The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology
Open accessAbstract
We present HepatoNet1, the first reconstruction of a comprehensive metabolic network of the human hepatocyte that is shown to accomplish a large canon of known metabolic liver functions. The network comprises 777 metabolites in six intracellular and two extracellular compartments and 2539 reactions, including 1466 transport reactions. It is based on the manual evaluation of >1500 original scientific research publications to warrant a high‐quality evidence‐based model. The final network is the result of an iterative process of data compilation and rigorous computational testing of network functionality by means of constraint‐based modeling techniques. Taking the hepatic detoxification of ammonia as an example, we show how the availability of nutrients and oxygen may modulate the interplay of various metabolic pathways to allow an efficient response of the liver to perturbations of the homeostasis of blood compounds.
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Cites
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“Hitherto, constraint-based modeling approaches for study of metabolism is much more advanced in unicellular systems”
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Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280
Self-citationSingle-cell spatial reconstruction reveals global division of labour in the mammalian liver
Halpern, K. B., Shenhav, R., Matcovitch-Natan, O., Tóth, B., Lemze, D., Golan, M., Massasa, E. E., Baydatch, S., Landen, S., Moor, A. E., et al. (2017) · Nature · doi:10.1038/nature21065 · Cited by 1,059
A community-driven global reconstruction of human metabolism
Thiele, I., Swainston, N., Fleming, R. M. T., Hoppe, A., Sahoo, S., Aurich, M. K., Haraldsdottir, H., Mo, M. L., Rolfsson, O., Stobbe, M. D., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2488 · Cited by 1,019
Self-citationConstraining the metabolic genotype–phenotype relationship using a phylogeny of in silico methods
Lewis, N. E., Nagarajan, H., & Palsson, B. O. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2737 · Cited by 779
The gut microbiota modulates host amino acid and glutathione metabolism in mice
Mardinoglu, A., Shoaie, S., Bergentall, M., Ghaffari, P., Zhang, C., Larsson, E., Bäckhed, F., & Nielsen, J. (2015) · Molecular Systems Biology · doi:10.15252/msb.20156487 · Cited by 383
Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions
Blais, E. M., Rawls, K. D., Dougherty, B. V., Li, Z. I., Kolling, G. L., Ye, P., Wallqvist, A., & Papin, J. A. (2017) · Nature Communications · doi:10.1038/ncomms14250 · Cited by 182
Using the reconstructed genome-scale human metabolic network to study physiology and pathology
Bordbar, A., & Palsson, B. O. (2012) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02494.x · Cited by 115
Genome-scale models in human metabologenomics
Mardinoglu, A., & Palsson, B. Ø. (2025) · Nature Reviews Genetics · doi:10.1038/s41576-024-00768-0 · Cited by 54
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Nogiec, C., Burkart, A., Dreyfuss, J. M., Lerin, C., Kasif, S., & Patti, M.-E. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2014.12.012 · Cited by 34
Advanced stoichiometric analysis of metabolic networks of mammalian systems
Orman, M. A., Berthiaume, F., Androulakis, I. P., & Ierapetritou, M. G. (2011) · Critical Reviews™ in Biomedical Engineering · doi:10.1615/critrevbiomedeng.v39.i6.30 · Cited by 32
Metadata
- Authors
- Gille, C., Bölling, C., Hoppe, A., Bulik, S., Hoffmann, S., Hübner, K., Karlstädt, A., Ganeshan, R., König, M., Rother, K., Weidlich, M., Behre, J., & Holzhütter, H.
- Venue
- Molecular Systems Biology
- Published
- 2010-01
- Volume
- 6
- Issue
- 1
- Pages
- 411-411
- ISSN
- 1744-4292 (ISSN-L)
- OpenAlex
- W1969067437
- Cited by
- 285
- References
- 7
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- gold
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