M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis
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M-cells are specialized cells found in the follicle-associated epithelium of intestinal Peyer's patches of gut-associated lymphoid tissue and in isolated lymphoid follicles, appendix and in mucosal-associated lymphoid tissue sites outside the gastrointestinal tract. In the gastrointestinal tract, M-cells play an important role in transport of antigen from the lumen of the small intestine to mucosal lymphoid tissues, where processing and initiation of immune responses occur. Thus, M-cells act as gateways to the mucosal immune system and this function has been exploited by many invading pathogens. Understanding the mechanism by which M-cells sample antigen will inform the design of oral vaccines with improved efficacy in priming mucosal and systemic immune responses. In this review, the origin and morphology of M-cells, and their role in mucosal immunity and pathogenesis of infections are discussed.
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Many enteropathogenic and nonenteropathogenic pathogens are primarily taken up by M cells.
“A number of enteropathogenic microorganisms, such as Vibrio cholerae [85,86], Salmonella typhimurium [87,88], Shigella flexneri [89–91], Yersinia pseudotuberculosis and Yersinia enterocolotica [92–94], and reoviruses [95], but also nonenteropathogenic pathogens, such as influenza virus A [96], or human immunodeficiency virus-1 (HIV-1) [97], are primarily taken up by M cells, as reviewed by Corr et”
From Use of lectin-functionalized particles for oral immunotherapy (2012) · cites this paper as [98]
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- Authors
- Corr, S. C., Gahan, C. C. G. M., & Hill, C.
- Affiliations
- University College Cork (IE)
- ORCID
- Hill, Colin
- Venue
- FEMS Immunology & Medical Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-01
- Volume
- 52
- Issue
- 1
- Pages
- 2-12
- ISSN
- 0928-8244 (ISSN-L)
- 1574-695X
- OpenAlex
- W2004051909
- Cited by
- 320
- References
- 84
- Citations by year
- 2026: 11 · 2025: 21 · 2024: 13 · 2023: 22 · 2022: 24 · 2021: 19 · 2020: 22 · 2019: 20 · 2018: 18 · 2017: 14 · 2016: 13 · 2015: 14 · 2014: 13 · 2013: 19 · 2012: 16
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Immunology & Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- M cells, follicle-associated epithelium, Peyer's patches, isolated lymphoid follicles, mucosa-associated lymphoid tissue, antigen sampling, mucosal immunity, microbial pathogenesis, oral vaccine, gut-associated lymphoid tissue
- MeSH terms
- Animals, Humans, Intestinal Mucosa, Peyer's Patches, Immunity, Mucosal
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