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Evidence for neuroplastic compensation in the cerebral cortex of persons with depressive illness

Bansal, R, Hellerstein, D J, Peterson, B S·2018·Molecular Psychiatry

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  • Evidence suggests that CBT or medication can modify the cascade of responses to real or perceived threat - CBT by altering behavioral avoidance and information processing related to threat detection and coping, and medication by altering neurotransmitter levels that affect the function and structure of brain circuits.

    “Evidence suggests that CBT or medication can modify the cascade of responses to real or perceived threat – CBT by altering behavioral avoidance and information processing related to threat detection and coping [56, 57], and medication by altering neurotransmitter levels that affect the function and structure of brain circuits [58–60].”

    From A Sequential Multiple Assignment Randomized Trial (SMART) study of medication and CBT sequencing in the treatment of pediatric anxiety disorders (2021) · cites this paper as [59]

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  • The few imaging studies combined with an RCT design have shown that SSRIs/SNRIs normalize pre-existing abnormalities in brain structure, function, and metabolism.

    “The few imaging studies that have been combined with an RCT design to provide stronger causal inference of the effects of these medications have shown that they normalize pre-existing abnormalities in brain structure [59], function [60], and metabolism [123].”
  • It is highly probable that medication mechanisms are initiated by effects on altering neurotransmitter levels, which in turn affect the function and structure of brain circuits.

    “It is highly probable, however, that those mechanisms are initiated by the effects that medication has on altering neurotransmitter levels, which in turn affect the function and structure of brain circuits [58–60].”

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Authors
Bansal, R., Hellerstein, D. J., & Peterson, B. S.
Venue
Molecular Psychiatry
Published
2017-03-07
Volume
23
Issue
2
Pages
375-383
ISSN
  • 1359-4184
  • 1476-5578
Cited by
38
References
8
Language
en

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