DOT1L and H3K79 Methylation in Transcription and Genomic Stability

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hDOT1L Links Histone Methylation to Leukemogenesis

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The diverse functions of Dot1 and H3K79 methylationPreprint

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DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

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Identification of High-Copy Disruptors of Telomeric Silencing in Saccharomyces cerevisiae

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PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.

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Ubiquitination of Histone H2B by Rad6 Is Required for Efficient Dot1-mediated Methylation of Histone H3 Lysine 79

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Structure of the Catalytic Domain of Human DOT1L, a Non-SET Domain Nucleosomal Histone Methyltransferase

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A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

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The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure

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A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription

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Fast signals and slow marks: the dynamics of histone modifications

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Tails of RNA polymerase II

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Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)Preprint

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Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development

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Disruptor of Telomeric Silencing-1 Is a Chromatin-specific Histone H3 Methyltransferase

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Role of Dot1-Dependent Histone H3 Methylation in G1 and S Phase DNA Damage Checkpoint Functions of Rad9

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The DNA Damage Checkpoint Response Requires Histone H2B Ubiquitination by Rad6-Bre1 and H3 Methylation by Dot1

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Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

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Rate of elongation by RNA polymerase II is associated with specific gene features and epigenetic modifications

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Histone modifications defining active genes persist after transcriptional and mitotic inactivation

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Histone H2B Ubiquitylation Controls Processive Methylation but Not Monomethylation by Dot1 and Set1

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The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure

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DOT1L cooperates with the c-Myc–p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression

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DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia

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Structure and function of the nucleosome-binding PWWP domain

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Leukemogenic MLL Fusion Proteins Bind across a Broad Region of the Hox a9 Locus, Promoting Transcription and Multiple Histone Modifications

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Linking Cell Cycle to Histone Modifications: SBF and H2B Monoubiquitination Machinery and Cell-Cycle Regulation of H3K79 Dimethylation

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Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states

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Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes

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A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response

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Genome-wide Profiling of Chromatin Signatures Reveals Epigenetic Regulation of MicroRNA Genes in Colorectal Cancer

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Histone modifying enzymes and cancer: Going beyond histones

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Characterization of the grappa Gene, the Drosophila Histone H3 Lysine 79 Methyltransferase

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The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states

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Chatting histone modifications in mammals

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Reciprocal intronic and exonic histone modification regions in humans

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A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathwayPreprint

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Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation

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The emerging roles of DOT1L in leukemia and normal development

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Dot1 and Histone H3K79 Methylation in Natural Telomeric and HM Silencing

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Human Histone H3K79 Methyltransferase DOT1L Methyltransferase Binds Actively Transcribing RNA Polymerase II to Regulate Gene Expression

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PARP1-DOT1L transcription axis drives acquired resistance to PARP inhibitor in ovarian cancer

Liu, C., Li, J., Xu, F., Chen, L., Ni, M., Wu, J., Zhao, H., Wu, Y., Li, J., Wu, X., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02025-8 · Cited by 22 · see citing works

An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation

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The Effects of Interferons on Allogeneic T Cell Response in GVHD: The Multifaced Biology and Epigenetic Regulations

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Beyond the tail: the consequence of context in histone post-translational modification and chromatin research

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Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery

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RBM30 recruits DOT1L to activate STAT1 transcription and drive immune evasion in hepatocellular carcinoma

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Targeting of histone methyltransferase DOT1L plays a dual role in chemosensitization of retinoblastoma cells and enhances the efficacy of chemotherapy

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Activating the Anaphase Promoting Complex to Enhance Genomic Stability and Prolong Lifespan

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DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to elicit DNA repair

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Keeping RNA polymerase II on the run: Functions of MLL fusion partners in transcriptional regulation.

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Transcriptional regulation by methyltransferases and their role in the heart: highlighting novel emerging functionality

Szulik, M. W., Davis, K., Bakhtina, A. A., Azarcon, P., Bia, R. D., Horiuchi, E., & Franklin, S. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00382.2020 · Cited by 19 · see citing works

Characterizing and exploiting the many roles of aberrant H2B monoubiquitination in cancer pathogenesis

Jeusset, L. M., & McManus, K. J. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.12.007 · Cited by 18 · see citing works

BMP4 drives primed to naïve transition through PGC-like state

Yu, S.-Y., Zhou, C.-H., He, J.-P., Yao, Z., Huang, X.-N., Rong, B.-W., Zhu, H., Wang, S.-J., Chen, S.-Y., Wang, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30325-4 · Cited by 20 · see citing works

DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres

Malla, A. B., Yu, H., Farris, D., Kadimi, S., Lam, T. T., Cox, A. L., Smith, Z. D., & Lesch, B. J. (2023) · EMBO Reports · doi:10.15252/embr.202256492 · Cited by 18 · see citing works

Structural Basis of Nucleosome Recognition and Modulation

Sundaram, R., & Vasudevan, D. (2020) · BioEssays · doi:10.1002/bies.201900234 · Cited by 18 · see citing works

Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes

Yi, D., Nguyen, H. P., Dinh, J., Viscarra, J. A., Xie, Y., Lin, F., Zhu, M., Dempersmier, J. M., Wang, Y., & Sul, H. S. (2020) · eLife · doi:10.7554/elife.59990 · Cited by 18 · see citing works

AAontology: An Ontology of Amino Acid Scales for Interpretable Machine Learning

Breimann, S., Kamp, F., Steiner, H., & Frishman, D. (2024) · Journal of Molecular Biology · doi:10.1016/j.jmb.2024.168717 · Cited by 15 · see citing works

Epigenetic Regulation of Nucleotide Excision Repair

Li, W., Jones, K., Burke, T. J., Hossain, M. A., & Lariscy, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.847051 · Cited by 17 · see citing works

Trimethylation of histone H3K76 by Dot1B enhances cell cycle progression after mitosis in Trypanosoma cruzi

Nunes, V. S., Moretti, N. S., da Silva, M. S., Elias, M. C., Janzen, C. J., & Schenkman, S. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118694 · Cited by 16 · see citing works

Targeting inflammatory macrophages rebuilds therapeutic efficacy of DOT1L inhibition in hepatocellular carcinoma

Yang, Y., Wu, C.-Y., Wang, X., Deng, J., Cao, W.-J., Tang, Y.-Z., Wan, C.-C., Chen, Z.-T., Zhan, W.-Y., Shan, H., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.09.019 · Cited by 15 · see citing works

An emerging maestro of immune regulation: how DOT1L orchestrates the harmonies of the immune system

Kealy, L. C., Runting, J., Thiele, D., & Scheer, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1385319 · Cited by 15 · see citing works

A machine learning-based framework for modeling transcription elongation

Feng, P., Xiao, A., Fang, M., Wan, F., Li, S., Peng, L., Zhao, D. Y., & Zeng, J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007450118 · Cited by 15 · see citing works

DOT1L Regulates Thermogenic Adipocyte Differentiation and Function via Modulating H3K79 Methylation

Shuai, L., Li, B., Jiang, H., Duan, Y.-N., Yang, L., Li, J., & Li, J. (2020) · Diabetes · doi:10.2337/db20-1110 · Cited by 15 · see citing works

Chemical Control System of Epigenetics

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Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression

de Cristoforis, A. G., Ferrari, F., Clotman, F., & Vogel, T. (2020) · Molecular Brain · doi:10.1186/s13041-020-00623-3 · Cited by 15 · see citing works

A comprehensive review of histone modifications during mammalian oogenesis and early embryo development

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Roles of Chromatin Remodelling and Molecular Heterogeneity in Therapy Resistance in Glioblastoma

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Loss of the Ash2l subunit of histone H3K4 methyltransferase complexes reduces chromatin accessibility at promoters

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Rare de novo gain-of-function missense variants in DOT1L are associated with developmental delay and congenital anomalies

Nil, Z., Deshwar, A. R., Huang, Y., Barish, S., Zhang, X., Choufani, S., Stabej, P. L. Q., Hayes, I., Yap, P., Haldeman‐Englert, C. R., et al. (2023) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2023.09.009 · Cited by 14 · see citing works

CRISPR/Cas9 system is a suitable gene targeting editing tool to filamentous fungus Monascus pilosus

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Mesenchyme-specific loss of Dot1L histone methyltransferase leads to skeletal dysplasia phenotype in mice

Sutter, P. A., Karki, S., Crawley, I., Singh, V., Bernt, K. M., Rowe, D. W., Crocker, S. J., Bayarsaihan, D., & Guzzo, R. M. (2020) · Bone · doi:10.1016/j.bone.2020.115677 · Cited by 15 · see citing works

Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells

Zhang, H., Fu, H. E., Fang, H., Deng, Q., Huang, H., Hou, D., Wang, M., Yao, Q., Si, Q., Chen, R., et al. (2022) · Stem Cells International · doi:10.1155/2022/5015856 · Cited by 13 · see citing works

DOT1L promotes spermatid differentiation by regulating expression of genes required for histone-to-protamine replacement

Malla, A. B., Rainsford, S. R., Smith, Z. D., & Lesch, B. J. (2023) · Development · doi:10.1242/dev.201497 · Cited by 14 · see citing works

Trans-tail regulation-mediated suppression of cryptic transcription

Choi, J., Ryoo, Z. Y., Cho, D., Lee, H., & Ryu, H. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00711-x · Cited by 13 · see citing works

Multi-omics data integration analysis identifies the spliceosome as a key regulator of DNA double-strand break repair

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The Relationship Between DOT1L, Histone H3 Methylation, and Genome Stability in Cancer

Guppy, B. J., Jeusset, L. M., & McManus, K. J. (2017) · Current Molecular Biology Reports · doi:10.1007/s40610-017-0051-0 · Cited by 5 · see citing works

The upstreams and downstreams of H3K79 methylation by DOT1L

Vlaming, H., & van Leeuwen, F. (2016) · Chromosoma · doi:10.1007/s00412-015-0570-5 · Cited by 102 · see citing works

The diverse functions of Dot1 and H3K79 methylationanh

Zhang, Y., & Nguyen, A. T. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/fk9p-bw90 · Cited by 1 · see citing works

The diverse functions of Dot1 and H3K79 methylationPreprint

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The many faces of histone H3K79 methylation

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