Wnt signaling in cancer

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

Wanchoo, R., Karam, S., Uppal, N. N., Barta, V. S., Deray, G., Devoe, C., Launay‐Vacher, V., Jhaveri, K. D., & on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (2017) · American Journal of Nephrology · doi:10.1159/000455014 · Cited by 15,314 · see citing works

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500596 · Cited by 9,377 · see citing works

Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer

Borghaei, H., Paz-Ares, L., Horn, L., Spigel, D. R., Steins, M., Ready, N. E., Chow, L. Q., Vokes, E. E., Felip, E., Holgado, E., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1507643 · Cited by 9,335 · see citing works

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

Larkin, J., Chiarion-Sileni, V., Gonzalez, R., Grob, J. J., Cowey, C. L., Lao, C. D., Schadendorf, D., Dummer, R., Smylie, M., Rutkowski, P., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1504030 · Cited by 8,157 · see citing works

Cancer Genome Landscapes

Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz, L. A., & Kinzler, K. W. (2013) · Science · doi:10.1126/science.1235122 · Cited by 7,863 · see citing works

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

Motzer, R. J., Escudier, B., McDermott, D. F., George, S., Hammers, H. J., Srinivas, S., Tykodi, S. S., Sosman, J. A., Procopio, G., Plimack, E. R., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1510665 · Cited by 5,807 · see citing works

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583 · see citing works

Wnt/β-Catenin Signaling in Development and Disease

Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568 · see citing works

The consensus molecular subtypes of colorectal cancer

Guinney, J., Dienstmann, R., Wang, X., de Reyniès, A., Schlicker, A., Soneson, C., Marisa, L., Roepman, P., Nyamundanda, G., Angelino, P., et al. (2015) · Nature Medicine · doi:10.1038/nm.3967 · Cited by 5,170 · see citing works

Mutations affecting segment number and polarity in Drosophila

Nüsslein‐Volhard, C., & Wieschaus, E. F. (1980) · Nature · doi:10.1038/287795a0 · Cited by 4,370 · see citing works

Wnt signalling in stem cells and cancer

Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666 · see citing works

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma

Kořínek, V., Barker, N., Morin, P. J., van Wichen, D. F., de Weger, R. A., Kinzler, K. W., Vogelstein, B., & Clevers, H. C. (1997) · Science · doi:10.1126/science.275.5307.1784 · Cited by 3,304 · see citing works

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

Spranger, S., Bao, R., & Gajewski, T. F. (2015) · Nature · doi:10.1038/nature14404 · Cited by 2,830 · see citing works

Regulatory networks defining EMT during cancer initiation and progression

Craene, B. D., & Berx, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3447 · Cited by 2,487 · see citing works

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

van de Wetering, M., Francies, H. E., Francis, J. M., Bounova, G., Iorio, F., Pronk, A., van Houdt, W., van Gorp, J., Taylor-Weiner, A., Kester, L., et al. (2015) · Cell · doi:10.1016/j.cell.2015.03.053 · Cited by 2,408 · see citing works

Identification of FAP Locus Genes from Chromosome 5q21

Kinzler, K. W., Nilbert, M. C., Su, L.-K., Vogelstein, B., Bryan, T. M., Levy, D. B., Smith, K. J., Preisinger, A. C., Hedge, P., McKechnie, D., et al. (1991) · Science · doi:10.1126/science.1651562 · Cited by 2,331 · see citing works

Crypt stem cells as the cells-of-origin of intestinal cancer

Barker, N., Ridgway, R. A., van Es, J. H., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A. R., Sansom, O. J., & Clevers, H. C. (2008) · Nature · doi:10.1038/nature07602 · Cited by 2,159 · see citing works

WNT signaling in bone homeostasis and disease: From human mutations to treatments

Baron, R., & Kneissel, M. (2013) · Nature Medicine · doi:10.1038/nm.3074 · Cited by 2,093 · see citing works

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Huang, S.-M. A., Mishina, Y., Liu, S.-M., Cheung, A. K., Stegmeier, F., Michaud, G., Charlat, O., Wiellette, E., Zhang, Y., Wiessner, S., et al. (2009) · Nature · doi:10.1038/nature08356 · Cited by 2,077 · see citing works

WNT signalling pathways as therapeutic targets in cancer

Anastas, J. N., & Moon, R. T. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3419 · Cited by 1,902 · see citing works

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

Nishisho, I., Nakamura, Y., Miyoshi, Y., Miki, Y., Ando, H., Horii, A., Koyama, K., Utsunomiya, J., Baba, S., Hedge, P., et al. (1991) · Science · doi:10.1126/science.1651563 · Cited by 1,891 · see citing works

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

Nusse, R., & VARMUS, H. E. (1982) · Cell · doi:10.1016/0092-8674(82)90409-3 · Cited by 1,864 · see citing works

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

Vermeulen, L., De Sousa E Melo, F., van der Heijden, M., Cameron, K., de Jong, J. H., Borovski, T., Tuynman, J. B., Todaro, M., Merz, C., Rodermond, H., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2048 · Cited by 1,804 · see citing works

A comprehensive catalogue of somatic mutations from a human cancer genome

Pleasance, E. D., Cheetham, R. K., Stephens, P. J., McBride, D. J., Humphray, S. J., Greenman, C. D., Varela, I., Lin, M.-L., Ordóñez, G. R., Bignell, G. R., et al. (2010) · Nature · doi:10.1038/nature08658 · Cited by 1,696 · see citing works

Interactions between cancer stem cells and their niche govern metastatic colonization

Malanchi, I., Santamaria-Martínez, A., Susanto, E., Peng, H., Lehr, H.-A., Delaloye, J.-F., & Huelsken, J. (2012) · Nature · doi:10.1038/nature10694 · Cited by 1,339 · see citing works

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

Luga, V., Zhang, L., Viloria-Petit, A. M., Ogunjimi, A. A., Inanlou, M. R., Chiu, E., Buchanan, M., Hosein, A. N., Basik, M., & Wrana, J. L. (2012) · Cell · doi:10.1016/j.cell.2012.11.024 · Cited by 1,311 · see citing works

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

de Lau, W., Barker, N., Low, T. Y., Koo, B., Li, V. S. W., Teunissen, H., Kujala, P., Haegebarth, A., Peters, P. J., van de Wetering, M., et al. (2011) · Nature · doi:10.1038/nature10337 · Cited by 1,267 · see citing works

Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context

Mikels, A. J., & Nusse, R. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040115 · Cited by 1,244 · see citing works

Association of the APC Gene Product with β-Catenin

Rubinfeld, B., Souza, B., Albert, I., Müller, O., Chamberlain, S. H., Masiarz, F. R., Munemitsu, S. M., & Polakis, P. G. (1993) · Science · doi:10.1126/science.8259518 · Cited by 1,223 · see citing works

Association of the APC Tumor Suppressor Protein with Catenins

Su, L.-K., Vogelstein, B., & Kinzler, K. W. (1993) · Science · doi:10.1126/science.8259519 · Cited by 1,193 · see citing works

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

Matano, M., Date, S., Shimokawa, M., Takano, A., Fujii, M., Ohta, Y., Watanabe, T., Kanai, T., & Sato, T. (2015) · Nature Medicine · doi:10.1038/nm.3802 · Cited by 1,135 · see citing works

YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response

Azzolin, L., Panciera, T., Soligo, S., Enzo, E., Bicciato, S., Dupont, S., Bresolin, S., Frasson, C., Basso, G., Guzzardo, V., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.013 · Cited by 1,094 · see citing works

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

Heallen, T. R., Zhang, M., Wang, J., Bonilla-Claudio, M., Klysik, E., Johnson, R. L., & Martin, J. F. (2011) · Science · doi:10.1126/science.1199010 · Cited by 1,092 · see citing works

Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas

Schepers, A. G., Snippert, H. J. G., Stange, D. E., van den Born, M., van Es, J. H., van de Wetering, M., & Clevers, H. C. (2012) · Science · doi:10.1126/science.1224676 · Cited by 1,072 · see citing works

Sequential cancer mutations in cultured human intestinal stem cells

Drost, J., van Jaarsveld, R. H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A., Sachs, N., Overmeer, R. M., Offerhaus, G. J., Begthel, H., et al. (2015) · Nature · doi:10.1038/nature14415 · Cited by 1,067 · see citing works

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

Schwitalla, S., Fingerle, A. A., Cammareri, P., Nebelsiek, T., Göktuna, S. İ., Ziegler, P. K., Canli, Ö., Heijmans, J., Huels, D. J., Moreaux, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.12.012 · Cited by 1,057 · see citing works

Can we safely target the WNT pathway?

Kahn, M. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4233 · Cited by 1,039 · see citing works

Active Wnt proteins are secreted on exosomes

Gross, J. C., Chaudhary, V., Bartscherer, K., & Boutros, M. (2012) · Nature Cell Biology · doi:10.1038/ncb2574 · Cited by 1,025 · see citing works

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

Koo, B., Spit, M., Jordens, I., Low, T. Y., Stange, D. E., van de Wetering, M., van Es, J. H., Mohammed, S., Heck, A. J. R., Maurice, M. M., et al. (2012) · Nature · doi:10.1038/nature11308 · Cited by 991 · see citing works

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Hao, H.-X., Xie, Y., Zhang, Y., Charlat, O., Oster, E., Avello, M., Lei, H., Mickanin, C., Liu, D., Ruffner, H., et al. (2012) · Nature · doi:10.1038/nature11019 · Cited by 962 · see citing works

Recurrent R-spondin fusions in colon cancer

Seshagiri, S., Stawiski, E. W., Durinck, S., Modrusan, Z., Storm, E. E., Conboy, C. B., Chaudhuri, S., Guan, Y., Janakiraman, V., Jaiswal, B. S., et al. (2012) · Nature · doi:10.1038/nature11282 · Cited by 960 · see citing works

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

Satoh, S., Daigo, Y., Furukawa, Y., Kato, T., Miwa, N., Nishiwaki, T., Kawasoe, T., Ishiguro, H., Fujita, M., Tokino, T., et al. (2000) · Nature Genetics · doi:10.1038/73448 · Cited by 960 · see citing works

EMT: When epithelial cells decide to become mesenchymal-like cells

Kalluri, R. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39675 · Cited by 953 · see citing works

Cold Spring Harbor Perspectives in BiologyPreprint

(2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect_biol/ · Cited by 949 · see citing works

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

Merlos-Suárez, A., Barriga, F. M., Jung, P., Iglesias, M., Céspedes, M. V., Rossell, D., Sevillano, M., Hernando-Momblona, X., da Silva-Diz, V., Muñoz, P., et al. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.02.020 · Cited by 934 · see citing works

The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

Rijsewijk, F. A. M., Schuermann, M., Wagenaar, E., Parren, P. W. H. I., Weigel, D., & Nusse, R. (1987) · Cell · doi:10.1016/0092-8674(87)90038-9 · Cited by 931 · see citing works

Unravelling cancer stem cell potential

Beck, B., & Blanpain, C. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3597 · Cited by 895 · see citing works

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

Scheel, C., & Weinberg, R. A. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.04.001 · Cited by 872 · see citing works

Wnt signaling in cancer.

Polakis, P. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008052 · Cited by 847 · see citing works

Exosomes in Tumor Microenvironment Influence Cancer Progression and Metastasis

Kahlert, C., & Kalluri, R. (2013) · Journal of molecular medicine · doi:10.1007/s00109-013-1020-6 · Cited by 842 · see citing works

Wnt/Frizzled Activation of Rho Regulates Vertebrate Gastrulation and Requires a Novel Formin Homology Protein Daam1

Habas, R., Kato, Y., & He, X. (2001) · Cell · doi:10.1016/s0092-8674(01)00614-6 · Cited by 842 · see citing works

The Wnt/β-catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

Wang, Y., Krivtsov, A., Sinha, A., North, T., Goessling, W., Feng, Z.-H., Zon, L., & Armstrong, S. (2010) · Science · doi:10.1126/science.1186624 · Cited by 812 · see citing works

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

Malladi, S., Macalinao, D. G., Jin, X., He, L., Basnet, H., Zou, Y., de Stanchina, E., & Massagué, J. (2016) · Cell · doi:10.1016/j.cell.2016.02.025 · Cited by 791 · see citing works

β-Catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression

Lin, S., Xia, W., Wang, J. C., Kwong, K. Y., Spohn, B., Wen, Y., Pestell, R. G., & Hung, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.060025397 · Cited by 785 · see citing works

Wntless, a Conserved Membrane Protein Dedicated to the Secretion of Wnt Proteins from Signaling Cells

Bänziger, C., Soldini, D., Schütt, C., Zipperlen, P., Hausmann, G., & Basler, K. (2006) · Cell · doi:10.1016/j.cell.2006.02.049 · Cited by 764 · see citing works

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

Rosenbluh, J., Nijhawan, D., Cox, A. G., Li, X., Neal, J. T., Schafer, E. J., Zack, T. I., Wang, X., Tsherniak, A., Schinzel, A. C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.11.026 · Cited by 757 · see citing works

Dishevelled: The hub of Wnt signaling

Gao, C., & Chen, Y. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.11.021 · Cited by 751 · see citing works

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

Tsukamoto, A. S., Grosschedl, R., Guzman, R. C., Parslow, T. G., & Varmus, H. E. (1988) · Cell · doi:10.1016/0092-8674(88)90220-6 · Cited by 747 · see citing works

<i>In vivo</i> Switching of Human Melanoma Cells between Proliferative and Invasive States

Hoek, K. S., Eichhoff, O. M., Schlegel, N. C., Döbbeling, U., Kobert, N., Schaerer, L., Hemmi, S., & Dummer, R. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2491 · Cited by 743 · see citing works

CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis

Todaro, M., Gaggianesi, M., Catalano, V., Benfante, A., Iovino, F., Biffoni, M., Apuzzo, T., Sperduti, I., Volpe, S., Cocorullo, G., et al. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.01.009 · Cited by 717 · see citing works

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

Taelman, V. F., Dobrowolski, R., Plouhinec, J.-L., Fuentealba, L. C., Vorwald, P. P., Gumper, I., Sabatini, D. D., & Robertis, E. M. D. (2010) · Cell · doi:10.1016/j.cell.2010.11.034 · Cited by 715 · see citing works

Telomerase modulates Wnt signalling by association with target gene chromatin

Park, J.-I., Venteicher, A. S., Hong, J. Y., Choi, J., Jun, S., Shkreli, M., Chang, W., Meng, Z., Cheung, P., Ji, H., et al. (2009) · Nature · doi:10.1038/nature08137 · Cited by 707 · see citing works

RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance

Miyamoto, D. T., Zheng, Y., Wittner, B. S., Lee, R. J., Zhu, H., Broderick, K. T., Desai, R. N., Fox, D. B., Brannigan, B. W., Trautwein, J., et al. (2015) · Science · doi:10.1126/science.aab0917 · Cited by 706 · see citing works

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

de Lau, W., Peng, W. C., Gros, P., & Clevers, H. (2014) · Genes &amp; Development · doi:10.1101/gad.235473.113 · Cited by 656 · see citing works

The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling

Wang, Y., He, L., Du, Y., Zhu, P., Huang, G., Luo, J., Yan, X., Ye, B., Li, C., Xia, P., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.03.003 · Cited by 634 · see citing works

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

Gurney, A., Axelrod, F., Bond, C. J., Cain, J., Chartier, C., Donigan, L., Fischer, M., Chaudhari, A., Ji, M., Kapoun, A. M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120068109 · Cited by 614 · see citing works

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

Nusse, R., van Ooyen, A., Cox, D. R., Fung, Y. K., & Varmus, H. E. (1984) · Nature · doi:10.1038/307131a0 · Cited by 611 · see citing works

Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

Dhomen, N. S., Reis-Filho, J. S., Dias, S. D. R., Hayward, R., Savage, K., Delmas, V., Larue, L., Pritchard, C. A., & Marais, R. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.02.022 · Cited by 595 · see citing works

Colorectal cancer and genetic alterations in the Wnt pathway

Segditsas, S., & Tomlinson, I. (2006) · Oncogene · doi:10.1038/sj.onc.1210059 · Cited by 591 · see citing works

WNT signalling in the immune system: WNT is spreading its wings

Staal, F. J. T., Luis, T. C., & Tiemessen, M. M. (2008) · Nature Reviews Immunology · doi:10.1038/nri2360 · Cited by 582 · see citing works

Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein

Bartscherer, K., Pelte, N., Ingelfinger, D., & Boutros, M. (2006) · Cell · doi:10.1016/j.cell.2006.04.009 · Cited by 580 · see citing works

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

Varelas, X., Miller, B. W., Sopko, R., Song, S., Gregorieff, A., Fellouse, F. A., Sakuma, R., Pawson, T. J., Hunziker, W., McNeill, H., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.03.007 · Cited by 571 · see citing works

LGR4 and LGR5 are R‐spondin receptors mediating Wnt/β‐catenin and Wnt/PCP signalling

Glinka, A., Dolde, C. E., Kirsch, N., Huang, Y., Kazanskaya, O., Ingelfinger, D., Boutros, M., Cruciat, C., & Niehrs, C. (2011) · EMBO Reports · doi:10.1038/embor.2011.175 · Cited by 565 · see citing works

Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature

Hoek, K. S., Schlegel, N. C., Brafford, P. A., Sucker, A., Ugurel, S., Kumar, R., Weber, B. L., Nathanson, K. L., Phillips, D. J., Herlyn, M., et al. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00322.x · Cited by 554 · see citing works

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer

Dow, L. E., O’Rourke, K. P., Simon, J. M., Tschaharganeh, D. F., van Es, J. H., Clevers, H. C., & Lowe, S. W. (2015) · Cell · doi:10.1016/j.cell.2015.05.033 · Cited by 549 · see citing works

Restriction of intestinal stem cell expansion and the regenerative response by YAP

Barry, E., Morikawa, T., Butler, B. L., Shrestha, K., de la Rosa, R., Yan, K. S., Fuchs, C. S., Magness, S. T., Smits, R., Ogino, S., et al. (2012) · Nature · doi:10.1038/nature11693 · Cited by 537 · see citing works

Wnt/Ca2+ signaling pathway: a brief overview

De, A. (2011) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmr079 · Cited by 532 · see citing works

Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis

McMahon, A. P., & Moon, R. T. (1989) · Cell · doi:10.1016/0092-8674(89)90506-0 · Cited by 530 · see citing works

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

Farin, H. F., Jordens, I., Mosa, M. H., Basak, O., Korving, J., Tauriello, D. V. F., de Punder, K., Angers, S., Peters, P. J., Maurice, M. M., et al. (2016) · Nature · doi:10.1038/nature16937 · Cited by 525 · see citing works

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

Li, Y., Welm, B. E., Podsypanina, K., Huang, S., Chamorro, M. N., Zhang, X., Rowlands, T. M., Egeblad, M., Cowin, P., Werb, Z., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2136825100 · Cited by 520 · see citing works

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

Chairoungdua, A., Smith, D. L., Pochard, P., Hull, M., & Caplan, M. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201002049 · Cited by 514 · see citing works

Wnt/β-Catenin Pathway Activation Is Enriched in Basal-Like Breast Cancers and Predicts Poor Outcome

Khramtsov, A., Khramtsova, G. F., Tretiakova, M., Huo, D., Olopade, O. I., & Goss, K. H. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091125 · Cited by 509 · see citing works

Wnt Signaling Gradients Establish Planar Cell Polarity by Inducing Vangl2 Phosphorylation through Ror2

Gao, B., Song, H., Bishop, K. S., Elliot, G., Garrett, L. J., English, M. A., Andre, P., Robinson, J., Sood, R. B., Minami, Y., et al. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.01.001 · Cited by 496 · see citing works

Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers

Chan-on, W., Nairismägi, M., Ong, C. K., Lim, W. K., Dima, S., Pairojkul, C., Lim, K. H., McPherson, J. R., Cutcutache, I., Heng, H. L., et al. (2013) · Nature Genetics · doi:10.1038/ng.2806 · Cited by 495 · see citing works

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

Yu, M., Ting, D. T., Stott, S. L., Wittner, B. S., Ozsolak, F., Paul, S., Ciciliano, J. C., Smas, M. E., Winokur, D., Gilman, A. J., et al. (2012) · Nature · doi:10.1038/nature11217 · Cited by 484 · see citing works

Dysregulation of Wnt/β-Catenin Signaling in Gastrointestinal Cancers

White, B. D., Chien, A. J., & Dawson, D. W. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.12.001 · Cited by 471 · see citing works

RNF43 is frequently mutated in colorectal and endometrial cancers

Giannakis, M., Hodis, E., Mu, X. J., Yamauchi, M., Rosenbluh, J., Cibulskis, K., Saksena, G., Lawrence, M. S., Qian, Z. R., Nishihara, R., et al. (2014) · Nature Genetics · doi:10.1038/ng.3127 · Cited by 470 · see citing works

Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers

Cleary, A. S., Leonard, T. L., Gestl, S. A., & Gunther, E. J. (2014) · Nature · doi:10.1038/nature13187 · Cited by 461 · see citing works

Prickle Mediates Feedback Amplification to Generate Asymmetric Planar Cell Polarity Signaling

Tree, D., Shulman, J. M., Rousset, R., Scott, M. P., Gubb, D., & Axelrod, J. D. (2002) · Cell · doi:10.1016/s0092-8674(02)00715-8 · Cited by 460 · see citing works

The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin

Latres, E., Chiaur, D. S., & Pagano, M. (1999) · Oncogene · doi:10.1038/sj.onc.1202653 · Cited by 442 · see citing works

R-Spondin2 Is a Secreted Activator of Wnt/β-Catenin Signaling and Is Required for Xenopus Myogenesis

Kazanskaya, O., Glinka, A., del Barco Barrantes, I., Stannek, P., Niehrs, C., & Wu, W. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.019 · Cited by 431 · see citing works

Activation of the Wnt signaling pathway in chronic lymphocytic leukemia

Lu, D., Zhao, Y., Tawatao, R. I., Cottam, H. B., Sen, M., Leoni, L. M., Kipps, T. J., Corr, M., & Carson, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308648100 · Cited by 420 · see citing works

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

Jiang, X., Hao, H.-X., Growney, J. D., Woolfenden, S., Bottiglio, C., Ng, N., Lu, B., Hsieh, M. H., Bagdasarian, L., Meyer, R., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307218110 · Cited by 415 · see citing works

WNT/PCP signaling pathway and human cancer (Review)

Katoh, M. (2005) · Oncology Reports · doi:10.3892/or.14.6.1583 · Cited by 413 · see citing works

Many roads lead to oncogene-induced senescence

Courtois-Cox, S., Jones, S. L., & Cichowski, K. (2008) · Oncogene · doi:10.1038/sj.onc.1210950 · Cited by 397 · see citing works

Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice.

Morris, J. P., Cano, D., Sekine, S., Wang, S. C., & Hebrok, M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40045 · Cited by 391 · see citing works

ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation

Myant, K., Cammareri, P., McGhee, E. J., Ridgway, R. A., Huels, D. J., Cordero, J. B., Schwitalla, S., Kalna, G., Ogg, E.-L., Athineos, D., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.04.006 · Cited by 386 · see citing works

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

Tenbaum, S. P., Ordóñez‐Morán, P., Puig, I., Chicote, I., Arqués, O., Landolfi, S., Fernández, Y., Herance, J. R., Gispert, J. D., Mendizabal, L., et al. (2012) · Nature Medicine · doi:10.1038/nm.2772 · Cited by 386 · see citing works

β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation

Geyer, F. C., Lacroix‐Triki, M., Savage, K., Arnedos, M., Lambros, M. B. K., Mackay, A. G., Natrajan, R., & Reis-Filho, J. S. (2010) · Modern Pathology · doi:10.1038/modpathol.2010.205 · Cited by 373 · see citing works

Wnt-Frizzled/Planar Cell Polarity Signaling: Cellular Orientation by Facing the Wind (Wnt)

Yang, Y., & Mlodzik, M. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125315 · Cited by 361 · see citing works

beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer.

Clements, W. M., Wang, J., Sarnaik, A. A., Kim, O. J., MacDonald, J., Fenoglio‐Preiser, C. M., Groden, J. L., & Lowy, A. M. (2002) · PubMed · Cited by 357 · see citing works

A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis

Gujral, T. S., Chan, M., Peshkin, L., Sorger, P. K., Kirschner, M. W., & MacBeath, G. (2014) · Cell · doi:10.1016/j.cell.2014.10.032 · Cited by 351 · see citing works

β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas

Damsky, W., Curley, D. P., Santhanakrishnan, M., Rosenbaum, L. E., Platt, J. T., Rothberg, B. E. G., Taketo, M. M., Dankort, D. L., Rimm, D. L., McMahon, M., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.10.030 · Cited by 351 · see citing works

Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos

Sheldahl, L. C., Slusarski, D. C., Pandur, P., Miller, J. R., Kühl, M., & Moon, R. T. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211094 · Cited by 350 · see citing works

The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing.Preprint

Kadowaki, T., Wilder, E. L., Klingensmith, J., Zachary, K., & Perrimon, N. (1996) · Genes & Development · doi:10.1101/gad.10.24.3116 · Cited by 348 · see citing works

Wnt addiction of genetically defined cancers reversed by PORCN inhibition

Madan, B., Ke, Z., Harmston, N., Ho, S. Y., Frois, A. O., Alam, J., Jeyaraj, D. A., Pendharkar, V. V., Ghosh, K., Virshup, I., et al. (2015) · Oncogene · doi:10.1038/onc.2015.280 · Cited by 342 · see citing works

Wnt Signaling and Breast Cancer

Howe, L. R., & Brown, A. M. C. (2004) · Cancer Biology & Therapy · doi:10.4161/cbt.3.1.561 · Cited by 342 · see citing works

Activated Wnt/ß-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model

Chien, A. J., Moore, E. C., Lonsdorf, A. S., Kulikauskas, R. M., Rothberg, B. G., Berger, A. J., Major, M. B., Hwang, S. T., Rimm, D. L., & Moon, R. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811902106 · Cited by 335 · see citing works

Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients

Melo, F. D. S. E., Çolak, S., Buikhuisen, J. Y., Köster, J., Cameron, K., de Jong, J. H., Tuynman, J. B., Prasetyanti, P. R., Fessler, E., van den Bergh, S., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.10.008 · Cited by 333 · see citing works

Circulating tumor cells: a window into cancer biology and metastasis

Maheswaran, S., & Haber, D. A. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.12.002 · Cited by 316 · see citing works

A Novel Tankyrase Small-Molecule Inhibitor Suppresses <i>APC</i> Mutation–Driven Colorectal Tumor Growth

Lau, T., Chan, E., Callow, M., Waaler, J., Boggs, J., Blake, R. A., Magnuson, S., Sambrone, A., Schutten, M., Firestein, R., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4562 · Cited by 316 · see citing works

β-Catenin induces immortalization of melanocytes by suppressing p16 INK4a expression and cooperates with N-Ras in melanoma developmentPreprint

Delmas, V., Beermann, F., Martinozzi, S., Carreira, S., Ackermann, J., Kumasaka, M. Y., Denat, L., GOODALL, J. C., Luciani, F., Virós, A., et al. (2007) · Genes & Development · doi:10.1101/gad.450107 · Cited by 312 · see citing works

A randomised controlled trial of a theory-based intervention to improve sun protective behaviour in adolescents ('you can still be HOT in the shade'): study protocol

Hawkes, A. L., Hamilton, K., White, K. M., & Young, R. M. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-1 · Cited by 312 · see citing works

Canonical Wnt signaling regulates Slug activity and links epithelial–mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression

Wu, Z.-Q., Li, X.-Y., Hu, C. Y., Ford, M., Kleer, C. G., & Weiss, S. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205822109 · Cited by 305 · see citing works

MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells

Hwang, W., Jiang, J., Yang, S.-H., Huang, T. S., Lan, H., Teng, H., Yang, C.-Y., Tsai, Y., Lin, C.-H., Wang, H., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2910 · Cited by 303 · see citing works

Translocation Products in Acute Myeloid Leukemia Activate the Wnt Signaling Pathway in Hematopoietic Cells

Müller‐Tidow, C., Steffen, B., Cauvet, T., Tickenbrock, L., Ji, P., Diederichs, S., Sargin, B., Köhler, G., Stelljes, M., Puccetti, E., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.2890-2904.2004 · Cited by 302 · see citing works

FZD7 has a critical role in cell proliferation in triple negative breast cancer

Yang, L., Wu, X., Wang, Y., Zhang, K., Wu, J., Yuan, Y.-C., Deng, X., Chen, L., Kim, C. C. H., Lau, S., et al. (2011) · Oncogene · doi:10.1038/onc.2011.145 · Cited by 298 · see citing works

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

Riffell, J. L., Lord, C. J., & Ashworth, A. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3868 · Cited by 290 · see citing works

Cell Cycle Control of Wnt Receptor Activation

Davidson, G. R., Shen, J., Huang, Y., Su, Y., Karaulanov, E., Bartscherer, K., Hassler, C., Stannek, P., Boutros, M., & Niehrs, C. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.11.006 · Cited by 276 · see citing works

Wnt Signaling in Skin Development, Homeostasis, and Disease

Lim, X., & Nusse, R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008029 · Cited by 268 · see citing works

β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells.

Yeung, J., Esposito, M., Gandillet, A., Zeisig, B., Griessinger, E., Bonnet, D., & So, C. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.10.032 · Cited by 264 · see citing works

WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells

Ekström, E. J., Bergenfelz, C., von Bülow, V., Serifler, F., Carlemalm, E., Jönsson, G., Andersson, T., & Leandersson, K. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-88 · Cited by 262 · see citing works

WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.

Boulter, L., Guest, R., Kendall, T., Wilson, D., Wojtacha, D., Robson, A., Ridgway, R., Samuel, K., van Rooijen, N., Barry, S., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76452 · Cited by 261 · see citing works

New Insights into the Mechanism of Wnt Signaling Pathway Activation

Kikuchi, A., Yamamoto, H., Sato, A., & Matsumoto, S. (2011) · International review of cytology · doi:10.1016/b978-0-12-386035-4.00002-1 · Cited by 259 · see citing works

Wnt Gradient Formation Requires Retromer Function in Wnt-Producing Cells

Coudreuse, D. Y. M., Roël, G., Betist, M. C., Destrée, O., & Korswagen, H. C. (2006) · Science · doi:10.1126/science.1124856 · Cited by 252 · see citing works

Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signalingPreprint

Lien, W., & Fuchs, E. V. (2014) · Genes & Development · doi:10.1101/gad.244772.114 · Cited by 252 · see citing works

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells

Voloshanenko, O., Erdmann, G., Dubash, T. D., Augustin, I., Metzig, M. O., Moffa, G., Hundsrucker, C., Kerr, G., Sandmann, T., Anchang, B., et al. (2013) · Nature Communications · doi:10.1038/ncomms3610 · Cited by 251 · see citing works

Targeted Disruption of the BCL9/β-Catenin Complex Inhibits Oncogenic Wnt Signaling

Takada, K., Zhu, D., Bird, G. H., Sukhdeo, K., Zhao, J., Mani, M., Lemieux, M. E., Carrasco, D. E., Ryan, J. A., Horst, D. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003808 · Cited by 247 · see citing works

Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal

Rebel, V. I., Kung, A. L., Tanner, E. A., Yang, H., Bronson, R. T., & Livingston, D. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232568499 · Cited by 246 · see citing works

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

Guo, W., Lasky, J. L., Chang, C.-J., Mosessian, S., Lewis, X., Xiao, Y., Yeh, J., Chen, J. Y., Iruela‐Arispe, M. L., Varella‐Garcia, M., et al. (2008) · Nature · doi:10.1038/nature06933 · Cited by 241 · see citing works

MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells

Ploper, D., Taelman, V. F., Robert, L., Perez, B. S., Titz, B., Chen, H.-W., Graeber, T. G., von Euw, E., Ribas, A., & De Robertis, E. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424576112 · Cited by 228 · see citing works

Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

O’Connell, M. P., Marchbank, K., Webster, M. R., Valiga, A. A., Kaur, A., Vultur, A., Li, L., Herlyn, M., Villanueva, J., Liu, Q., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0005 · Cited by 223 · see citing works

Aberrant Wnt/β-Catenin Signaling in Pancreatic Adenocarcinoma

Zeng, G., Germinaro, M., Micsenyi, A., Monga, N. K., Bell, A. W., Sood, A., Malhotra, V., Sood, N., Midda, V., Monga, D. K., et al. (2006) · Neoplasia · doi:10.1593/neo.05607 · Cited by 222 · see citing works

Mitotic Wnt Signaling Promotes Protein Stabilization and Regulates Cell Size

Acebrón, S. P., Karaulanov, E., Berger, B. S., Huang, Y., & Niehrs, C. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.04.014 · Cited by 220 · see citing works

Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells

Ertych, N., Stolz, A., Stenzinger, A., Weichert, W., Kaulfuß, S., Burfeind, P., Aigner, A. M., Wordeman, L. G., & Bastians, H. (2014) · Nature Cell Biology · doi:10.1038/ncb2994 · Cited by 216 · see citing works

Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas.

Dahmen, R. P., Koch, A., Denkhaus, D., Tonn, J.-C., Sörensen, N., Berthold, F., Behrens, J., Birchmeier, W., Wiestler, O. D., & Pietsch, T. (2001) · PubMed · Cited by 216 · see citing works

Wnt/Planar cell polarity signaling: A new paradigm for cancer therapy

Wang, Y. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0282 · Cited by 216 · see citing works

Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesisPreprint

Gunther, E. J., Moody, S. E., Belka, G. K., Hahn, K. T., Innocent, N., Dugan, K. D., Cardiff, R. D., & Chodosh, L. A. (2003) · Genes & Development · doi:10.1101/gad.1051603 · Cited by 214 · see citing works

Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation.

Koch, S., Acebrón, S., Herbst, J., Hatiboglu, G., & Niehrs, C. (2015) · Cell · doi:10.1016/j.cell.2015.10.029 · Cited by 212 · see citing works

Receptor Tyrosine Kinase Ror2 Mediates Wnt5a-induced Polarized Cell Migration by Activating c-Jun N-terminal Kinase via Actin-binding Protein Filamin A

Nomachi, A., Nishita, M., Inaba, D., Enomoto, M., Hamasaki, M., & Minami, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802325200 · Cited by 211 · see citing works

Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development

Luis, T. C., Ichii, M., Brugman, M. H., Kincade, P. W., & Staal, F. J. T. (2011) · Leukemia · doi:10.1038/leu.2011.387 · Cited by 209 · see citing works

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

Liu, C., Prior, J. L., Piwnica-Worms, D. R., & Bu, G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911220107 · Cited by 209 · see citing works

Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis

Zhang, Y., Morris, J. P., Yan, W., Schofield, H. K., Gurney, A. L., Simeone, D. M., Millar, S. E., Hoey, T., Hebrok, M., & di Magliano, M. P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4384 · Cited by 207 · see citing works

Regulation of protein stability by GSK3 mediated phosphorylation

Xu, C. B., Kim, N., & Gumbiner, B. M. (2009) · Cell Cycle · doi:10.4161/cc.8.24.10111 · Cited by 205 · see citing works

The role of NOTCH1 signaling in T-ALL

Ferrando, A. A. (2009) · Hematology · doi:10.1182/asheducation-2009.1.353 · Cited by 203 · see citing works

Detection of Recurrent Prostate Cancer After Radical Prostatectomy: Comparison of 11C-Choline PET/CT with Pelvic Multiparametric MR Imaging with Endorectal Coil

Kitajima, K., Murphy, R. C., Nathan, M. A., Froemming, A. T., Hagen, C. E., Takahashi, N., & Kawashima, A. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.123018 · Cited by 201 · see citing works

Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases

Jiang, X., Charlat, O., Zamponi, R., Yang, Y., & Cong, F. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.015 · Cited by 192 · see citing works

Importance of P-Cadherin, β-Catenin, and Wnt5a/Frizzled for Progression of Melanocytic Tumors and Prognosis in Cutaneous Melanoma

Bachmann, I. M., Straume, O., Puntervoll, H. E., Kalvenes, M. B., & Akslen, L. A. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0011 · Cited by 187 · see citing works

miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway

Isobe, T., Hisamori, S., Hogan, D. J., Zabala, M., Hendrickson, D. G., Dalerba, P. D., Cai, S., Scheeren, F. A., Kuo, A. H., Sikandar, S. S., et al. (2014) · eLife · doi:10.7554/elife.01977 · Cited by 187 · see citing works

Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility

Mulligan, K. A., Fuerer, C., Ching, W., Fish, M., Willert, K., & Nusse, R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119197109 · Cited by 187 · see citing works

PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation

Jung, H., Jun, S., Lee, M., Kim, H.-C., Wang, X., Ji, H. L., McCrea, P. D., & Park, J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.028 · Cited by 185 · see citing works

β-Catenin Is Required for the Tumorigenic Behavior of Triple-Negative Breast Cancer Cells

Xu, J., Prosperi, J. R., Choudhury, N. J., Olopade, O. I., & Goss, K. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117097 · Cited by 185 · see citing works

Effect of Carotene and Lycopene on the Risk of Prostate Cancer: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies

Wang, Y., Cui, R., Xiao, Y., Fang, J., & Xu, Q. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137427 · Cited by 175 · see citing works

WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors

Anastas, J. N., Kulikauskas, R. M., Tamir, T. Y., Rizos, H., Long, G. V., von Euw, E. M., Yang, P., Chen, H., Haydu, L. E., Toroni, R. A., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci70156 · Cited by 174 · see citing works

Comparative genomics on Fgf11 orthologs.

Katoh, Y., & Katoh, M. (2005) · Oncology Reports · doi:10.3892/or.14.1.291 · Cited by 169 · see citing works

MicroRNA expressions associated with progression of prostate cancer cells to antiandrogen therapy resistance

Ottman, R., Nguyen, C., Lorch, R., & Chakrabarti, R. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-1 · Cited by 167 · see citing works

Immune Suppression and Resistance Mediated by Constitutive Activation of Wnt/β-Catenin Signaling in Human Melanoma Cells

Yaguchi, T., Goto, Y., Kido, K., Mochimaru, H., Sakurai, T., Tsukamoto, N., Kudo‐Saito, C., Fujita, T., Sumimoto, H., & Kawakami, Y. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102282 · Cited by 164 · see citing works

APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in <i>Min</i> mice

Caldwell, C. M., Green, R. A., & Kaplan, K. B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200703186 · Cited by 164 · see citing works

Differential niche and Wnt requirements during acute myeloid leukemia progression.

Lane, S. W., Wang, Y., Celso, C. L., Ragu, C., Bullinger, L., Sykes, S. M., Ferraro, F., Shterental, S., Lin, C. P., Gilliland, D., et al. (2011) · Blood · doi:10.1182/blood-2011-03-345165 · Cited by 162 · see citing works

Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia

Gang, E. J., Hsieh, Y.-T., Pham, J., Zhao, Y., Nguyen, C., Huantes, S., Park, E., Naing, K. W., Klemm, L., Swaminathan, S., et al. (2013) · Oncogene · doi:10.1038/onc.2013.169 · Cited by 161 · see citing works

Wnt/β-Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAF V600E in Human Melanoma

Biechele, T. L., Kulikauskas, R. M., Toroni, R. A., Lucero, O. M., Swift, R. D., James, R. G., Robin, N. C., Dawson, D. W., Moon, R. T., & Chien, A. J. (2012) · Science Signaling · doi:10.1126/scisignal.2002274 · Cited by 158 · see citing works

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis

Christie, M., Jorissen, R. N., Mouradov, D., Sakthianandeswaren, A., Li, S., Day, F. L., Tsui, C. S., Lipton, L. R., Desai, J., Jones, I. T., et al. (2012) · Oncogene · doi:10.1038/onc.2012.486 · Cited by 152 · see citing works

The Small GTPase ARF6 Stimulates β-Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis

Grossmann, A. H., Yoo, J. H., Clancy, J. W., Sorensen, L. K., Sedgwick, A., Tong, Z., Ostanin, K., Rogers, A., Grossmann, K. F., Tripp, S. R., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2003398 · Cited by 150 · see citing works

ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1

Wang, Y., Bu, F., Royer, C., Serres, S., Larkin, J. R., Soto, M. S., Sibson, N. R., Salter, V., Fritzsche, F. R., Turnquist, C., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3050 · Cited by 146 · see citing works

WLS Retrograde Transport to the Endoplasmic Reticulum during Wnt Secretion

Yu, J., Chia, J., Canning, C. A., Jones, C. M., Bard, F., & Virshup, D. M. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.03.016 · Cited by 143 · see citing works

Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling

Fang, L., Cai, J., Chen, B., Wu, S., Li, R., Xu, X., Yang, Y., Guan, H., Zhu, X., Zhang, L., et al. (2015) · Nature Communications · doi:10.1038/ncomms9640 · Cited by 143 · see citing works

Loss of beta-catenin expression associated with disease progression in malignant melanoma

Kageshita, T., Hamby, C. V., Ishihara, T., Matsumoto, K., Saida, T., & Ono, T. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.04336.x · Cited by 137 · see citing works

Wnt Signaling in Normal and Malignant HematopoiesisPreprint

Lento, W. E., Congdon, K. L., Voermans, C., Kritzik, M. R., & Reya, T. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008011 · Cited by 135 · see citing works

A Role for Matrix Metalloproteinases in Regulating Mammary Stem Cell Function via the Wnt Signaling Pathway

Kessenbrock, K., Dijkgraaf, G. J. P., Lawson, D. A., Littlepage, L. E., Shahi, P., Pieper, U., & Werb, Z. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.06.005 · Cited by 129 · see citing works

Epigenetic gene silencing in the Wnt pathway in breast cancer

Klarmann, G. J., Decker, A., & Farrar, W. L. (2008) · Epigenetics · doi:10.4161/epi.3.2.5899 · Cited by 124 · see citing works

WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma

Arensman, M., Kovochich, A., Kulikauskas, R. M., Lay, A. R., Yang, P.-T., Li, X., Donahue, T. R., Major, M. B., Moon, R. T., Chien, A. J., et al. (2013) · Oncogene · doi:10.1038/onc.2013.23 · Cited by 122 · see citing works

Global Alterations of DNA Methylation in Cholangiocarcinoma Target the Wnt Signaling Pathway

Goeppert, B. F., Konermann, C., Schmidt, C. R., Bogatyrova, O., Geiselhart, L., Ernst, C., Gu, L., Becker, N., Zucknick, M., Mehrabi, A., et al. (2013) · Hepatology · doi:10.1002/hep.26721 · Cited by 122 · see citing works

Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling

Giambra, V., Jenkins, C. E., Lam, S. H. L., Hoofd, C., Belmonte, M., Wang, X., Gusscott, S., Gracias, D., & Weng, A. P. (2015) · Blood · doi:10.1182/blood-2014-10-609370 · Cited by 116 · see citing works

Mammalian Wnt3a is Released on Lipoprotein Particles

Neumann, S., Coudreuse, D. Y. M., van der Westhuyzen, D. R., Eckhardt, E. R. M., Korswagen, H. C., Schmitz, G., & Sprong, H. (2009) · Traffic · doi:10.1111/j.1600-0854.2008.00872.x · Cited by 112 · see citing works

Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization

Metcalfe, C., Mendoza-Topaz, C., Mieszczanek, J., & Bienz, M. (2010) · Journal of Cell Science · doi:10.1242/jcs.067546 · Cited by 111 · see citing works

Adaptability of non-genetic diversity in bacterial chemotaxis

Frankel, N. W., Pontius, W., Dufour, Y. S., Long, J., Hernandez-Nunez, L., & Emonet, T. (2014) · eLife · doi:10.7554/elife.03526 · Cited by 110 · see citing works

Activated macrophages promote Wnt/β-catenin signaling in cholangiocarcinoma cells

Loilome, W., Bungkanjana, P., Techasen, A., Namwat, N., Yongvanit, P., Puapairoj, A., Khuntikeo, N., & Riggins, G. J. (2014) · Tumor Biology · doi:10.1007/s13277-014-1698-2 · Cited by 104 · see citing works

Insight into the Role of Wnt5a-Induced Signaling in Normal and Cancer Cells

Endo, M., Nishita, M., Fujii, M., & Minami, Y. (2014) · International review of cytology · doi:10.1016/bs.ircmb.2014.10.003 · Cited by 102 · see citing works

Association of early malignant melanoma with nevocytic nevi

Stolz, W., Schmoeckel, C., Landthaler, M., & Braun‐Falco, O. (1989) · Cancer · doi:10.1002/1097-0142(19890201)63:3 · Cited by 100 · see citing works

Genetic Dissection of Differential Signaling Threshold Requirements for the Wnt/β-Catenin Pathway In Vivo

Büchert, M., Athineos, D., Abud, H. E., Burke, Z. D., Faux, M. C., Samuel, M. S., Jarnicki, A., Winbanks, C. E., Newton, I. P., Méniel, V. S., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000816 · Cited by 99 · see citing works

A genome‐wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion

Port, F., Hausmann, G., & Basler, K. (2011) · EMBO Reports · doi:10.1038/embor.2011.165 · Cited by 96 · see citing works

p24 proteins are required for secretion of Wnt ligands

Buechling, T., Chaudhary, V., Spirohn, K., Weiß, M., & Boutros, M. (2011) · EMBO Reports · doi:10.1038/embor.2011.212 · Cited by 95 · see citing works

W nt5 A promotes an adaptive, senescent‐like stress response, while continuing to drive invasion in melanoma cells

Webster, M. R., Xu, M., Kinzler, K. A., Kaur, A., Appleton, J., O’Connell, M. P., Marchbank, K., Valiga, A. A., Dang, V. M., Perego, M., et al. (2014) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12330 · Cited by 88 · see citing works

Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells

Aoki, K., Aoki, M., Sugai, M., Harada, N., Miyoshi, H., Tsukamoto, T., Mizoshita, T., Tatematsu, M., Seno, H., Chiba, T., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210141 · Cited by 82 · see citing works

First-in-human evaluation of the human monoclonal antibody vantictumab (OMP-18R5; anti-Frizzled) targeting the WNT pathway in a phase I study for patients with advanced solid tumors.

Smith, D. C., Rosen, L. S., Chugh, R. K., Goldman, J. W., Xu, L., Kapoun, A. M., Brachmann, R. K., Dupont, J., Stagg, R., Tolcher, A. W., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2013.31.15_suppl.2540 · Cited by 81 · see citing works

Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine

Dodge, M. E., Moon, J., Tuladhar, R., Lü, J., Jacob, L. S., Zhang, L.-S., Shi, H., Wang, X., Moro, E., Mongera, A., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.372029 · Cited by 79 · see citing works

Diminished WNT → β-catenin → c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumorsPreprint

Juan, J. M., Muraguchi, T., Iezza, G., Sears, R. C., & McMahon, M. (2014) · Genes & Development · doi:10.1101/gad.233627.113 · Cited by 75 · see citing works

Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL

Wang, L., Shalek, A. K., Lawrence, M. S., Ding, R., Gaublomme, J. T., Pochet, N. L. M. M., Stojanov, P., Sougnez, C. L., Shukla, S. A., Stevenson, K. E., et al. (2014) · Blood · doi:10.1182/blood-2014-01-552067 · Cited by 74 · see citing works

LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction

Li, J., Chen, X., Ding, X., Cheng, Y., Zhao, B., Lai, Z.-C., Hezaimi, K. A., Hakem, R., Guan, K., & Wang, C. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.037 · Cited by 74 · see citing works

Wnt5A Activates the Calpain-Mediated Cleavage of Filamin A

O’Connell, M. P., Fiori, J. L., Baugher, K. M., Indig, F. E., French, A. D., Camilli, T. C., Frank, B. P., Earley, R. B., Hoek, K. S., Hasskamp, J. H., et al. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.433 · Cited by 70 · see citing works

Wnt signaling potentiates nevogenesis

Pawlikowski, J. S., McBryan, T., van Tuyn, J., Drotar, M. E., Hewitt, R. N., Maier, A. B., King, A., Blyth, K., Wu, H. G., & Adams, P. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303491110 · Cited by 67 · see citing works

A Wnt-er Migration: The Confusing Role of β-Catenin in Melanoma Metastasis

Webster, M. R., & Weeraratna, A. T. (2013) · Science Signaling · doi:10.1126/scisignal.2004114 · Cited by 66 · see citing works

Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis

Huang, Y., Anvarian, Z., Döderlein, G., Acebrón, S. P., & Niehrs, C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423533112 · Cited by 65 · see citing works

Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERα-negative and ERα-positive mammary preneoplasia and cancer

Jones, L. P., Tilli, M. T., Assefnia, S., Torre, K. M., Halama, E. D., Parrish, A. R., Rosen, E. M., & Furth, P. A. (2007) · Oncogene · doi:10.1038/sj.onc.1210674 · Cited by 65 · see citing works

Interleukin‐6 drives melanoma cell motility through p38α‐MAPK‐dependent up‐regulation of WNT5A expression

Linnskog, R., Jönsson, G., Axelsson, L., Prasad, C. P., & Andersson, T. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.05.008 · Cited by 65 · see citing works

Original CIN: reviewing roles for APC in chromosome instability

Rusan, N. M., & Peifer, M. A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200802107 · Cited by 64 · see citing works

Identification of an Endocytosis Motif in an Intracellular Loop of Wntless Protein, Essential for Its Recycling and the Control of Wnt Protein Signaling

Gasnereau, I., Herr, P., Chia, P. Z. C., Basler, K., & Gleeson, P. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.307231 · Cited by 57 · see citing works

The expression of β-catenin in different subtypes of breast cancer and its clinical significance

Li, S., Li, S., Sun, Y. H., & Li, L. (2014) · Tumor Biology · doi:10.1007/s13277-014-1975-0 · Cited by 53 · see citing works

Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells

Klauzińska, M., Baljinnyam, B., Raafat, A. M., Rodriguez‐Canales, J., Strizzi, L., Greer, Y. E., Rubin, J. S., & Callahan, R. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22924 · Cited by 53 · see citing works

Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia

Cheng, C. K., Li, L., Cheng, S. H., Lau, K., Chan, N. P. H., Wong, R. S. M., Shing, M. M. K., Li, C. K., & Ng, M. H. L. (2008) · Blood · doi:10.1182/blood-2008-02-137083 · Cited by 51 · see citing works

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

Dongre, A., & Weinberg, R. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0080-4 · Cited by 3,876 · see citing works

The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers

Sondka, Z., Bamford, S., Cole, C. G., Ward, S. A., Dunham, I., & Forbes, S. A. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0060-1 · Cited by 1,597 · see citing works

Tumour-intrinsic resistance to immune checkpoint blockade

Kalbasi, A. K., & Ribas, A. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0218-4 · Cited by 1,491 · see citing works

Targeting signalling pathways and the immune microenvironment of cancer stem cells — a clinical update

Clara, J., Monge, C., Yang, Y., & Takebe, N. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0293-2 · Cited by 752 · see citing works

Iron Homeostasis and Ferroptosis in Human Diseases: Mechanisms and Therapeutic Prospects

Ru, Q., Li, Y., Chen, L., Wu, Y., Min, J., & Wang, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01969-z · Cited by 724 · see citing works

The impact of sex on gene expression across human tissues

Oliva, M., Muñoz-Aguirre, M., Kim-Hellmuth, S., Wucher, V., Gewirtz, A. D., Cotter, D. J., Parsana, P., Kasela, S., Balliu, B., Viñuela, A., et al. (2020) · Science · doi:10.1126/science.aba3066 · Cited by 679 · see citing works

Mechanisms of Resistance to Immune Checkpoint Blockade: Why Does Checkpoint Inhibitor Immunotherapy Not Work for All Patients?

Fares, C. M., Allen, E. M. V., Drake, C. G., Allison, J. P., & Hu‐Lieskovan, S. (2019) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_240837 · Cited by 648 · see citing works

Stem cell programs in cancer initiation, progression, and therapy resistance

Huang, T., Song, X., Xu, D., Tiek, D., Goenka, A., Wu, B., Sastry, N., Hu, B., & Cheng, S.-Y. (2020) · Theranostics · doi:10.7150/thno.41648 · Cited by 524 · see citing works

Developmental pathways in the pathogenesis of lung fibrosis

Chanda, D., Otoupalova, E., Smith, S. R., Volckaert, T., Langhe, S. D., & Thannickal, V. J. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.08.004 · Cited by 513 · see citing works

Alternative splicing and cancer: a systematic review

Zhang, Y., Qian, J., Gu, C., & Yang, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00486-7 · Cited by 503 · see citing works

Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells

Kröger, C., Afeyan, A. B., Mraz, J., Eaton, E. N., Reinhardt, F., Khodor, Y. L., Thiru, P., Bierie, B., Ye, X., Burge, C. B., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1812876116 · Cited by 493 · see citing works

The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators

Rim, E. Y., Clevers, H. C., & Nusse, R. (2022) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-040320-103615 · Cited by 488 · see citing works

Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)

Katoh, M. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4129 · Cited by 467 · see citing works

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

Yang, Q., Ciebiera, M., Bariani, M. V., Ali, M. K., Elkafas, H., Boyer, T., & Al-Hendy, A. A. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab039 · Cited by 467 · see citing works

pathfindR: An R Package for Comprehensive Identification of Enriched Pathways in Omics Data Through Active Subnetworks

Ülgen, E., Özışık, O., & Sezerman, O. U. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00858 · Cited by 456 · see citing works

MYC Deregulation in Primary Human Cancers

Kalkat, M., Melo, J. D., Hickman, K. A., Lourenco, C., Redel, C., Resetca, D., Tamachi, A., Tu, W. B., & Penn, L. Z. (2017) · Genes · doi:10.3390/genes8060151 · Cited by 445 · see citing works

Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer

Wang, Y., Zheng, L., Shang, W., Yang, Z., Li, T., Liu, F., Shao, W., Lv, L. L., Chai, L., Qu, L., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01008-w · Cited by 432 · see citing works

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

Jung, Y., & Park, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0380-6 · Cited by 423 · see citing works

Resistance Mechanisms of Anti-PD1/PDL1 Therapy in Solid Tumors

Lei, Q., Wang, D., Sun, K., Wang, L., & Zhang, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00672 · Cited by 414 · see citing works

Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk

Bhat, A. A., Uppada, S. B., Achkar, I. W., Hashem, S., Yadav, S. K., Shanmugakonar, M., Al‐Naemi, H. A., Haris, M., & Shahab Uddin, M. S. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01942 · Cited by 400 · see citing works

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396 · see citing works

Mesenchymal stem/stromal cells in cancer therapy

Lan, T., Luo, M., & Wei, X. (2021) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-021-01208-w · Cited by 374 · see citing works

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

Zhao, L.-Y., Mei, J.-X., Yu, G., Lei, L., Zhang, W.-H., Liu, K., Chen, X.-L., Kołat, D., Yang, K., & Hu, J.-K. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01406-7 · Cited by 359 · see citing works

Wnt signaling pathway: A comprehensive review

Hayat, R., Manzoor, M., & Hussain, A. (2022) · Cell Biology International · doi:10.1002/cbin.11797 · Cited by 356 · see citing works

Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response

Arora, R., Cao, C., Kumar, M., Sinha, S., Chanda, A., McNeil, R., Samuel, D., Arora, R. K., Matthews, T. W., Chandarana, S. P., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40271-4 · Cited by 336 · see citing works

Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

Mehta, M., Dhanjal, D. S., Paudel, K. R., Singh, B., Gupta, G., Rajeshkumar, S., Thangavelu, L. P., Tambuwala, M. M., Bakshi, H. A., Chellappan, D. K., et al. (2020) · Inflammopharmacology · doi:10.1007/s10787-020-00698-3 · Cited by 331 · see citing works

Design of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations

Chen, S., Lin, T., Basu, R., Ritchey, J., Wang, S., Luo, Y., Li, X., Pei, D., Kara, L. B., & Cheng, X. (2024) · Nature Communications · doi:10.1038/s41467-024-45766-2 · Cited by 324 · see citing works

Biomolecular Condensates and Cancer

Boija, A., Klein, I. A., & Young, R. A. (2021) · Cancer Cell · doi:10.1016/j.ccell.2020.12.003 · Cited by 320 · see citing works

Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression

Huang, D., Wang, Y., Thompson, J. W., Yin, T., Alexander, P. B., Qin, D., Mudgal, P., Wu, H., Liang, Y., Tan, L., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-021-00820-9 · Cited by 320 · see citing works

Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances

Chen, X., Chu, Q., Shi, Q., Zeng, Y., Lu, J., & Li­, ­. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02142-w · Cited by 321 · see citing works

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

Zanconato, F., Battilana, G., Forcato, M., Filippi, L., Azzolin, L., Manfrin, A., Quaranta, E. G., Biagio, D. D., Sigismondo, G., Guzzardo, V., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0158-8 · Cited by 309 · see citing works

Wnt Pathway in Bone Repair and Regeneration – What Do We Know So Far

Houschyar, K. S., Tapking, C., Borrelli, M. R., Popp, D., Duscher, D., Maan, Z. N., Chelliah, M. P., Li, J., Harati, K., Wallner, C., et al. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00170 · Cited by 296 · see citing works

WNT Signaling in Tumors: The Way to Evade Drugs and Immunity

Martín-Orozco, E., Sánchez-Fernández, A., Ortiz-Parra, I., & Nicolas, M. A.-S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02854 · Cited by 218 · see citing works

Wnt Signaling and Its Significance Within the Tumor Microenvironment: Novel Therapeutic Insights

Patel, S., Alam, A., Pant, R., & Chattopadhyay, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02872 · Cited by 284 · see citing works

Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K‐Akt signaling in gastric cancer

Zhang, C., Zhang, M., Ge, S., Huang, W., Lin, X., Gao, J. X., Gong, J., & Shen, L. (2019) · Cancer Medicine · doi:10.1002/cam4.2360 · Cited by 283 · see citing works

Long-term and sequential treatment for osteoporosis

Foessl, I., Dimai, H. P., & Obermayer-Pietsch, B. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00866-9 · Cited by 273 · see citing works

The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies

Kumar, V., Vashishta, M., Kong, L., Wu, X., Lu, J. J., Guha, C., & Dwarakanath, B. S. R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.650772 · Cited by 263 · see citing works

WNT as a Driver and Dependency in Cancer

Parsons, M. J., Tammela, T., & Dow, L. E. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0190 · Cited by 257 · see citing works

Photodegradation of carbon dots cause cytotoxicity

Liu, Y., Yu, N., Fang, W., Tan, Q., Ji, R., Yang, L., Wei, S., Zhang, X., & Miao, A. (2021) · Nature Communications · doi:10.1038/s41467-021-21080-z · Cited by 252 · see citing works

A central role for cadherin signaling in cancer

Kourtidis, A., Lu, R., Pence, L. J., & Anastasiadis, P. Z. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.04.006 · Cited by 251 · see citing works

A Review of Gut Microbiota‐Derived Metabolites in Tumor Progression and Cancer Therapy

Yang, Q., Wang, B., Zheng, Q., Li, H., Meng, X., Zhou, F., & Zhang, L. (2023) · Advanced Science · doi:10.1002/advs.202207366 · Cited by 249 · see citing works

WNT Signaling in Cancer Immunosurveillance

Galluzzi, L., Spranger, S., Fuchs, E. V., & López‐Soto, A. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.08.005 · Cited by 240 · see citing works

Wnt Signaling and Drug Resistance in Cancer

Zhong, Z., & Virshup, D. M. (2019) · Molecular Pharmacology · doi:10.1124/mol.119.117978 · Cited by 240 · see citing works

Wnt signaling deregulation in the aging and Alzheimer’s brain

Palomer, E., Buechler, J., & Salinas, P. C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00227 · Cited by 237 · see citing works

The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation

Scarth, J. A., Patterson, M. R., Morgan, E. L., & Macdonald, A. (2021) · Journal of General Virology · doi:10.1099/jgv.0.001540 · Cited by 237 · see citing works

AKT and ERK dual inhibitors: The way forward?

Cao, Z., Liao, Q., Su, M., Huang, K., Jin, J., & Cao, D. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.05.025 · Cited by 234 · see citing works

Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

Ang, H. L., Mohan, C. D., Shanmugam, M. K., Leong, H. C., Makvandi, P., Rangappa, K. S., Bishayee, A., Kumar, A. P., & Sethi, G. (2023) · Medicinal Research Reviews · doi:10.1002/med.21948 · Cited by 234 · see citing works

Genetic and epigenetic characteristics of inflammatory bowel disease-associated colorectal cancer

Rajamäki, K., Taira, A., Katainen, R., Välimäki, N., Kuosmanen, A., Plaketti, R.-M., Seppälä, T. T., Ahtiainen, M., Wirta, E.-V., Vartiainen, E., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.04.042 · Cited by 230 · see citing works

Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments

Testa, U., Castelli, G., & Pelosi, E. (2020) · Medical Sciences · doi:10.3390/medsci8010018 · Cited by 226 · see citing works

Glomerular mesangial cell and podocyte injuries in diabetic nephropathy

Tung, C., Hsu, Y., Shih, Y., Chang, P., & Lin, C. (2018) · Nephrology · doi:10.1111/nep.13451 · Cited by 225 · see citing works

Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

Qin, K. H., Yu, M. S., Fan, J., Wang, H., Zhao, P., Zhao, G., Zeng, W., Chen, C., Wang, Y., Wang, A., et al. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.01.030 · Cited by 226 · see citing works

WNT Signaling in Melanoma

Gajos-Michniewicz, A., & Czyż, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144852 · Cited by 223 · see citing works

WNT Signaling in Disease

Li, N., Kaur, P., Bunnag, N., Suresh, J., Sung, I. C. H., Tan, Q. H., Gruber, J., & Tolwinski, N. S. (2019) · Cells · doi:10.3390/cells8080826 · Cited by 219 · see citing works

Naringin and naringenin as anticancer agents and adjuvants in cancer combination therapy: Efficacy and molecular mechanisms of action, a comprehensive narrative review

Memariani, Z., Abbas, S. Q., Hassan, S. S. U., Ahmadi, A., & Chabra, A. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105264 · Cited by 219 · see citing works

The Pathogenesis of Cardiac Fibrosis: A Review of Recent Progress

Maruyama, K., & Imanaka‐Yoshida, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052617 · Cited by 216 · see citing works

Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches

Uddin, M. S., Mamun, A. A., Alghamdi, B. S. A., Tewari, D., Jeandet, P., Sarwar, M. S., & Ashraf, G. M. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.12.015 · Cited by 215 · see citing works

Cancer, metastasis, and the epigenome

Kiri, S., & Ryba, T. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02069-w · Cited by 214 · see citing works

Single-cell transcriptome analysis reveals tumor immune microenvironment heterogenicity and granulocytes enrichment in colorectal cancer liver metastases

Zhang, Y., Song, J., Zhao, Z., Yang, M., Chen, M., Liu, C., Ji, J., & Zhu, D. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.10.016 · Cited by 212 · see citing works

Mechanism of Drug Tolerant Persister Cancer Cells: The Landscape and Clinical Implication for Therapy

Mikubo, M., Inoue, Y., Liu, G., & Tsao, M. (2021) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2021.07.017 · Cited by 212 · see citing works

Multi-Omics Characterization of the 4T1 Murine Mammary Gland Tumor Model

Schrörs, B., Boegel, S., Albrecht, C. H., Bukur, T., Bukur, V., Holtsträter, C., Ritzel, C., Manninen, K., Tadmor, A. D., Vormehr, M., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01195 · Cited by 207 · see citing works

TGF-β Signaling in Liver, Pancreas, and Gastrointestinal Diseases and Cancer

Gough, N. R., Xiang, X., & Mishra, L. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.04.064 · Cited by 204 · see citing works

Resistance mechanisms to immune checkpoint inhibitors: updated insights

Al-Saafeen, B. H., Ali, B. R., & Elkord, E. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02212-7 · Cited by 207 · see citing works

Precision medicine for human cancers with Notch signaling dysregulation (Review)

Katoh, M., & Katoh, M. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4418 · Cited by 196 · see citing works

Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy

Chelko, S. P., Asimaki, A., Lowenthal, J., Bueno-Beti, C., Bedja, D., Scalco, A., Amat-Alarcon, N., Andersen, P., Judge, D. P., Tung, L., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.040676 · Cited by 192 · see citing works

MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

Zhan, T., Ambrosi, G., Wandmacher, A. M., Rauscher, B., Betge, J., Rindtorff, N., Häussler, R. S., Hinsenkamp, I., Bamberg, L., Hessling, B., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09898-0 · Cited by 189 · see citing works

Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma

McDonald, M. M., Reagan, M. R., Youlten, S. E., Mohanty, S. T., Seckinger, A., Terry, R. L., Pettitt, J. A., Simic, M. K., Cheng, T. L., Morse, A., et al. (2017) · Blood · doi:10.1182/blood-2017-03-773341 · Cited by 186 · see citing works

Epigenetic Modifications and Head and Neck Cancer: Implications for Tumor Progression and Resistance to Therapy

CASTILHO, R. M., SQUARIZE, C. H., & Almeida, L. O. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071506 · Cited by 185 · see citing works

Sexual Dimorphism in Colon Cancer

Abancens, M., Bustos, V., Harvey, H. M., McBryan, J., & Harvey, B. J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.607909 · Cited by 185 · see citing works

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

Chehelgerdi, M., Dehkordi, F. B., Chehelgerdi, M., Kabiri, H., Salehian-Dehkordi, H., Abdolvand, M. A., Salmanizadeh, S., Rashidi, M., Niazmand, A., Ahmadi, S., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01873-0 · Cited by 184 · see citing works

Phase 1 study of single-agent WNT974, a first-in-class Porcupine inhibitor, in patients with advanced solid tumours

Rodon, J. A., Argilés, G., Connolly, R. M., Vaishampayan, U. N., de Jonge, M. J. A., Garralda, E., Giannakis, M., Smith, D. C., Dobson, J. R., McLaughlin, M. E., et al. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01389-8 · Cited by 181 · see citing works

The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug.

Juárez, M., Schcolnik‐Cabrera, A., & Dueñas‐González, A. (2018) · PubMed Central · Cited by 180 · see citing works

Wnt/β-Catenin Signaling: The Culprit in Pancreatic Carcinogenesis and Therapeutic Resistance

Makena, M. R., Gatla, H. R., Verlekar, D. U., Sukhavasi, S., Pandey, M. K., & Pramanik, K. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174242 · Cited by 178 · see citing works

CD146, from a melanoma cell adhesion molecule to a signaling receptor

Wang, Z., Xu, Q., Zhang, N., Du, X., Xu, G., & Yan, X. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00259-8 · Cited by 178 · see citing works

Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy

Mahmoud, Y. K., & Abdelrazek, H. M. A. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108783 · Cited by 177 · see citing works

Illuminating the Onco-GPCRome: Novel G protein–coupled receptor-driven oncocrine networks and targets for cancer immunotherapy

Wu, V. H., Yeerna, H., Nohata, N., Chiou, J., Harismendy, O., Raimondi, F., Inoue, A., Russell, R. B., Tamayo, P., & Gutkind, J. S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.005601 · Cited by 176 · see citing works

Role of DNA Methylation in the Resistance to Therapy in Solid Tumors

Romero‐Garcia, S., Prado-Garcı́a, H., & Carlos‐Reyes, Á. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01152 · Cited by 176 · see citing works

GPCRs: Emerging anti-cancer drug targets

Nieto, A., & McDonald, P. H. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.09.005 · Cited by 173 · see citing works

Inhibitors of the PD-1 Pathway in Tumor Therapy

LaFleur, M. W., Muroyama, Y., Drake, C. G., & Sharpe, A. H. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701044 · Cited by 173 · see citing works

A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression

Peng, Y., Xu, Y., Zhang, X., Deng, S., Yuan, Y., Luo, X., Hossain, M. T., Zhu, X., Du, K., Hu, F., et al. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01457-w · Cited by 171 · see citing works

Cancer stem cells: Road to therapeutic resistance and strategies to overcome resistance

Makena, M. R., Ranjan, A., Thirumala, V., & Reddy, A. P. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.11.015 · Cited by 170 · see citing works

Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers

Park, H., Kim, J.-W., & Baek, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113904 · Cited by 166 · see citing works

Tumor-associated macrophages promote epithelial–mesenchymal transition and the cancer stem cell properties in triple-negative breast cancer through CCL2/AKT/β-catenin signaling

Chen, X., Yang, M., Yin, J., Li, P., Zeng, S., Zheng, G., He, Z., Liu, H., Wang, Q., Zhang, F., et al. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00888-2 · Cited by 165 · see citing works

Genomics of response to immune checkpoint therapies for cancer: implications for precision medicine

Conway, J. R., Kofman, E., Mo, S. S., Elmarakeby, H., & Van Allen, E. (2018) · Genome Medicine · doi:10.1186/s13073-018-0605-7 · Cited by 165 · see citing works

Integrative single-cell analysis of human colorectal cancer reveals patient stratification with distinct immune evasion mechanisms

Chu, X., Li, X., Zhang, Y., Dang, G., Miao, Y., Xu, W., Wang, J., Zhang, Z., & Cheng, S. (2024) · Nature Cancer · doi:10.1038/s43018-024-00807-z · Cited by 163 · see citing works

The role of ubiquitin-specific peptidases in cancer progression

Young, M.-J., Hsu, K., Lin, T. E., Chang, W., & Hung, J. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0522-0 · Cited by 161 · see citing works

Mechanisms of intercellular Wnt transport

Routledge, D., & Scholpp, S. (2019) · Development · doi:10.1242/dev.176073 · Cited by 146 · see citing works

Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights

Farooqı, A. A., de la Roche, M., Djamgoz, M. B. A., & Siddik, Z. H. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.01.001 · Cited by 156 · see citing works

Significance of Streptococcus gallolyticus subsp. gallolyticus Association With Colorectal Cancer

Pasquereau-Kotula, E., Martins, M., Aymeric, L., & Dramsi, S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00614 · Cited by 155 · see citing works

Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a

Dou, H., Shen, R., Tao, J., Huang, L., Shi, H., Chen, H., Wang, Y., & Wang, T. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00877 · Cited by 153 · see citing works

From instruction to output: Wnt/PCP signaling in development and cancer

Humphries, A. C., & Mlodzik, M. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.12.005 · Cited by 144 · see citing works

Gene Size Matters: An Analysis of Gene Length in the Human Genome

Lopes, I., Altab, G., Raina, P., & de Magalhães, J. P. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.559998 · Cited by 152 · see citing works

WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death

Fischer, M. M., Cancilla, B., Yeung, V. P., Cattaruzza, F., Chartier, C., Murriel, C. L., Cain, J., Tam, R., Cheng, C.-Y., Evans, J., et al. (2017) · Science Advances · doi:10.1126/sciadv.1700090 · Cited by 151 · see citing works

The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models

Tam, B. Y. Y., Chiu, K., Chung, H., Bossard, C., Nguyen, J. D., Creger, E., Eastman, B. W., Mak, C. C., Ibanez, M., Ghias, A., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.09.009 · Cited by 151 · see citing works

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain

Steenwinckel, J. V., Schang, A., Krishnan, M. L., Degos, V., Delahaye‐Duriez, A., Bokobza, C., Csaba, Z., Verdonk, F., Montané, A., Sigaut, S., et al. (2019) · Brain · doi:10.1093/brain/awz319 · Cited by 150 · see citing works

Emerging Roles of Wnt Ligands in Human Colorectal Cancer

Nie, X., Liu, H., Liu, L., Wang, Y., & Chen, W. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01341 · Cited by 150 · see citing works

Colon cancer therapy by focusing on colon cancer stem cells and their tumor microenvironment

Jahanafrooz, Z., Mosafer, J., Akbari, M., Hashemzaei, M., Mokhtarzadeh, A., & Baradaran, B. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29337 · Cited by 148 · see citing works

Therapeutic Potential of Targeting Wnt/β-Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress

Bahrami, A., Amerizadeh, F., Shahidsales, S., Khazaei, M., Ghayour‐Mobarhan, M., Sadeghnia, H. R., Maftouh, M., Hassanian, S. M., & Avan, A. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25903 · Cited by 148 · see citing works

Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications

Kciuk, M., Alam, M., Ali, N., Rashid, S., Głowacka, P., Rajamanikandan, S., Çeli̇k, İ., Yahya, E. B., Dubey, A., Zerroug, E., et al. (2023) · Molecules · doi:10.3390/molecules28135246 · Cited by 148 · see citing works

Circulating tumor DNA as an emerging liquid biopsy biomarker for early diagnosis and therapeutic monitoring in hepatocellular carcinoma

Wu, X., Li, J., Gassa, A., Buchner, D., Alakus, H., Dong, Q., Ren, N., Liu, M., Odenthal, M., Stippel, D. L., et al. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.44024 · Cited by 147 · see citing works

Wnt Signaling in Cancer Pathogenesis and Therapeutics

Takebe, N., Lum, L., & Ivy, S. P. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1216-8_6

Wnt Signaling: Paths for Cancer Progression

Carreira-Barbosa, F., & Nunes, S. C. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34025-4_10 · Cited by 20 · see citing works

Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling Networks

Sharma, M., & Pruitt, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218018 · Cited by 57 · see citing works

Wnt Signaling in Stem Cells and Non–Small-Cell Lung Cancer

He, B., Barg, R. N., You, L., Xu, Z., Reguart, N., Mikami, I., Batra, S., Rosell, R., & Jablons, D. M. (2005) · Clinical Lung Cancer · doi:10.3816/clc.2005.n.022 · Cited by 64 · see citing works

Wnt Signaling in Stem Cells and Lung Cancer

He, B., & Jablons, D. M. (2007) · Springer eBooks · doi:10.1007/2789_2007_043 · Cited by 26 · see citing works