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Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4
Open accessAbstract
Successful hematopoietic stem cell transplant requires the infusion of a sufficient number of hematopoietic stem/progenitor cells (HSPCs) that are capable of homing to the bone marrow cavity and regenerating durable trilineage hematopoiesis in a timely manner. Stem cells harvested from peripheral blood are the most commonly used graft source in HSCT. Although granulocyte colony-stimulating factor (G-CSF) is the most frequently used agent for stem cell mobilization, the use of G-CSF alone results in suboptimal stem cell yields in a significant proportion of patients. Both the chemokine receptor CXCR4 and the integrin α4β1 (very late antigen 4 (VLA-4)) have important roles in the homing and retention of HSPCs within the bone marrow microenvironment. Preclinical and/or clinical studies have shown that targeted disruption of the interaction of CXCR4 or VLA-4 with their ligands results in the rapid and reversible mobilization of hematopoietic stem cells into the peripheral circulation and is synergistic when combined with G-CSF. In this review, we discuss the development of small-molecule CXCR4 and VLA-4 inhibitors and how they may improve the utility and convenience of peripheral blood stem cell transplantation.
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Stem cell programs in cancer initiation, progression, and therapy resistance
Huang, T., Song, X., Xu, D., Tiek, D., Goenka, A., Wu, B., Sastry, N., Hu, B., & Cheng, S.-Y. (2020) · Theranostics · doi:10.7150/thno.41648 · Cited by 524
The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
Döring, Y., Pawig, L., Weber, C., & Noels, H. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00212 · Cited by 289
A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity
Chung, K.-J., Chatzigeorgiou, A., Economopoulou, M., Garcia-Martin, R., Alexaki, V. I., Mitroulis, I., Nati, M., Gebler, J., Ziemssen, T., Goelz, S. E., et al. (2017) · Nature Immunology · doi:10.1038/ni.3728 · Cited by 175
The role of CXCR4 in multiple myeloma: Cells’ journey from bone marrow to beyond
Ullah, T. R. (2019) · Journal of Bone Oncology · doi:10.1016/j.jbo.2019.100253 · Cited by 141
Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines
Porter, S. N., Cluster, A. S., Signer, R. A. J., Voigtmann, J., Monlish, D. A., Schuettpelz, L. G., & Magee, J. A. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.04.008 · Cited by 22
Metadata
- Authors
- Rettig, M. P., Ansstas, G., & DiPersio, J. F.
- Venue
- Leukemia
- Published
- 2011-09-02
- Volume
- 26
- Issue
- 1
- Pages
- 34-53
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- OpenAlex
- W2028030685
- Cited by
- 176
- References
- 5
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Rettig, M. P., Ansstas, G., & DiPersio, J. F. (2012). Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4. Leukemia. https://doi.org/10.1038/leu.2011.197
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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