The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A stele‐enriched gene regulatory network in the Arabidopsis root
Open accessAbstract
Tightly controlled gene expression is a hallmark of multicellular development and is accomplished by transcription factors (TFs) and microRNAs (miRNAs). Although many studies have focused on identifying downstream targets of these molecules, less is known about the factors that regulate their differential expression. We used data from high spatial resolution gene expression experiments and yeast one-hybrid (Y1H) and two-hybrid (Y2H) assays to delineate a subset of interactions occurring within a gene regulatory network (GRN) that determines tissue-specific TF and miRNA expression in plants. We find that upstream TFs are expressed in more diverse cell types than their targets and that promoters that are bound by a relatively large number of TFs correspond to key developmental regulators. The regulatory consequence of many TFs for their target was experimentally determined using genetic analysis. Remarkably, molecular phenotypes were identified for 65% of the TFs, but morphological phenotypes were associated with only 16%. This indicates that the GRN is robust, and that gene expression changes may be canalized or buffered.
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CANALIZATION OF DEVELOPMENT AND THE INHERITANCE OF ACQUIRED CHARACTERS
WADDINGTON, C. H. (1942) · Nature · doi:10.1038/150563a0 · Cited by 3,255
The IntAct molecular interaction database in 2010
Aranda, B., Achuthan, P., Alam-Faruque, Y., Armean, I., Bridge, A., Derow, C., Feuermann, M., Ghanbarian, A. T., Kerrien, S., Khadake, J., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp878 · Cited by 620
Insights from genomic profiling of transcription factors
Farnham, P. J. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2636 · Cited by 519
Smith, J., & Davidson, E. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806442105 · Cited by 69
Cited by
The Plant Vascular System: Evolution, Development and Functions F
Lucas, W. J., Groover, A., Lichtenberger, R., Furuta, K., Yadav, S., Helariutta, Y., He, X., Fukuda, H., Kang, J., Brady, S. M., et al. (2013) · Journal of Integrative Plant Biology · doi:10.1111/jipb.12041 · Cited by 772
Self-citationMacNeil, L. T., & Walhout, A. J. M. (2011) · Genome Research · doi:10.1101/gr.097378.109 · Cited by 365
Self-citationStem cell function during plant vascular development
Miyashima, S., Sebastian, J., Lee, J., & Helariutta, Y. (2013) · The EMBO Journal · doi:10.1038/emboj.2012.301 · Cited by 295
Tian, C., Zhang, X., He, J., Yu, H., Wang, Y., Shi, B., Han, Y., Wang, G., Feng, X., Zhang, C., et al. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145470 · Cited by 133
Metadata
- Authors
- Brady, S. M., Zhang, L., Megraw, M., Martinez, N. J., Jiang, E., Yi, C. S., Liu, W., Zeng, A., Taylor‐Teeples, M., Kim, D., Ahnert, S., Ohler, U., Ware, D., Walhout, A. J. M., & Benfey, P. N.
- Venue
- Molecular Systems Biology
- Published
- 2011-01
- Volume
- 7
- Issue
- 1
- Pages
- 459-459
- ISSN
- 1744-4292 (ISSN-L)
- OpenAlex
- W2141440692
- Cited by
- 169
- References
- 4
- FWCI
- 25.07
- Type
- journal article
- Language
- en
- Open access
- gold
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- Brady, S. M., Zhang, L., Megraw, M., Martinez, N. J., Jiang, E., Yi, C. S., Liu, W., Zeng, A., Taylor‐Teeples, M., Kim, D., Ahnert, S., Ohler, U., Ware, D., Walhout, A. J. M., & Benfey, P. N. (2011). A stele‐enriched gene regulatory network in the Arabidopsis root. Molecular Systems Biology. https://doi.org/10.1038/msb.2010.114
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