Cited by 186Acute Myeloid Leukemia ResearchHematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

The DOI matches its Crossref record; 108 of the 109 references it cites were found in a registry or an index.

The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis

Burda, P, Laslo, P, Stopka, T·2010·Leukemia

DOI 10.1038/leu.2010.104

Open this paper in CoChat — free account

Abstract

Hematopoiesis is coordinated by a complex regulatory network of transcription factors and among them PU.1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein-protein interactions with additional factors. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of 'differentiation therapy' to restore normal cellular differentiation of leukemic cells is discussed.

Integrity signals

Registry

Crossref · 10.1038/leu.2010.104

Cites

108 of 108 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051
Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia
Huang, M., Ye, Y., Chen, S. R., Chai, J., Lu, J., Zhoa, L., Gu, L.-J., & Wang, Z.-Y. (1988) · Blood · doi:10.1182/blood.v72.2.567.567 · Cited by 2,445
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., Sleeman, J. P., Coco, F. L., Nervi, C., Pelicci, P. G., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6969 · Cited by 1,930
Requirement of bic/microRNA-155 for Normal Immune Function
Rodriguez, A., Vigorito, E., Clare, S., Warren, M. V., Couttet, P., Soond, D. R., van Dongen, S., Grocock, R. J., Das, P. P., Miska, E. A., et al. (2007) · Science · doi:10.1126/science.1139253 · Cited by 1,833
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
Metzger, E., Wissmann, M., Yin, N., Müller, J. M., Schneider, R., Peters, A. H. F. M., Günther, T., Buettner, R., & Schüle, R. (2005) · Nature · doi:10.1038/nature04020 · Cited by 1,780
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532
Accumulation of miR-155 and BIC RNA in human B cell lymphomas
Eis, P. S., Tam, W., Sun, L., Chadburn, A., Li, Z., Gomez, M. F., Lund, E., & Dahlberg, J. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500613102 · Cited by 1,322
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00949.x · Cited by 1,130
Role of the histone deacetylase complex in acute promyelocytic leukaemia
Lin, R. J., Nagy, L., Inoue, S., Shao, W., Miller, W. H., & Evans, R. M. (1998) · Nature · doi:10.1038/35895 · Cited by 1,060

Show all 109 references

Sorted by citations

Dissecting cell identity via network inference and in silico gene perturbation
Kamimoto, K., Stringa, B., Hoffmann, C. M., Jindal, K., Solnica-Krezel, L., & Morris, S. A. (2023) · Nature · doi:10.1038/s41586-022-05688-9 · Cited by 677
Role of RUNX1 in hematological malignancies
Sood, R. B., Kamikubo, Y., & Liu, P. (2017) · Blood · doi:10.1182/blood-2016-10-687830 · Cited by 509
Trop2 and its overexpression in cancers: regulation and clinical/ therapeutic implications
Shvartsur, A., & Bonavida, B. (2014) · Genes & Cancer · doi:10.18632/genesandcancer.40 · Cited by 412
DeepSTARR predicts enhancer activity from DNA sequence and enables the de novo design of enhancers
de Almeida, B. P., Reiter, F., Pagani, M., & Stark, A. (2021) · doi:10.1101/2021.10.05.463203 · Cited by 284
DeepSTARR predicts enhancer activity from DNA sequence and enables the de novo design of synthetic enhancers
de Almeida, B. P., Reiter, F., Pagani, M., & Stark, A. (2022) · Nature Genetics · doi:10.1038/s41588-022-01048-5 · Cited by 283
Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation
Linder, J., Srivastava, D., Yuan, H., Agarwal, V., & Kelley, D. R. (2025) · Nature Genetics · doi:10.1038/s41588-024-02053-6 · Cited by 265
ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury
Huo, S., Wang, Q., Shi, W., Peng, L., Jiang, Y., Zhu, M., Guo, J., Peng, D., Wang, M., Men, L., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021667 · Cited by 239
Induction of a hemogenic program in mouse fibroblasts
Pereira, C.-F., Chang, B., Qiu, J., Niu, X., Papatsenko, D., Hendry, C. E., Clark, N. R., Nomura-Kitabayashi, A., Kovacic, J. C., Ma’ayan, A., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.05.024 · Cited by 216
The interplay between macrophages and angiogenesis in development, tissue injury and regeneration
Nucera, S., Biziato, D., & Palma, M. D. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.103227sn · Cited by 211
PBX1 Genomic Pioneer Function Drives ERα Signaling Underlying Progression in Breast Cancer
Magnani, L., Ballantyne, E. B., Zhang, X., & Lupien, M. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002368 · Cited by 198
Pioneer factors: directing transcriptional regulators within the chromatin environment
Magnani, L., Eeckhoute, J., & Lupien, M. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.07.002 · Cited by 173
Analysis of Genomic Sequence Motifs for Deciphering Transcription Factor Binding and Transcriptional Regulation in Eukaryotic Cells
Boeva, V. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00024 · Cited by 163
High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer
Pierce, S. E., Granja, J. M., & Greenleaf, W. J. (2021) · Nature Communications · doi:10.1038/s41467-021-23213-w · Cited by 146
Physiology and pathophysiology of renal erythropoietin-producing cells
Shih, H., Wu, C., & Lin, S. (2018) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2018.03.017 · Cited by 140
FOG‐1 and GATA‐1 act sequentially to specify definitive megakaryocytic and erythroid progenitors
Mancini, E., Sanjuán-Pla, A., Luciani, L., Moore, S., Grover, A., Zay, A., Rasmussen, K. D., Luc, S., Bilbao, D., O’Carroll, D., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.390 · Cited by 117
Single-cell epigenomic variability reveals functional cancer heterogeneity
Litzenburger, U. M., Buenrostro, J. D., Wu, B., Shen, Y., Sheffield, N. C., Kathiria, A., Greenleaf, W. J., & Chang, H. Y. (2017) · Genome Biology · doi:10.1186/s13059-016-1133-7 · Cited by 115
The origins and roles of osteoclasts in bone development, homeostasis and repair
Yahara, Y., Nguyen, T., Ishikawa, K., Kamei, K., & Alman, B. A. (2022) · Development · doi:10.1242/dev.199908 · Cited by 111
Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development
Rothenberg, E. V., Hosokawa, H., & Ungerbäck, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00228 · Cited by 99
“1—GATA-1 antagonism in hematopoiesis [reviewed in (4, 7, 25)].”
Method
Transcription factor PU.1 and immune cell differentiation (Review)
Li, G., Hao, W., & Hu, W. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4763 · Cited by 98
MicroRNA and mRNA expression profile screening in multiple sclerosis patients to unravel novel pathogenic steps and identify potential biomarkers
Boneschi, F. M., Fenoglio, C., Brambilla, P., Sorosina, M., Giacalone, G., Esposito, F., Serpente, M., Cantoni, C., Ridolfi, E., Rodegher, M., et al. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.11.006 · Cited by 93
Surprising new roles for PU.1 in the adaptive immune response
Carotta, S., Wu, L., & Nutt, S. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00955.x · Cited by 93
Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs
Wang, Q. S., Kelley, D. R., Ulirsch, J. C., Kanai, M., Sadhuka, S., Cui, R., Albors, C., Cheng, N., Okada, Y., The Biobank Japan Project, et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23134-8 · Cited by 98
ETS transcription factors as emerging drug targets in cancer
Hsing, M., Wang, Y. Z., Rennie, P. S., Cox, M., & Cherkasov, A. R. (2019) · Medicinal Research Reviews · doi:10.1002/med.21575 · Cited by 87
New Advances and Contributions to Fish Biology
Türker, H. (2012) · InTech eBooks · doi:10.5772/45635 · Cited by 82
PU.1 and Haematopoietic Cell Fate: Dosage Matters
Mak, K. S., Funnell, A. P. W., Pearson, R. C. M., & Crossley, M. (2011) · International Journal of Cell Biology · doi:10.1155/2011/808524 · Cited by 77
Mammalian Transcription Factor Networks: Recent Advances in Interrogating Biological Complexity
Wilkinson, A. C., Nakauchi, H., & Göttgens, B. (2017) · Cell Systems · doi:10.1016/j.cels.2017.07.004 · Cited by 76
Stability and Multiattractor Dynamics of a Toggle Switch Based on a Two-Stage Model of Stochastic Gene Expression
Strasser, M. K., Theis, F. J., & Marr, C. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2011.11.4000 · Cited by 68
PU.1 promotes development of rheumatoid arthritis via repressing FLT3 in macrophages and fibroblast-like synoviocytes
Tu, J., Chen, W., Fang, Y., Han, D., Chen, Y., Jiang, H., Tan, X., Xu, Z., Wu, X., Wang, H., et al. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-222708 · Cited by 70
The Genetics and Mechanisms of T-Cell Acute Lymphoblastic LeukemiaPreprint
Gianni, F., Belver, L., & Ferrando, A. A. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a035246 · Cited by 69
Therapeutic targeting of SPIB/SPI1‐facilitated interplay of cancer cells and neutrophils inhibits aerobic glycolysis and cancer progression
Wang, J., Wang, X., Guo, Y., Ye, L., Li, D., Hu, A., Cai, S., Yuan, B., Jin, S., Zhou, Y., et al. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.588 · Cited by 62
SPI1-induced downregulation of FTO promotes GBM progression by regulating pri-miR-10a processing in an m6A-dependent manner
Zhang, S., Zhao, S., Qi, Y., Li, B., Wang, H., Pan, Z., Xue, H., Jin, C., Qiu, W., Chen, Z., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.12.035 · Cited by 64
Mapping genotypes to chromatin accessibility profiles in single cells
Izzo, F., Myers, R. M., Ganesan, S., Mekerishvili, L., Kottapalli, S., Prieto, T., Eton, E. O., Botella, T., Dunbar, A. J., Bowman, R. L., et al. (2024) · Nature · doi:10.1038/s41586-024-07388-y · Cited by 67
Role and Regulation of Transcription Factors in Osteoclastogenesis
Jiang, T., Xia, T., Qiao, F., Wang, N., Jiang, Y., & Xin, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216175 · Cited by 60
Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark
Zhao, S., Zhang, X., Chen, S., & Zhang, S. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01700-0 · Cited by 59
RNA-Binding Proteins in Acute Leukemias
Schuschel, K., Helwig, M., Hüttelmaier, S., Heckl, D., Klusmann, J., & Hoell, J. I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103409 · Cited by 57
Single-cell analyses reveal early thymic progenitors and pre-B cells in zebrafish
Rubin, S. A., Baron, C. S., Pessoa Rodrigues, C., Duran, M., Corbin, A. F., Yang, S. P., Trapnell, C., & Zon, L. I. (2022) · Journal of Experimental Medicine · doi:10.1084/jem.20220038 · Cited by 56
High‐throughput sequencing analysis of the chromosome 7q32 deletion reveals IRF 5 as a potential tumour suppressor in splenic marginal‐zone lymphoma
Fresquet, V. J., Robles, E. F., Parker, A. E., Martínez‐Useros, J., Mena, M. P., Malumbres, R., Agirre, X., Catarino, S., Arteta, D., Osaba, L., et al. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09226.x · Cited by 49
Acute myeloid leukemia: A central role for the ETS factor ERG
Martens, J. H. A. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.05.014 · Cited by 51
Microglia in Alzheimer's Disease: a Key Player in the Transition Between Homeostasis and Pathogenesis
McFarland, K. N., & Chakrabarty, P. (2022) · Neurotherapeutics · doi:10.1007/s13311-021-01179-3 · Cited by 48
Adult Hematopoiesis is Regulated by TIF1γ, a Repressor of TAL1 and PU.1 Transcriptional Activity
Kusy, S., Gault, N., Ferri, F., Lewandowski, D., Barroca, V., Jaracz-Ros, A., Losson, R., & Romeo, P.-H. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.02.005 · Cited by 47
GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia
Maroz, A., Stachorski, L., Emmrich, S., Reinhardt, K., Xu, J., Shao, Z., Käbler, S., Dertmann, T., Hitzler, J. K., Roberts, I. A. G., et al. (2013) · Leukemia · doi:10.1038/leu.2013.373 · Cited by 45
The molecular determinants of microglial developmental dynamics
Barry-Carroll, L., & Gómez‐Nicola, D. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00813-1 · Cited by 49
A review of granulocyte colony-stimulating factor receptor signaling and regulation with implications for cancer
Park, S. D., Saunders, A. S., Reidy, M. A., Bender, D. E., Clifton, S. C., & Morris, K. T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.932608 · Cited by 44
The p53 target Wig-1: a regulator of mRNA stability and stem cell fate?
Vilborg, A., Bersani, C., Wilhelm, M., & Wiman, K. G. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.20 · Cited by 43
Concise Review: Erythroid Versus Myeloid Lineage Commitment: Regulating the Master Regulators
Wolff, L., & Humeniuk, R. (2013) · Stem Cells · doi:10.1002/stem.1379 · Cited by 47
PU.1 Suppresses Th2 Cytokine Expression via Silencing of GATA3 Transcription in Dendritic Cells
Yashiro, T., Kubo, M., Ogawa, H., Okumura, K., & Nishiyama, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137699 · Cited by 43
Synergistic anti-AML effects of the LSD1 inhibitor T-3775440 and the NEDD8-activating enzyme inhibitor pevonedistat via transdifferentiation and DNA rereplication
Ishikawa, Y., Nakayama, K., Morimoto, M., Mizutani, A., Nakayama, A., Toyoshima, K., Hayashi, A., Takagi, S., Dairiki, R., Miyashita, H., et al. (2017) · Oncogenesis · doi:10.1038/oncsis.2017.76 · Cited by 42
Tumor Immune Evasion Induced by Dysregulation of Erythroid Progenitor Cells Development
Grzywa, T. M., Justyniarska, M., Nowis, D., & Gołąb, J. (2021) · Cancers · doi:10.3390/cancers13040870 · Cited by 41
Histological chorioamnionitis shapes the neonatal transcriptomic immune response
Weitkamp, J.-H., Guthrie, S. O., Wong, H. R., Moldawer, L. L., Baker, H. V., & Wynn, J. L. (2016) · Early Human Development · doi:10.1016/j.earlhumdev.2016.06.001 · Cited by 38
MicroRNA-155 expression and function in AML: An evolving paradigm
Narayan, N., Bracken, C. P., & Ekert, P. G. (2018) · Experimental Hematology · doi:10.1016/j.exphem.2018.03.007 · Cited by 35
Epigenetic Control of SPI1 Gene by CTCF and ISWI ATPase SMARCA5
Dluhošová, M., Čuřík, N., Vargova, J., Jonasova, A. T., Zikmund, T., & Stopka, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087448 · Cited by 35
Self-citation
Mathematical modeling of GATA-switching for regulating the differentiation of hematopoietic stem cell
Tian, T., & Smith‐Miles, K. (2014) · BMC Systems Biology · doi:10.1186/1752-0509-8-s1-s8 · Cited by 36
The journey of neutropoiesis: how complex landscapes in bone marrow guide continuous neutrophil lineage determination
Overbeeke, C., Tak, T., & Koenderman, L. (2022) · Blood · doi:10.1182/blood.2021012835 · Cited by 35
MEIS1 regulates early erythroid and megakaryocytic cell fate
Zeddies, S., Jansen, S. B. G., di Summa, F. M., Geerts, D., Zwaginga, J. J., van der Schoot, C. E., Lindern, M. V., & Thijssen‐Timmer, D. C. (2014) · Haematologica · doi:10.3324/haematol.2014.106567 · Cited by 33
Fully automated high-throughput chromatin immunoprecipitation for ChIP-seq: Identifying ChIP-quality p300 monoclonal antibodies
Gasper, W. C., Marinov, G. K., Pauli, F., Scott, M. T., Newberry, K. M., DeSalvo, G., Ou, S. K.-H., Myers, R., Vielmetter, J., & Wold, B. J. (2014) · Scientific Reports · doi:10.1038/srep05152 · Cited by 34
Control of ribosomal RNA synthesis by hematopoietic transcription factors
Charles Antony, A., George, S. S., Blum, J., Somers, P., Thorsheim, C. L., Wu-Corts, D. J., Ai, Y., Gao, L., Lv, K., Tremblay, M. G., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.08.027 · Cited by 32
The Role of a Key Transcription Factor PU.1 in Autoimmune Diseases
Fang, Y., Chen, W., Li, Z., Chen, Y., Wu, X., Zhu, X., Wang, H., Chen, X., Liang, Q., Huang, J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1001201 · Cited by 31
Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice
Wang, Y., Zhang, W., Zhang, C., Van, H. Q. T., Seino, T., & Zhang, Y. (2025) · Cell Research · doi:10.1038/s41422-024-01057-5 · Cited by 34
A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation
Campbell, C. A., Fursova, O. V., Cheng, X., Snella, E. M., McCune, A., Li, L., Solchenberger, B., Schmid, B., Sahoo, D., Morton, M., et al. (2021) · Blood Advances · doi:10.1182/bloodadvances.2020003096 · Cited by 28
A transcription factor PU.1 is critical for Ccl22 gene expression in dendritic cells and macrophages
Yashiro, T., Nakano, S., Nomura, K., Uchida, Y., Kasakura, K., & Nishiyama, C. (2019) · Scientific Reports · doi:10.1038/s41598-018-37894-9 · Cited by 29
Characterization of granulocyte colony stimulating factor receptor of the goldfish (Carassius auratus L.)
Katzenback, B. A., & Belosevic, M. (2011) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2011.07.005 · Cited by 29
Identification and Characterization of CCAAT Enhancer-binding Protein (C/EBP) as a Transcriptional Activator for Epstein-Barr Virus Oncogene Latent Membrane Protein 1
Noda, C., Murata, T., Kanda, T., Yoshiyama, H., Sugimoto, A., Kawashima, D., Saito, S., Isomura, H., & Tsurumi, T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.271734 · Cited by 28
Macrophages: The Bad, the Ugly, and the Good in the Inflammatory Response to Biomaterials
Scatena, M., Eaton, K. V., Jackson, M. F., Lund, S. A., & Giachelli, C. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-45433-7_3 · Cited by 27
T-cell acute lymphoblastic leukaemia: subtype prevalence, clinical outcome, and emerging targeted treatments
Buckley, M., Yeung, D. T. O., White, D. L., & Eadie, L. N. (2025) · Leukemia · doi:10.1038/s41375-025-02599-2 · Cited by 26
Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence and preserves hematopoietic homeostasis
Menéndez-Gutierrez, M. P., Porcuna, J., Nayak, R. C., Paredes, A. L., Niu, H., Núñez, V., Paranjpe, A., Gómez, M. J., Bhattacharjee, A., Schnell, D., et al. (2022) · Blood · doi:10.1182/blood.2022016832 · Cited by 29
Transcription factor antagonism regulates heterogeneity in embryonic stem cell states
Hu, S., Metcalf, E., Mahat, D. B., Chan, L., Sohal, N., Chakraborty, M., Hamilton, M., Singh, A., Singh, A., Lees, J. A., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.10.022 · Cited by 24
Transcriptional and Microenvironmental Regulation of Lineage Ambiguity in Leukemia
Hu, T., Murdaugh, R. L., & Nakada, D. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00268 · Cited by 26
Bone marrow hematopoietic dysfunction in untreated chronic lymphocytic leukemia patients
Manso, B. A., Zhang, H., Mikkelson, M. G., Gwin, K. A., Secreto, C. R., Ding, W., Parikh, S. A., Kay, N. E., & Medina, K. L. (2018) · Leukemia · doi:10.1038/s41375-018-0280-0 · Cited by 26
Critical Role of Transcription Factor PU.1 in the Function of the OX40L/TNFSF4 Promoter in Dendritic Cells
Yashiro, T., Hara, M., Ogawa, H., Okumura, K., & Nishiyama, C. (2016) · Scientific Reports · doi:10.1038/srep34825 · Cited by 26
Hematopoietic Differentiation of Human Pluripotent Stem Cells: HOX and GATA Transcription Factors as Master Regulators
Alsayegh, K. N., Cortés-Medina, L. V., Ramos‐Mandujano, G., Badraiq, H., & Li, M. (2019) · Current Genomics · doi:10.2174/1389202920666191017163837 · Cited by 27
PI3K/AKT pathway: A potential therapeutic target in cerebral ischemia-reperfusion injury
Han, Y., Sun, Y., Peng, S., Tang, T., Zhang, B., Yu, R., Sun, X., Guo, S., Ma, L., Li, P., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177505 · Cited by 27
Enhancers display constrained sequence flexibility and context-specific modulation of motif functionPreprint
Reiter, F., de Almeida, B. P., & Stark, A. (2023) · Genome Research · doi:10.1101/gr.277246.122 · Cited by 27
Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development
Tu, J., Chen, W., Huang, W. H., Wang, X., Fang, Y., Wu, X., Zhang, H., Liu, C., Tan, X., Zhu, X., et al. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2024-226067 · Cited by 22
Single-Cell Transcriptome Analysis of CD34+ Stem Cell-Derived Myeloid Cells Infected With Human Cytomegalovirus
Galinato, M. H., Shimoda, K., Aguiar, A., Hennig, F., Boffelli, D., McVoy, M. A., & Hertel, L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00577 · Cited by 23
Pediatric Mixed-Phenotype Acute Leukemia: What’s New?
Batra, S., & Ross, A. J. (2021) · Cancers · doi:10.3390/cancers13184658 · Cited by 22
GATA2 mitotic bookmarking is required for definitive haematopoiesis
Silvério-Alves, R., Kurochkin, I., Rydström, A., Echegaray, C. V., Haider, J., Nicholls, M., Rode, C., Thelaus, L., Lindgren, A. Y., Ferreira, A. G., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40391-x · Cited by 22
SPI1 activates TGF ‐β1/ PI3K /Akt signaling through transcriptional upregulation of FKBP12 to support the mesenchymal phenotype of glioma stem cells
Song, Y., Zhang, Y., Wang, X., Han, X., Shi, M., Xu, L., Yu, J., Zhang, L., & Han, S. (2022) · Brain Pathology · doi:10.1111/bpa.13217 · Cited by 21
Distribution and expression analysis of transcription factors in tissues and progenitor cell populations of the goldfish (Carassius auratus L.) in response to growth factors and pathogens
Katzenback, B. A., Karpman, M., & Belosevic, M. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.03.007 · Cited by 23
Dissolved oxygen concentration regulates human hepatic organoid formation from pluripotent stem cells in a fully controlled bioreactor
Farzaneh, Z., Abbasalizadeh, S., Asghari, M. H., Alikhani, M., Cabral, J. M. S., & Baharvand, H. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27521 · Cited by 21
Exploring the Leukemogenic Potential of GATA-1S, the Shorter Isoform of GATA-1: Novel Insights into Mechanisms Hampering Respiratory Chain Complex II Activity and Limiting Oxidative Phosphorylation Efficiency
Trombetti, S., Sessa, R., Catapano, R., Rinaldi, L., Bianco, A. L., Feliciello, A., Izzo, P., & Grosso, M. (2021) · Antioxidants · doi:10.3390/antiox10101603 · Cited by 21
p15Ink4b Functions in determining hematopoietic cell fates: Implications for its role as a tumor suppressor
Wolff, L., & Bies, J. (2013) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2013.01.006 · Cited by 21
Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories
Kellaway, S. G., Keane, P., Edginton‐White, B., Regha, K., Kennett, E., & Bonifer, C. (2021) · Life Science Alliance · doi:10.26508/lsa.202000864 · Cited by 17
Measuring cell-to-cell expression variability in single-cell RNA-sequencing data: a comparative analysis and applications to B cell aging
Zheng, H., Vijg, J., Fard, A. T., & Mar, J. C. (2023) · Genome biology · doi:10.1186/s13059-023-03036-2 · Cited by 20
Spi-1, Fli-1 and Fli-3 (miR-17-92) Oncogenes Contribute to a Single Oncogenic Network Controlling Cell Proliferation in Friend Erythroleukemia
Kayali, S., Giraud, G., Morlé, F., & Guyot, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046799 · Cited by 19
SPI1 activates mitochondrial unfolded response signaling to inhibit chondrocyte senescence and relieves osteoarthritis
Zu, X., Chen, S., Li, Z., Hao, L., Fu, W., Zhang, H., Yin, Z., Wang, Y., & Wang, J. (2025) · Bone Research · doi:10.1038/s41413-025-00421-4 · Cited by 18
DNA methylation-mediated silencing of PU.1 in leukemia cells resistant to cell differentiation
Fernández-Nestosa, M. J., Monturus, E., Sánchez, Z., Torres, F. S., Fernández, A. F., Fraga, M. F., Hernández, P., Schvartzman, J. B., & Krimer, D. B. (2013) · SpringerPlus · doi:10.1186/2193-1801-2-392 · Cited by 18
Immortalized erythroid cells as a novel frontier for in vitro blood production: current approaches and potential clinical application
Cervellera, C. F., Mazziotta, C., Mauro, G. D., Iaquinta, M. R., Mazzoni, E., Torreggiani, E., Tognon, M. G., Martini, F., & Rotondo, J. C. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03367-8 · Cited by 18
The role of tumor suppressor p15Ink4b in the regulation of hematopoietic progenitor cell fate
Humeniuk, R., Rosu‐Myles, M., Fares, J., Koller, R. P., Bies, J., & Wolff, L. (2013) · Blood Cancer Journal · doi:10.1038/bcj.2012.44 · Cited by 17
A network including PU.1, Vav1 and miR-142-3p sustains ATRA-induced differentiation of acute promyelocytic leukemia cells - a short report
Grassilli, S., Nika, E., Lambertini, E., Brugnoli, F., Piva, R., Capitani, S., & Bertagnolo, V. (2016) · Cellular Oncology · doi:10.1007/s13402-016-0292-6 · Cited by 16
Regulation of Teleost Macrophage and Neutrophil Cell Development by Growth Factors and Transcription Factors
Barbara, A., Katakura, F., & Belosevic, M. (2012) · InTech eBooks · doi:10.5772/53589 · Cited by 16
Acute myeloid leukemia with expanded erythropoiesis
Porwit‐MacDonald, A., & Vardiman, J. (2011) · Haematologica · doi:10.3324/haematol.2011.050526 · Cited by 16
GATA‐1 isoforms differently contribute to the production and compartmentation of reactive oxygen species in the myeloid leukemia cell line K562
Riccio, P., Sessa, R., Nicola, S. M. D., Petruzziello, F., Trombetti, S., Menna, G., Pepe, G., Maddalena, P., Izzo, P., & Grosso, M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28688 · Cited by 16
Cytotoxicity and Differentiating Effect of the Poly(ADP-Ribose) Polymerase Inhibitor Olaparib in Myelodysplastic Syndromes
Faraoni, I., Consalvo, M. I., Aloisio, F. M., Fabiani, E., Giansanti, M., Cristino, F. D., Falconi, G., Tentori, L., Veroli, A. D., Curzi, P., et al. (2019) · Cancers · doi:10.3390/cancers11091373 · Cited by 16
A mathematical model exhibiting the effect of DNA methylation on the stability boundary in cell-fate networks
Chen, T., Al-Radhawi, M. A., & Sontag, E. D. (2020) · Epigenetics · doi:10.1080/15592294.2020.1805686 · Cited by 16
M2a macrophages regulate fibrosis and affect the outcome after stroke via PU.1/mTOR pathway in fibroblasts
Huang, J., Chen, Y., Zhou, L., Ren, J., Tian, M., Yang, Q., Wang, L., Wu, Y., Wen, J., & Yang, Q. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105674 · Cited by 16
Myelopoiesis during Solid Cancers and Strategies for Immunotherapy
Wildes, T. J., Dean, B. D., & Flores, C. (2021) · Cells · doi:10.3390/cells10050968 · Cited by 15
Epigenetics and tissue immunity—Translating environmental cues into functional adaptations*
Tuong, Z. K., Stewart, B. J., Guo, S. A., & Clatworthy, M. R. (2021) · Immunological Reviews · doi:10.1111/imr.13036 · Cited by 13
hnRNP K in PU.1-containing complexes recruited at theCD11bpromoter: a distinct role in modulating granulocytic and monocytic differentiation of AML-derived cells
Nika, E., Brugnoli, F., Piazzi, M., Lambertini, E., Grassilli, S., Bavelloni, A., Piva, R., Capitani, S., & Bertagnolo, V. (2014) · Biochemical Journal · doi:10.1042/bj20140358 · Cited by 13
Central gene transcriptional regulatory networks shaping monocyte development in bone marrow
Zhang, Z., Bossila, E. A., Li, L., Hu, S., & Zhao, Y. X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1011279 · Cited by 12
Unveiling the complexity of transcription factor networks in hematopoietic stem cells: implications for cell therapy and hematological malignancies
Benyoucef, A., Haigh, J. J., & Brand, M. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1151343 · Cited by 12

Authors: Burda, P., Laslo, P., & Stopka, T.
Affiliations: Charles University (CZ)
St James's University Hospital (GB)
Corresponding author: Stopka, T
ORCID: Burda, P
Laslo, P
Stopka, T
Venue: Leukemia
Publisher: Springer Science and Business Media LLC
Published: 2010-06-03
Volume: 24
Issue: 7
Pages: 1249-1257
ISSN: 0887-6924 (ISSN-L)
1476-5551
DOI: 10.1038/leu.2010.104
OpenAlex: W2023603100
Cited by: 184
References: 109
Citations by year: 2026: 10 · 2025: 19 · 2024: 14 · 2023: 18 · 2022: 25 · 2021: 19 · 2020: 10 · 2019: 9 · 2018: 7 · 2017: 7 · 2016: 6 · 2015: 1 · 2014: 7 · 2013: 8 · 2012: 7
FWCI: 1.60
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Leukemia (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Ministerstvo Zdravotnictví Ceské Republiky
Topics: Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: PU.1, GATA-1, transcription factors, hematopoiesis, leukemogenesis, protein-protein interaction, negative regulation, differentiation therapy
MeSH terms: Proto-Oncogene Protein Spi-1, Animals, Hematopoiesis, Humans, Leukemia, Proto-Oncogene Proteins, Trans-Activators, GATA Transcription Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks