The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development
Open accessAbstract
A strict balance between self-renewal and differentiation of hematopoietic stem cells (HSCs) is required in order to maintain homeostasis, as well as to efficiently respond to injury and infections. Numbers and fate decisions made by progenitors derived from HSC must also be carefully regulated to sustain large-scale production of blood cells. The complex Wnt family of molecules generally is thought to be important to these processes, delivering critical signals to HSC and progenitors as they reside in specialized niches. Wnt proteins have also been extensively studied in connection with malignancies and are causatively involved in the development of several types of leukemias. However, studies with experimental animal models have produced contradictory findings regarding the importance of Wnt signals for normal hematopoiesis and lymphopoiesis. Here, we will argue that dose dependency of signaling via particular Wnt pathways accounts for much, if not all of this controversy. We conclude that there seems little doubt that Wnt proteins are required to sustain normal hematopoiesis, but are likely to be presented in carefully controlled gradients in a tissue-specific manner.
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Cites
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“65 In Chronic Myeloid Leukemia caused by the t(9,22) translocation leading to the production of the abnormal BCR–ABL fusion protein, Wnt signaling is activated during blast crises”
APC, Signal transduction and genetic instability in colorectal cancer
Fodde, R., Smits, R., & Clevers, H. (2001) · Nature Reviews Cancer · doi:10.1038/35094067 · Cited by 937
Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling
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Zhan, T., Rindtorff, N., & Boutros, M. (2017) · Oncogene · doi:10.1038/onc.2016.304 · Cited by 2,626
Cabezas-Wallscheid, N., Klimmeck, D., Hansson, J., Lipka, D. B., Reyes, A., Wang, Q., Weichenhan, D., Lier, A., von Paleske, L., Renders, S., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.07.005 · Cited by 589
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Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options
van Andel, H., Kocemba, K. A., Spaargaren, M., & Pals, S. T. (2019) · Leukemia · doi:10.1038/s41375-019-0404-1 · Cited by 188
Metadata
- Authors
- Luis, T. C., Ichii, M., Brugman, M. H., Kincade, P., & Staal, F. J. T.
- Venue
- Leukemia
- Published
- 2011-12-15
- Volume
- 26
- Issue
- 3
- Pages
- 414-421
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- OpenAlex
- W2071781451
- Cited by
- 208
- References
- 5
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Luis, T. C., Ichii, M., Brugman, M. H., Kincade, P., & Staal, F. J. T. (2012). Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development. Leukemia. https://doi.org/10.1038/leu.2011.387
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
