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AKT is a therapeutic target in myeloproliferative neoplasms
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“Inhibitors of PI3K-AKT have been proved to exert anti-tumor effects in both mouse models and cell lines of the disease43,44.”
From Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms (2024) · cites this paper as [43]
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Citations
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Targeting PI3K signalling in cancer: opportunities, challenges and limitations
Engelman, J. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2664 · Cited by 2,445
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., Catalano, J. V., Deininger, M., Miller, C., Silver, R. T., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110557 · Cited by 2,103
Mutation in TET2 in Myeloid Cancers
Delhommeau, F., Dupont, S., Valle, V. D., James, C., Trannoy, S., Massé, A., Kosmider, O., Le Couedic, J.-P., Robert, F., Alberdi, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810069 · Cited by 1,776
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Cited by
Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms
Zhang, P., You, N., Ding, Y., Zhu, W., Wang, N., Xie, Y., Huang, W., Ren, Q., Qin, T., Fu, R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47297-2 · Cited by 11
Metadata
- Authors
- Khan, I., Huang, Z., Wen, Q., Stankiewicz, M. J., Gilles, L., Goldenson, B., Schultz, R., Diebold, L., Gurbuxani, S., Finke, C. M., Lasho, T. L., Koppikar, P., Pardanani, A., Stein, B., Altman, J. K., Levine, R. L., Tefferi, A., & Crispino, J. D.
- Venue
- Leukemia
- Published
- 2013-06-10
- Volume
- 27
- Issue
- 9
- Pages
- 1882-1890
- ISSN
- 0887-6924
- 1476-5551
- PMC
- PMC4023863
- Cited by
- 74
- References
- 3
- Language
- en
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- Khan, I., Huang, Z., Wen, Q., Stankiewicz, M. J., Gilles, L., Goldenson, B., Schultz, R., Diebold, L., Gurbuxani, S., Finke, C. M., Lasho, T. L., Koppikar, P., Pardanani, A., Stein, B., Altman, J. K., Levine, R. L., Tefferi, A., & Crispino, J. D. (2013). AKT is a therapeutic target in myeloproliferative neoplasms. Leukemia. https://doi.org/10.1038/leu.2013.167