Histopathological and immunohistochemical findings of 20 autopsy cases with 2009 H1N1 virus infection
Open accessAbstract
Twenty autopsy cases with 2009 pandemic influenza A (2009 H1N1) virus infection, performed between August 2009 and February 2010, were histopathologically analyzed. Hematoxylin-eosin staining, immunohistochemistry for type A influenza nucleoprotein antigen, and real-time reverse transcription-PCR assay for viral RNA were performed on formalin-fixed and paraffin-embedded specimens. In addition, the D222G amino acid substitution in influenza virus hemagglutinin, which binds to specific cell receptors, was analyzed in formalin-fixed and paraffin-embedded trachea and lung sections by direct sequencing of PCR-amplified products. There were several histopathological patterns in the lung according to the most remarkable findings in each case: acute diffuse alveolar damage (DAD) with a hyaline membrane (four cases), organized DAD (one case), acute massive intra-alveolar edema with variable degrees of hemorrhage (three cases), neutrophilic bronchopneumonia (five cases) and tracheobronchitis with limited histopathological changes in alveoli (four cases). In two cases, the main findings were due to preexisting disease. Influenza virus antigen was only detected in the respiratory tract in 10 cases by immunohistochemistry. The antigen was detected in type II pneumocytes (three cases) in the epithelial cells of the trachea, bronchi and glands (six cases), and in the epithelial cells in both of the above (one case). The four cases with acute DAD presented with antigen-positive type II pneumocytes. In one case, the D222G substitution was detected in the lung as a major sequence, although 222D was prominent in the trachea, suggesting that selection of the viral clones occurred in the respiratory tract. In five cases, the pathogenesis of 2009 H1N1 was confirmed to be viral infection in pneumocytes, which caused severe alveolar damage and fatal viral pneumonia. Further studies on both host and viral factors in autopsy or biopsy materials will be essential to elucidate the other pathogenic factors involved in influenza virus infection.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Bacterial infection complicating A(H1N1)pdm09 ranged from 5 to 14% of fatal cases in the four studies reporting data from clinical testing prior to death.
“On this basis, bacterial infection complicating A(H1N1)pdm09 ranged from 5 to 14% of fatal cases in the four studies [1, 17, 21, 22] reporting data from clinical testing prior to death”
From The role of pneumonia and secondary bacterial infection in fatal and serious outcomes of pandemic influenza a(H1N1)pdm09. (2018) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans
Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0903810 · Cited by 3,047 · see citing works
Influenza virus receptors in the human airway
Shinya, K., Ebina, M., Yamada, S., Ono, M., Kasai, N., & Kawaoka, Y. (2006) · Nature · doi:10.1038/440435a · Cited by 1,398 · see citing works
Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico
Perez-Padilla, R., de la Rosa-Zamboni, D., Ponce de Leon, S., Hernandez, M., Quiñones-Falconi, F., Bautista, E., Ramirez-Venegas, A., Rojas-Serrano, J., Ormsby, C. E., Corrales, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0904252 · Cited by 1,325 · see citing works
The Pathology of Influenza Virus Infections
Taubenberger, J. K., & Morens, D. M. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.154316 · Cited by 1,111 · see citing works
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
Itoh, Y., Shinya, K., Kiso, M., Watanabe, T., Sakoda, Y., Hatta, M., Muramoto, Y., Tamura, D., Sakai‐Tagawa, Y., Noda, T., et al. (2009) · Nature · doi:10.1038/nature08260 · Cited by 1,058 · see citing works
Lung Pathology in Fatal Novel Human Influenza A (H1N1) Infection
Mauad, T., Hajjar, L. A., Callegari, G. D., da Silva, L. F. F., Schout, D., Galas, F. R. B. G., Alves, V. A. F., Malheiros, D. M. A. C., Auler, J. O. C., Ferreira, A. F., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200909-1420oc · Cited by 547 · see citing works
2009 Pandemic Influenza A (H1N1)
Shieh, W.-J., Blau, D. M., Denison, A. M., DeLeon-Carnes, M., Adem, P., Bhatnagar, J., Sumner, J., Liu, L., Patel, M., Batten, B., et al. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100115 · Cited by 429 · see citing works
Pulmonary Pathologic Findings of Fatal 2009 Pandemic Influenza A/H1N1 Viral Infections
Gill, J. R., Sheng, Z.-M., Ely, S. F., Guinee, D. G., Beasley, M. B., Suh, J., Deshpande, C., Mollura, D. J., Morens, D. M., Bray, M., et al. (2010) · Archives of Pathology & Laboratory Medicine · doi:10.5858/134.2.235 · Cited by 426 · see citing works
Pathology of human influenza revisited
Kuiken, T., & Taubenberger, J. K. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.07.025 · Cited by 359 · see citing works
Childs, R. A., Palma, A. S., Wharton, S. A., Matrosovich, T. Y., Liu, Y., Chai, W., Campanero‐Rhodes, M. A., Zhang, Y.-B., Eickmann, M., Kiso, M., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt0909-797 · Cited by 330 · see citing works
Pathology, Molecular Biology, and Pathogenesis of Avian Influenza A (H5N1) Infection in Humans
Korteweg, C., & Gu, J. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070791 · Cited by 321 · see citing works
Chutinimitkul, S., Herfst, S., Steel, J., Lowen, A. C., Ye, J., van Riel, D. A. J., Schrauwen, E. J. A., Bestebroer, T. M., Koel, B. F., Burke, D. F., et al. (2010) · Journal of Virology · doi:10.1128/jvi.01136-10 · Cited by 216 · see citing works
Liu, Y., Childs, R. A., Matrosovich, T. Y., Wharton, S. A., Palma, A. S., Chai, W., Daniels, R. S., Gregory, V., Uhlendorff, J., Kiso, M., et al. (2010) · Journal of Virology · doi:10.1128/jvi.01639-10 · Cited by 202 · see citing works
Influenza-associated acute encephalopathy in Japanese children in 1994?2002
Togashi, T., Matsuzono, Y., Narita, M., & Morishima, T. (2004) · Virus Research · doi:10.1016/j.virusres.2004.02.016 · Cited by 176 · see citing works
Fulminant Myocarditis Associated With Pandemic H1N1 Influenza A Virus in Children
Bratincsák, A., El-Said, H. G., Bradley, J. S., Shayan, K., Grossfeld, P., & Cannavino, C. R. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.01.004 · Cited by 151 · see citing works
Guarner, J., Paddock, C. D., Shieh, W., Packard, M. M., Patel, M., Montague, J. L., Uyeki, T. M., Bhat, N., Balish, A., Lindstrom, S., et al. (2006) · Clinical Infectious Diseases · doi:10.1086/505122 · Cited by 131 · see citing works
Fatalities Associated with the 2009 H1N1 Influenza A Virus in New York City
Lee, E. H., Wu, C., Lee, E. U., Stoute, A., Hanson, H., Cook, H. A., Nivin, B., Fine, A. D., Kerker, B. D., Harper, S. A., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/652446 · Cited by 126 · see citing works
Ichiyama, T., Isumi, H., Ozawa, H., Matsubara, T., Morishima, T., & Furukawa, S. (2003) · Scandinavian Journal of Infectious Diseases · doi:10.1080/0036554021000026986 · Cited by 116 · see citing works
Aspects on antibacterial treatment of anaerobic infections.
Nordbring, F., & Nord, C. E. (1982) · PubMed · Cited by 115 · see citing works
Kuroda, M., Katano, H., Nakajima, N., Tobiume, M., Ainai, A., Sekizuka, T., Hasegawa, H., Tashiro, M., Sasaki, Y., Arakawa, Y., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010256 · Cited by 111 · see citing works
Comparison of the ability of viral protein-expressing plasmid DNAs to protect against influenza
Chen, Z., Sahashi, Y., Matsuo, K., Asanuma, H., Takahashi, H., Iwasaki, T., Suzuki, Y., Aizawa, C., Kurata, T., & Tamura, S. (1998) · Vaccine · doi:10.1016/s0264-410x(98)00043-7 · Cited by 105 · see citing works
Chen, H., Wen, X., To, K. K., Wang, P., Tse, H., Chan, J. F., Tsoi, H., Fung, K. S. C., Tse, C. W. S., Lee, R. A., et al. (2010) · The Journal of Infectious Diseases · doi:10.1086/652661 · Cited by 99 · see citing works
Kuramochi, H., Hayashi, K., Uchida, K., Miyakura, S., Shimizu, D., Vallböhmer, D., Park, S.-J., Danenberg, K. D., Takasaki, K., & Danenberg, P. V. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1275 · Cited by 98 · see citing works
Immunohistochemical and In Situ Hybridization Studies of Influenza A Virus Infection in Human Lungs
Guarner, J., Shieh, W., Dawson, J. E., Subbarao, K., Shaw, M. W., Ferebee, T., Morken, T., Nolte, K. B., Freifeld, A. G., Cox, N., et al. (2000) · American Journal of Clinical Pathology · doi:10.1309/hv74-n24t-2k2c-3e8q · Cited by 94 · see citing works
A National Survey on Myocarditis Associated With the 2009 Influenza A (H1N1) Pandemic in Japan
Ukimura, A., Izumi, T., & Matsumori, A. (2010) · Circulation Journal · doi:10.1253/circj.cj-10-0452 · Cited by 92 · see citing works
Pathological Changes Associated with the 2009 H1N1 Virus
Abraham, V. S., Rosas, J. S., Díaz-Quiñónez, J. A., Silva‐Pereyra, J., Vazquez-Hernandez, P., Torres-López, O., Roldán, A., Cruz-Gordillo, A., Alonso-Viveros, P., & Navarro-Reynoso, F. P. (2009) · New England Journal of Medicine · doi:10.1056/nejmc0907171 · Cited by 89 · see citing works
Nakajima, N., Hata, S., Sato, Y., Tobiume, M., Katano, H., Kaneko, K., Nagata, N., Kataoka, M., Ainai, A., Hasegawa, H., et al. (2010) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.63.67 · Cited by 72 · see citing works
Self-citationLiêm, N. T., Nakajima, N., Phat, L. P., Sato, Y., Thach, H. N., Hung, P. V., Luong, S. T., Katano, H., Kumasaka, T., Oka, T., et al. (2008) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.jjid.2008.157 · Cited by 36 · see citing works
Self-citationPostmortem findings in eight cases of influenza A/H1N1
Rosen, D. G., Lopez, A. E., Anzalone, M. L., Wolf, D. A., Derrick, S. M., Florez, L. F., Gonsoulin, M., Hines, M. O., Mitchell, R. A., Phatak, D. R., et al. (2010) · Modern Pathology · doi:10.1038/modpathol.2010.148 · Cited by 36 · see citing works
Efstathiou, P. A., Tseroni, M., Baka, A., Manolidou, Z., Karageorgou, K., Sypsa, V., & Hatzakis, A. (2010) · MMWR Morbidity and Mortality Weekly Report · Cited by 30 · see citing works
(2010) · PubMed · Cited by 24 · see citing works
Takiyama, A., Wang, L., Tanino, M. A., Kimura, T., Kawagishi, N., Kunieda, Y., Katano, H., Nakajima, N., Hasegawa, H., Takagi, T., et al. (2010) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.63.72 · Cited by 22 · see citing works
Self-citationAcute Encephalopathy and Pandemic (H1N1) 2009
Moon, S. M., Kim, S., Jeong, M. H., Lee, E. H., & Ko, T.-S. (2010) · Emerging infectious diseases · doi:10.3201/eid1611.100682 · Cited by 9 · see citing works
Flagged first, then by citations
1 of the 35 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Radiographic and CT Features of Viral Pneumonia
Koo, H. J., Lim, S., Choe, J., Choi, S., Sung, H., & Do, K. (2018) · Radiographics · doi:10.1148/rg.2018170048 · Cited by 712 · see citing works
Kumar, P., Hu, Y., Yamamoto, Y., Hoe, N. B., Wei, T. S., Mu, D., Sun, Y., Lim, S. J., Dagher, R., Zielonka, E. M., et al. (2011) · Cell · doi:10.1016/j.cell.2011.10.001 · Cited by 578 · see citing works
Schurink, B., Roos, E., Radonic, T. R., Barbé, E., Bouman, C. S. C., de Boer, H. H., de Bree, G. J., Bulle, E., Aronica, E., Florquin, S., et al. (2020) · The Lancet Microbe · doi:10.1016/s2666-5247(20)30144-0 · Cited by 505 · see citing works
COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City
Borczuk, A. C., Salvatore, S. P., Seshan, S. V., Patel, S. S., Bussel, J. B., Mostyka, M., Elsoukkary, S., He, B., Del Vecchio, C., Fortarezza, F., et al. (2020) · Modern Pathology · doi:10.1038/s41379-020-00661-1 · Cited by 452 · see citing works
MacIntyre, C. R., Chughtai, A. A., Barnes, M., Ridda, I., Seale, H., Toms, R., & Heywood, A. (2018) · BMC Infectious Diseases · doi:10.1186/s12879-018-3548-0 · Cited by 323 · see citing works
IL-22 Is Essential for Lung Epithelial Repair following Influenza Infection
Pociask, D. A., Scheller, E. V., Mandalapu, S., McHugh, K. J., Enelow, R. I., Fattman, C. L., Kolls, J. K., & Alcorn, J. F. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.12.007 · Cited by 221 · see citing works
Secondary Bacterial Infections in Patients With Viral Pneumonia
Manohar, P., Loh, B., Nachimuthu, R., Hua, X., Welburn, S. C., & Leptihn, S. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00420 · Cited by 173 · see citing works
Virus infection induced pulmonary fibrosis
Huang, W., & Tang, X. X. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03159-9 · Cited by 167 · see citing works
Pneumonia, Acute Respiratory Distress Syndrome, and Early Immune-Modulator Therapy
Lee, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020388 · Cited by 161 · see citing works
von Ranke, F. M., Zanetti, G. M. R., a, B. H., & Marchiori, E. D. S. (2012) · Lung · doi:10.1007/s00408-012-9431-7 · Cited by 138 · see citing works
Bradley, B. T., & Bryan, A. B. (2019) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2019.04.006 · Cited by 124 · see citing works
Innate Immune Sensing and Response to Influenza
Pulendran, B., & Maddur, M. S. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_405 · Cited by 115 · see citing works
The state of the art for artificial intelligence in lung digital pathology
Viswanathan, V. S., Toro, P., Corredor, G., Mukhopadhyay, S., & Madabhushi, A. (2022) · The Journal of Pathology · doi:10.1002/path.5966 · Cited by 105 · see citing works
Francis, M. E., King, M., & Kelvin, A. A. (2019) · Viruses · doi:10.3390/v11020122 · Cited by 93 · see citing works
van de Veerdonk, F. L., Brüggemann, R. J. M., Vos, S., Hertogh, G. D., Wauters, J., Reijers, M. H. E., Netea, M. G., Schouten, J. A., & Verweij, P. E. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00138-7 · Cited by 82 · see citing works
Immunohistochemical diagnosis of human infectious diseases: a review
Hama, H. O., Aboudharam, G., Barbieri, R., Lépidi, H., & Drancourt, M. (2022) · Diagnostic Pathology · doi:10.1186/s13000-022-01197-5 · Cited by 57 · see citing works
Zukerberg, L. R., Mahadevan, K. K., Selig, M. K., & Deshpande, V. (2015) · Histopathology · doi:10.1111/his.12892 · Cited by 56 · see citing works
A Three-Dimensional Human Tissue-Engineered Lung Model to Study Influenza A Infection
Bhowmick, R., Derakhshan, T. M., Liang, Y., Ritchey, J. W., Liu, L., & Gappa‐Fahlenkamp, H. (2018) · Tissue Engineering Part A · doi:10.1089/ten.tea.2017.0449 · Cited by 54 · see citing works
Tissue factor deficiency increases alveolar hemorrhage and death in influenza A virus‐infected mice
Antoniak, S., Tatsumi, K., Hisada, Y., Milner, J. J., Neidich, S. D., Shaver, C. M., Pawliński, R., Beck, M. A., Bastarache, J. A., & Mackman, N. (2016) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13307 · Cited by 53 · see citing works
Pathological study of archival lung tissues from five fatal cases of avian H5N1 influenza in Vietnam
Nakajima, N., Tin, N. V., Sato, Y., Thach, H. N., Katano, H., Diep, P. H., Kumasaka, T., Thuy, N. T., Hasegawa, H., Luong, S. T., et al. (2012) · Modern Pathology · doi:10.1038/modpathol.2012.193 · Cited by 51 · see citing works
Self-citationHuang, S. S. H., Banner, D., Degousée, N., Leon, A. J., Xu, L., Paquette, S. G., Kanagasabai, T., Yuan, F., Rubino, S., Rubin, B. B., et al. (2012) · Journal of Virology · doi:10.1128/jvi.01456-12 · Cited by 51 · see citing works
Molecular profiling of male breast cancer – Lost in translation?
Johansson, I., Killander, F., Linderholm, B. K., & Hedenfalk, I. A. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.05.007 · Cited by 47 · see citing works
Stem cells in pulmonary alveolar regeneration
Wu, H., & Tang, N. (2021) · Development · doi:10.1242/dev.193458 · Cited by 43 · see citing works
Vangeti, S., Yu, M., & Smed‐Sörensen, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01521 · Cited by 43 · see citing works
DiPiazza, A. T., Nogales, A., Poulton, N. C., Wilson, P. C., Martínez‐Sobrido, L., & Sant, A. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-11313-x · Cited by 43 · see citing works
Kelly, J. N., Laloli, L., V’kovski, P., Holwerda, M., Portmann, J., Thiel, V., & Dijkman, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.978824 · Cited by 35 · see citing works
Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection
Huang, S. S. H., Banner, D., Paquette, S. G., Leon, A. J., Kelvin, A. A., & Kelvin, D. J. (2014) · Journal of General Virology · doi:10.1099/vir.0.064352-0 · Cited by 37 · see citing works
Calabrese, F., Pezzuto, F., Fortarezza, F., Boscolo, A., Lunardi, F., Giraudo, C., Cattelan, A. M., Vecchio, C. D., Lorenzoni, G., Vedovelli, L., et al. (2021) · The Journal of Pathology · doi:10.1002/path.5653 · Cited by 38 · see citing works
Alveolar macrophages: novel therapeutic targets for respiratory diseases
Lim, P. N., Cervantes, M. M., Pham, L. K., & Rothchild, A. C. (2021) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2021.21 · Cited by 35 · see citing works
Zhou, W. J., Tian, D., He, J., Yan, X., Zhao, J., Yuan, X., & Peng, S. (2018) · Journal of Applied Toxicology · doi:10.1002/jat.3721 · Cited by 34 · see citing works
Xue-qing, H., Li, Z., Chen, H., Wang, H., Mei, L., Wu, S., Zhang, T., Liu, B., & Lin, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048340 · Cited by 32 · see citing works
Rykkvin, R., Kilander, A., Dudman, S. G., & Hungnes, O. (2013) · Eurosurveillance · doi:10.2807/ese.18.03.20369-en · Cited by 31 · see citing works
Characterization In Vitro and In Vivo of a Pandemic H1N1 Influenza Virus from a Fatal Case
Rodríguez-Frandsen, A., Falcón, A. M., Cuevas, M. T., Pozo, F., Guerra, S., García‐Barreno, B., Martínez-Orellana, P., Pérez‐Breña, P., Montoya, M., Melero, J. A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053515 · Cited by 26 · see citing works
Fukushi, M., Yamashita, M., Miyoshi‐Akiyama, T., Kubo, S., Yamamoto, K., & Kudo, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042419 · Cited by 26 · see citing works
Histopathological Findings in COVID-19 Cases: A Systematic Review
Hammoud, H., Bendari, A., Bendari, T., & Bougmiza, I. M. (2022) · Cureus · doi:10.7759/cureus.25573 · Cited by 25 · see citing works
Bahadoran, A., Bezavada, L., & Smallwood, H. S. (2020) · Immunological Reviews · doi:10.1111/imr.12851 · Cited by 26 · see citing works
Peptide Targeting and Imaging of Damaged Lung Tissue in Influenza-Infected Mice
Li, N., Yin, L., Thévenin, D., Yamada, Y., Limmon, G. V., Chen, J., Chow, V. T. K., Engelman, D. M., & Engelward, B. P. (2013) · Future Microbiology · doi:10.2217/fmb.12.134 · Cited by 23 · see citing works
Selenium-ruthenium complex blocks H1N1 influenza virus-induced cell damage by activating GPx1/TrxR1
Li, Y., Chen, D., Su, J., Chen, M., Chen, T., Jia, W., & Zhu, B. (2023) · Theranostics · doi:10.7150/thno.83522 · Cited by 23 · see citing works
Kataoka, M., Ishida, K., Ogasawara, K., Nozaki, T., Satoh, Y.-I., Sata, T., Sato, Y., Hasegawa, H., & Nakajima, N. (2019) · Journal of Virology · doi:10.1128/jvi.00644-19 · Cited by 21 · see citing works
Self-citationImaging in pulmonary infections of immunocompetent adult patients
Pochepnia, S., Grabczak, E. M., Johnson, E. J., Eyüboğlu, F. Ö., Akkerman, O. W., & Prosch, H. (2024) · Breathe · doi:10.1183/20734735.0186-2023 · Cited by 19 · see citing works
Clinicopathological Findings of Four Cases of Pure Influenza Virus A Pneumonia
Fujita, J., Ohtsuki, Y., Higa, H., Azuma, M., Yoshinouchi, T., Haranaga, S., Higa, F., & Tateyama, M. (2014) · Internal Medicine · doi:10.2169/internalmedicine.53.1174 · Cited by 17 · see citing works
Cytokine storm and translating IL-6 biology into effective treatments for COVID-19
Li, T., Wang, D., Wei, H., & Xu, X. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-1044-4 · Cited by 16 · see citing works
Bhatnagar, J., Jones, T., Blau, D. M., Shieh, W., Paddock, C. D., Drew, C. P., Denison, A. M., Rollin, D. C., Patel, M. M., & Zaki, S. R. (2012) · Journal of Clinical Virology · doi:10.1016/j.jcv.2012.11.014 · Cited by 16 · see citing works
Fujimoto, Y., Hasegawa, S., Matsushige, T., Wakiguchi, H., Nakamura, T., Hasegawa, H., Nakajima, N., Ainai, A., Oga, A., Itoh, H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08030-w · Cited by 15 · see citing works
Self-citationSantana, M. F., Pinto, R. A. D. A., Marcon, B. H., Medeiros, L. C. S., de Morais, T. B. D. N., Dias, L. C., de Souza, L. P., de Melo, G. C., Monteiro, W. M., Lacerda, M., et al. (2021) · Revista da Sociedade Brasileira de Medicina Tropical · doi:10.1590/0037-8682-0850-2020 · Cited by 15 · see citing works
Aquila, I., Gratteri, S., Sacco, M. A., & Ricci, P. (2017) · Journal of Forensic Sciences · doi:10.1111/1556-4029.13639 · Cited by 15 · see citing works
Qi, Y., Wang, L., Qian, L., & Zhang, X. (2021) · Translational Pediatrics · doi:10.21037/tp-21-283 · Cited by 13 · see citing works
Zhang, L., Li, Y., Kibler, K. V., Kraberger, S. J., Varsani, A., Turk, J., Elmadbouly, N., Aliskevich, E., Spaccarelli, L., Estifanos, B., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202317376 · Cited by 12 · see citing works
Lower Respiratory Tract Myeloid Cells Harbor SARS-Cov-2 and Display an Inflammatory Phenotype
Bain, W., Peñaloza, H. F., Ladinsky, M. S., van der Geest, R., Sullivan, M. L. G., Ross, M., Kitsios, G. D., Methé, B. A., McVerry, B. J., Morris, A. M., et al. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.10.083 · Cited by 11 · see citing works
Respiratory viruses as a cause of sudden death
Garcia, M., Beby‐Defaux, A., & Lévêque, N. (2016) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2016.1157470 · Cited by 10 · see citing works
Kelly, J. N., Laloli, L., V’kovski, P., Holwerda, M., Portmann, J., Thiel, V., & Dijkman, R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.03.014282 · Cited by 7 · see citing works
Necrotizing tracheobronchitis causing airway obstruction complicated by pandemic 2009 H1N1 influenza
Chang, J., Kim, T.-O., Yoon, J., Kho, B., Shin, H., Kwon, Y. S., Kim, Y., & Lim, S. C. (2020) · Medicine · doi:10.1097/md.0000000000018647 · Cited by 9 · see citing works
Waugh, T., Ching, J. C. H., Zhou, Y., & Loewen, M. E. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.08.012 · Cited by 9 · see citing works
Nara, A., Nagai, H., Yamaguchi, R., Yoshida, K.-I., Iwase, H., & Mizuguchi, M. (2014) · American Journal of Forensic Medicine & Pathology · doi:10.1097/paf.0000000000000129 · Cited by 9 · see citing works
Moore, C., & Jones, R. (2014) · Journal of Clinical Virology · doi:10.1016/j.jcv.2014.11.031 · Cited by 8 · see citing works
Glud, H. A., Polhaus, C. H., Kristensen, C. S., Henriksen, B. L., Zhang, Y., Brogaard, L., Larsen, C. A., Trebbien, R., Larsen, L. E., Kalogeropoulos, K., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1432743 · Cited by 7 · see citing works
Shi, W., Hu, S., Zhang, H.-L., Liu, T., Zhou, S., Tang, Y.-H., Zhang, X.-L., Shi, Y., Zhang, Z., Xiong, N., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.651556 · Cited by 7 · see citing works
Wang, S., Yang, J., Sun, W., & Tao, Y. (2024) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/s12941-024-00715-1 · Cited by 6 · see citing works
Influenza A/H1N1 Severe Pneumonia: Novel Morphocytological Findings in Bronchoalveolar Lavage
Faverio, P., Aliberti, S., Ezekiel, C., Messinesi, G., Brenna, A., & Pesci, A. (2014) · Interdisciplinary Perspectives on Infectious Diseases · doi:10.1155/2014/470825 · Cited by 6 · see citing works
Corredor, G., Toro, P., Bera, K., Fu, P., Barton, L. M., Gilmore, H. L., Mukhopadhyay, S., Madabhushi, A., Rasmussen, D., Viswanathan, V. S., et al. (2021) · Journal of medical imaging · doi:10.1117/1.jmi.8.s1.017501 · Cited by 6 · see citing works
Viral Pneumonias in Forensic Autopsies
Daş, T., Sargan, A., Yağmur, G., Yıldırım, M., Topal, C. S., Gürler, A. S., Aslıyüksek, H., Arslan, M. N., & Özdemirel, R. Ö. (2016) · American Journal of Forensic Medicine & Pathology · doi:10.1097/paf.0000000000000261 · Cited by 6 · see citing works
The protein disulfide isomerase A3 and osteopontin axis promotes influenza‐induced lung remodelling
Kumar, A., Mark, Z. F., Carbajal, M. P., de Lima, D. S., Chamberlain, N., Walzer, J., Ruban, M., Chandrasekaran, R., Daphtary, N., Aliyeva, M., et al. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16511 · Cited by 6 · see citing works
Zhang, J. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.968193 · Cited by 5 · see citing works
Diagnosis and clinic-pathological findings of influenza virus infection in Brazilian pigs
Rajão, D. S., Couto, D. H., Gasparini, M. R., Costa, A. T. R., dos Reis, J. K. P., Lobato, Z. I. P., Guedes, R. M. C., & Leite, R. C. (2013) · Pesquisa Veterinária Brasileira · doi:10.1590/s0100-736x2013000100006 · Cited by 5 · see citing works
Ravenhill, B. J., Oliveira, M., Wood, G., Di, Y., Kite, J., Wang, X., Davies, C. T. R., Lu, Y., Antrobus, R., Elliott, G., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115263 · Cited by 4 · see citing works
Yu, M., Zhu, Y., Qu, X., Hou, X., Xin, T., & Li, G. (2023) · The Clinical Respiratory Journal · doi:10.1111/crj.13591 · Cited by 3 · see citing works
The Identification Distinct Antiviral Factors Regulated Influenza Pandemic H1N1 Infection
Wang, B., Zheng, H., Dong, X., Zhang, W., Wu, J., Chen, H., Zhang, J., & Zhou, A. (2024) · International Journal of Microbiology · doi:10.1155/2024/6631882 · Cited by 3 · see citing works
Emergence of HA mutants during influenza virus pneumonia.
Manríquez, M. E. V., Makino, A., Tanaka, M., Abe, Y., Yoshida, H., Morioka, I., Arakawa, S., Takeshima, Y., Iwata, K., Takasaki, J., et al. (2012) · Europe PMC (PubMed Central) · Cited by 3 · see citing works
In defence of extrapolation but not improvisation in SARS-CoV-2 lung disease
Epelbaum, O., & Galperin, I. (2020) · Breathe · doi:10.1183/20734735.0113-2020 · Cited by 3 · see citing works
Funaki, T., Shoji, K., Yotani, N., Katsuta, T., Miyazaki, O., Nosaka, S., Masaki, H., & Saitoh, A. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-516 · Cited by 3 · see citing works
Zhang, L., Li, Y., Kibler, K. V., Kraberger, S. J., Varsani, A., Turk, J., Elmadbouly, N., Aliskevich, E., Spaccarelli, L., Estifanos, B., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.09.507363 · Cited by 3 · see citing works
Liao, F., Li, S., Wu, L., Chen, J., Luo, Z., Zhong, M., Li, Q., Wang, W., & Li, G. (2025) · Pharmaceuticals · doi:10.3390/ph18091306 · Cited by 2 · see citing works
Lukashova, O. P., Граділь, Г. І., Starenkyі, V. P., Насонова, А. М., Zakrutko, A. O., & Teslenko, I. N. (2024) · Український радіологічний та онкологічний журнал · doi:10.46879/ukroj.2.2024.199-215 · Cited by 2 · see citing works
Infecção pelo vírus influenza A em suínos no sul de Moçambique
Laisse, C. J. M., Bianchi, M. V., Pereira, P. R., Lorenzo, C. D., Pavarini, S. P., & Driemeier, D. (2018) · Pesquisa Veterinária Brasileira · doi:10.1590/1678-5150-pvb-5291 · Cited by 2 · see citing works
Градиль, Г. И. (2016) · ScienceRise · doi:10.15587/2313-8416.2016.65103 · Cited by 2 · see citing works
Hayashi, K., Yoshida, H., Sato, Y., Tobiume, M., Suzuki, Y., Ariyoshi, K., Hasegawa, H., & Nakajima, N. (2016) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.jjid.2016.120 · Cited by 2 · see citing works
Self-citationA Case of H1N1 Pneumonia with Alveolar Hemorrhage that Resolved Rapidly with Steroid Therapy
Şentürk, A., Babaoğlu, E., Aykun, G., Karalezli, A., Filiz, Ç. K., & Hasanoğlu, H. C. (2013) · Respiratory Case Reports · doi:10.5505/respircase.2013.36855 · Cited by 1 · see citing works
Wang, P., Fu, J., Cheng, L., Yan, S., Wu, H. Z., Liu, F., Yao, H., Xu, L., Wu, H., & Wu, H. (2025) · Veterinary Research · doi:10.1186/s13567-025-01504-0 · Cited by 1 · see citing works
Santiago, H. J. A., Barbosa, J., & Saavedra, C. (2019) · Infectio · doi:10.22354/in.v23i2.771 · Cited by 1 · see citing works
H1N1 Influenza in Pregnancy: Yet Another Dreaded Flu
Amonkar, G. P., & Jashnani, K. D. (2022) · Springer eBooks · doi:10.1007/978-981-19-3420-9_19 · Cited by 1 · see citing works
Forgotten Resources – The Autopsy
Smith, D. S., Reed, A. E. M., & Lakhani, S. R. (2016) · Springer eBooks · doi:10.1007/978-1-4939-6643-1_15
Reporte de casos por infección de virus de Influenza A H1N1: Hallazgos de autopsia
Vásquez, E. A., Matamoros, M., & Sabillón, N. (2018) · Revista de Ciencias Forenses de Honduras · doi:10.5377/rcfh.v4i1.8697
Pathology of Severe Influenza Virus Pneumonia: What Is the Importance of Alveolar Mouths?
Ohtsuki, Y., & Fujita, J. (2020) · Respiratory disease series · doi:10.1007/978-981-15-9109-9_5
Strategies to fight COVID-19: Beyond the difference between SARS-CoV-2 and Influenza virus
Huihui, L., & Hequan, L. (2022) · International Journal of Sexual and Reproductive Health Care · doi:10.17352/ijsrhc.000034
Comparison of Chest CT Findings between COVID-19 Pneumonia and Influenza Pneumonia
Bayani, M., Asadi, M., Ghaemian, N., & Baziboroun, M. (2023) · The Russian Archives of Internal Medicine · doi:10.20514/2226-6704-2023-13-2-110-115
Study of SARS-Cov-2 using microscopy: Microscopy and its uses in challenging times
Peenya Industrial Area, P. I., & Gopal, G. (2023) · Open Journal of Clinical and Medical Images · doi:10.52768/2833-2725/1098
IgA antibodies contribute to protection against influenza virus infection
Suzuki, T., & Hasegawa, H. (2019) · Uirusu · doi:10.2222/jsv.69.153
Self-citationRavenhill, B. J., Oliveira, M., Wood, G., Di, Y., Davies, C. T. R., Lu, Y., Antrobus, R., Elliott, G., Irigoyen, N., Hughes, D. J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.04.588067
Li, W., Gao, M., Hao, Y., Chi, H., & Yu, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-76400-2
Tracheitis following Influenza A infection
Tanaka, S., Watanabe, S., Matsubayashi, R., Tamori, S., Nomura, S., & Yano, S. (2025) · Respiratory Endoscopy · doi:10.58585/respend.2025-0016
Self-citationYamaya, M., Kikuchi, A., Deng, X., Sugawara, M., Nomura, K., Hagino, A., Suzuki, J., Momma, H., Nishimura, H., Nagatomi, R., et al. (2026) · Respiratory Investigation · doi:10.1016/j.resinv.2026.101471
Yu, M., Li, S., Li, X., Qu, X., Zhu, Y., Ma, Z., Gao, Y., Han, Y., Li, G., Li, W., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10918735/v1
Karimi, S., Valiante, T. A., & Kiehl, T. (2015) · Human Pathology Case Reports · doi:10.1016/j.ehpc.2015.06.001
- Authors
- Nakajima, N., Sato, Y., Katano, H., Hasegawa, H., Kumasaka, T., Hata, S., Tanaka, S., Amano, T., Kasai, T., Chong, J.-M., Iiduka, T., Nakazato, I., Hino, Y., Hamamatsu, A., Horiguchi, H., Tanaka, T., Hasagawa, A., Kanaya, Y., Oku, R., Oya, T., & Sata, T.
- Affiliations
- National Institute of Infectious Diseases (JP)
- Japanese Red Cross Medical Center (JP)
- Nagano Red Cross Hospital (JP)
- Hokkaido University (JP)
- Uji-Tokushukai Medical Center (JP)
- Nara Medical University Hospital (JP)
- Toshima Hospital (JP)
- National Center for Global Health and Medicine (JP)
- Okinawa Prefectural Nanbu Medical Center & Children's Medical Center (JP)
- Kyoto City Hospital (JP)
- Tokyo Medical Examiner's Office (JP)
- Hitachinaka General Hospital (JP)
- Sakai City Institute of Public Health (JP)
- Odawara Municipal Hospital (JP)
- Oita Prefectural Hospital (JP)
- Japanese Red Cross Narita Hospital (JP)
- Niigata Prefectural Central Hospital (JP)
- Corresponding author
- Nakajima, Noriko
- ORCID
- Venue
- Modern Pathology
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 25
- Issue
- 1
- Pages
- 1-13
- ISSN
- 0893-3952 (ISSN-L)
- OpenAlex
- W2071039804
- Cited by
- 95
- References
- 35
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 10 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 6 · 2015: 2 · 2014: 7 · 2013: 9 · 2012: 7
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Update notices
- erratum (2012-03-01)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Modern Pathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Health, Labour and Welfare (Shinko-Ippan-014)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Autopsy Techniques and Outcomes
- Keywords
- 2009 H1N1 influenza, pandemic influenza A, lung histopathology, hyaline membranes, alveolar type II cells, viral pneumonia, tracheobronchitis, bronchopneumonia
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Antigens, Viral, Autopsy, Child, Child, Preschool, DNA Mutational Analysis, Female, Fixatives, Formaldehyde, Humans, Immunohistochemistry, Influenza, Human, Japan, Lung, Male, Middle Aged, Mutation, RNA, Viral, Time Factors, Paraffin Embedding, Tissue Fixation, Hemagglutinin Glycoproteins, Influenza Virus, Reverse Transcriptase Polymerase Chain Reaction, Influenza A Virus, H1N1 Subtype, Young Adult, Pandemics, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
