The DOI matches its Crossref record; 117 of the 118 references it cites were found in a registry or an index.
Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium
Open accessAbstract
The transcytosis of antigens across the gut epithelium by microfold cells (M cells) is important for the induction of efficient immune responses to some mucosal antigens in Peyer's patches. Recently, substantial progress has been made in our understanding of the factors that influence the development and function of M cells. This review highlights these important advances, with particular emphasis on: the host genes which control the functional maturation of M cells; how this knowledge has led to the rapid advance in our understanding of M-cell biology in the steady state and during aging; molecules expressed on M cells which appear to be used as "immunosurveillance" receptors to sample pathogenic microorganisms in the gut; how certain pathogens appear to exploit M cells to infect the host; and finally how this knowledge has been used to specifically target antigens to M cells to attempt to improve the efficacy of mucosal vaccines.
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“Since they have a plasma membrane rich in specific carbohydrate residues, such as α-L fucose and monoganglioside (GM1) [10–12]”
From Characterization of Vibrio cholerae neuraminidase as an immunomodulator for novel formulation of oral allergy immunotherapy (2018) · cites this paper as [12]
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“Although the incidence is rare in the steady state, certain inflammatory stimuli appear to recruit MNP from the lamina propria to the gut epithelium where they insert their dendrites through the tight junctions between enterocytes to directly sample the luminal contents.(108,109) In addition to this ‘‘periscoping’’ ac…”
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“Viable commensal bacteria and unprocessed antigen can also be recovered from classical DCmigrating within afferent mesenteric lymph.(113,114) These contrasting characteristics raise the question of whether the cells throughwhich antigens are initially sampled across the intestinal epithelium (M cells, enterocytes, gob…”
BackgroundSecretory IgA's complex roles in immunity and mucosal homeostasis in the gut
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Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine
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“In the absence of GP2 expression by M cells, the transcytosis of type-I-piliated bacteria was impeded.(9) Furthermore, GP2-dependent bacterial transcytosis by M cells was shown to be important for the immunosurveillance of FimHþ bacteria in the gut lumen.”
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Intestinal epithelial cells: regulators of barrier function and immune homeostasis
Peterson, L. W., & Artis, D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3608 · Cited by 3,367
Regional specialization within the intestinal immune system
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A single-cell survey of the small intestinal epithelium
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Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis
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“Microfold (M) cells are typically associated with lymphoid tissue in the human small intestine, where they are important for recognition of the gut microbiota (Mabbott et al., 2013).”
BackgroundTales from the crypt: new insights into intestinal stem cells
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Metadata
- Authors
- Mabbott, N. A., Donaldson, D. S., Ohno, H., Williams, I. R., & Mahajan, A.
- Affiliations
- Roslin Institute (GB)
- RIKEN Center for Integrative Medical Sciences (JP)
- Emory University (US)
- Corresponding author
- Mabbott, N A
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 6
- Issue
- 4
- Pages
- 666-677
- ISSN
- 1933-0219 (ISSN-L)
- PMC
- PMC3686595
- OpenAlex
- W2085355903
- Cited by
- 721
- References
- 118
- Citations by year
- 2026: 52 · 2025: 48 · 2024: 61 · 2023: 66 · 2022: 50 · 2021: 68 · 2020: 71 · 2019: 54 · 2018: 78 · 2017: 56 · 2016: 43 · 2015: 46 · 2014: 22 · 2013: 5
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mucosal Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- National Institutes of Health
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council (BB/G003947/1, BB/F019726/1, BB/J014672/1, BBS/E/D/20231759, BB/J0004332/1, BB/K021257/1, BBS/E/D/20251968, BBS/E/D/20251967, JPA1797)
- Japan Society for the Promotion of Science (24249029)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK064730, DK-064730)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- M cells, Peyer's patches, intestinal epithelium, mucosal immunity, immune surveillance, host genes, aging, mucosal vaccines, antigen targeting
- MeSH terms
- Age Factors, Animals, Antigens, Antigens, Surface, Cell Communication, Cell Differentiation, Humans, Intestinal Mucosa, Peyer's Patches, Stem Cells, Transcription Factors, Monitoring, Immunologic, Receptors, G-Protein-Coupled, RANK Ligand, Host-Pathogen Interactions
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