The DOI matches its Crossref record; 234 of the 234 references it cites were found in a registry or an index.
The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
Open accessAbstract
The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic function by mediating the homing of progenitor cells in the bone marrow and regulating their mobilization into peripheral tissues upon injury or stress. Although the CXCL12/CXCR4 interaction has long been regarded as a monogamous relation, the identification of the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) as an important second ligand for CXCR4, and of CXCR7 as an alternative receptor for CXCL12, has undermined this interpretation and has considerably complicated the understanding of CXCL12/CXCR4 signaling and associated biological functions. This review aims to provide insight into the current concept of the CXCL12/CXCR4 axis in myocardial infarction (MI) and its underlying pathologies such as atherosclerosis and injury-induced vascular restenosis. It will discuss main findings from in vitro studies, animal experiments and large-scale genome-wide association studies. The importance of the CXCL12/CXCR4 axis in progenitor cell homing and mobilization will be addressed, as will be the function of CXCR4 in different cell types involved in atherosclerosis. Finally, a potential translation of current knowledge on CXCR4 into future therapeutical application will be discussed.
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Cites
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Genome-wide association studies for common diseases and complex traits
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The Wellcome Trust Case Control Consortium, U.K.
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Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C. (2004) · Nature Medicine · doi:10.1038/nm1075 · Cited by 2,600
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Cited by
Frangogiannis, N. G. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvaa324 · Cited by 1,229
CXCR4 signaling in health and disease
Pozzobon, T., Goldoni, G., Viola, A., & Molon, B. (2016) · Immunology Letters · doi:10.1016/j.imlet.2016.06.006 · Cited by 256
Molecular Imaging of the Chemokine Receptor CXCR4 After Acute Myocardial Infarction
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Immunotherapy for cardiovascular disease
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Self-citationVallecillo-García, P., Orgeur, M., vom Hofe-Schneider, S., Stumm, J., Kappert, V., Ibrahim, D. M., Börno, S. T., Hayashi, S., Relaix, F., Hildebrandt, K., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01120-3 · Cited by 126
Metadata
- Authors
- Döring, Y., Pawig, L., Weber, C., & Noels, H.
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2014-06-11
- Volume
- 5
- Pages
- 212-212
- ISSN
- 1664-042X (ISSN-L)
- OpenAlex
- W2081077945
- Cited by
- 289
- References
- 234
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- gold
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- Döring, Y., Pawig, L., Weber, C., & Noels, H. (2014). The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease. Frontiers in Physiology. https://doi.org/10.3389/fphys.2014.00212
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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