The DOI matches its Crossref record; 108 of the 109 references it cites were found in a registry or an index.
The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis
Abstract
Hematopoiesis is coordinated by a complex regulatory network of transcription factors and among them PU.1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein-protein interactions with additional factors. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of 'differentiation therapy' to restore normal cellular differentiation of leukemic cells is discussed.
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“Borzoi correctly predicts the upregulation of SHTN1 expression owing to the creation of a CEBP binding motif69–72 (see Supplementary Fig. 9a and Extended Data Fig. 6a,b for additional examples).”
From Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation (2025) · cites this paper as [69]
In the citing paper
“its action is also important or indispensable for sustained generation of all known hematopoietic precursors that have lymphoid developmental potentials (1–9).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [7]
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Metadata
- Authors
- Burda, P., Laslo, P., & Stopka, T.
- Affiliations
- Charles University (CZ)
- St James's University Hospital (GB)
- Corresponding author
- Stopka, T
- Venue
- Leukemia
- Published
- 2010-06-03
- Volume
- 24
- Issue
- 7
- Pages
- 1249-1257
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- OpenAlex
- W2023603100
- Cited by
- 184
- References
- 109
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 14 · 2023: 18 · 2022: 25 · 2021: 19 · 2020: 10 · 2019: 9 · 2018: 7 · 2017: 7 · 2016: 6 · 2015: 1 · 2014: 7 · 2013: 8 · 2012: 7
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Leukemia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Ministerstvo Zdravotnictví Ceské Republiky
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- PU.1, GATA-1, transcription factors, hematopoiesis, leukemogenesis, protein-protein interaction, negative regulation, differentiation therapy
- MeSH terms
- Proto-Oncogene Protein Spi-1, Animals, Hematopoiesis, Humans, Leukemia, Proto-Oncogene Proteins, Trans-Activators, GATA Transcription Factors
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