The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Cell type‐specific nuclear pores: a case in point for context‐dependent stoichiometry of molecular machines
Open accessAbstract
To understand the structure and function of large molecular machines, accurate knowledge of their stoichiometry is essential. In this study, we developed an integrated targeted proteomics and super‐resolution microscopy approach to determine the absolute stoichiometry of the human nuclear pore complex (NPC), possibly the largest eukaryotic protein complex. We show that the human NPC has a previously unanticipated stoichiometry that varies across cancer cell types, tissues and in disease. Using large‐scale proteomics, we provide evidence that more than one third of the known, well‐defined nuclear protein complexes display a similar cell type‐specific variation of their subunit stoichiometry. Our data point to compositional rearrangement as a widespread mechanism for adapting the functions of molecular machines toward cell type‐specific constraints and context‐dependent needs, and highlight the need of deeper investigation of such structural variants.
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Cites
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS
Gerber, S. A., Rush, J., Stemman, O., Kirschner, M. W., & Gygi, S. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0832254100 · Cited by 1,733
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Picotti, P., Bodenmiller, B., Mueller, L. N., Domon, B., & Aebersold, R. (2009) · Cell · doi:10.1016/j.cell.2009.05.051 · Cited by 744
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The Human Nuclear Pore Complex as Revealed by Cryo-Electron Tomography
Maimon, T., Elad, N., Dahan, I., & Medalia, O. (2012) · Structure · doi:10.1016/j.str.2012.03.025 · Cited by 196
Cited by
Mass-spectrometry-based draft of the human proteome
Wilhelm, M., Schlegl, J., Hahne, H., Gholami, A. M., Lieberenz, M., Savitski, M. M., Ziegler, E., Butzmann, L., Gessulat, S., Marx, H., et al. (2014) · Nature · doi:10.1038/nature13319 · Cited by 1,820
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
Geiger, R., Rieckmann, J. C., Wolf, T., Basso, C., Feng, Y., Fuhrer, T., Kogadeeva, M., Picotti, P., Meissner, F., Mann, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.031 · Cited by 1,775
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome
Huttlin, E. L., Bruckner, R. J., Navarrete-Perea, J., Cannon, J. R., Baltier, K., Gebreab, F., Gygi, M. P., Thornock, A., Zarraga, G., Tam, S., et al. (2020) · doi:10.1101/2020.01.19.905109 · Cited by 960
Probing nuclear pore complex architecture with proximity-dependent biotinylation
Kim, D. I., KC, B., Zhu, W., Motamedchaboki, K., Doye, V., & Roux, K. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406459111 · Cited by 560
The Structure of the Nuclear Pore Complex (An Update)
Lin, D. H., & Hoelz, A. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062917-011901 · Cited by 478
Metadata
- Authors
- Ori, A., Banterle, N., Iskar, M., Andrés‐Pons, A., Escher, C., Khanh Bui, H., Sparks, L., Solis‐Mezarino, V., Rinner, O., Bork, P., Lemke, E. A., & Beck, M.
- Venue
- Molecular Systems Biology
- Published
- 2013-01
- Volume
- 9
- Issue
- 1
- Pages
- 648-648
- ISSN
- 1744-4292 (ISSN-L)
- OpenAlex
- W2171135008
- Cited by
- 315
- References
- 4
- FWCI
- 13.58
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ori, A., Banterle, N., Iskar, M., Andrés‐Pons, A., Escher, C., Khanh Bui, H., Sparks, L., Solis‐Mezarino, V., Rinner, O., Bork, P., Lemke, E. A., & Beck, M. (2013). Cell type‐specific nuclear pores: a case in point for context‐dependent stoichiometry of molecular machines. Molecular Systems Biology. https://doi.org/10.1038/msb.2013.4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
