The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The MLL recombinome of acute leukemias in 2013
Open accessAbstract
Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients. We present data of the molecular characterization of 1590 MLL-rearranged biopsy samples obtained from acute leukemia patients. The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and novel TPGs identified. All patients were classified according to their gender (852 females and 745 males), age at diagnosis (558 infant, 416 pediatric and 616 adult leukemia patients) and other clinical criteria. Combined data of our study and recently published data revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level. However, only seven rearrangements seem to be predominantly associated with illegitimate recombinations of the MLL gene (≈ 90%): AFF1/AF4, MLLT3/AF9, MLLT1/ENL, MLLT10/AF10, ELL, partial tandem duplications (MLL PTDs) and MLLT4/AF6, respectively. The MLL breakpoint distributions for all clinical relevant subtypes (gender, disease type, age at diagnosis, reciprocal, complex and therapy-induced translocations) are presented. Finally, we present the extending network of reciprocal MLL fusions deriving from complex rearrangements.
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Cites
Frequent chromosomal translocations induced by DNA double-strand breaks
Richardson, C., & Jasin, M. (2000) · Nature · doi:10.1038/35015097 · Cited by 517
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Cited by
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias
for The St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project, Andersson, A. K., Ma, J., Wang, J., Chen, X., Gedman, A. L., Dang, J., Nakitandwe, J., Holmfeldt, L., Parker, M., et al. (2015) · Nature Genetics · doi:10.1038/ng.3230 · Cited by 490
Self-citationMolecular landscape of acute myeloid leukemia in younger adults and its clinical relevance
Grimwade, D., Ivey, A., & Huntly, B. J. P. (2016) · Blood · doi:10.1182/blood-2015-07-604496 · Cited by 445
DOT1L and H3K79 Methylation in Transcription and Genomic Stability
Wood, K., Tellier, M., & Murphy, S. (2018) · Biomolecules · doi:10.3390/biom8010011 · Cited by 209
Requirement for CDK6 in MLL-rearranged acute myeloid leukemia
Placke, T., Faber, K., Nonami, A., Putwain, S. L., Salih, H. R., Heidel, F. H., Krämer, A., Root, D. E., Barbie, D. A., Krivtsov, A. V., et al. (2014) · Blood · doi:10.1182/blood-2014-02-558114 · Cited by 170
Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia
on behalf of the International CML Foundation Genomics Alliance, Branford, S., Kim, D. D. H., Apperley, J. F., Eide, C. A., Mustjoki, S., Ong, S. T., Nteliopoulos, G., Ernst, T., Chuah, C., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0512-y · Cited by 149
Metadata
- Authors
- Meyer, C., Hofmann, J., Burmeister, T., Gröger, D., Park, T. S., Emerenciano, M., Pombo de Oliveira, M., Renneville, A., Villarese, P., Macintyre, E., Cavé, H., Clappier, E., Mass-Malo, K., Zuna, J., Trka, J., De Braekeleer, E., De Braekeleer, M., Oh, S. H., Tsaur, G., Fechina, L., van der Velden, V. H. J., van Dongen, J. J. M., Delabesse, E., Binato, R., Silva, M. L. M., Kustanovich, A., Aleinikova, O., Harris, M. H., Lund-Aho, T., Juvonen, V, Heidenreich, O., Vormoor, J., Choi, W. W. L., Jarosova, M., Kolenova, A., Bueno, C., Menendez, P., Wehner, S., Eckert, C., Talmant, P., Tondeur, S., Lippert, E., Launay, E., Henry, C., Ballerini, P., Lapillone, H., Callanan, M. B., Cayuela, J. M., Herbaux, C., Cazzaniga, G., Kakadiya, P. M., Bohlander, S., Ahlmann, M., Choi, J. R., Gameiro, P., Lee, D. S., Krauter, J., Cornillet-Lefebvre, P., Te Kronnie, G., Schäfer, B. W., Kubetzko, S., Alonso, C. N., zur Stadt, U., Sutton, R., Venn, N. C., Izraeli, S., Trakhtenbrot, L., Madsen, H. O., Archer, P., Hancock, J., Cerveira, N., Teixeira, M. R., Lo Nigro, L., Möricke, A., Stanulla, M., Schrappe, M., Sedék, L., Szczepański, T., Zwaan, C. M., Coenen, E. A., van den Heuvel-Eibrink, M. M., Strehl, S., Dworzak, M., Panzer-Grümayer, R., Dingermann, T., Klingebiel, T., & Marschalek, R.
- Venue
- Leukemia
- Published
- 2013-04-30
- Volume
- 27
- Issue
- 11
- Pages
- 2165-2176
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- OpenAlex
- W2101782876
- Cited by
- 491
- References
- 2
- FWCI
- 35.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Meyer, C., Hofmann, J., Burmeister, T., Gröger, D., Park, T. S., Emerenciano, M., Pombo de Oliveira, M., Renneville, A., Villarese, P., Macintyre, E., Cavé, H., Clappier, E., Mass-Malo, K., Zuna, J., Trka, J., De Braekeleer, E., De Braekeleer, M., Oh, S. H., Tsaur, G., . . . Marschalek, R. (2013). The MLL recombinome of acute leukemias in 2013. Leukemia. https://doi.org/10.1038/leu.2013.135
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