Mutation in TET2 in Myeloid Cancers

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Myelodysplastic syndromes

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Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation.

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The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation

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Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders

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Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML

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Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates

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Genetic and clinical implications of the Val617Phe JAK2 mutation in 72 families with myeloproliferative disorders

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Polycythemia vera is not initiated by JAK2 mutation

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The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera

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NF- B constitutes a potential therapeutic target in high-risk myelodysplastic syndrome

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Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations

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Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia

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The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity

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A Role for JAK2 Mutations in Myeloproliferative Diseases

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SNP Array Karyotyping Allows for the Detection of Uniparental Disomy and Cryptic Chromosomal Abnormalities in MDS/MPD-U and MPD

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Oncogenic mechanisms in myeloproliferative disorders

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Common 4q24 deletion in four cases of hematopoietic malignancy: early stem cell involvement?

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Human cell engraftment after busulfan or irradiation conditioning of NOD/SCID mice.

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New Insights into the Pathogenesis of JAK2 V617F-Positive Myeloproliferative Disorders and Consequences for the Management of Patients

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Cancer epigenetics: from mechanism to therapy

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Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

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Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

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Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

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Age-related mutations associated with clonal hematopoietic expansion and malignancies

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Clinical and biological implications of driver mutations in myelodysplastic syndromes

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Somatic <i>CALR</i> Mutations in Myeloproliferative Neoplasms with Nonmutated <i>JAK2</i>

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TET-mediated active DNA demethylation: mechanism, function and beyond

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TET enzymes, TDG and the dynamics of DNA demethylation

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Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

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Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

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Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

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Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials

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Role of TET enzymes in DNA methylation, development, and cancer

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Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions

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TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

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TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

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Influence of Metabolism on Epigenetics and Disease

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Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

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Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

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Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

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Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells

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Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma

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Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

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Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia

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Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal

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( <i>R</i> )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

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Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

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Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

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Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

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What a difference a hydroxyl makes: mutant IDH, (<i>R</i>)-2-hydroxyglutarate, and cancer

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Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

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The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers

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SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts

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Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

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Targeting cancer vulnerabilities with high-dose vitamin C

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Regulation of the epigenome by vitamin C

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Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

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<scp>l</scp> -2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer

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Tet2 restrains inflammatory gene expression in macrophages

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Marked for death: Targeting epigenetic changes in cancer

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Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

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