Using the reconstructed genome-scale human metabolic network to study physiology and pathology
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Abstract. Bordbar A, Palsson BO (University of California San Diego, La Jolla, CA, USA). Using the reconstructed genome‐scale human metabolic network to study physiology and pathology (Key Symposium). J Intern Med 2012; 271: 131–141. Metabolism plays a key role in many major human diseases. Generation of high‐throughput omics data has ushered in a new era of systems biology. Genome‐scale metabolic network reconstructions provide a platform to interpret omics data in a biochemically meaningful manner. The release of the global human metabolic network, Recon 1, in 2007 has enabled new systems biology approaches to study human physiology, pathology and pharmacology. There are currently more than 20 publications that utilize Recon 1, including studies of cancer, diabetes, host–pathogen interactions, heritable metabolic disorders and off‐target drug binding effects. In this mini‐review, we focus on the reconstruction of the global human metabolic network and four classes of its application. We show that computational simulations for numerous pathologies have yielded clinically relevant results, many corroborated by existing or newly generated experimental data.
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The global human metabolic network Recon 1 was released in 1997.
“A good example of this is the global human metabolic network, Recon 1, which was released in 1997 (308).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [308]
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- Authors
- Bordbar, A., & Palsson, B. O.
- Affiliations
- University of California San Diego (US)
- ORCID
- Bordbar, A.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2012-01-17
- Volume
- 271
- Issue
- 2
- Pages
- 131-141
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- PMC
- PMC3243107
- OpenAlex
- W1869952022
- Cited by
- 115
- References
- 78
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 16 · 2015: 15 · 2014: 12 · 2013: 14 · 2012: 12
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM068837, R01GM068837)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- genome-scale metabolic reconstruction, human metabolism, metabolic modeling, systems biology, cancer metabolism, diabetes mellitus, host-pathogen interaction, metabolic physiology, metabolic disorders
- MeSH terms
- Chromosome Mapping, Computer Simulation, Humans, Metabolic Diseases, Metabolism, Models, Biological, Phenotype, Genome, Human, Systems Biology, Metabolomics
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