Int J Cancer. 2011; 129(11):2651-2661. 105. Kluwe J, et al. Absence of hepatic stellate cell retin- oid lipid droplets does not enhance hepatic fibro- sis but decreases hepatic carcinogenesis. Gut. 2011; 60(9):1260-1268. 106. Shirakami Y, Gottesman ME, Blaner WS. Diethyl- nitrosamine-induced hepatocarcinogenesis is sup- pressed in lecithin:retinol acyltransferase-deficient mice primarily through retinoid actions immedi- ately after carcinogen administration. Carcinogenesis. 2012;33(2):268-274. 107. Huang X, Zhou L, Gong Z. Liver tumor models in transgenic zebrafish: an alternative in vivo approach to study hepatocarcinogenes. Future Oncol. 2012;8(1):21-28. 108. Liu S, Leach SD. Zebrafish models for cancer. Annu Rev Pathol. 2011;6:71-93. 109. Goessling W, North TE, Zon LI. New waves of discov- ery: modeling cancer in zebrafish. J Clin Oncol. 2007; 25(17):2473-2479. 110. Mudbhary R, Sadler KC. Epigenetics, development, and cancer: zebrafish make their mark. Birth Defects Res C Embryo Today. 2011;93(2):194-203. 111. Liu W, et al. A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepati- tis B virus X and hepatitis C virus core protein in liver. Hepatology. 2012;56(6):2268-2276. 112. Bertino G, Ardiri A, Malaguarnera M, Mala- guarnera G, Bertino N, Calvagno GS. Hepatocellu- alar carcinoma serum markers. Semin Oncol. 2012; 39(4):410-433. 113. Shirai Y, et al. Plasma transforming growth fac- tor-beta 1 in patients with hepatocellular carci- noma. Comparison with chronic liver diseases. Cancer. 1994;73(9):2275-2279. 114. Shang S, et al. Identification of osteopontin as a novel marker for early hepatocellular carcinoma. Hepatology. 2012;55(2):483-490.

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Authors
Yin, C., Evason, K. J., Asahina, K., & Stainier, D. Y. R.
Affiliations
  • University of California, San Francisco (US)
  • University of Southern California (US)
ORCID
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2013-05-01
Volume
123
Issue
5
Pages
1902-1910
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci66369
PMC
PMC3635734
OpenAlex
W2139256273
Cited by
719
References
8
Citations by year
2026: 30 · 2025: 49 · 2024: 46 · 2023: 71 · 2022: 64 · 2021: 82 · 2020: 68 · 2019: 57 · 2018: 61 · 2017: 50 · 2016: 64 · 2015: 43 · 2014: 28 · 2013: 6
FWCI
5.99
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
Funders
  • David and Lucile Packard Foundation
  • Damon Runyon Cancer Research Foundation
  • Cincinnati Children's Hospital Medical Center
  • National Institutes of Health
  • National Institute on Alcohol Abuse and Alcoholism (R00AA020514, K99AA020514, R01AA020753)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK060322, P30DK026743)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Keywords
hepatic stellate cells, liver development, liver regeneration, liver cancer, liver fibrosis, space of Disse, sinusoidal endothelial cells, mesenchymal cells, liver disease
MeSH terms
Animals, Cell Differentiation, Fibrosis, Carcinoma, Hepatocellular, Humans, Liver, Liver Diseases, Liver Neoplasms, Liver Regeneration, Microscopy, Phase-Contrast, Liver Failure, Acute, Endothelial Cells, Mice, Hepatic Stellate Cells

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