Cited by 367Monoclonal and Polyclonal Antibodies ResearchT-cell and B-cell ImmunologyImmunodeficiency and Autoimmune Disorders

Structure and function relationships in IgA

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Woof, J M, Russell, M W·2011·Mucosal Immunology

Abstract

Immunoglobulin A (IgA) has a critical role in immune defense particularly at the mucosal surfaces, and is equipped to do so by the unique structural attributes of its heavy chain and by its ability to polymerize. Here, we provide an overview of human IgA structure, describing the distinguishing features of the IgA1 and IgA2 subclasses and mapping the sites of interaction with host receptors important for IgA's functional repertoire. Remarkably, these same interaction sites are targeted by binding proteins and proteases produced by various pathogens as a means to subvert the protective IgA response. As interest in the prospect of therapeutic IgA-based monoclonal antibodies grows, the emerging understanding of the relationship between IgA structure and function will be invaluable for maximizing the potential of these novel reagents.

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Crossref · 10.1038/mi.2011.39

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  • Many pathogens that infect mucosal surfaces encode proteases that cleave immunoglobulin such as Neisseria meningitides, N. gonorrhoeae or Streptococcus pneumoniae.

    “Many pathogens that infect mucosal surfaces encode proteases that cleave immunoglobulin such as Neisseria meningitides, N. gonorrhoeae or Streptococcus pneumoniae.150,151”

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Authors
Woof, J. M., & Russell, M. W.
Affiliations
  • University of Dundee (GB)
  • University at Buffalo, State University of New York (US)
Corresponding author
  • Woof, J M
  • Russell, M W
Venue
Mucosal Immunology
Publisher
Elsevier BV
Published
2011-11
Volume
4
Issue
6
Pages
590-597
ISSN
1933-0219 (ISSN-L)
OpenAlex
W1974260720
Cited by
367
References
88
Citations by year
2026: 40 · 2025: 26 · 2024: 36 · 2023: 36 · 2022: 28 · 2021: 27 · 2020: 38 · 2019: 29 · 2018: 15 · 2017: 21 · 2016: 13 · 2015: 22 · 2014: 13 · 2013: 10 · 2012: 10
FWCI
1.81
Type
journal article
Language
en
Open access
Locations
  • Mucosal Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Discovery Research Portal (University of Dundee) (submittedVersion)
Funders
  • Asthma and Lung UK
  • U.S. Public Health Service
  • National Institute of Allergy and Infectious Diseases (AI092348, AI074791, R21AI092348, R21AI074791)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords
immunoglobulin A, IgA1, IgA2, mucosal immunity, host cell receptors, proteolytic enzymes, structure-function relationship
MeSH terms
Animals, Binding, Competitive, Humans, Immunoglobulin A, Immunotherapy, Receptors, Fc, Structure-Activity Relationship, Immunity, Mucosal, Host-Pathogen Interactions, Immune Evasion

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