Structure and function relationships in IgA
Open accessAbstract
Immunoglobulin A (IgA) has a critical role in immune defense particularly at the mucosal surfaces, and is equipped to do so by the unique structural attributes of its heavy chain and by its ability to polymerize. Here, we provide an overview of human IgA structure, describing the distinguishing features of the IgA1 and IgA2 subclasses and mapping the sites of interaction with host receptors important for IgA's functional repertoire. Remarkably, these same interaction sites are targeted by binding proteins and proteases produced by various pathogens as a means to subvert the protective IgA response. As interest in the prospect of therapeutic IgA-based monoclonal antibodies grows, the emerging understanding of the relationship between IgA structure and function will be invaluable for maximizing the potential of these novel reagents.
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Many pathogens that infect mucosal surfaces encode proteases that cleave immunoglobulin such as Neisseria meningitides, N. gonorrhoeae or Streptococcus pneumoniae.
“Many pathogens that infect mucosal surfaces encode proteases that cleave immunoglobulin such as Neisseria meningitides, N. gonorrhoeae or Streptococcus pneumoniae.150,151”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [151]
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- Authors
- Woof, J. M., & Russell, M. W.
- Affiliations
- University of Dundee (GB)
- University at Buffalo, State University of New York (US)
- Corresponding author
- Woof, J M
- Russell, M W
- ORCID
- Russell, M W
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 4
- Issue
- 6
- Pages
- 590-597
- ISSN
- 1933-0219 (ISSN-L)
- OpenAlex
- W1974260720
- Cited by
- 367
- References
- 88
- Citations by year
- 2026: 40 · 2025: 26 · 2024: 36 · 2023: 36 · 2022: 28 · 2021: 27 · 2020: 38 · 2019: 29 · 2018: 15 · 2017: 21 · 2016: 13 · 2015: 22 · 2014: 13 · 2013: 10 · 2012: 10
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mucosal Immunology (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Funders
- Asthma and Lung UK
- U.S. Public Health Service
- National Institute of Allergy and Infectious Diseases (AI092348, AI074791, R21AI092348, R21AI074791)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Keywords
- immunoglobulin A, IgA1, IgA2, mucosal immunity, host cell receptors, proteolytic enzymes, structure-function relationship
- MeSH terms
- Animals, Binding, Competitive, Humans, Immunoglobulin A, Immunotherapy, Receptors, Fc, Structure-Activity Relationship, Immunity, Mucosal, Host-Pathogen Interactions, Immune Evasion
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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