Marked reduction of soluble superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with recent-onset schizophrenia
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GSH levels are lower in chronic schizophrenia as measured in CSF, post-mortem brain, and by MRS-based in vivo imaging, and the GSH system enzymes GPX and GR are dysregulated.
“GSH levels have been shown to be lower in chronic schizophrenia, as measured in the CSF and post-mortem brain, and by MRS-based in vivo imaging 41,42 and the GSH system enzymes glutathione peroxidase (GPX) and glutathione reductase (GR) are also dysregulated 36 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [41]
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Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain
DiFiglia, M., Sapp, E., Chase, K. O., Davies, S. W., Bates, G. P., Vonsattel, J., & D, N. A. M. (1997) · Science · doi:10.1126/science.277.5334.1990 · Cited by 2,849 · see citing works
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Redox dysregulation, neurodevelopment, and schizophrenia
Do, K. Q., Cabungcal, J. H., Frank, A., Steullet, P., & Cuenod, M. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.001 · Cited by 384 · see citing works
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Self-citationUrushitani, M., Ezzi, S. A., & Julien, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606201104 · Cited by 237 · see citing works
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Aggregation of Copper–Zinc Superoxide Dismutase in Familial and Sporadic ALS
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Biomarkers in translational research of Alzheimer’s Disease
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Neuroinflammation and psychiatric illness
Najjar, S., Pearlman, D. M., Alper, K., Najjar, A., & Devinsky, O. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-43 · Cited by 733 · see citing works
Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis
Hardingham, G. E., & Do, K. Q. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.19 · Cited by 304 · see citing works
Early interventions in risk groups for schizophrenia: what are we waiting for?
Sommer, I. E., Bearden, C. E., van Dellen, E., Breetvelt, E. J., Duijff, S. N., Maijer, K., van Amelsvoort, T., de Haan, L., Gur, R. E., Arango, C., et al. (2016) · npj Schizophrenia · doi:10.1038/npjschz.2016.3 · Cited by 140 · see citing works
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Tezuka, T., Tamura, M., Kondo, M. A., Sakaue, M., Okada, K., Takemoto, K., Fukunari, A., Miwa, K., Ohzeki, H., Kano, S.-I., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.07.003 · Cited by 64 · see citing works
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- Authors
- Coughlin, J. M., Ishizuka, K., Kano, S. I., Edwards, J. A., Seifuddin, F. T., Shimano, M. A., Daley, E. L., Zandi, P. P., Leweke, F. M., Cascella, N. G., Pomper, M. G., Yolken, R. H., & Sawa, A.
- Affiliations
- Johns Hopkins University (US)
- Heidelberg University (DE)
- Corresponding author
- Sawa, A
- ORCID
- Venue
- Molecular Psychiatry
- Published
- 2012-02-21
- Volume
- 18
- Issue
- 1
- Pages
- 10-11
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC4113962
- OpenAlex
- W2078552320
- Cited by
- 66
- References
- 10
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 8 · 2016: 11 · 2015: 9 · 2014: 6 · 2013: 3
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50MH094268, R01MH092443)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Keywords
- SOD1, cerebrospinal fluid, recent-onset schizophrenia, oxidative stress, biomarkers
- MeSH terms
- Superoxide Dismutase-1, Adult, Female, Follow-Up Studies, Humans, Male, Peptide Fragments, Psychiatric Status Rating Scales, Schizophrenia, Superoxide Dismutase, Linear Models, Case-Control Studies, Amyloid beta-Peptides, Young Adult
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